Preparation and Basic Characterizations of Alginate-Chitosan Hydrogel

2012 ◽  
Vol 490-495 ◽  
pp. 3396-3400
Author(s):  
Nan Xing ◽  
Feng Tian ◽  
Jian Yang ◽  
Yu Kun Li
Keyword(s):  
Cross Section ◽  
Wound Dressing ◽  
Morphological Structure ◽  
Skin Layer ◽  
Amino Group ◽  
Chitosan Hydrogel ◽  
Outer Skin ◽  
Dsc Measurements ◽  
Protonated Amino Group ◽  
Polyelectrolyte Hydrogel

The aim of this study is to prepare and characterize an alginate-chitosan hydrogel for wound dressing application. The influence of alginate concentrations (1%, 2%, 3% and 4% (w/v)) was investigated. This polyelectrolyte hydrogel is observed to be transparent and flexible. The SEM morphological structure of hydrogel is composed of a dense outer skin layer and a porous cross-section layer. The FTIR and DSC measurements indicated the protonated amino group of chitosan has reacted with the carbonyl group of alginate. Some other properties for the wound dressing application are also reported in other paper. Taken together these results point out that alginate-chitosan polyelectrolyte hydrogel can be considered for wound dressing applications.

II. Characterizations of Alginate-Chitosan Hydrogel for Wound Dressing Application

2012 ◽  
Vol 490-495 ◽  
pp. 3124-3128 ◽  
Author(s):  
Nan Xing ◽  
Feng Tian ◽  
Jian Yang ◽  
Yu Kun Li
Keyword(s):  
Mtt Assay ◽  
Wound Dressing ◽  
Chitosan Hydrogel ◽  
Alginate Concentration ◽  
Swelling Capacity ◽  
Water Holding ◽  
Polyelectrolyte Hydrogel

The aim of this study is to evaluate the characterizations of alginate-chitosan hydrogel for wound dressing application. The influence of alginate concentrations (1%, 2%, 3% and 4% (w/v)) was investigated. An increase in alginate concentration leads to a decrease in swelling capacity but an increase in holding capacity. All the hydrogels exhibited above 80% water holding abilities. The hydrogel leach outs were nontoxic to the cells, as confirmed by MTT assay. Taken together these results point out that alginate-chitosan polyelectrolyte hydrogel can be considered for wound dressing applications.

Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

2016 ◽  
Vol 91 ◽  
pp. 85-91 ◽  
Author(s):  
Qiong Jiang ◽  
Wei zhou ◽  
Jun Wang ◽  
Rupei Tang ◽  
Di Zhang ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Chitosan Hydrogel ◽  
Crosslinked Chitosan ◽  
Hydrogel Films

scholarly journals Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 10638-10649 ◽  
Author(s):  
Meisam Omidi ◽  
Amir Yadegari ◽  
Lobat Tayebi
Keyword(s):  
Carbon Dots ◽  
Wound Dressing ◽  
Healing Process ◽  
Ph Sensitive ◽  
Chitosan Hydrogel

Monitoring the pH of wounds as an essential diagnosis factor during the healing process.

scholarly journals Evaluation of PVA/dextran/chitosan hydrogel for wound dressing

2019 ◽  
Vol 38 (1-2) ◽  
pp. 15-30 ◽  
Author(s):  
Shin-Ping Lin ◽  
Kai-Yin Lo ◽  
Tien-Ni Tseng ◽  
Jui-Ming Liu ◽  
Ting-Yu Shih ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wound Dressing ◽  
Antimicrobial Property ◽  
High Water ◽  
Poly Vinyl Alcohol ◽  
High Water Content ◽  
Chitosan Hydrogel ◽  
Proliferation Ability ◽  
Pva Hydrogel

Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

scholarly journals Retraction of “Flexible and Microporous Chitosan Hydrogel/Nano ZnO Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation”

2019 ◽  
Vol 11 (31) ◽  
pp. 28596-28596 ◽  
Author(s):  
P. T. Sudheesh Kumar ◽  
Vinoth-Kumar Lakshmanan ◽  
T.V. Anilkumar ◽  
C. Ramya ◽  
P. Reshmi ◽  
...  
Keyword(s):  
Wound Dressing ◽  
In Vivo Evaluation ◽  
Chitosan Hydrogel ◽  
Nano Zno

scholarly journals Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jakob Kljun ◽  
Saša Petriček ◽  
Dušan Žigon ◽  
Rosana Hudej ◽  
Damijan Miklavčič ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Side Chain ◽  
Synthesis And Characterization ◽  
Medical Applications ◽  
Amino Group ◽  
Heterocyclic Derivative ◽  
Biological Assays ◽  
X Ray ◽  
Protonated Amino Group

Novel ruthenium(III) complexes with histamine[RuCl4(dmso-S)(histamineH)]⋅O(1a) and[RuCl4(dmso-S)(histamineH)](1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound1bcombined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing

2015 ◽  
Vol 125 ◽  
pp. 189-199 ◽  
Author(s):  
Di Zhang ◽  
Wei Zhou ◽  
Bing Wei ◽  
Xin Wang ◽  
Rupei Tang ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Chitosan Hydrogel ◽  
Crosslinked Chitosan ◽  
Hydrogel Films

scholarly journals Ecology of onions in Transbaikalia

2021 ◽  
Vol 20 (1) ◽  
pp. 195-197
Author(s):  
O. I. Zhapova ◽  
T. P. Antsupova
Keyword(s):  
Cross Section ◽  
Leaf Blade ◽  
Morphological Structure ◽  
Light Conditions ◽  
Ecological Plasticity ◽  
Number Of Leaves ◽  
Growing Conditions

The article presents the results of studying the influence of growing conditions on the morphological andanatomical features of representatives of the genus Allium. The study concluded that xeromesophytic and mesoxerophyticspecies have high ecological plasticity. Within a species, a difference in anatomical and morphological structure can beobserved, depending on the conditions of germination. Growing conditions affect the number of leaves and the shape ofthe leaf cross-section, the degree of development of chlorenchyma, depending on the light conditions, and the location ofthe conductive bundles in the leaves. The height of the peduncle, the length of the leaf blade, the number of flowers in theinflorescence vary depending on the growing conditions.The article presents the results of studying the influence of growing conditions on the morphological andanatomical features of representatives of the genus Allium. The study concluded that xeromesophytic and mesoxerophyticspecies have high ecological plasticity. Within a species, a difference in anatomical and morphological structure can beobserved, depending on the conditions of germination. Growing conditions affect the number of leaves and the shape ofthe leaf cross-section, the degree of development of chlorenchyma, depending on the light conditions, and the location ofthe conductive bundles in the leaves. The height of the peduncle, the length of the leaf blade, the number of flowers in theinflorescence vary depending on the growing conditions.

scholarly journals Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 8 ◽  
Author(s):  
Selenia Ternullo ◽  
Laura Victoria Schulte Werning ◽  
Ann Mari Holsæter ◽  
Nataša Škalko-Basnet
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Chronic Wound ◽  
Skin Penetration ◽  
The Novel ◽  
Chitosan Hydrogel ◽  
Wound Model ◽  
Skin Delivery ◽  
Poorly Soluble ◽  
Dermal Delivery

A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel’s hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system’s bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.

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