Non Invasive Electrophysiological Evaluation of Brugada Type ECG and Early Repolarization Potential in Healthy Young People

Aim. To investigate the state of systemic hemodynamics (SHD) in young people to assess the potential impact of its disorders in the formation of arterial hypertension (AH) and to carry out preventive measures.Methods. A random sample of 91 young people from 17 to 25 years old was examined; 27 of them were men (average age 23.7±1.6 years) and 64 women (average age 20.4±1.1 years). The study involved clinical residents and students who, according to preliminary and periodic medical examinations, excluded the presence of cardiovascular diseases. The indicators of SHD were investigated by the method of volumetric compression oscillometry using a portable automated software and hardware complex for non-invasive research of central hemodynamics (Device “CAP TsG osm-“Globus”).Results. AH was detected in 4.4%; “white coat” AH in 8.79%; arterial hypotension – in 5.49%. In individuals with normal blood pressure (BP) (75 people), an increase in specific peripheral vascular resistance was most often revealed in 30.6%. An unchanged hemodynamic profile in the group with a normal BP level was recorded only in 28.0% of the examinees.Conclusion. The obtained results indicate that even among “healthy” young people aged 18- 25 years with a normal BP level, the proportion of people with impaired SHD values is 72%. People with hypertension and with altered SHD indicators should be included in the regular medical check-up observation group.

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Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review

Systematic Reviews ◽

10.1186/s13643-021-01627-3 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Yael D. Lewis ◽

Lucy Gallop ◽

Iain C. Campbell ◽

Ulrike Schmidt

Keyword(s):

Systematic Review ◽

Young People ◽

Psychiatric Disorders ◽

Brain Stimulation ◽

Grey Literature ◽

Significant Proportion ◽

Clinical Effects ◽

Children And Young People ◽

Non Invasive ◽

Specific Symptoms

Abstract Background Most psychiatric disorders have their onset in childhood or adolescence, and if not fully treated have the potential for causing life-long psycho-social and physical sequelae. Effective psychotherapeutic and medication treatments exist, but a significant proportion of children and young people do not make a full recovery. Thus, novel, safe, brain-based alternatives or adjuncts to conventional treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation (NIBS) techniques which have shown clinical benefits in adult psychiatric conditions. However, in children and young people their efficacy is not well established. The objective of this study will be to systematically evaluate the evidence on clinical effects of NIBS in children and young people with psychiatric disorders, assessing disorder-specific symptoms, mood and neurocognitive functions. Methods We designed and registered a study protocol for a systematic review. We will include randomised and non-randomised controlled trials and observational studies (e.g. cohort, case-control, case series) assessing the effects of NIBS in children and young people (aged ≤ 24 years old) for psychiatric disorders. The primary outcome will be reduction of disorder-specific symptoms. Secondary outcomes will include effects on mood and cognition. A comprehensive search from database inception onwards will be conducted in MEDLINE, EMBASE and PsycINFO. Grey literature will be identified through searching multiple clinical trial registries. Two reviewers will independently screen all citations, full-text articles and abstract data. The methodological quality of the studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence and according to heterogeneity will conduct an appropriate meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity. Discussion This systematic review will provide a broad and comprehensive evaluation of the evidence on clinical effects of NIBS in children and young people with psychiatric disorders. Our findings will be reported according to the PRISMA guidelines and will be of interest to multiple audiences (including patients, researchers, healthcare professionals and policy-makers). Results will be published in a peer-reviewed journal. Systematic review registration PROSPERO CRD42019158957

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Visual Attention and Aging: an Age-Related Cognitive Model of Positive Adaptation

European Journal of Investigation in Health, Psychology and Education ◽

10.3390/ejihpe4030017 ◽

2014 ◽

Vol 4 (3) ◽

pp. 181-191

Author(s):

José Manuel Rodríguez-Ferrer

Keyword(s):

Young People ◽

Visual Attention ◽

Response Times ◽

Age Groups ◽

Cognitive Model ◽

Covert Attention ◽

Positive Adaptation ◽

Healthy Elderly ◽

Age Related ◽

Healthy Young People

We have studied the effects of normal aging on visual attention. Have participated a group of 38 healthy elderly people with an average age of 67.8 years and a group of 39 healthy young people with average age of 19.2 years. In a first experiment of visual detection, response times were recorded, with and without covert attention, to the presentation of stimuli (0.5º in diameter grey circles) appearing in three eccentricities (2.15, 3.83 and 5.53° of visual field) and with three levels of contrast (6, 16 and 78%). In a second experiment of visual form discrimination circles and squares with the same features as in the previous experiment were presented, but in this case subjects only should respond to the emergence of the circles. In both age groups, the covert attention reduced response times. Compared to young people, the older group achieved better results in some aspects of attention tests and response times were reduced more in the stimuli of greater eccentricity. The data suggest that there is a mechanism of adaptation in aging, in which visual attention especially favors the perception of those stimuli more difficult to detec

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EFFECTS OF MOTION WITH UNSUPPORTED ARM ELEVATION AND GENDER DIFFERENCES ON OXYGEN UPTAKE AND VENTILATION DURING LOW-LOAD ADL IN HEALTHY YOUNG PEOPLE

CHEST Journal ◽

10.1016/j.chest.2021.07.1917 ◽

2021 ◽

Vol 160 (4) ◽

pp. A2170

Author(s):

Miki Takahata ◽

Michiyasu Yamaki ◽

Toshiaki Sato

Keyword(s):

Gender Differences ◽

Young People ◽

Oxygen Uptake ◽

Low Load ◽

Healthy Young People ◽

Arm Elevation ◽

And Gender

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On the issue of sudden death while swimming

Kazan medical journal ◽

10.17816/kazmj50614 ◽

1935 ◽

Vol 31 (3-4) ◽

pp. 538-538

Author(s):

E. Strauge

Keyword(s):

Young People ◽

Sudden Death ◽

Clinical Observation ◽

Sensitive Skin ◽

Healthy Young People

Based on the experience gained with a single clinical observation, the author concludes that the sudden death of healthy young people during swimming is in some cases due to shock caused by the absorption of toxic amounts of H-substants (histamine), which are released in the overly sensitive skin due to cooling.

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Perceived exertion and energy expenditure during physical activities in healthy young people and older adults

Folia Medica ◽

10.3897/folmed.63.e56679 ◽

2021 ◽

Vol 63 (4) ◽

pp. 502-510

Author(s):

Oyéné Kossi ◽

Justine Lacroix ◽

Maxence Compagnat ◽

Jean Christophe Daviet ◽

Stéphane Mandigout

Keyword(s):

Older Adults ◽

Young People ◽

Energy Expenditure ◽

Perceived Exertion ◽

Cross Sectional Study ◽

Rating Of Perceived Exertion ◽

Treadmill Running ◽

Single Session ◽

Cross Sectional ◽

Healthy Young People

Aim: To test the validity of Borg’s 6–20 rating of perceived exertion scale in assessing the exertion intensity over a multi-activity session in young and older adults.Materials and methods: This cross-sectional study included 56 healthy participants. All participants underwent a single session of activities including working on a computer, treadmill walking, biking, and treadmill running. Results: Results showed a non-significant correlation between the overall perceived exertion and energy expenditure in young people (Rho=−0.05, p=0.75) and in older adults (Rho=−0.05, p=0.78) for the whole session. However, results showed that older adults perceived significantly higher exertion compared to young people while working on a computer, walking and running, whereas they presented lower energy expenditure while resting and working on a computer. Conclusions: Combining the perceived exertion method with other commonly used methods to estimate exercise intensity would be recommended for older adults.

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Reactive Response of Older Tennis Practitioners and Healthy Young People in Relation to Balance Perturbations

Journal of Science in Sport and Exercise ◽

10.1007/s42978-021-00130-4 ◽

2021 ◽

Author(s):

Nathana Alves de França ◽

Lucca Zambuzzi Nardin do Nascimento ◽

Caluê Papcke ◽

Eduardo Mendonça Scheeren

Keyword(s):

Young People ◽

Healthy Young People

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Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise Healthy Young People Who Use Electronic Cigarettes in a Cross‐Sectional Single‐Center Study: Implications for Future Cardiovascular Risk

Journal of the American Heart Association ◽

10.1161/jaha.120.016983 ◽

2020 ◽

Vol 9 (18) ◽

Cited By ~ 2

Author(s):

Theodoros Kelesidis ◽

Elizabeth Tran ◽

Sara Arastoo ◽

Karishma Lakhani ◽

Rachel Heymans ◽

...

Keyword(s):

Oxidative Stress ◽

Young People ◽

Dose Response ◽

Fluorescent Probes ◽

Immune Cell ◽

Electronic Cigarettes ◽

Study Groups ◽

Cross Sectional ◽

Premature Cardiovascular Disease ◽

Healthy Young People

Background Tobacco cigarettes (TCs) increase oxidative stress and inflammation, both instigators of atherosclerotic cardiac disease. It is unknown if electronic cigarettes (ECs) also increase immune cell oxidative stress. We hypothesized an ordered, “dose‐response” relationship, with tobacco‐product type as “dose” (lowest in nonsmokers, intermediate in EC vapers, and highest in TC smokers), and the “response” being cellular oxidative stress (COS) in immune cell subtypes, in otherwise, healthy young people. Methods and Results Using flow cytometry and fluorescent probes, COS was determined in immune cell subtypes in 33 otherwise healthy young people: nonsmokers (n=12), EC vapers (n=12), and TC smokers (n=9). Study groups had similar baseline characteristics, including age, sex, race, and education level. A dose‐response increase in proinflammatory monocytes and lymphocytes, and their COS content among the 3 study groups was found: lowest in nonsmokers, intermediate in EC vapers, and highest in TC smokers. These findings were most striking in CD14 dim CD16 + and CD14 ++ CD16 + proinflammatory monocytes and were reproduced with 2 independent fluorescent probes of COS. Conclusions These findings portend the development of premature cardiovascular disease in otherwise healthy young people who chronically vape ECs. On the other hand, that the COS is lower in EC vapers compared with TC smokers warrants additional investigation to determine if switching to ECs may form part of a harm‐reduction strategy. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03823885.

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