Effects of Thermal Crosslinking on the Properties and Release Profiles of Three-Dimensional (3D)-Printed Poly Vinyl Alcohol (PVA) Tablets

The objective of this study was to investigate the effects of thermal crosslinking on the properties of 3D-printed poly-vinyl alcohol (PVA) tablets loaded with fluorescein sodium (NaFl). The PVA filaments were selected for the fabrication of 3D-printed tablets. Different infill densities (80% and 100%) of the tablets were applied. The tablets were crosslinked at different temperatures and times. The physiochemical properties of the tablets and the release profiles of fluorescein from the 3D-tablets were investigated. The 3D-printed PVA tablets were successfully produced with favorable physical and mechanical properties. A smooth surface with a mesh pattern was obtained with a yellow color of NaFl. The 100% infilled tablets provided slightly greater loading efficiency and loading capacity in comparison with the 80% infilled tablets. The release of NaFl increased with an increase in crosslinking time and temperature. However, crosslinking at 140 °C for 4 h (80% CFT4 and 100%CFT4) showed similar release characteristic compared to the non-crosslink one. The release kinetics of 3D-printed tablets were observed to be Quasi-Fickian diffusion mechanism.

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Swelling Kinetic Study of Poly(Vinyl Alcohol)/Poly(γ-Glutamic Acid) Blend Hydrogel

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1095.423 ◽

2015 ◽

Vol 1095 ◽

pp. 423-426

Author(s):

Mian Mian Zhang ◽

Yu Xi Chen ◽

Xia Ma

Keyword(s):

Glutamic Acid ◽

Kinetic Study ◽

Vinyl Alcohol ◽

Diffusion Mechanism ◽

Fickian Diffusion ◽

Poly Vinyl Alcohol ◽

Swelling Kinetics ◽

Swelling Mechanism ◽

Swelling Kinetic ◽

Sensitive Property

In this article, the swelling behavior and swelling kinetic of poly (vinyl alcohol)/poly (γ-glutamic acid) hydrogel were investigated. It was found that the PGA/PVA hydrogels revealed the pH-sensitive property and exhibited a faster swelling at pH7.4. The study of swelling kinetics revealed that the swelling mechanism followed the non-Fickian diffusion mechanism.

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Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽

10.3390/polym13050691 ◽

2021 ◽

Vol 13 (5) ◽

pp. 691

Author(s):

O. Sánchez-Aguinagalde ◽

Ainhoa Lejardi ◽

Emilio Meaurio ◽

Rebeca Hernández ◽

Carmen Mijangos ◽

...

Keyword(s):

Mechanical Properties ◽

Drug Release ◽

Bioactive Glass ◽

Vinyl Alcohol ◽

Release Kinetics ◽

The Body ◽

Poly Vinyl Alcohol ◽

X Ray Diffraction ◽

Inorganic Particles ◽

Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

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Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs

Biomolecules ◽

10.3390/biom11050635 ◽

2021 ◽

Vol 11 (5) ◽

pp. 635

Author(s):

Ding Li ◽

Menglong Wang ◽

Wen-Liang Song ◽

Deng-Guang Yu ◽

Sim Wan Annie Bligh

Keyword(s):

Controlled Release ◽

Combined Therapy ◽

Diffusion Mechanism ◽

Amorphous State ◽

Electrospinning Process ◽

Fickian Diffusion ◽

In Vitro Dissolution ◽

Sem Images ◽

Release Profiles

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.

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Xanthan and Poly(vinyl alcohol) - Based Composite Films, as Supports for Chloramphenicol Immobilization

Eurasian Chemico-Technological Journal ◽

10.18321/ectj566 ◽

2017 ◽

Vol 3 (3) ◽

pp. 195

Author(s):

Alupei Iulian Corneliu ◽

Popa Marcel ◽

Hamcerencu Mihaela ◽

Savin Alexandru ◽

Abadie Marc Jean

Keyword(s):

Vinyl Alcohol ◽

Composite Films ◽

Three Dimensional ◽

Biological Action ◽

Zero Order ◽

Experimental Program ◽

Poly Vinyl Alcohol ◽

Knowing That ◽

Zero Order Kinetics ◽

Dimensional Network

The paper discusses a method for the realization of some polymer - drug systems in which the macromolecular support is represented by a three-dimensional network based on xanthan and poly(vinyl alcohol). Knowing that the drug (chloramphenicol) was to be inserted through a diffusion process, the support – selected according to an experimental program – had the highest degree of swelling. Several variants of chloramphenicol inclusion into the synthesized support are analyzed by studying the process kinetics. The study of chloramphenicol release from the inclusion products, in the form of films, indicated the installation of a “zero order” kinetics. The tests devoted to the system’s antimicrobial activity evidenced their biological action.

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Silver/poly(vinyl alcohol)/chitosan/graphene hydrogels – Synthesis, biological and physicochemical properties and silver release kinetics

Composites Part B Engineering ◽

10.1016/j.compositesb.2018.08.005 ◽

2018 ◽

Vol 154 ◽

pp. 175-185 ◽

Cited By ~ 24

Author(s):

Katarina Nešović ◽

Ana Janković ◽

Vesna Kojić ◽

Maja Vukašinović-Sekulić ◽

Aleksandra Perić-Grujić ◽

...

Keyword(s):

Physicochemical Properties ◽

Vinyl Alcohol ◽

Release Kinetics ◽

Poly Vinyl Alcohol ◽

Silver Release

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Viscosity, Miscibility Studies and Mechanical Properties of Pullulan/Poly(vinyl alcohol) Blends at 30 ºC and 40 ºC

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22316 ◽

2019 ◽

Vol 32 (2) ◽

pp. 260-264

Author(s):

M.S. Jayaprakash ◽

K Shivakumar ◽

Shashidhar ◽

T.K. Vishnuvardhan

Keyword(s):

Mechanical Properties ◽

Vinyl Alcohol ◽

Physical And Mechanical Properties ◽

Sem Analysis ◽

Poly Vinyl Alcohol ◽

Refractive Indices ◽

Ultrasonic Velocities ◽

Reduced Viscosity ◽

Ubbelohde Viscometer ◽

Miscibility Studies

The miscibility studies of pullulan and poly(vinyl alcohol) (PVA) blends by reduced viscosity measurements, refractometry, mechanical properties and SEM analysis. Viscometric measurements at 30 and 40 ºC were taken using Ubbelohde viscometer. Ultrasonic interferometric was used to measure the ultrasonic velocities of different blend compositions. Refractive indices of blend solutions with different compositions were measured directly with an Abbe′s refractometer with thermostat containing water circulated at 30 and 40 ºC. The mechanical properties, refractive index, ultrasonic velocity and density studies showed that there is an increase of all these with PVA content in the blends. But SEM studies have given an indication of immiscibility in the blend system. Overall, pullulan/PVA blends have shown good physical and mechanical properties particularly for 90/10 composition.

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Poly(vinyl alcohol): Physical Approaches to Designing Biomaterials for Biomedical Applications

Conference Papers in Science ◽

10.1155/2014/403472 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Shathani Nkhwa ◽

Kristo Fernando Lauriaga ◽

Evren Kemal ◽

Sanjukta Deb

Keyword(s):

Vinyl Alcohol ◽

Biomedical Applications ◽

Physical And Mechanical Properties ◽

Poly Vinyl Alcohol ◽

Biocompatible Polymers ◽

Chemical Crosslinking ◽

Biocompatible Polymer ◽

Physical Methods ◽

Physically Crosslinked ◽

Physical Crosslinking

Poly(vinyl alcohol) is a non-toxic, biosynthetic polymer and biocompatible polymer that has the ability to form hydrogels either via chemical or physical crosslinking. Whilst chemical crosslinking provides greater control on the properties of the resultant hydrogel, physically crosslinked hydrogels or blends with other biocompatible polymers are more suited for biomedical applications. In this paper we report a systematic study on the effect of varying concentrations of PVA, physical methods of crosslinking, and PVA-gelatin and PVA-PVP blends on the physical and mechanical properties of the hydrogels.

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