Development and Evaluation of Astaxanthin Orally Disintegrating Tablets Prepared from Coprocessed Excipients for Use in the Elderly

2020 ◽  
Vol 859 ◽  
pp. 295-300
Author(s):  
Tanikan Sangnim ◽  
Kampanart Huanbutta
Keyword(s):  
Mechanical Properties ◽  
Age Groups ◽  
The Elderly ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Pharmaceutical Dosage Forms ◽  
Orally Disintegrating Tablets ◽  
Type C ◽  
Tablet Hardness

The world’s population is aging; therefore, conventional pharmaceutical dosage forms designed for adult are not suitable. Orally disintegrating tablets (ODTs) are innovative dosage forms designed to overcome the problem of difficulty in swallowing or dysphagia, which is a common problem among all age groups, especially the elderly. This study aimed to develop and assess ODTs loaded with astaxanthin and manufactured by direct compression method using different coprocessed pharmaceutical excipients, including F-Melt® Type C, F-Melt® Type M, and Pearlitol Flash®. The results found that the ODTs prepared from F-Melt® Type C and F-Melt® Type M offered better mechanical properties. An astaxanthin concentration of 20–40 mg in the tablets did not retard the disintegration mechanism. From the taste modified formulation, the tablets disintegrated within 82 seconds. The tablet hardness was higher than 35.33 N and its friability was less than 0.5%. Lastly, active ingredient dissolved more than 80% in 2 minutes.

scholarly journals Preparation and evaluation of diclofenac sodium orally disintegrating tablets

2016 ◽  
Vol 27 (1) ◽  
pp. 58-61
Author(s):  
Valeriu Iancu ◽  
Florentina Roncea ◽  
Radu George Cazacincu ◽  
Dumitru Lupuleasa
Keyword(s):  
Diclofenac Sodium ◽  
Magnesium Stearate ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Preparation And Evaluation

Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.

scholarly journals Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen

2019 ◽  
Vol 56 (1) ◽  
pp. 239-244
Author(s):  
Monica Iliuta Stamate ◽  
Ciprian Stamate ◽  
Daniel Timofte ◽  
Bogdan Ciuntu ◽  
Carmen Gafitanu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Methyl Cellulose ◽  
Physicochemical Characteristics ◽  
Direct Compression ◽  
Mechanical Parameters ◽  
Compression Method ◽  
Drug Substances ◽  
Polymeric Binders ◽  
Made In

In this study, the effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied. Many polymers are added in formulation of compressed tablets in order to improve the physicochemical characteristics of the drug release system. The samples were made in the form of cylindrical tablet about 9 mm in diameter, containing different mixtures of drug substances and excipients acording to seven formulations. Cylindrical tablets containing mixtures of ketoprofen and various types of polymers are made by direct compression method. Among the binders used were a series of different polymers like Kollidon va 64, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. Mechanical parameters such as hardness, mechanical strenght, friability and roughness were studied in order to determine how they are influenced by polymeric binders.

scholarly journals FORMULATION OF ORALLY DISINTEGRATING TABLETS OF CINNARIZINE BY USING DIRECT COMPRESSION METHOD

2019 ◽  
Vol 11 (1) ◽  
pp. 117
Author(s):  
Rasha Khalid Al-dhahir ◽  
Myasar Al-kotaji
Keyword(s):  
Evaluation Studies ◽  
Spectroscopic Studies ◽  
Stability Study ◽  
Compatibility Study ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Compression Method ◽  
Orally Disintegrating Tablets ◽  
Different Types ◽  
Rapid Dissolution

Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (CP), sodium starch glycolate (SSG) and Kyron T-314; Kyron T-314 was used in different concentrations of 5%, 6%, 7%, and 8%. The prepared formulae (F1-F9c) were subjected to flowability studies and post-compression evaluation studies. The optimized formula was selected depending on the time of disintegration and dissolution; then it was subjected to drug-excipient compatibility study and stability study.Results: Flowability results were ranging from excellent, excellent to good, and good to fair according to the type of the diluent used. All of the prepared tablets showed acceptable hardness, friability, drug content, and disintegration. A rapid disintegration of 11.66±2.25 s with the highest percentage 2 min-drug release of 74.55±3.01% was obtained by using the diluent lactose and the super disintegrant Kyron T-314 (8%) in the formula F9c. The infrared spectroscopic studies of the formula F9c showed no drug-excipient interaction. In addition, the stability study indicated that the optimized formula is a stable formula.Conclusion: Formula F9c of a rapidly disintegrating tablet was easy to be manufactured, and the results showed that this formula had a rapid disintegration, high dissolution profile, no noticeable chemical incompatibility and it was stable upon storage.

scholarly journals Stability studies of hydralazine hydrochloride orodispersible formulations

2020 ◽  
Vol 11 (1) ◽  
pp. 75-86
Author(s):  
Muthukumar ◽  
Sundaraganapathy R ◽  
Sankar C ◽  
Sundaramoorthy C ◽  
Yuvaraja K R
Keyword(s):  
Thin Films ◽  
Age Groups ◽  
Direct Compression ◽  
Solvent Casting ◽  
Compression Method ◽  
Casting Method ◽  
Onset Of Action ◽  
Solid Dosage ◽  
Sublimation Method ◽  
Hydralazine Hydrochloride

Solid dosage forms also have a impervious difficulties in patients especially for geriatric and paediatric patients.Dysphagia is common among all age groups. Orodispersible formulations (Fast  dissolving tablets & Fast dissolving oral thin films) constitute an inventive dosage form that overcome the problems swallowing and provides speedy onset of action. The objective of present study was to formulate orodispersible formulations of Hydralazine HCL by different methods (Direct compression method, Sublimation method and solvent casting method). Based on physiochemical evaluations F9 (Direct compression method),SF9 (Sublimation method) for Fast dissolving tablets and H2 formulations (Solvent casting method) for Fast dissolving oral thin films were found optimized formula.The optimized formula were kept for stability under long term, accelerated and intermediate conditions for the study period of six months as per ICH guidelines.Based on stability reports the H2 formulations (Fast dissolving oral thin films) got a better drug release than Fast dissolving tablets.

scholarly journals The method of random balance for studying the influence of excipients quantities on technological parameters of tablets based on Origanum vulgare L. dry extract

2021 ◽  
pp. 73-81
Author(s):  
Svitlana Chernetska ◽  
Natalia Beley ◽  
Mariana Demchuk
Keyword(s):  
Silicon Dioxide ◽  
Magnesium Carbonate ◽  
Direct Compression ◽  
Compression Method ◽  
Technological Parameters ◽  
Origanum Vulgare ◽  
Dry Extract ◽  
Hausner Ratio ◽  
Type C ◽  
Tapped Density

The aim. The aim of the research was to study the influence of excipients amount on the technological parameters of the compression mixture and tablets based on dry extract of Origanum vulgare L. herb using the method of random balance. Materials and methods. Objects of the study – Origanum vulgare L. herb dry extract, 8 excipients that have been studied at two quantitative levels. The tablets were prepared by direct compression method. The formulations were designed according to the method of random balance. The technological parameters of the compression mixture and tablets based on Origanum vulgare L. herb dry extract have been studied as a function of quantitative factors: silicon, magnesium carbonate basic, dioxide magnesium aluminometasilicate (Neusilin S1®), isomalt (GalenIQ™720), F-melt® Type C (co-spray dried excipients), sucralose, berry flavor and citric acid. Results and discussion. The increase in the amount of Neusilin S1®, GalenIQ™720 and F-melt®, and the decrease in the amount of magnesium carbonate basic and silicon dioxide improved the flowability expressed by the Hausner ratio. Results of bulk density and tapped density of the compression mixture depended on the quantities of GalenIQ™720 and F-melt®. All formulations of the prepared tablets had the rapid disintegration and ranging from 6 to 15 minutes. Resistance for crushing and friability tablets’ were improved with a decrease in the amount of silicon dioxide and increase in the amount of Neusilin S1®, F-melt® and sucralose. Higher resistance to moisture of tablets based on Origanum vulgare L. dry extract was obtained by using Neusilin S1®, F-melt® and sucralose on the upper levels. Conclusions. The tablets based on Origanum vulgare L. herb dry extract were successfully manufactured by direct compression method. The random balance method enabled us to identify the most significant quantitative factors to optimize their composition in the tablets based on the dry extract of Origanum vulgare L. herb.

scholarly journals Development and evaluation of mosapride citrate orally disintegrating tablets for dogs

2016 ◽  
Vol 46 (11) ◽  
pp. 2064-2069
Author(s):  
Tingting Yi
Keyword(s):  
Low Cost ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Mosapride Citrate ◽  
Orally Disintegrating Tablets ◽  
Croscarmellose Sodium ◽  
Sodium Carboxymethyl Starch ◽  
In Vitro Disintegration

ABSTRACT: The purpose of the study was to prepare orally disintegrating tablets (ODTs) of mosapride citrate for dogs with fast disintegration and low cost. The ODTs were developed by varying the components and the ratio of excipients. A direct compression method was used. The properties of the ODTs, including hardness, friability, active ingredient content, and in vitro disintegration time, were investigated, and an economic analysis of the formulations was performed. For all formulations, friability was less than 1%, and the hardness varied from 37.69±4.08 to 48.73±5.62 N, which indicated that the tablets had sufficient mechanical integrity to withstand packaging and carrying. Results showed that Formulation (F) 2, containing 5% sodium carboxymethyl starch; F3, containing 5% low-substituted hydroxypropylcellulose; and F5 had not only shorter disintegration times but also lower costs, which were suitable for mosapride citrate ODTs. Although F1, contained 5% croscarmellose sodium, and F4, contained 5% crospovidone, with shorter disintegration times, the costs of F1 and F4 were 25.8% and 22.6% higher than that of F5, respectively. Results also revealed that the disintegration time of F5 was not significantly different from those of F1, F2, F3, and F4 (p>0.05), all of which contained superdisintegrants. Without superdisintegrants, F5, which contained a mixture of microcrystalline cellulose, mannitol, and lactose, was also able to achieve a short disintegration time and to meet the requirements of ODTs for dogs.

scholarly journals THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (CROSPOVIDONE-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS

2018 ◽  
Vol 11 (2) ◽  
pp. 318 ◽  
Author(s):  
Nani Parfati ◽  
Karina Citra Rani ◽  
Meilany Meilany
Keyword(s):  
Area Under The Curve ◽  
Physicochemical Characteristics ◽  
Angle Of Repose ◽  
Direct Compression ◽  
Dissolution Test ◽  
Compression Method ◽  
Orally Disintegrating Tablet ◽  
Sodium Starch Glycolate ◽  
Orally Disintegrating Tablets ◽  
Dissolution Efficiency

 Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91±0.11)% and area under the curve value (11149.13±13.15) compared to formula 2 and formula 3.Conclusion: The results from this study showed that coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.

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