Assess the Effect of the Foot and Mouth Disease Type O Inactivated Vaccine (O/MYA98/BY/2010 Strain) for Pigs

2012 ◽  
Vol 468-471 ◽  
pp. 365-369 ◽  
Author(s):  
Ke Bin Li ◽  
Jian Ping Liang
Keyword(s):  
Adverse Reactions ◽  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Disease Type ◽  
Mouth Disease ◽  
Inactivated Vaccine ◽  
Serum Samples ◽  
Animal Damage ◽  
Foot And Mouth ◽  
The Individual

Recently, O-type foot and mouth disease epidemic situation has changed, there has been MYA98 epidemic strains, has caused many Asian countries for many kinds of animal damage. In January 2011, a new matching vaccine developed, namely Foot and mouth disease type O inactivated vaccine (O/MYA98/BY/2010 strain). In order to master this vaccine effectiveness in pig production, all the individual pigs in the ten farms had been immunized.A total of 97786 individuals or times immunized pigs were observed. All pigs were traced surveillance for foot and mouth clinical signs. A total of 295 serum samples were detected for antibody titers.The results show that although there adverse side effects, but other than the vaccine adverse reactions and extent has significantly decreased, pigs immunized were non-occurrence of type O foot and mouth disease, the antibody titer is eligible. So here we show , the vaccine is safe and effective, can be widely used.

scholarly journals Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle

2015 ◽  
Vol 23 (2) ◽  
pp. 125-136 ◽  
Author(s):  
Gisselle N. Medina ◽  
Nestor Montiel ◽  
Fayna Diaz-San Segundo ◽  
Diego Sturza ◽  
Elizabeth Ramirez-Medina ◽  
...  
Keyword(s):  
Cultured Cells ◽  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Adenovirus Vector ◽  
Human Adenovirus ◽  
Mouth Disease ◽  
Cell Mediated Immunity ◽  
Serum Samples ◽  
Vector Vaccine ◽  
Foot And Mouth

ABSTRACTNovel vaccination approaches against foot-and-mouth disease (FMD) include the use of replication-defective human adenovirus type 5 (Ad5) vectors that contain the capsid-encoding regions of FMD virus (FMDV). Ad5 containing serotype A24 capsid sequences (Ad5.A24) has proved to be effective as a vaccine against FMD in livestock species. However, Ad5-vectored FMDV serotype O1 Campos vaccine (Ad5.O1C.2B) provides only partial protection of cattle against homologous challenge. It has been reported that a fiber-modified Ad5 vector expressing Arg-Gly-Asp (RGD) enhances transduction of antigen-presenting cells (APC) in mice. In the current study, we assessed the efficacy of a fiber-modified Ad5 (Adt.O1C.2B.RGD) in cattle. Expression of FMDV capsid proteins was superior in cultured cells infected with the RGD-modified vector. Furthermore, transgene expression of Adt.O1C.2B.RGD was enhanced in cell lines that constitutively express integrin αvβ6, a known receptor for FMDV. In contrast, capsid expression in cattle-derived enriched APC populations was not enhanced by infection with this vector. Our data showed that vaccination with the two vectors yielded similar levels of protection against FMD in cattle. Although none of the vaccinated animals had detectable viremia, FMDV RNA was detected in serum samples from animals with clinical signs. Interestingly, CD4+and CD8+gamma interferon (IFN-γ)+cell responses were detected at significantly higher levels in animals vaccinated with Adt.O1C.2B.RGD than in animals vaccinated with Ad5.O1C.2B. Our results suggest that inclusion of an RGD motif in the fiber of Ad5-vectored FMD vaccine improves transgene delivery and cell-mediated immunity but does not significantly enhance vaccine performance in cattle.

scholarly journals Clinical signs of foot and Mouth disease in flick of Saanen goats in the village of N. Sofiko

2018 ◽  
Vol 51 (1) ◽  
pp. 69
Author(s):  
G. L. MAVRIDIS (Γ.Λ.ΜΑΥΡΙΔΗΣ)
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Way Of Life ◽  
Serum Samples ◽  
Sheep And Goats ◽  
Foot And Mouth ◽  
Foot Disease ◽  
The Village ◽  
Positive Results

This research describes the clinical signs of foot and mouth disease (type O), observed for ten days in a isolated flick of Saanen goats in the village of N. Sofiko, Prefecture of Evros, in August 1994. The disease appeared in Evros ten years after the last incident of foot and Mouth disease in two herbs of cattle in Delta of Evros in 1984. Young animals (kids) were affected by the disease first and the older ones presented clinical signs in the following five or six days. Nearly every animal presented a high fever (up to 41,9) diarrhoea, frothy nasal and oral secretion, lacrimation, small vesicles and necrosis of the mucosal membranes of the oral cavity. The serological research, gave positive results for 3 animals in a herd for cattle, located 10 Km far from the focus of the disease. Sera from 45 sheep and goats in 14 flocks, gave also positive results, but no clinical signs were observed. Finally, the goats of the flock affected by mouth and foot disease, were killed as well as the animals of a sheep flock and a cattle herd. Those sheep and cattle browsed in the same field with the goats affected by the disease and serum samples taken from them, gave positive results. Besides, all sheep and goats in the limits of protective and supervision zone having title >200, were lifted according to the Headship's of Veterinary Service in Evros decision, so the region returned to its former way of life.

scholarly journals Hematological and serum biochemical profile in cattle experimentally infected with foot-and-mouth disease virus

2020 ◽  
Vol 13 (3) ◽  
pp. 426-432
Author(s):  
S. Saravanan ◽  
V. Umapathi ◽  
M. Priyanka ◽  
M. Hosamani ◽  
B. P. Sreenivasa ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Feed Water ◽  
Serum Samples ◽  
Cardiac Damage ◽  
Infectious Dose ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Serum Biochemical

Background and Aim: Foot-and-mouth disease (FMD) is an acute viral infection affecting cloven-hoofed animals causing vesicular erosions in the oral cavity and interdigital space. The present study was undertaken to ascertain the time-dependent changes in clinical, hematological, and biochemical profiles in different breeds of cattle following experimental infection. Materials and Methods: The animals were inoculated with 1.0×104 50% bovine tongue infectious dose (BTID50) by intradermolingual route. Clinical signs were observed, and blood/serum samples were collected at different time intervals. Results: The white blood cell count declined sharply on days 7-13 and recovered on day 14 post-FMD infection. Biochemical analysis of serum markers for vital organ profile revealed no marked damage. However, a significant increase in blood urea nitrogen (BUN) value indicated pre-renal azotemia. Transient hyperthyroidism was indicated by the rise in T3 and T4 that can be correlated with a decrease in triglyceride and total cholesterol levels. In the cardiac damage assessment study, a distinct breed difference was observed wherein Malnad Gidda calves showed no cardiac damage. Conclusion: Except thyroid profile, BUN, and creatine kinase-myocardial band, all other serum biochemical parameters showed no significant abnormalities, whereas lymphopenia is the only hematological change and it is suggested that effective ameliorative measures should be targeted mainly on the feed/water intake, thyroid gland, and the level of lymphocytes.

scholarly journals Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease

2019 ◽  
Vol 20 (6) ◽  
pp. 1256 ◽  
Author(s):  
Mohd Anasir ◽  
Chit Poh
Keyword(s):  
Neutralizing Antibodies ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antigenic Peptide ◽  
Effective Vaccine ◽  
Inactivated Vaccine ◽  
Antigenic Peptides ◽  
Foot And Mouth ◽  
Etiological Agents

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents.

scholarly journals A serological evaluation of 1979–1982 Kenyan foot-and-mouth disease type SAT 2 viruses

1983 ◽  
Vol 91 (2) ◽  
pp. 335-341 ◽  
Author(s):  
C. G. Ndiritu ◽  
E. J. Ouldridge ◽  
M. Head ◽  
M. M. Rweyemamu
Keyword(s):  
Asymptomatic Carrier ◽  
Foot And Mouth Disease ◽  
Vaccine Virus ◽  
Disease Type ◽  
Mouth Disease ◽  
Two Dimensional ◽  
Foot And Mouth ◽  
Vaccine Virus Strain ◽  
Microneutralization Test ◽  
Central Kenya

SUMMARYSerological evaluations of foot-and-mouth disease type SAT 2 viruses isolated in Kenya between 1979 and 1982 were performed using the two-dimensional microneutralization test. Nine field isolates of epizootiological significance were compared with four vaccine viruses. The results obtained identified Tan 5/68 as the most appropriate reference vaccine virus strain since it had the broadest serological spectrum. Potent Tan 5/68 vaccines would be expected to provide adequate protection against the contemporary SAT 2 field viruses. In the case of K 83/74, which also was shown to have a broad spectrum with viruses isolated in Kenya, the results show that the 1982 isolate from central Kenya was significantly divergent (r < 1·00 at P = 0·01) and warranted tactical revaccination for its control. The study highlighted the fact that strain R1215 which had been isolated from the oesophageal-pharyngeal swabs of asymptomatic carrier cattle had a narrow serological spectrum suggesting that such viruses could be unsuitable as vaccine for the national campaign.

scholarly journals Hemato-Biochemical studies on Egyptian Buffaloes and Calves naturally infected with Foot and Mouth Disease Virus serotype SAT 2

2016 ◽  
Vol 73 (2) ◽  
pp. 230
Author(s):  
Essam A Mahmoud ◽  
Ahmed N.F Neamat-allah
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Cardiac Markers ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Infected Adult ◽  
Apparently Healthy

Foot and mouth disease (FMD) is a highly contagious viral disease of all cloven footed domestic and wild animals. This work was planned to study the different markers for diagnosis of FMDV serotype Sat2 in adult buffaloes and calves including clinical, hematological and biochemical examinations. A total number of sixty animals were divided into four groups. The first group was apparently healthy adult buffaloes, while the second was naturally infected adult buffaloes, a third group was apparently healthy suckling calves and finally the fourth group was naturally infected suckling calves. The recorded clinical signs were fever, salivation, loss of appetite, depression, lameness, blisters or vesicles, erosions and ulcers in the mucosa of the mouth, tongue, lips, gums, pharynx, palate and between the claws. Anemia, leucopenia, lymphopenia and monocytopenia were recorded in infected adult buffaloes and calves. Myocardial injury proved by presence of degenerated myocardial fibers and lymphocyte cell infiltration with a significant increase in cardiac markers like cardiac torponin I, CPK and LDH in addition to a significant hyperkalemia, hypocalcaemia and hypomagnesemia in buffaloe calves. Moreover, electrophoresis showed hyoproteinemia, hypoalbuminemia and hypoglobulinemia in infected animals. It could be concluded that the elevation of cardiac markers emphasized that FMD is more severe in young calves than adult animals. Therefore, it is recommended to evaluate the prognosis of FMD infection in calves by these markers.

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