scholarly journals Evaluation of PVA/dextran/chitosan hydrogel for wound dressing

2019 ◽  
Vol 38 (1-2) ◽  
pp. 15-30 ◽  
Author(s):  
Shin-Ping Lin ◽  
Kai-Yin Lo ◽  
Tien-Ni Tseng ◽  
Jui-Ming Liu ◽  
Ting-Yu Shih ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wound Dressing ◽  
Antimicrobial Property ◽  
High Water ◽  
Poly Vinyl Alcohol ◽  
High Water Content ◽  
Chitosan Hydrogel ◽  
Proliferation Ability ◽  
Pva Hydrogel

Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

scholarly journals Preparation of Foam Dressings Based on Gelatin, Hyaluronic Acid, and Carboxymethyl Chitosan Containing Fibroblast Growth Factor-7 for Dermal Regeneration

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3279
Author(s):  
Longhao Jin ◽  
Sun-Jung Yoon ◽  
Dae Hoon Lee ◽  
Yun Chang Pyun ◽  
Woo Youp Kim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Carboxymethyl Chitosan ◽  
Amide Bond ◽  
Fibroblast Growth

Wound recovery close to the function of the native skin is the goal of wound healing. In this study, we prepared foam dressings (FDs; 2-GHC-FD-1–9, 5-GHC-FD-1–9, and 10-GHC-FD-1–9) composed of various concentrations of gelatin, hyaluronic acid, and carboxymethyl chitosan, which are chemically interconnected through amide bond formation, for evaluating wound healing. Tensile and cell proliferation tests showed that 2-GHC-FD-1–9 are suitable for wound dressing. For further evaluation, three types of FDs, 2-GHC-FD-1, 2-GHC-FD-4, and 2-GHC-FD-8 were chosen. The results of animal intradermal reactivity, water vapor transmission rate, and absorption rate of the three FDs indicated that 2-GHC-FD-8 is the most appropriate scaffold for wound healing. For wound healing acceleration, various concentrations of fibroblast growth factor-7 (FGF-7) was soaked in 2-GHC-FD-8 (2-GHC-FD-8/F1-6) and evaluated by using scanning electron microscopy, cell proliferation, release behavior, and in vivo animal tests. The FDs showed interconnected porous structures, increased cell proliferation until 8.0 × 10−11 M, controlled release with initial burst within 1 h, and sustained release for 48 h. The results of the animal test showed an appropriate concentration of FGF-7 for wound healing. In addition, 2-GHC-FD-8 is a suitable scaffold for wound healing. Therefore, we suggest that 2-GHC-FD-8/F3 is a useful wound dressing for accelerating wound healing.

Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing

2015 ◽  
Vol 125 ◽  
pp. 189-199 ◽  
Author(s):  
Di Zhang ◽  
Wei Zhou ◽  
Bing Wei ◽  
Xin Wang ◽  
Rupei Tang ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Chitosan Hydrogel ◽  
Crosslinked Chitosan ◽  
Hydrogel Films

A high water-content and high elastic dual-responsive polyurethane hydrogel for drug delivery

2015 ◽  
Vol 3 (42) ◽  
pp. 8401-8409 ◽  
Author(s):  
Jinze Li ◽  
Li Ma ◽  
Guangxin Chen ◽  
Zheng Zhou ◽  
Qifang Li
Keyword(s):  
Drug Delivery ◽  
Water Content ◽  
Wound Dressing ◽  
High Water ◽  
High Water Content ◽  
Dual Responsive ◽  
High Elasticity ◽  
Polyurethane Hydrogel

A light- and reductant-responsive hydrogel with high elasticity can be used for drug delivery and wound dressing.

scholarly journals Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 8 ◽  
Author(s):  
Selenia Ternullo ◽  
Laura Victoria Schulte Werning ◽  
Ann Mari Holsæter ◽  
Nataša Škalko-Basnet
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Chronic Wound ◽  
Skin Penetration ◽  
The Novel ◽  
Chitosan Hydrogel ◽  
Wound Model ◽  
Skin Delivery ◽  
Poorly Soluble ◽  
Dermal Delivery

A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel’s hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system’s bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.

Fabrication and Characterization of Macroporous Chitosan/PVA Composite Sponges for Wound Dressing

2014 ◽  
Vol 1626 ◽  
Author(s):  
Changfeng Chen ◽  
Li Liu ◽  
Qiong Wang ◽  
Tao Huang ◽  
Yue`e Fang
Keyword(s):  
Wound Dressing ◽  
Freeze Drying ◽  
Transmission Rate ◽  
High Water ◽  
Poly Vinyl Alcohol ◽  
Drying Method ◽  
Moisture Permeability ◽  
Liquid Absorption ◽  
Fabrication And Characterization

ABSTRACTThe present investigation involves the synthesis of chitosan based composite sponges in view of their applications in wound dressing, antibacterial and haemostatic. A facile CO2 bubbles template freeze-drying method was developed for the fabrication of macroporous chitosan- poly(vinyl alcohol) (PVA) composite sponges with a typical porosity of 50% and pore size of 100-300 µm. The composite sponges show a high water absorption rate up to 60 times of its weight and a water vapor transmission rate of 30 ∼ 70g/m2 • h. Effects of the content of cross-linking agent and PVA on mechanical properties and moisture permeability were examined. Improved strength and flexibility of the chitosan sponges were observed with the presence of PVA. Further, the antibacterial and haemostatic activities have been demonstrated. The Chitosan/PVA sponges of high liquid absorption, appropriate moisture permeability, excellent antimicrobial and haemostatic activities have a great potential for wound dressing applications.

Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo

2014 ◽  
Vol 24 (2) ◽  
pp. 1527-1536 ◽  
Author(s):  
Gökçe Coşkun ◽  
Esra Karaca ◽  
Mustafa Ozyurtlu ◽  
Serhat Özbek ◽  
Aysun Yermezler ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Histological Evaluation ◽  
Poly Vinyl Alcohol
Sign in / Sign up

Export Citation Format

Share Document