scholarly journals Diabetic peripheral neuropathy and its determinants among patients attending a tertiary health care centre in Mangalore, India

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Monisha D’Souza ◽  
Vaman Kulkarni ◽  
Unnikrishnan Bhaskaran ◽  
Humam Ahmed ◽  
Hegde Naimish ◽  
...  

<p><em>Background</em>. The burden of diabetes mellitus (DM) is on the rise especially in developing countries like India. Due to its chronic nature DM tends to cause many debilitating complications and diabetic peripheral neuropathy (DPN) is one of them. The aim of this study is to determine the prevalence of DPN among patients attending a tertiary care hospital and to identify the determinants associated with it. <br /><em>Design and methods</em>. A cross sectional study was conducted in Government Wenlock Hospital, Mangalore (India), during January-February 2014. A total of 208 patients with &gt;5 year duration of DM were asked to respond to the patient history version of Michigan Neuropathy Screening Instrument (MNSI) and examinations were conducted after obtaining consent from them. The statistical analysis was done in terms of descriptive statistics and association between variables was tested using logistic regression test.<br /><em>Results</em>. The prevalence of DPN using the MNSI history version and MNSI examination were found to be 18.3% and 32.2% respectively. The major determinants associated with DPN were found to be male gender (OR: 2.7, CI: 1.4-5.1, P=0.001), smoking (OR: 5.8, CI: 1.9-17.3, P=0.001) and age &gt;40 years (OR: 2.7, CI: 1.2-5.8, P=0.011). <br /><em>Conclusions</em>. The burden of undetected DPN was found to be higher among diabetics, with an especially higher prevalence among males, smokers and those with long standing diabetes mellitus. Interventions in the form of early detection through routine screening, smoking cessation and regular follow up examinations would go a long way in reducing the burden of disability among diabetics and improve their quality of life significantly.</p>

Author(s):  
Sujeet A. Divhare ◽  
Satyashil Ingale

Background: Potential importance of drug –drug interactions (DDIs) is increasing as polypharmacy becomes more prevalent. Because additional data on the incidence and pattern of potential DDIs among diabetic patients are lacking in India, and supplemental pharmacodynamic or clinical outcome information is needed to address importance of a drug- drug interaction. Aim and objectives: To identify and analyze the pattern of DDIs in patients being prescribed anti-diabetic drugs in a tertiary care hospital. Material and Methods: This prospective cross-sectional study was carried out for a period of three months in 200 Type 2 diabetes mellitus (Type 2 DM) patients who were taking at least one antidiabetic agent during the period of past six months, of any age and either sex admitted in medicine ward of a tertiary care teaching hospital. Only one prescription was included for each patient on his/her 3rd day of hospitalization in the ward. Results: A total of 1217 drugs were prescribed in 200 prescriptions, resulting in an average of 6.1 drugs per prescription. A total of 637 potential DDIs were noted. The majority were seen in middle aged and elderly people. No overall difference was detected in the patients on insulin or metformin therapy taking or not taking additional drugs with the potential to interact. Worse control was found in the group of patients on sulphonylurea therapy taking interacting drugs (P <0.05). This difference was most marked in the group of patients over 60 years of age, who also had the highest intake of potentially interacting drugs (57%; <35 years-37%). Conclusion: Antidiabetic drugs have numerous interactions. A good practice is to use a drug­–drug interaction checker if any questions arise, several are available online. Quality care starts with the clinician obtaining a complete medication list for each patient at the start of each visit. Keywords: diabetes mellitus, drug interactions, hypoglycemic agents, drug therapy, co-morbidity, polypharmacy


Author(s):  
Sushama S. Thakre ◽  
Subhash B. Thakre ◽  
Priti N. Tiwari ◽  
Hitesh C. Tayade

Background: Breastfeeding is the most important intervention for reducing infant mortality and ensuring normal growth and development of a child. Objective of this study was to assess the knowledge, attitude, and practices toward Breastfeeding among lactating mothers visiting immune-prophylaxis clinic of tertiary health care centre, Nagpur Maharashtra.Methods: A hospital-based cross-sectional study was conducted among 400 mothers at tertiary health care centre, Nagpur in the state of Maharashtra, India. The lactating mothers whose children under the age of 3 years were interviewed.Results: Maximum number of women were in the age group of 26-30 years (46%). Mothers with parity >1 had satisfactory knowledge regarding breastfeeding (p=0.0001). Prevalence of exclusive breastfeeding rate was found to be 86%.Conclusions: Efforts should be strengthened to make mothers aware of health benefits of breastfeeding for themselves and their offspring to improve the overall maternal and child health.


Author(s):  
Srishti Dixit ◽  
Nirmal Verma ◽  
Neha Shrivastava ◽  
Mini Sharma ◽  
Somen Kumar Pradhan ◽  
...  

Background: ART centres provide the comprehensive care to the people living with HIV (PLHIV) in public sector. Patients’ satisfaction is one of the commonly used outcome measures of patient care. The objective was to assess the level of satisfaction of PLHIV and factors associated with PLHIV satisfaction with the services at ART centre.Methods: The study was a cross-sectional design carried out at a tertiary level health care centre, Raipur during March 2016 to May 2016. A total of 320 PLHIV were selected into the study using systematic sampling. A pre-designed, pre-tested questionnaire was used to obtain data from the participants.Results: The mean age of the PLHIV was 37.76 years±8.59. The highest score was in “satisfaction with interaction with the pharmacist” (15.38±2.786), and the lowest in “satisfaction with general services” (13.67±2.822). 61.3% of all 320 respondents were satisfied with the overall services provided at ART centre. Older, less educated, those who take lesser time to reach ART centre and adherent respondents were more likely to be satisfied with the services.Conclusions: The study shows generally high satisfaction with services but there is still need for improvement of services in some areas where the patients showed dissatisfaction.


Author(s):  
Sadhna Sharma ◽  
Shaik Afsar Pasha ◽  
Mohammad Khawja Mohidden ◽  
E. Srikanth

Background: A wide range of commotions affecting the central and peripheral nervous systems, either directly or indirectly, may be observed in patients with diabetes mellitus. The spectrum of neurological complications among diabetes are quite varied.Methods: Authors conducted a Cross-sectional prospective observational study to study different neurological manifestations of diabetes mellitus. at NRI General Hospital, Chinakakani, Guntur District, Andhra Pradesh. The selected patients were studied in detail with history and physical examination. The investigations included Fasting Blood Sugar (FBS), Postprandial Blood Sugar (PPBS), Glycosylated Hemoglobin (HbA1C).Results: A total of 100 subjects were included in the final analysis. Majority of participants were aged between 46 to 65 years, and 55% of them were males. Only 13% of the participants had HBA1c value below 7.5 gm%. Out of 100 participants, 82% participants had diabetic peripheral neuropathy. A total of 6 subjects had cranial neuropathy, with 5% participants having 3rd nerve and one participant had 6th nerve. Involuntary movements (Chorea) was present in 4% of patients. Among the people with Seizures, 6% participants had Hyperglycemic, and 2% participants had Hypoglycemic seizures. Out of 100 participants, 7 participants had dysautonomia.Conclusions: Peripheral neuropathy was the most common neurological manifestation among the diabetic population. The other key neurological abnormalities include cranial nerve palsy, dysautonomia, seizures and Chorea. Clinicians need to be aware the entire spectrum of neurological abnormalities among patients with type 2 Diabetes.


Author(s):  
Amruta V. Dashputra ◽  
Rupesh T. Badwaik ◽  
Archana S. Borker ◽  
Amit P. Date ◽  
Priyanka Survase

Background: Vitamin-D is critically important for development, growth and maintenance of health of human being. Many evidences show association between vit-D deficiency and several serious health conditions. Data collection on use of drugs is being obtained with the aim of optimizing drug therapy. So far till date only few studies about prescription pattern of vit-D have been found. Hence it is very important to do audit of prescriptions of vit-D. The aim of the study is to provide concise and updated information about the use of vit-D in tertiary care hospital and to record demographic details of patients.Methods: After ethical approval, this cross sectional study was conducted at tertiary health centre. Patient and drug data (name of drug, dose, dosage form and route of administration) was collected from the patient’s prescriptions in OPD.Results: Highest prescriptions of vit-D were found in orthopedic department (22% of total prescriptions of that department). Prescribing percentage of vit-D in medicine department was 4.6%, dermatology 1.5% and in psychiatry 0.8% of total prescriptions. Prescriptions of vit-D in combination with calcium were found in orthopedics (52%), medicine (7%) and obstetrics and gynecology (10%) departments.Conclusions: Highest prescriptions of vit-D alone and with calcium found in orthopedic department. Periodic therapeutic audit is necessary to rationalise the use of vit D.


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