Scientific Approaches to the Creation of Biocompatible Implant Materials

Author(s):  
Alexander Markov ◽  
Georgy Soloviev ◽  
Ivan Petrov ◽  
Kureish Khamchiyev ◽  
Asylbek Shandaulov ◽  
...  

In modern medicine, biotechnological products and systems are used and widely studied, in which various elements and parts interact with biological fluids, soft and hard muscle tissues. This mainly concerns products used in cardiovascular surgery, orthopaedic surgery, dentistry and reconstructive surgery, as well as in ophthalmology. The article studies scientific approaches to the creation of biocompatible implant materials, considers their types, defines the basic requirements for biocompatible materials.

2017 ◽  
Vol 100 (4) ◽  
pp. 1110-1122
Author(s):  
Joe O Boison ◽  
Patricia Dowling ◽  
Johanna L Matus ◽  
Jana Kinar ◽  
Ron Johnson

Abstract This study reports the use of two validated LC with tandem MS (MS/MS) methods to study the residue depletion profile of phenylbutazone (PBZ) and its metabolite oxyphenbutazone (OXPBZ) from equine serum, urine, and muscle, kidney, and liver tissues. One LC-MS/MS method, with an LOQ of 1.0 ng/mL for PBZ and 2.0 ng/mL for OXPBZ, was used for the analysis of the two drugs in the biological fluids (equine urine and serum); the other LC-MS/MS method, with an LOQ of 0.5 ng/g for PBZ and OXPBZ, was used for the analysis of the drugs in the equine tissue samples. PBZ was administered intravenously to two horses dosed with 8.8 mg/kg PBZ once daily for 4 days and sacrificed humanely at a slaughter plant 7 days after the last drug administration. Urine, serum, and kidney, liver, and muscle tissues were collected from the two horses and shipped on ice to the laboratory and stored at −20°C until analysis. The concentrations of PBZ and OXPBZ residues in the biological fluid and tissue samples collected at slaughter were measured with the two validated LC-MS/MS methods using deuterated internal standards. The results demonstrate that the validated methods are fit for studying the depletion kinetics of PBZ residues in equine tissues and biological fluids.


2013 ◽  
Vol 37 (4) ◽  
pp. 723-727 ◽  
Author(s):  
François Durand ◽  
Philippe Berthelot ◽  
Celine Cazorla ◽  
Frederic Farizon ◽  
Frederic Lucht

2007 ◽  
Vol 177 (4S) ◽  
pp. 57-57
Author(s):  
Paul Kokorowski ◽  
Steve Kim ◽  
Laura Perin ◽  
Stefano Giuliani ◽  
Sarkis Sedrakyan ◽  
...  

2007 ◽  
Vol 4 (2) ◽  
pp. 31-33 ◽  
Author(s):  
P. Kulhara ◽  
A. Avasthi

Education in modern medicine in India began in 1835 with the establishment of the Madras Medical College, in what is now Chennai. Initially the growth of new medical schools was slow but it gathered pace after independence in 1947. In the past decade or so, the growth in terms of the creation of new medical schools has been phenomenal.


2020 ◽  
pp. 287-298
Author(s):  
Antigona Aliu ◽  
Matthias Aust

AbstractMedical needling or percutaneous collagen induction (PCI) is a nonablative and innovative method for the treatment of scars. The method of PCI displays a minimal invasive intervention that has developed in the last 25 years and gets significantly more integrated in the fields of plastic and reconstructive surgery. Medical needling is based on a simple therapy concept with a focus on sustainability and clinical data reveal new pathways for the treatment of especially HTS and keloids. In the context of modern medicine, medical needling overcomes deficits of conventional treatments by stimulating and modifying the endogenous potential of skin regeneration.


Author(s):  
 Hadi Erfani ◽  

<!-- wp:paragraph {"align":"justify"} --> <p class="has-text-align-justify">This article examines the medicinal and dietary supplement on the biological activities of identified chemicals from Ginger (<em>Zingiber officinale</em>) of Zingibracea family. Ginger have long been used in traditional medicine. One of the plants that is very effective in extracting essential oils is ginger, which has been studied by researchers in agricultural sciences and chemistry. The use of medicinal plants has a long history and one It has been one of the most important sources for overcoming the disease. Then From the creation of modern medicine and the widespread use of drugs chemically, people's tendency to medicinal plants decreased. Ginger plants are used, which can lead to the development and progress of countries. Ginger is a rhizome plant that grows to a height of 90cm centimeters.


2007 ◽  
Vol 22 (2) ◽  
pp. 70-74 ◽  
Author(s):  
J T Christenson

Background: The establishment of specialty vein clinics has proven beneficial in terms of expansion of clinical volume. Depending on the local situation, the creation of a venous surgical centre may, in addition, result in better collaboration between various specialties, enable active participation in the development and evaluation of new treatment modalities, offer better training/education and provide venues for more complex treatment modalities such as reconstructive surgery of the deep venous system. Objectives: The aim of this study was to analyse the impact of the creation of a venous surgical centre under the auspices of a department of cardiovascular surgery at a university hospital. Methods: A venous surgical centre was established on 1 October 2003, under the direction of one senior surgeon. The impact on clinical activity was measured in terms of patient volume, percentage distribution between venous and arterial surgery and surgical procedures performed, complications following venous surgery as well as evaluation of patient and referring physician satisfaction. Data, from the department's databank, on all patients evaluated and surgically treated for venous and arterial problems from 1 January 2000 to 30 June 2006 were analysed. Number of outpatient clinic visits and operations (patients and surgical procedures) were calculated. Results: The establishment of the venous surgical centre, without additional funding, led to a significant increase in clinical volume. There was a 433% increase in vein surgical procedures and a 774% increase in outpatient clinic visits (comparing 2002 with 2004). Endovenous laser treatment of varicose veins and reconstructive surgery for the deep venous system was started, and a program for training surgeons was established. Complication rate following varicose vein surgery decreased from 5.8% to 1.2% (hematomas and groin infection). Patient and referring physician satisfaction was documented in 2004 and 2006 using questionnaires. Conclusions: The establishment of an academic venous surgical centre has proven useful in increasing clinical activity in terms of patient volume, providing more efficient and better continuity of care, ensuring less complications following varicose vein surgery, allowing the introduction of new treatment modalities, and resulting in overwhelming patient and treating physician satisfaction.


2011 ◽  
Vol 04 (01) ◽  
pp. 9-38 ◽  
Author(s):  
ALEXEY N. BASHKATOV ◽  
ELINA A. GENINA ◽  
VALERY V. TUCHIN

The development of optical methods in modern medicine in the areas of diagnostics, therapy, and surgery has stimulated the investigation of optical properties of various biological tissues, since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated tissues. In this work, an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is presented. Basic principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.


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