scholarly journals Operational analysis of the national sickle cell screening programme in the Republic of Uganda

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Arielle G. Hernandez ◽  
Charles Kiyaga ◽  
Thad A. Howard ◽  
Isaac Ssewanyana ◽  
Grace Ndeezi ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Screening Programme ◽  
Cost Effective ◽  
Sub Saharan Africa ◽  
Sample Collection ◽  
Healthcare Facilities ◽  
Central Public Health ◽  
Disease Case ◽  
Sub Saharan

Background: Sickle cell anaemia is a common global life-threatening haematological disorder. Most affected births occur in sub-Saharan Africa where children usually go undiagnosed and die early in life. Uganda’s national sickle cell screening programme was developed in response to a 2014 sickle cell surveillance study that documented a high disease prevalence.Objective: This study describes the temporal and financial aspects of Uganda’s 2014–2019 sickle cell screening programme.Methods: National sickle cell screening data from Uganda’s Central Public Health Laboratories were used to calculate turn-around times (TATs) from sample collection to delivery, testing, and result reporting for blood samples collected from February 2014 to March 2019. The parameters affecting specific TATs were assessed. The exact programme expenditures were analysed to determine cost per test and per positive sickle cell disease case detected.Results: A total of 278 651 samples were analysed. The median TAT from sample collection to laboratory receipt was 8 days (interquartile range [IQR]: 6–12), receipt to testing was 3 days (IQR: 1–7), and testing to result reporting was 6 days (IQR: 3–12). Altogether, the sample continuum averaged 16 days (IQR: 11–24). Lower level healthcare facilities were associated with longer sample delivery TATs. Calendar months (January and December) and larger sample volumes impacted testing and result reporting TATs. The cost per test was $4.46 (United States dollars [USD]) and $483.74 USD per positive case detected.Conclusion: Uganda’s sickle cell screening programme is efficient and cost-effective. Universal newborn screening is the best strategy for detecting sickle cell anaemia in Uganda.

Lung function in children with sickle cell disease from Central Africa

Thorax ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 604-606 ◽  
Author(s):  
Michele Arigliani ◽  
Robert Kitenge ◽  
Luigi Castriotta ◽  
Pathy Ndjule ◽  
Vincenzo Barbato ◽  
...  
Keyword(s):  
Lung Function ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Democratic Republic ◽  
Central Africa ◽  
Sub Saharan Africa ◽  
Increased Risk ◽  
Republic Of The Congo ◽  
Sub Saharan ◽  
Restrictive Pattern

Lung function in patients with sickle cell anaemia (SCA) living in sub-Saharan Africa is largely unknown. Anthropometry and spirometry were cross-sectionally evaluated in patients with SCA (HbSS) aged 6–18 years and in schoolchildren from the Democratic Republic of the Congo. The Global Lung Initiative 2012 spirometry reference values were used. A total of 112 patients and 377 controls were included. Twenty-six per cent of patients with SCA had spirometry findings suggestive of a restrictive pattern and 41% had a FEV1 z-score <5th percentile. Wasting, increasing age and female sex were independently associated with increased risk of restrictive spirometry pattern in patients with SCA. Longitudinal studies could clarify the prognostic meaning of these findings.

Initiation of prenatal genetic diagnosis of sickle cell anaemia in Cameroon (sub-Saharan Africa)

2011 ◽  
Vol 31 (12) ◽  
pp. 1210-1212 ◽  
Author(s):  
Ambroise Wonkam ◽  
Cedrik Ngongang Tekendo ◽  
Huguette Zambo ◽  
Michael A. Morris
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Genetic Diagnosis ◽  
Sub Saharan Africa ◽  
Prenatal Genetic Diagnosis ◽  
Sub Saharan

scholarly journals Prevalence of sickle cell disease and sickle cell trait among children admitted to Al Fashir Teaching Hospital North Darfur State, Sudan

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Mudathir A. Adam ◽  
Nassreldeen K. Adam ◽  
Babiker A. Mohamed
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Sickle Cell Anaemia ◽  
Sickle Cell Trait ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Normal Individuals ◽  
Sub Saharan ◽  
Hb Concentration

Abstract Objective It is estimated that 50% to 90% of infants born with (SCA) in sub-Saharan Africa die before 5 years old. Northern Darfur State at western Sudan region has a multiethnic population with a high frequency of sickle cell anaemia, but little about it is published. This study aimed to determine the prevalence of sickle cell anaemia among children admitted to Al Fashir Teaching Hospital in Al Fashir, Northern Darfur State, Sudan. Results The prevalence of sickle cell disease by haemoglobin electrophoresis among these 400 children patients was 59 (14.8%). Sickle cell trait patients were 11.3% and Sickle cell disease positive patients were 3.5%. Individuals with SCA have consistently low blood Hb concentration, normal MCV and high mean WBC’s. Individuals with sickle cell trait had haematological parameters near to those of normal individuals.

scholarly journals Incidence of Sickle Cell Anaemia among Children Attending Maryam Abacha Women and Children Hospital, Sokoto

2020 ◽  
pp. 66-71
Author(s):  
S. Y. Lema ◽  
J. Suleiman ◽  
J. Ibrahim
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Sub Saharan Africa ◽  
Age Group ◽  
The World ◽  
Genotype Test ◽  
Women And Children ◽  
Sub Saharan ◽  
Male Subjects

Sickle Cell Anaemia is still considered the most common genetic disease worldwide, causing morbidity and mortality in Sub-Saharan Africa, Mediterranean areas, Middle East and India. Nigeria, being the most populous black nation in the world, bears its greatest burden in Sub-Saharan Africa. This study was conducted to determine the incidence of Sickle Cell Anaemia among children attending Maryam Abacha Women and Children Hospital, Sokoto. A total of one hundred (100) blood samples were examined for the disease. Out of the 100 children tested for the disease. (59%) were normal (HbAA), (35%) were carrier (HbAS) and (6%) were Sicklers (HbSS). The result based on gender showed that female has the highest percentage of the disease (5%) against male subjects with only (1%). A child between the age group 6-10 years has the highest rate of sickle cell anaemia (3%) while age group 11-15 years had the lowest rate of the infection. Improved knowledge regarding Sickle cell anaemia disease and its comprehensive care among Nigerian physicians will enhance quality of care for affected childrens and policy for regular genotype test by government and other stakeholders before marriage among Nigerians will help to prevent the disease.

scholarly journals Gene Therapy : The New Weapon Against Diseases Until There Difficult To Overcome: Some Current Facts Of Gene Therapy And Cases Of Sickle Cell Anaemia

2020 ◽  
Vol 4 (3) ◽  
pp. 01-07
Author(s):  
Carolle Kpoumie
Keyword(s):  
Gene Therapy ◽  
Sickle Cell ◽  
Genetic Disease ◽  
Sickle Cell Anaemia ◽  
Black People ◽  
The Body ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Mass Migration ◽  
Sub Saharan

Sickle cell anaemia is an inherited genetic disease that affects the hemoglobin chains of red blood cell hemoglobin, carrying oxygen less well through the body. It is a rare disease, however, it is the most widespread genetic disease in the world and especially widespread in sub-Saharan Africa. It causes anemia, painful seizures that affect several organs, it is also called sickle cell anemia, this disease results in a deformation of red blood cells in the form of sickle or a crescent moon, which prevents normal circulation in the blood vessels. This will cause blood flow to be blocked. It is a disease that is geographically concentrated in certain areas such as Africa, India, Brazil, the Mediterranean Basin, but it is currently found everywhere because of mass migration and has been considered since 2008 by United Nations as a public health priority. Sickle cell disease affects black people and accounts for 50% of deaths in childhood.

High rate of sickle cell anaemia in Sub-Saharan Africa underlines the need to screen all children with severe anaemia for the disease

2015 ◽  
Vol 104 (12) ◽  
pp. 1269-1273 ◽  
Author(s):  
Bertin Tshimanga Kadima ◽  
Jean Lambert Gini Ehungu ◽  
René Makwala Ngiyulu ◽  
Pépé Mfutu Ekulu ◽  
Michel Ntetani Aloni
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Severe Anaemia ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Sub Saharan

scholarly journals Evaluation of Vitamin D in Sickle Cell Anaemia Patients at Steady State

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Umar Aminu Abdullah ◽  
Mohammed Bashir AbdulRahman ◽  
Bello Aminu ◽  
Abubakar Umar Musa ◽  
Isah Balarabe
Keyword(s):  
Vitamin D ◽  
Steady State ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Public Health Problem ◽  
Bone Fragility ◽  
Sub Saharan Africa ◽  
Major Public Health Problem ◽  
The Mean ◽  
Sub Saharan

Background: Sickle cell anaemia is a major public health problem in sub-Saharan Africa with high morbidities like bony alterations and bone fragility especially in those with vitamin D deficiency. There is paucity of research data on bone biomarkers in patients with sickle cell anaemia especially in Northern Nigeria. The aim of this study was to evaluate vitamin D in adult sickle cell anaemia patients at steady state. Materials and Methods: Seventy-seven patients with sickle cell anaemia and equal number of apparently healthy matched controls were recruited for the study. Various biochemical parameters of bone metabolism were measured. Data were analysed using IBM SPSS version 23.0. Results: The mean age of SCA adult patients and controls wer

Living with sickle cell disease: voices from sub-Saharan Africa

2021 ◽  
Author(s):  
Arafa Said Salim ◽  
Emmy Mwita ◽  
Joseph Sarfo Antwi ◽  
Olamide Agunkejoye ◽  
Paul Mdliva
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Sub Saharan

Abstract 65: Anemia-related Heart Failure in Sub-saharan African Sickle Cell Disease Patients

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Adebayo C Atanda ◽  
Yahya Aliyu ◽  
Oluwafunmilayo Atanda ◽  
Aliyu Babadoko ◽  
Aisha Suleiman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Hemoglobin Level ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Jet Velocity ◽  
Sub Saharan

Introduction: Anemia has been implicated in heart failure. Existing literatures, involving predominantly African-Americans, suggests that Sickle Cell Disease (SCD) maybe linked to various cardiovascular complications including pulmonary hypertension and left venticular dysfunction. Peculiarly, our study involves exclusively Sub-Saharan population. Method: We conducted a cross sectional observational study of 208 hydroxyurea-naive consecutive SCD patients aged 10-52 years at steady state and 94 healthy non-matched controls who were studied in an out patient clinic in Sub-Saharan Africa. SCD patients were required to have electrophoretic or liquid chromatography documentation of major sickling phenotypes. Control group was required to have non-sickling phenotypes. Cardiac measurements were performed with TransThoracic Echo according to American Society of Echocardiography guidelines. Hemoglobin level was also obtained. Results: Hemoglobin level in SCD group (8.5+/- 1.5) was significant (P<0.001) compared to control (13.8+/- 1.7). Although SCD group had significantly higher values of left ventricular (LV) size, there was no qualitative evidence of LV dysfunction. SCD group had higher values of Ejection Fraction but not statistically significant. There was no evidence of LV wall stiffening to impair proper filling in SCD group, with the ratio of early to late ventricular filling velocities, E/A ratio elevated (1.7+/-0.4 compared to 1.6+/- 0.4; P=0.010). Right ventricular systolic pressure was determined using the formula of 4x Tricuspid Reugurgitant jet (TRV) square as an indirect measurement of Pulmonary arterial systolic pressure. SCD patients had significantly higher mean±SD values for tricuspid regurgitant jet velocity than did the controls (2.1±0.6 vs. 1.8±0.5; p= 0.001). Within the SCD group, there was no clear pattern of worsening diastolic function with increased TRV. Furthermore, E/A had a significant positive relationship with jet velocity in bivariate analysis (R=0.20; P=0.013). Conclusions: We were unable to demonstrate existence of anemia-associated left ventricular dysfunction in Sub-Saharan African with SCD. Further studies is required to highlight the reason behind this finding.

Sign in / Sign up

Export Citation Format

Share Document