Probiotics as an Alternative Food Therapy

Antibiotics have been responsible for the evolution of multidrug-resistant microbes. The side-effects of existing drugs and increased treatment costs have led to nutraceuticals gaining popularity. Nutraceuticals have therapeutic applications due to the ability of the probiotics to be viable in encapsulated pills and drinks. Due to their ability to exclude carcinogenic microorganisms by limiting the nutrients available and by competing for receptors nutraceuticals are useful against cancers. Nutraceuticals are useful against diabetes by controlling the genes involved in the insulin-signaling pathway. The future perspective for nutraceuticals includes an increase in production, reduction in manufacturing cost, and enhanced benefits.

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Probiotics as an Alternative Food Therapy

Advances in Environmental Engineering and Green Technologies - Technological Developments in Food Preservation, Processing, and Storage ◽

10.4018/978-1-7998-1924-0.ch006 ◽

2020 ◽

pp. 97-127

Author(s):

Thejaswi Bhandary ◽

Monisha M ◽

Ilavarasan Vickraman ◽

Paari K. A.

Keyword(s):

Side Effects ◽

Signaling Pathway ◽

Insulin Signaling ◽

Multidrug Resistant ◽

Treatment Costs ◽

Insulin Signaling Pathway ◽

Alternative Food ◽

Future Perspective ◽

Manufacturing Cost ◽

Therapeutic Applications

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Faculty Opinions recommendation of Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717147814.792402971 ◽

2012 ◽

Author(s):

Roger McIntyre

Keyword(s):

Side Effects ◽

Signaling Pathway ◽

Antipsychotic Drug ◽

Insulin Signaling ◽

Insulin Signaling Pathway ◽

Therapeutic Effects ◽

Metabolic Side Effects

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Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway

Molecular Psychiatry ◽

10.1038/mp.2008.40 ◽

2008 ◽

Vol 13 (10) ◽

pp. 918-929 ◽

Cited By ~ 68

Author(s):

R R Girgis ◽

J A Javitch ◽

J A Lieberman

Keyword(s):

Side Effects ◽

Signaling Pathway ◽

Antipsychotic Drug ◽

Insulin Signaling ◽

Insulin Signaling Pathway ◽

Therapeutic Effects ◽

Metabolic Side Effects

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Faculty Opinions recommendation of The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020955.240571 ◽

2004 ◽

Author(s):

Michael Hall

Keyword(s):

Life Span ◽

Larval Development ◽

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Signaling Pathway ◽

Tor Pathway ◽

C Elegans

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Faculty Opinions recommendation of Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031392.365635 ◽

2006 ◽

Author(s):

Daniel Klionsky

Keyword(s):

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Signaling Pathway

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The potential antioxidant ability of hydroxytyrosol on Caenorhabditis elegans against oxidative damage via the insulin signaling pathway

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2021.103149 ◽

2021 ◽

Vol 14 (6) ◽

pp. 103149

Author(s):

Yujie Wang ◽

Siyuan Luo ◽

Zhou Xu ◽

Li Liu ◽

Shiling Feng ◽

...

Keyword(s):

Caenorhabditis Elegans ◽

Oxidative Damage ◽

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Signaling Pathway ◽

Antioxidant Ability

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Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol

Nutrients ◽

10.3390/nu13072268 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2268

Author(s):

Dina Medina-Vera ◽

Juan Antonio Navarro ◽

Rubén Tovar ◽

Cristina Rosell-Valle ◽

Alfonso Gutiérrez-Adan ◽

...

Keyword(s):

Oral Administration ◽

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Response ◽

Pharmacological Action ◽

Akt Signaling ◽

Insulin Signaling Pathway ◽

Acute Administration ◽

Insulin Sensitizer ◽

Peripheral Tissues

D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the hypothalamic insulin signaling pathway. To this end we investigated the Phosphatidylinositol-3-kinase (PI3K)/Protein Kinase B (Akt) signaling cascade in a rat model following oral administration of DPIN. The PI3K/Akt-associated proteins were quantified by Western blot in terms of phosphorylation and total expression. Results indicate that the acute administration of DPIN induced time-dependent phosphorylation of PI3K/Akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. This profile is consistent with DPIN as an insulin sensitizer since we also found a decrease in the circulating concentration of this hormone. Overall, the present study shows the pharmacological action of DPIN in the hypothalamus through the PI3K/Akt pathway when giving in fasted animals. These findings suggest that DPIN might be a candidate to treat brain insulin-resistance associated disorders by activating insulin response beyond the insulin receptor.

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