scholarly journals Implementation of broad screening with Ebola rapid diagnostic tests in Forécariah, Guinea

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Frantz Jean Louis ◽  
Jennifer Y. Huang ◽  
Yacouba K. Nebie ◽  
Lamine Koivogui ◽  
Gayatri Jayaraman ◽  
...  
Keyword(s):  
Diagnostic Tests ◽  
Ebola Virus ◽  
Virus Disease ◽  
Febrile Illness ◽  
Emergency Situation ◽  
Rapid Diagnostic Tests ◽  
Lessons Learned ◽  
Healthcare Facilities ◽  
Implementation Team ◽  
Pilot Implementation

Background: Laboratory-enhanced surveillance is critical for rapidly detecting the potential re-emergence of Ebola virus disease. Rapid diagnostic tests (RDT) for Ebola antigens could expand diagnostic capacity for Ebola virus disease.Objectives: The Guinean National Coordination for Ebola Response conducted a pilot implementation to determine the feasibility of broad screening of patients and corpses with the OraQuick® Ebola RDT.Methods: The implementation team developed protocols and trained healthcare workers to screen patients and corpses in Forécariah prefecture, Guinea, from 15 October to 30 November 2015. Data collected included number of consultations, number of fevers reported or measured, number of tests performed for patients or corpses and results of confirmatory RT-PCR testing. Data on malaria RDT results were collected for comparison. Feedback from Ebola RDT users was collected informally during supervision visits and forums.Results: There were 3738 consultations at the 15 selected healthcare facilities; 74.6% of consultations were for febrile illness. Among 2787 eligible febrile patients, 2633 were tested for malaria and 1628 OraQuick® Ebola RDTs were performed. A total of 322 OraQuick® Ebola RDTs were conducted on corpses. All Ebola tests on eligible patients were negative.Conclusions: Access to Ebola testing was expanded by the implementation of RDTs in an emergency situation. Feedback from Ebola RDT users and lessons learned will contribute to improving quality for RDT expansion.

scholarly journals Clinical Evaluation of QuickNaviTM-Ebola in the 2018 Outbreak of Ebola Virus Disease in the Democratic Republic of the Congo

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 589 ◽  
Author(s):  
Sheila Makiala ◽  
Daniel Mukadi ◽  
Anja De Weggheleire ◽  
Shino Muramatsu ◽  
Daisuke Kato ◽  
...  
Keyword(s):  
West Africa ◽  
Diagnostic Tests ◽  
Ebola Virus ◽  
Democratic Republic ◽  
Virus Disease ◽  
Point Of Care ◽  
Rapid Diagnostic Tests ◽  
Ebola Virus Disease ◽  
Blood Samples ◽  
Republic Of The Congo

The recent large outbreaks of Ebola virus disease (EVD) in West Africa and the Democratic Republic of the Congo (DRC) have highlighted the need for rapid diagnostic tests to control this disease. In this study, we clinically evaluated a previously developed immunochromatography-based kit, QuickNaviTM-Ebola. During the 2018 outbreaks in DRC, 928 blood samples from EVD-suspected cases were tested with QuickNaviTM-Ebola and the WHO-approved GeneXpert. The sensitivity and specificity of QuickNaviTM-Ebola, estimated by comparing it to GeneXpert-confirmed cases, were 85% (68/80) and 99.8% (846/848), respectively. These results indicate the practical reliability of QuickNaviTM-Ebola for point-of-care diagnosis of EVD.

scholarly journals Dispensary level pilot implementation of rapid diagnostic tests: an evaluation of RDT acceptance and usage by providers and patients – Tanzania, 2005

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Holly Ann Williams ◽  
Louise Causer ◽  
Emmy Metta ◽  
Aggrey Malila ◽  
Terrence O'Reilly ◽  
...  
Keyword(s):  
Diagnostic Tests ◽  
Rapid Diagnostic Tests ◽  
Pilot Implementation

scholarly journals Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial

BMJ ◽  
2007 ◽  
Vol 334 (7590) ◽  
pp. 403 ◽  
Author(s):  
Hugh Reyburn ◽  
Hilda Mbakilwa ◽  
Rose Mwangi ◽  
Ombeni Mwerinde ◽  
Raimos Olomi ◽  
...  
Keyword(s):  
Outpatient Treatment ◽  
Diagnostic Tests ◽  
Randomised Trial ◽  
Febrile Illness ◽  
Rapid Diagnostic Tests ◽  
Malaria Microscopy

scholarly journals Implementation of a study to examine the persistence of Ebola virus in the body fluids of Ebola virus disease survivors in Sierra Leone: Methodology and lessons learned

2017 ◽  
Vol 11 (9) ◽  
pp. e0005723 ◽  
Author(s):  
Gibrilla Fadlu Deen ◽  
Suzanna L. R. McDonald ◽  
Jaclyn E. Marrinan ◽  
Foday R. Sesay ◽  
Elizabeth Ervin ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Body Fluids ◽  
Lessons Learned ◽  
The Body ◽  
Ebola Virus Disease

scholarly journals Post-Ebola Epidemic and Sustenance of Healthy Behaviour, Looking Back and Moving Forward

2019 ◽  
Vol 10 (1) ◽  
pp. 11
Author(s):  
Veronica Akwenabuaye Undelikwo ◽  
Rosemary Ine Eneji ◽  
Eucharia Nwabugo Nwagbara
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Electronic Media ◽  
Personal Hygiene ◽  
Depth Information ◽  
Healthcare Facilities ◽  
Hygiene Practices ◽  
Preventive Practices ◽  
Or Organization ◽  
The University

In 2014 the Ebola virus disease became a significant health challenge in much of West Africa, notably Guinea, Liberia, Sierra Leone, even Nigeria. The Ebola epidemic knows no geographical boundary as both developed and developing countries are susceptible to its menace. Key facts about the disease and what could be done to mitigate its spread were awash in both the print and electronic media at the height of its outbreak. There was increased awareness of personal hygiene practices of constant washing of hands and using hand-sanitizers. Body temperature was checked in public places such as airports, schools, etc. There were hardly anywhere, home or organization that you will not find sanitizers and clean water dispensers for hand-washing strategically stationed. 798 respondents from the University of Calabar (staff and students) were surveyed as well as five key informants for in-depth information on what has become of the healthy hygienic practices, and to determine whether Nigerians are still conscious of Ebola and how to achieve sustained healthy practices even after the epidemic. These preventive practices need to be intensified and sustained to consolidate the gains attained in the fight against the dreaded virus. We found a total decline in safety practices by individuals and organizations and this itself raises a major concern about their repercussions, given the paucity and unpreparedness of healthcare facilities. Worse still, relevant agencies such as the print and electronic media are no longer carrying out the awareness campaign.

Ebola Virus Disease - clinical manifestations, management and future therapies

2019 ◽  
Vol 105 (2) ◽  
pp. 113-120
Author(s):  
D O’Brien ◽  
M K O’Shea ◽  
T E Fletcher
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Armed Forces ◽  
Lessons Learned ◽  
The Body ◽  
Ebola Virus Disease ◽  
International Response ◽  
The Uk ◽  
Specific Symptoms

AbstractThe largest epidemic of Ebola Virus Disease in recorded human history occurred in West Africa in 2014 and resulted in significant morbidity and mortality. The causative pathogen, Ebola virus, is readily transmitted through contact with the body fluids of infected individuals and from the bodies of those who have died from the disease. In its early stages, the illness is characterised by non-specific symptoms that mimic many other endemic infectious diseases in countries with limited healthcare resources. These factors contributed to the rapid spread of the outbreak, which required an international response in which the UK Armed Forces played an important role. This review describes the clinical presentation, lessons learned from managing the West African outbreak, and potential future treatments.

Participatory Monitoring and Evaluation of Ebola Response Activities in Lofa County, Liberia: Some Lessons Learned

2019 ◽  
Vol 40 (1) ◽  
pp. 57-66
Author(s):  
Ithar Hassaballa ◽  
Stephen Fawcett ◽  
Charles Sepers ◽  
Florence DiGennaro Reed ◽  
Jerry Schultz ◽  
...  
Keyword(s):  
Evaluation System ◽  
Quantitative Methods ◽  
Ebola Virus ◽  
Virus Disease ◽  
Monitoring And Evaluation ◽  
Lessons Learned ◽  
Ebola Virus Disease ◽  
World Health ◽  
Response Effort ◽  
Participatory Monitoring

To address the Ebola outbreak in West Africa, the World Health Organization and the United Nations Children’s Fund led a multilevel and multisectoral intervention known as the Ebola response effort. Although surveillance systems were able to detect reduction in Ebola incidence, there was little understanding of the implemented activities within affected areas. To address this gap, this empirical case study examined (a) implementation of Ebola response activities and associated bending the curve of incidence of Ebola virus disease and (b) candidate factors associated with fuller implementation of the Ebola response effort. A mix of qualitative and quantitative methods were used to address these questions. A participatory monitoring and evaluation system was used to capture, code, characterize, and communicate nearly a hundred Ebola response activities implemented in Lofa County, a highly affected area in Liberia. The Ebola response effort was enabled by community engagement and collaboration across different sectors. Results showed fuller implementation corresponded with a marked reduction in Ebola virus disease. This report concludes with a discussion of how monitoring and evaluation can strengthen implementation of activities needed to address disease outbreaks.

scholarly journals Obstetrical Surgery in the Context of Ebola Virus Disease (Ebola) in Guinea: Lessons Learned from 2 Cases

2019 ◽  
Vol 09 (10) ◽  
pp. 1305-1314
Author(s):  
Bah Elhadj Mamoudou ◽  
Diallo Ibrahima Sory ◽  
DialloThierno Saidou ◽  
Leno W. Daniel ◽  
Soumah Aboubacar Fode Momo ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Lessons Learned ◽  
Ebola Virus Disease
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