Can ratio of neutrophil-tolymphocyte count and erythrocyte sedimentation rate in diabetic foot infection predict osteomyelitis and/or amputation?

The aim of this study was to search for any relations between the neutrophil-tolymphocyte ratio (NLR) and the development of osteomyelitis and the need for amputation in patients with diabetic foot infection (DFI). All data included DFI patients who were hospitalized in our Infectious Diseases Clinic between 2012 and 2015 and who were classified according to International Classification Disease Code System. 75 patients were analyzed in the study. The DFI patients were stratified into 3 groups of whom had amputation procedure, whom had only debridement/drainage procedure and whom had any surgery procedure. Sidac post hoc analysis was used to perform the effects of NLR, C-reactive protein, erythrocyte sedimentation rate and glycosylated hemoglobin on the surgery procedure status. The DFI patients were also stratified into two another separate group for another analysis to search for the effect of NLR values on the development of osteomyelitis. The mean value of NLR in the amputated patients’ group (15.7±10.3 was significantly higher than those with debridement procedure (9.9±5.6) and those without any surgery (6.0±2.8) (P=0.001). NLR values were also found significantly higher in patients with osteomyelitis in the second analysis (P=0.004). In this study, the NLR was found to have a predictive value on the development of osteomyelitis and on the progression to amputation in patients with DFI.

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A New Case of Schnitzler Syndrome in Bulgaria

Acta Medica Bulgarica ◽

10.2478/amb-2018-0021 ◽

2018 ◽

Vol 45 (2) ◽

pp. 58-62

Author(s):

M. Kirilova-Doneva ◽

M. Kamusheva ◽

S. Donev ◽

I. Popova

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Time Course ◽

Mean Value ◽

C Reactive Protein ◽

Immunoglobulin Kappa ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Schnitzler Syndrome ◽

The Mean

Abstract We describe the case of a 74-year-old Bulgarian woman with a long history of chronic urticaria with severe burning sensation, arthralgia and fever. Additional symptoms of Schnitzler such as monoclonal immunoglobulin – kappa component, elevated erythrocyte sedimentation rate and enlarged lymph nodes were detected six years after the onset of the symptoms. The first diagnoses hypersensitive vasculitis and dermatitis were established in 2009. Schnitzler syndrome was recognized and the diagnosis was established 2 years later after some examination tests. The time course of the values of IgM, C-reactive protein, erythrocyte sedimentation rate and neutrophils were presented. The mean value of IgM is 13.8 ± 2.19 g/l, the mean value of erythrocyte sedimentation rate is 48.6 ± 14.46 mm/h and the mean value of C-reactive protein – 29.8 ± 7.34 mg/l. The use of nonsteroid anti-inflammatory drugs throughout the period and corticosteroids prescribed parenterally and orally resulted in the relief of arthralgia and fever.

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Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot

Human Antibodies ◽

10.3233/hab-210439 ◽

2021 ◽

pp. 1-7

Author(s):

Zahra Soleimani ◽

Fatemeh Amighi ◽

Zarichehr Vakili ◽

Mansooreh Momen-Heravi ◽

Seyyed Alireza Moravveji

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Roc Curve ◽

Diabetic Foot ◽

Diagnostic Value ◽

Clinical Findings ◽

Diabetic Patients ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation

BACKGROUND: The diagnosis of osteomyelitis is a key step of diabetic foot management. Procalcitonin (PCT) is a novel infection marker. This study aimed to investigate the diagnostic value of procalcitonin and other conventional infection markers and clinical findings in diagnosis of osteomyelitis in diabetic foot patients. METHODS AND MATERIALS: This diagnostic value study was carried out on ninety patients with diabetic infected foot ulcers admitted in Kashan Beheshti Hospital, 2016. After obtaining consent, 10 cc blood sample was taken for measuring serum PCT, CBC, ESR, CRP and FBS. Clinical characteristics of the wounds were noted. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis. All statistical analyses were done with the use of SPSS-16. RESULTS: PCT levels were 0.13 ± 0.02 ng/mili patients with osteomyelitis (n= 45) and 0.04 ± 0.02 ng/ml in patients without osteomyelitis (n= 45). PCT, Erythrocyte sedimentation rate and C-reactive protein was found significantly higher in patients with osteomyelitis (p< 0.001). The ROC curve was calculated for PCT. The area under the ROC curve for infection identification was 1 (p< 0.001). The best cut-off value for PCT was 0.085 ng/ml. Sensitivity, specificity, and positive and negative predictive values were 100%, 97.8%,97.8% and 100%, respectively. CONCLUSION: In this group of patients, PCT was useful to discriminate patients with bone infection. Also, Erythrocyte sedimentation rate and C-reactive protein can be used as a marker of osteomyelitis in diabetic patients.

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Erythrocyte sedimentation rate and C-reactive protein to monitor treatment outcomes in diabetic foot osteomyelitis

International Wound Journal ◽

10.1111/iwj.12574 ◽

2016 ◽

Vol 14 (1) ◽

pp. 142-148 ◽

Cited By ~ 20

Author(s):

Suzanne AV van Asten ◽

Daniel C Jupiter ◽

Moez Mithani ◽

Javier La Fontaine ◽

Kathryn E Davis ◽

...

Keyword(s):

Treatment Outcomes ◽

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Diabetic Foot ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Diabetic Foot Osteomyelitis

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Role of erythrocyte sedimentation rate and C-reactive protein as a predictor of severity of cellulitis and necrotising fasciitis

International Surgery Journal ◽

10.18203/2349-2902.isj20202816 ◽

2020 ◽

Vol 7 (7) ◽

pp. 2176

Author(s):

Sanjay Jain ◽

Manish Kumar ◽

M. C. Songara

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Mean Value ◽

Necrotising Fasciitis ◽

Industrialized Countries ◽

C Reactive Protein ◽

Specific Test ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Erythrocyte Sedimentation

Background: Skin infections are major cause of morbidity and mortality worldwide, affecting more than one person/1000 person/year. Sepsis has a worldwide incidence of more than 20 million cases a year, with mortality due to septic shock reaching up to 50% even in industrialized countries. Acute phase reactants like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been used traditionally as markers for inflammation and are readily available in most centres. Aim was to study the correlation between the values of ESR and CRP with severity of cellulitis and necrotising fasciitis (in term of hospital stay and disease outcome).Methods: This was a prospective observational study conducted at Department of Surgery, GMC and Hamidia Hospital, Bhopal from a period of March 2016 to August 2018.Results: Skin and soft tissue infections are most commonly affects male, diabetes mellitus most common co-morbid condition. Mean value of ESR and CRP in patients who could not survived was 64.44 and 145.92 respectively and value more than 54.95 and 93.41 requires longer hospital stay.Conclusions: ESR and CRP are non-specific test but they are good predictors of severity of cellulitis and necrotising fasciitis not only in planning of management of these cases but also predicting outcome of the disease.

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Estimation of Variations in the Erythrocyte Sedimentation Rate in COVID-19 Recovered Patients

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i59a34285 ◽

2021 ◽

pp. 413-418

Author(s):

Manoj Aravindan ◽

Palati Sinduja ◽

R. Priyadharshini ◽

V. Meghashree

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Signs And Symptoms ◽

Mean Value ◽

Multiple Organ ◽

P Value ◽

Cross Sectional ◽

Erythrocyte Sedimentation ◽

The Mean ◽

Novel Coronavirus

Background: A cluster of patients with pneumonia and severe acute respiratory syndrome developed in Wuhan, China in December 2019, and infection with a novel coronavirus virus called COVID -19 was later verified. Although fever and cough were the most common early signs and symptoms of COVID -19, extrapulmonary symptoms have also been reported. Many studies demonstrate that called COVID -19 swiftly progresses to acute respiratory distress syndrome and even multiple organ dysfunction. Aim:The study aims to evaluate the erythrocyte sedimentation rate count in COVID -19 recovered individuals and compare it with healthy controls. Materials & Methods: A cross-sectional pilot study in 5 healthy COVID -19 uninfected and 5 COVID -19 recovered individuals was conducted, the blood samples were collected and the erythrocyte sedimentation rate was calculated for each set of controls and samples. Statistical analysis was performed using SPSS software. An independent t-test was done to compare the results. Results: The mean value of the control participants was found to be 8.08 ± 4.38 and the mean value of COVID -19 recovered patients was 20.60 ± 1.81. The difference in Erythrocyte Sedimentation Rate (ESR) values between control individuals and COVID -19 recovered patients was statistically significant with p value of less than 0.005. Conclusion: Within the limitations of the study, we conclude that the COVID -19 recovered patients has higher ESR values compared to the healthy uninfected individuals.

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