II. Characterizations of Alginate-Chitosan Hydrogel for Wound Dressing Application

The aim of this study is to evaluate the characterizations of alginate-chitosan hydrogel for wound dressing application. The influence of alginate concentrations (1%, 2%, 3% and 4% (w/v)) was investigated. An increase in alginate concentration leads to a decrease in swelling capacity but an increase in holding capacity. All the hydrogels exhibited above 80% water holding abilities. The hydrogel leach outs were nontoxic to the cells, as confirmed by MTT assay. Taken together these results point out that alginate-chitosan polyelectrolyte hydrogel can be considered for wound dressing applications.

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Utilizing Alginate to Improve Elasticity and Moisture Balance of Polyvinyl Alcohol/Chitosan Hydrogel Wound Dressing

Materials Science Forum ◽

10.4028/www.scientific.net/msf.988.153 ◽

2020 ◽

Vol 988 ◽

pp. 153-161

Author(s):

Ria Barleany Dhena ◽

Alwan Hafid ◽

Milawati Aini ◽

Bustomi Ahmad ◽

Erizal

Keyword(s):

Polyvinyl Alcohol ◽

Wound Dressing ◽

Three Dimensional ◽

Chitosan Hydrogel ◽

Equilibrium Degree ◽

Dimensional Network ◽

Alginate Concentration ◽

Swelling Capacity ◽

Moisture Balance ◽

Moisture Vapour

Uncontrolled hemorrhage is the leading cause of death. The efficient hemostatic dressings are needed to promote coagulation and hold ongoing hemorrhage. Hydrogels are hydrophilic polymers with three-dimensional network structures with high swelling capacity to prevent accumulation of exudates. Hydrogels prepared from polyvinyl alcohol (PVA) grafted with chitosan have attracted considerable attentions due to their biocompatibility, high moisture balance property, and transparency. In this study, alginate was utilized to improve elasticity and thermal stability, also enhance hydrophilicity and increase swelling ability. The hydrogels composed of PVA (7.5 % w/v), chitosan (0.05 % w/v), and alginate (0.2, 0.4, and 0.6 % w/v) were synthesized by gamma irradiation technique at total dose of 15 kGy. The results showed that the increasing of alginate concentration in the total reactant mixture can improve elasticity, swelling capacity and the equilibrium degree of swelling (EDS), and decrease water vapour transmitted rate/moisture vapour transmitted rate (MVTR). The hydrogel wound dressing with 0.6 % of alginate concentration was the best product in this study with 79.49 % gel content, 608.65 % swelling ratio, 628.32 % EDS in 22 hours, elasticity 62.58 KPa, evaporation rate (MVTR) 105g/m2 h, degraded at temperature of 298.89oC, and the weight loss was reached 88.84 % (w/w).

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Preparation and Basic Characterizations of Alginate-Chitosan Hydrogel

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.490-495.3396 ◽

2012 ◽

Vol 490-495 ◽

pp. 3396-3400

Author(s):

Nan Xing ◽

Feng Tian ◽

Jian Yang ◽

Yu Kun Li

Keyword(s):

Cross Section ◽

Wound Dressing ◽

Morphological Structure ◽

Skin Layer ◽

Amino Group ◽

Chitosan Hydrogel ◽

Outer Skin ◽

Dsc Measurements ◽

Protonated Amino Group ◽

Polyelectrolyte Hydrogel

The aim of this study is to prepare and characterize an alginate-chitosan hydrogel for wound dressing application. The influence of alginate concentrations (1%, 2%, 3% and 4% (w/v)) was investigated. This polyelectrolyte hydrogel is observed to be transparent and flexible. The SEM morphological structure of hydrogel is composed of a dense outer skin layer and a porous cross-section layer. The FTIR and DSC measurements indicated the protonated amino group of chitosan has reacted with the carbonyl group of alginate. Some other properties for the wound dressing application are also reported in other paper. Taken together these results point out that alginate-chitosan polyelectrolyte hydrogel can be considered for wound dressing applications.

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Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2016.05.077 ◽

2016 ◽

Vol 91 ◽

pp. 85-91 ◽

Cited By ~ 40

Author(s):

Qiong Jiang ◽

Wei zhou ◽

Jun Wang ◽

Rupei Tang ◽

Di Zhang ◽

...

Keyword(s):

Wound Dressing ◽

Chitosan Hydrogel ◽

Crosslinked Chitosan ◽

Hydrogel Films

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Biosynthesis of Carboxymethylated Bacterial Cellulose Composite for Wound Dressing

Materials Science Forum ◽

10.4028/www.scientific.net/msf.685.322 ◽

2011 ◽

Vol 685 ◽

pp. 322-326 ◽

Cited By ~ 5

Author(s):

Jun Wei Yu ◽

Xiao Li Liu ◽

Chang Sheng Liu ◽

Dong Ping Sun

Keyword(s):

Bacterial Cellulose ◽

Wound Dressing ◽

Culture Medium ◽

Acetobacter Xylinum ◽

Water Holding Capacity ◽

Water Soluble ◽

Transmission Rates ◽

Measurement Results ◽

Water Holding ◽

Cellulose Composite

A novel bacterial cellulose (BC) composite (carboxymethylated-bacterial cellulose, CM-BC) was synthesized by Acetobacter xylinum by adding water-soluble carboxymethylated cellulose (CMC) in the culture medium. FTIR results showed that CM-BC is obtained by the incorporation of CMC in the network of BC. Water-holding capacity and water vapor transmission rates (WVTR) of CM-BC and BC are determined. The WVTR of CM-BC is comparable to that of BC, but the water-holding capacity of CM-BC is improved compared with BC. Tensile strengths measurement results showed that the fracture stress of CM-BC is higher than that of BC, indicating that CM-BC have more potential wound dressing applications than BC.

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Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

RSC Advances ◽

10.1039/c6ra25340g ◽

2017 ◽

Vol 7 (18) ◽

pp. 10638-10649 ◽

Cited By ~ 47

Author(s):

Meisam Omidi ◽

Amir Yadegari ◽

Lobat Tayebi

Keyword(s):

Carbon Dots ◽

Wound Dressing ◽

Healing Process ◽

Ph Sensitive ◽

Chitosan Hydrogel

Monitoring the pH of wounds as an essential diagnosis factor during the healing process.

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Comparative Evaluation of Functional Properties of Some Commonly Used Cereal and Legume Flours and Their Blends

International Journal of Food and Allied Sciences ◽

10.21620/ijfaas.v1i2.12 ◽

2015 ◽

Vol 1 (2) ◽

pp. 67

Author(s):

Haq Nawaz ◽

Muhammad Aslam Shad ◽

Rabia Mehmood ◽

Tanzila Rehman ◽

Hira Munir

Keyword(s):

Bulk Density ◽

Functional Properties ◽

Protein Solubility ◽

High Water ◽

Water Holding Capacity ◽

Functional Score ◽

Chickpea Flour ◽

Significant Difference ◽

Swelling Capacity ◽

Water Holding

<p>Functional properties such as protein solubility, swelling capacity, water holding capacity, gelling ability, bulk density and foaming capacity of flours of some commonly used cereals and legume (wheat, refined wheat, maize and chickpea) and their blends were studied. Blends of flours were prepared by mixing equal proportions of selected floors. Statistically significant difference in studied functional properties except bulk density was observed among cereal flours and their blends. Chickpea flour was found to possess comparatively high water holding capacity, protein solubility index and swelling capacity. The functional properties of maize and wheat flours were found to be improved when blended with chickpea. Chickpea flour and its blends with cereal flours were found to possess good functional score and suggested as favorable candidates for use in the preparation of viscous foods and bakery products. The data provide guidelines regarding the improvement in functional properties of economically favorable cereal flours.<strong></strong></p>

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Evaluation of PVA/dextran/chitosan hydrogel for wound dressing

Cellular Polymers ◽

10.1177/0262489319839211 ◽

2019 ◽

Vol 38 (1-2) ◽

pp. 15-30 ◽

Cited By ~ 3

Author(s):

Shin-Ping Lin ◽

Kai-Yin Lo ◽

Tien-Ni Tseng ◽

Jui-Ming Liu ◽

Ting-Yu Shih ◽

...

Keyword(s):

Cell Proliferation ◽

Wound Healing ◽

Wound Dressing ◽

Antimicrobial Property ◽

High Water ◽

Poly Vinyl Alcohol ◽

High Water Content ◽

Chitosan Hydrogel ◽

Proliferation Ability ◽

Pva Hydrogel

Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

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Evaluation of Different Methods for Cultivating Gluconacetobacter hansenii for Bacterial Cellulose and Montmorillonite Biocomposite Production: Wound-Dressing Applications

Polymers ◽

10.3390/polym12020267 ◽

2020 ◽

Vol 12 (2) ◽

pp. 267 ◽

Cited By ~ 2

Author(s):

Katharine Valéria Saraiva Hodel ◽

Larissa Moraes dos Santos Fonseca ◽

Isa Moreira da Silva Santos ◽

Jamile Costa Cerqueira ◽

Raimundo Evangelista dos Santos-Júnior ◽

...

Keyword(s):

Bacterial Cellulose ◽

Wound Dressing ◽

Industrial Applications ◽

Medical Product ◽

Water Holding Capacity ◽

Mechanical And Thermal Properties ◽

Water Release ◽

Thermal Stabilities ◽

Gluconacetobacter Hansenii ◽

Water Holding

Bacterial cellulose (BC) has received considerable attention due to its unique properties, including an ultrafine network structure with high purity, mechanical strength, inherent biodegradability, biocompatibility, high water-holding capacity and high crystallinity. These properties allow BC to be used in biomedical and industrial applications, such as medical product. This research investigated the production of BC by Gluconacetobacter hansenii ATCC 23769 using different carbon sources (glucose, mannitol, sucrose and xylose) at two different concentrations (25 and 50 g∙L−1). The BC produced was used to develop a biocomposite with montmorillonite (MMT), a clay mineral that possesses interesting characteristics for enhancing BC physical-chemical properties, at 0.5, 1, 2 and 3% concentrations. The resulting biocomposites were characterized in terms of their physical and barrier properties, morphologies, water-uptake capacities, and thermal stabilities. Our results show that bacteria presented higher BC yields in media with higher glucose concentrations (50 g∙L−1) after a 14-day incubation period. Additionally, the incorporation of MMT significantly improved the mechanical and thermal properties of the BC membranes. The degradation temperature of the composites was extended, and a decrease in the water holding capacity (WHC) and an improvement in the water release rate (WRR) were noted. Determining a cost-effective medium for the production of BC and the characterization of the produced composites are extremely important for the biomedical applications of BC, such as in wound dressing materials.

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