Cytotoxicity of Various Calcium Phosphate Ceramics
2006 ◽
Vol 309-311
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pp. 263-266
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Keyword(s):
The cytotoxicity of five calcium phosphate ceramics, hydroxyapatite (HAp), flouroapatite (FAp), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP), was investigated. Based on the guidelines of biological test for medical devices in Japan, a cytotoxicity test of these calcium phosphates was carried out using Chinese hamster V79 lung fibroblasts. The cytotoxic study revealed that FAp and α-TCP showed high cytotoxicities. From various analyses, it was considered that the cytotoxicity of the FAp was due to fluorine ions extracted in a culture medium and the cytotoxicity of α-TCP resulted from a decrease in pH of the medium by the phosphoric acid, which produced by hydrolysis of( the α-TCP.
2007 ◽
Vol 330-332
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pp. 91-94
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2005 ◽
Vol 288-289
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pp. 549-552
2012 ◽
Vol 610-613
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pp. 2328-2331
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