scholarly journals Neoadjuvant, adjuvant and long-term intravenous/intraperitoneal chemotherapy, hyperthermic intraperitoneal chemotherapy, early postoperative intraperitoneal chemotherapy for ovarian cancer

2017 ◽  
Author(s):  
Evgenia Halkia ◽  
Paul Sugarbaker
Keyword(s):  
Ovarian Cancer ◽  
Intraperitoneal Chemotherapy ◽  
Screening Tests ◽  
Advanced Stage ◽  
Multimodal Approach ◽  
Early Postoperative Intraperitoneal Chemotherapy ◽  
Current Trends ◽  
Stage Disease ◽  
Review Current

Ovarian cancer is commonly diagnosed after dissemination and is accompanied by a poorer overall prognosis. Treatment incorporates a multimodal approach, utilizing various combinations of surgery and chemotherapy. Ultimately, better screening tests are needed for ovarian cancer to help reduce the burden of advanced-stage disease. For those women with advanced-stage tumors, newer therapeutic strategies may help prolong survival and increase the chance for cure. The aim of this study is to review current trends in the treatment of women diagnosed with advanced-stage epithelial ovarian cancer.

Long-Term Adjustment of Survivors of Ovarian Cancer Treated for Advanced-Stage Disease

2010 ◽  
Vol 28 (5) ◽  
pp. 451-469 ◽  
Author(s):  
Alice B. Kornblith ◽  
Kristina Mirabeau-Beale ◽  
Hang Lee ◽  
Anne Kathryn Goodman ◽  
Richard T. Penson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Advanced Stage ◽  
Stage Disease

Hallucinogen Use in College Students: Current Trends and Consequences of Use

2020 ◽  
Vol 9 (2) ◽  
pp. 115-127
Author(s):  
Lena S. Jia ◽  
Jessica A. Gold
Keyword(s):  
College Students ◽  
Drug Class ◽  
Positive Effects ◽  
Current Trends ◽  
College Population ◽  
Therapy Studies ◽  
Recreational Use ◽  
Perception Disorder ◽  
Review Current

Hallucinogens are a drug class that is growing in popularity with college students. Recent experimental trends, such as microdosing, have helped promote the use of hallucinogens on campus, and students may be tempted to use these substances due to their beliefs about the drugs’ positive effects on mood. Although hallucinogens are not currently an established form of medical therapy, studies have shown that they have significant benefits as adjunctive treatments for psychological disorders. However, the recreational use of these drugs in college students often occurs in uncontrolled doses or with drug mixing, which is often dangerous. Furthermore, students with mental health disorders may have their symptoms masked by hallucinogenic drug use, which could delay treatment and have serious consequences. Long-term use of these drugs may also result in tolerance or hallucinogen persisting perception disorder. This article attempts to review current information regarding hallucinogen use and how it applies to the college population.

scholarly journals Quality of life among long-term survivors of advanced stage ovarian cancer: A cross-sectional approach

2017 ◽  
Vol 146 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Susan K. Lutgendorf ◽  
Eileen Shinn ◽  
Jeanne Carter ◽  
Susan Leighton ◽  
Keith Baggerly ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Advanced Stage ◽  
Cross Sectional ◽  
Long Term Survivors

scholarly journals Novel Indications of Epigenetic Therapy in Ovarian Cancer

2021 ◽  
Author(s):  
Courtney Griffiths ◽  
Michelle Bilbao ◽  
Lauren Krill ◽  
Olga Ostrovsky
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Gynecologic Cancer ◽  
Epigenetic Modifications ◽  
Epigenetic Therapy ◽  
Intratumor Heterogeneity ◽  
Survival Outcomes ◽  
Advanced Stage ◽  
Stage Disease

Early diagnosis and intervention are some of the longstanding challenges associated with ovarian cancer, which is the leading cause of gynecologic cancer mortality. While the majority of patients who present with advanced stage disease at time of diagnosis will initially respond to traditional combination platinum and taxane-based chemotherapy in conjunction with cytoreductive surgery, approximately 70% will ultimately recur due to chemoresistance within the first two years. Intratumor heterogeneity is proposed to be a leading factor in the development of chemoresistance and resultant poorer outcomes for those with recurrent or advanced stage disease. Both inherent and acquired mechanisms of chemoresistance are postulated to be a result of alterations in gene expression, also known as epigenetic modifications. Therefore, epigenetic therapy is a pivotal avenue which allows for reversal of chemoresistance in cancer through the targeting of aberrant mutations. In this chapter, we discuss how these epigenetic modifications prove to be promising targets in cancer therapy leading to heightened drug sensitivity and improved patient survival outcomes.

Surgical Prevention in Ovarian Cancer

2021 ◽  
pp. 194-206
Author(s):  
Alexios Papanikolaou ◽  
Anastasios Liberis ◽  
Anastasia Vatopoulou
Keyword(s):  
Ovarian Cancer ◽  
Primary Prevention ◽  
Early Detection ◽  
Early Diagnosis ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Current Evidence ◽  
Advanced Stage ◽  
Stage Disease

Ovarian cancer is the second most common malignant disease of the female genital tract, but the first in mortality because it is usually diagnosed at an advanced stage. Options for early detection, diagnosis, and treatment are limited. Prevention of ovarian cancer relates to primary prevention by avoiding factors that are epidemiologically associated with an increased incidence of ovarian cancer and the adoption of protective habits. These include interventions to exclude the fallopian tubes and ovaries. Secondary prevention is related to early diagnosis. The chapter aims to summarize current evidence on prevention of ovarian cancer as well as role of surgery to prevent advanced-stage disease.

Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation

Blood ◽  
2008 ◽  
Vol 112 (8) ◽  
pp. 3082-3087 ◽  
Author(s):  
Suzanne O. Arulogun ◽  
H. Miles Prince ◽  
Jonathan Ng ◽  
Stephen Lade ◽  
Gail F. Ryan ◽  
...  
Keyword(s):  
De Novo ◽  
Cell Transformation ◽  
Early Stage ◽  
Large Cell ◽  
Tumor Stage ◽  
Advanced Stage ◽  
Long Term Outcomes ◽  
Stage Disease ◽  
Large Cell Transformation

Abstract Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term outcomes and identify clinical predictors of outcome in patients with advanced-stage disease (ASD, n = 92) and large cell transformation (LCT, n = 22). Two-thirds of patients with ASD presented with de novo ASD. The median overall survival (OS) for ASD was 5 years with a 10-year predicted OS of 32%. Age at initial diagnosis (P = .01), tumor stage (P = .01), and clinical stage (P = .001) were found to be significant predictors of outcome. Patients who presented with de novo ASD demonstrated better outcomes that were not statistically significant than those with a prior diagnosis of early-stage MF (P = .25). Transformation developed in 22 of the 297 MF/SS patients (7.4%), with a transformation rate of only 1.4% in patients with early-stage disease, compared with stage IIB (27%) and stage IV (56%-67%) disease. The median OS from diagnosis of LCT was 2 years. We confirm that the incidence of LCT is strongly dependent on tumor stage at diagnosis, and we demonstrate a much lower overall risk of LCT than previously reported.

Investigating the impact of body mass index on intraperitoneal chemotherapy outcomes in patients with advanced stage ovarian cancer

2015 ◽  
Vol 136 (2) ◽  
pp. 402-403
Author(s):  
M. Davis ◽  
A. Rauh-Hain ◽  
M. Worley ◽  
R. Berkowitz ◽  
J. Schorge ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Intraperitoneal Chemotherapy ◽  
Advanced Stage ◽  
The Impact
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