scholarly journals Staphylococcus intermedius infections: case report and literature review

2013 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
Nancy Wang ◽  
Anne M. Neilan ◽  
Michael Klompas
Keyword(s):  
Close Contact ◽  
Case Reports ◽  
Normal Skin ◽  
Complete Recovery ◽  
Invasive Infection ◽  
Mechanical Prosthesis ◽  
Oral Flora ◽  
True Incidence ◽  
Staphylococcus Intermedius ◽  
Total Arthroplasty

<em>Staphylococcus intermedius</em> is part of the normal skin and oral flora of dogs. Case reports of human infections are rare, but the true incidence is unknown because the pathogen is frequently misidentified as <em>Staphylococcus aureus</em>. Reported cases range from soft tissue infections to brain abscess. Most reported cases in humans have been related to dog exposure. We report a case of a 73 year old female with <em>S. intermedius</em> surgical wound infection one month following a left elbow total arthroplasty. This is the first reported human case of <em>S. intermedius</em> infection of a mechanical prosthesis. The presumed source of infection was the patient’s dog. The patient was treated with vancomycin, then switched to cefazolin and rifampin once susceptibilities were known. Case reports suggest that patients generally respond well to tailored antibiotics with complete or near-complete recovery. <em>S. intermedius</em> should be included in the differential diagnosis of invasive infection amongst patients with close contact with dogs.

Capnocytophaga canimorsus meningitis and bacteraemia without a dog bite in an immunocompetent individual

2021 ◽  
Vol 14 (7) ◽  
pp. e242432
Author(s):  
Fiona O'Riordan ◽  
Aoife Ronayne ◽  
Arthur Jackson
Keyword(s):  
Complete Recovery ◽  
Human Infection ◽  
Blood Cultures ◽  
Invasive Infection ◽  
Dog Bite ◽  
Capnocytophaga Canimorsus ◽  
Oral Flora ◽  
Immunocompetent Individual ◽  
Laboratory Confirmation ◽  
History Of

We describe the case of an immunocompetent 75-year-old man with Capnocytophaga canimorsus bacteraemia and meningitis. C. canimorsus is commonly found in the oral flora of dogs with human infection typically occurring following a bite. Unusually, while our patient was a dog owner, there was no history of bite nor scratch mark. Admission blood cultures flagged positive for Gram-negative bacilli, but prolonged molecular analysis was required before C. canimorsus was isolated in blood and cerebrospinal fluid. There is a high mortality rate in invasive infection, and in our patient’s case, antibiotic therapy was commenced prior to laboratory confirmation with our patient making a complete recovery. This case highlights the importance of including C. canimorsus in the differential diagnosis of unwell patients who keep dogs, even without a bite. This case occurred amid heightened awareness of COVID-19, which may represent predisposition for zoonoses during social isolation and increased human–pet contact.

scholarly journals Adult Measles – Case Reports of a Highly Contagious Disease

2019 ◽  
Vol 7 (18) ◽  
pp. 3009-3012 ◽  
Author(s):  
André Koch ◽  
Claudia Krönert ◽  
Torello Lotti ◽  
Aleksandra Vojvodic ◽  
Uwe Wollina
Keyword(s):  
Measles Virus ◽  
Case Reports ◽  
Complete Recovery ◽  
Maculopapular Rash ◽  
Adult Patients ◽  
Older Patient ◽  
Active Immunisation ◽  
Younger Patient ◽  
Initial Improvement ◽  
Polymerase Chain

BACKGROUND: Measles is highly contagious and is caused by the RNA morbillivirus. The best protection is active immunisation in early childhood. Without immunisation morbidity and mortality of measles are high. In recent years, an increasing number of adult measles has been recognised in Europe. CASE REPORTS: We report here on two adult patients – a 40-year-old male and a 55-year-old female – who presented with fever, fatigue, cough, coryza, conjunctivitis and maculopapular rash. The suspicion of adult measles infection was confirmed by positivity for IgM antibodies against measles virus and reverse-transcriptase polymerase chain reaction in blood and urine. Patients were isolated, and the treatment was symptomatic. In the younger patient, complete recovery was achieved within two weeks. In the older patient, an acute encephalopathy developed after initial improvement characterised by cognitive impairment. CONCLUSIONS: In patients presenting with fever and maculopapular rash and fatigue, measles should be considered even in adult patients. Early diagnosis with subsequent isolation and registration of patients are important measures to prevent local outbreaks of the disease.

Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome of Uncertain Treatment and Prognosis

2020 ◽  
Vol 51 (04) ◽  
pp. 286-291 ◽  
Author(s):  
Maria Serra ◽  
Anna Presicci ◽  
Martina Fucci ◽  
Mariella Margari ◽  
Roberto Palumbi ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Clinical Laboratory ◽  
Case Reports ◽  
Oral Prednisone ◽  
Clinical History ◽  
Complete Recovery ◽  
Acute Disseminated Encephalomyelitis ◽  
Cochrane Library ◽  
High Dose ◽  
Intravenous Steroid

Abstract Aim Acute Disseminated Encephalomyelitis followed by optic neuritis (ADEM-ON), first described in 2013, is a rare demyelinating syndrome, typical of the pediatric age. We conducted a mini review of the existing literature, focusing on clinical, laboratory, radiological, therapeutic, and prognostic aspects in order to improve the identification of new cases. Methods We searched PubMed and Cochrane Library for studies on ADEM-ON between 2013 and 2018. Results Examination of the reported cases (three case reports and eight observational studies) established the following features. Time between ADEM and ON is highly variable. Almost all patients show antimyelin oligodendrocyte glycoprotein antibody (MOG-abs) seropositivity. High-dose intravenous steroid and plasmapheresis efficacy is reported for the acute phase; oral prednisone and other maintenance drugs may be useful in avoiding relapses. The clinical history may lead to a complete recovery but also to residual deficits. Conclusion MOG-abs detection strongly supports ADEM-ON diagnosis, confirming this entity as part of MOG-abs spectrum disorder. Owing to the very small number of cases so far reported, predicting clinical evolution is very difficult.

scholarly journals Staphylococcus intermedius Brain Abscess as a Complication of Pulmonary Arteriovenous Malformation in a Patient With Hereditary Hemorrhagic Telangiectasia

2020 ◽  
Vol 7 (11) ◽  
Author(s):  
Leon S Moskatel ◽  
Joslyn N Vo ◽  
Keshav R Nayak ◽  
Nancy F Crum-Cianflone
Keyword(s):  
Arteriovenous Malformation ◽  
Brain Abscess ◽  
Hereditary Hemorrhagic Telangiectasia ◽  
Clinical Manifestations ◽  
Complete Recovery ◽  
Pulmonary Arteriovenous Malformation ◽  
Staphylococcus Intermedius ◽  
First Case ◽  
Human Infections ◽  
The Brain

Abstract Staphylococcus intermedius is a rare cause of human infections ranging from skin and soft tissue infections to bacteremia. It is particularly known for its association with exposure to dogs. We report an unusual case of a 73-year-old female with a brain abscess caused by S intermedius who was recently diagnosed with hereditary hemorrhagic telangiectasia and a pulmonary arteriovenous malformation. The patient underwent debridement of the brain abscess followed by a 6-week course of vancomycin and rifampin, after which she made a near complete recovery. This is the first case of a brain abscess in an adult due to S intermedius in the published literature, and we provide a comprehensive review of the literature of all human infections caused by this pathogen and summarize its clinical manifestations, treatment recommendations, and outcomes.

Rescue of a deep burned elbow using a radial forearm pedicled flap, an original irrigation system and a specific immobilization

2020 ◽  
Author(s):  
Marie Benayoun ◽  
Marie-Charlotte Dutot ◽  
Céline Aboud ◽  
Kévin Serror ◽  
Marc Chaouat ◽  
...  
Keyword(s):  
Irrigation System ◽  
Case Reports ◽  
Donor Site ◽  
Drainage System ◽  
Complete Recovery ◽  
Pedicled Flap ◽  
Treatment Center ◽  
Burn Treatment ◽  
Efficient Treatment ◽  
Radial Forearm

Abstract Introduction Deep soft tissue defects next to the joints can rapidly lead to irreversible damages and have to be covered urgently and effectively. In severely burned patients the usual approach is to use a flap even though it has its limitations in regards to the extent of the burn and the general condition of the patient. Case report A twenty seven-year-old male was admitted at the Burn Treatment Center for a thermic burn of seventy-two percent of his body surface area. At first he has benefited from several skin grafts and later on a major open right elbow had to be treated urgently to rescue the joint. Results After the burn, a revascularization of the donor site was noticed, sufficient to use the radial forearm pedicled flap as a cover for the elbow. This case reports an innovative approach based on the use of an irrigation and drainage system placed underneath the flap. The elbow was rigidly immobilized with an external fixator in order to facilitate an optimal healing of the flap. Conclusion In this case, the choice of this flap, combined with the irrigation and drainage system and the immobilization by external fixation, provided an original and efficient treatment. Post operatively the healing of the flap and of the donor site was complete. The functional results exceeded the expectations with a complete recovery of the joint amplitude. Thus, in case of no other therapeutic options, it is probably possible to use a variety of flaps recently healed.

Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury

2018 ◽  
Vol 48 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Mercedes Cao ◽  
Bruna N. Leite ◽  
Tamara Ferreiro ◽  
María Calvo ◽  
Constantino Fernández ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Kidney Function ◽  
Case Reports ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Genetic Abnormalities ◽  
Uremic Syndrome ◽  
Meta Analyses

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with congenital or acquired genetic abnormalities that result in uncontrolled complement activation, leading to thrombotic microangiopathy and kidney failure. Until recently, the only treatment was plasma exchange or plasma infusion (PE/PI), but 60% of patients died or had permanent kidney damage despite treatment. Eculizumab, a complement inhibitor, has shown promising results in aHUS. However, data are mainly extracted from case reports or studies of heterogeneous cohorts, and no direct comparison with PE/PI is available. Methods: An observational retrospective study of adult, dialysis-dependent aHUS patients with acute kidney injury (AKI) who were treated with either PE/PI alone or with second-line eculizumab in our center. We compared the effect of PE/PI and eculizumab on kidney function, hypertension, proteinuria, hematologic values, relapse, and death. Results: Thirty-one patients were included (females, 18; sporadic aHUS, 29; mean age, 46 ± 20 years). Twenty-six patients were treated with PE/PI alone, and 5 were deemed to be plasma-resistant and received eculizumab after stopping PE/PI. Among patients receiving eculizumab, 80% attained complete recovery of kidney function, 100% stopped dialysis, 20% had decreased proteinuria, and no patient relapsed (vs. 38.5, 50, 15.4, and 11.5%, respectively, of patients receiving only PE/PI). At 1-year of follow-up, no deaths had occurred in either group. Conclusion: Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance.

Clinical case: Gynecological side effects caused by methylphenidate

2017 ◽  
Vol 41 (S1) ◽  
pp. S430-S430
Author(s):  
A. Ballesteros ◽  
Á.S. Rosero ◽  
F. Inchausti ◽  
E. Manrique ◽  
H. Sáiz ◽  
...  
Keyword(s):  
Side Effects ◽  
Attention Deficit Disorder ◽  
Clinical Case ◽  
Case Reports ◽  
Treatment Plan ◽  
Complete Recovery ◽  
Current Evidence ◽  
Drug Discontinuation ◽  
Pubmed Search ◽  
Competing Interest

IntroductionMethylphenidate drugs is prescribed in attention deficit disorder and hyperactivity. Among its rare side effects, include alterations in the gynecological. We report a clinical case and review current evidence regarding the tolerability this drug in this area.MethodsWe performed a PubMed search of articles published in English of different types (case reports or case/controls studies). We collected the clinical practice guidelines conclusions regarding adverse drug reactions.Case presentationOur patient is a 14-year-old male diagnosed of ADHD treated with methylphenidate (0.8–1 mg\kg). He developed bilateral and asymmetric gynecomastia under this treatment plan so a referral was made to rule out other causes of this event. After performing several work up tests, it was concluded that this clinical presentation was caused by methylphenidate. Hence, we initiated crossed titration swapping this drug to atomoxetine. Four months later, he was mentally stable and he experimented a volumetric decrease as concerns his gynecomastia.As regards methylphenidate, in 2009 a couple of cases in which alterations in the sexual sphere presented with the oros presentation were reported. There are series of reported pharmacological side effects (gynecomastia) and also denoted an improvement of the same months after drug discontinuation.ConclusionsGynecological clinic secondary to the use of psychotropic drugs in ADHD is uncommon. In line with our case, the current evidence suggests a drug suspension as adverse effects are usually reversible (although it may take several months to complete recovery). Further studies are needed to understand the mechanisms underlying these tolerability issues.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Blunt external laryngeal trauma: Two case reports

2007 ◽  
Vol 60 (9-10) ◽  
pp. 489-492
Author(s):  
Slobodan Mitrovic
Keyword(s):  
Computerized Tomography ◽  
Computer Tomography ◽  
Motor Vehicle ◽  
Clinical Symptoms ◽  
Case Reports ◽  
Thyroid Cartilage ◽  
Complete Recovery ◽  
Valve Mechanism ◽  
Laryngeal Trauma ◽  
First Case

Introduction. External laryngeal trauma, blunt or penetrating, is rare but potentially life-threatening. Most frequently it occurs in motor vehicle accidents. The most common symptoms of external laryngeal injuries are: dysphagia, odynophagia, dysphonia, odynophonia, reduction of the laryngeal prominence, hemoptysis and neck crepitation. Two case reports. This paper reviews two cases of blunt laryngeal injury caused by a direct blow to the neck. After admission, both patients underwent clinical examination, as well as radiography of the neck, and computer tomography of the neck and larynx. GIRBAS scale was used for voice analysis. In the first case, computer tomography showed a fracture of the right thyroid cartilage in the posterior lamina where it is attached to the upper horn. In the other case, the presence of air was confirmed by radiography of the upper aperture. Computerized tomography showed the presence of air in the neck, underneath the skin, which was probably the consequence of the larygeal valve mechanism trauma. Both patients were treated conservatively. Discussion and Conclusion. The symptomatology of external larygeal trauma may include: hoarseness, swallowing difficulties and/or painful swallowing, painful phonation, neck pain, bloody sputum and breathing difficulties. The clinical symptoms of blunt laryngeal trauma may be hidden and non-specific, but also clear, indicating a larynx trauma, and vice versa. Quick diagnosis using computerized tomography, hospitalization and adequate therapy, can reduce the consequences of these injuries and increase the chances for a complete recovery of larygeal musculature and function. .

scholarly journals Quantitative functional outcomes of the conservative management of partial segmental thrombosis of the corpus cavernosum

2015 ◽  
Vol 97 (7) ◽  
pp. e108-e111 ◽  
Author(s):  
H Gresty ◽  
S Tadtayev ◽  
N Arumainayagam ◽  
S Patel ◽  
C King ◽  
...  
Keyword(s):  
Sexual Function ◽  
Conservative Management ◽  
Erectile Function ◽  
Functional Outcomes ◽  
Case Reports ◽  
Formal Analysis ◽  
Corpus Cavernosum ◽  
Complete Recovery ◽  
Low Incidence

The low incidence of partial segmental thrombosis of the corpus cavernosum (PSTCC) means its management is guided by isolated case reports. Erectile function is an important outcome that has not been described quantitatively in the literature. We present two cases of PSTCC managed conservatively. Although both patients reported resolution of local symptoms, formal analysis of sexual function at follow-up review has revealed that only one achieved complete recovery.

scholarly journals Hoffa’s Osteochondroma - Para-articular Extrasynovial Infrapatellar Fat Pad Osteochondroma: A Case Report

2021 ◽  
Vol 59 (240) ◽  
Author(s):  
Sunil Panta ◽  
Shrawan Kumar Thapa ◽  
Krishna Prasad Paudel ◽  
Manoj Kandel ◽  
Bishwa Raj Adhikari
Keyword(s):  
Case Reports ◽  
Complete Recovery ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Connective Tissues ◽  
One Year ◽  
Fibrous Tissues ◽  
Anterior Knee ◽  
Metaphyseal Region

Osteochondroma usually arises from the metaphyseal region of growing bones. The occurrence of extraskeletal osteochondroma is rare with very few case reports. Para-articular osteochondroma is a type of extraskeletal osteochondroma. It frequently occurs around the knee, usually at infrapatellar Hoffa’s fat pad. It is usually intracapsular but extrasynovial and arises from the capsule and connective tissues due to osteocartilaginous metaplasia. We present a case of 19-years male with anterior knee pain for 3 years, swelling, and deformity of the knee with flexion limitation for one year. Radiography revealed ovoid, corticated lesion free from adjoining bones. Mass interpreted as benign, so planned for excision. Well circumscribed nodule excised from the medial parapatellar approach. Histology revealed cartilaginous tissues surrounded by fibrous tissues with scattered enchondral ossification.Postoperatively and subsequent follow-up resulted in pain-free joint, complete recovery of range of motion with no clinicoradiological evidence of recurrence.

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