scholarly journals A comparison of the ability of three common contact lens solutions with different constituents to inhibit growth of Staphylococcus aureus

2015 ◽  
Vol 74 (1) ◽  
Author(s):  
Marsha Oberholzer ◽  
Jacques Raubenheimer ◽  
Marga Lyell ◽  
Sade Pieterse ◽  
Aveli Keyser ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Contact Lens ◽  
Contact Lenses ◽  
Iso Standard ◽  
Iso Standards ◽  
Soft Contact Lenses ◽  
Log Reduction ◽  
Contact Lens Solutions ◽  
Mucosal Surfaces ◽  
Solution Saline

Background: Staphylococcus aureus is a common commensal on skin and mucosal surfaces; its contact with the eye may cause a variety of ocular inflammations and infections such as blepharitis, conjunctivitis and keratitis, amongst others. Soft contact lenses provide perfect conditions for the breeding of certain pathogens, and disinfecting solutions for contact lenses are therefore of utmost importance. These solutions should be effective in inhibiting the growth of a variety of pathogens to protect the user from ocular infections.Aim: To highlight the need for clinicians to be aware of the effects of various recommended disinfecting contact lens solutions.Method: Three popular disinfecting contact lens solutions readily available in South Africa were chosen. These and a control solution (saline) were prepared and inoculated with S. aureus to evaluate the antimicrobial efficacy of each solution. The primary stand-alone test was used to evaluate the solutions according to the ISO standard specifically for this purpose.Results: The test results indicated that two of the solutions met the ISO standards; the third failed. Of the two that passed the test, only one showed the required 3-log reduction after 30 minutes, as per the ISO standard, although this solution is marketed as a ’10 minute system’.Conclusion: It is important for clinicians to be aware of the complications that may be caused by contaminated solutions, and patients should be warned about the effects thereof. To ensure healthy eyes for our patients, sufficient knowledge regarding the efficacy of recommended multipurpose solutions is necessary. Solutions that meet ISO standards promote good ocular health and ensure sufficient cleaning and disinfecting of contact lenses.

scholarly journals Comparison of the Antimicrobial Efficacy of Various Contact Lens Solutions to Inhibit the Growth of Pseudomonas aeruginosa and Staphylococcus aureus

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
B. Laxmi Narayana ◽  
Pooja Rao ◽  
Sevitha Bhat ◽  
K. Vidyalakshmi
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Contact Lenses ◽  
Bacterial Species ◽  
Antimicrobial Effect ◽  
Test Method ◽  
Medical College ◽  
Soft Contact Lenses ◽  
Contact Lens Solution

Soft contact lenses provide perfect conditions for the breeding of pathogens. The study is a prospective, experimental study, conducted to know the antimicrobial ability of multipurpose contact lens solution against standard strains of Staphylococcus aureus and Pseudomonas aeruginosa by the stand-alone test. The test method is based on the procedures in the ISO 14729 standard primary stand-alone test. Three multipurpose contact lens care solutions commercially available in Mangalore markets, namely, Biotrue (Bausch & Lomb), Opti-Free Replenish (Alcon), and Aquasoft (Stericon Pharma), were tested for its antimicrobial effect in the microbiology lab at Kasturba Medical College, Mangalore. According to this study, the solutions named “Biotrue” and “Aquasoft” met the primary stand-alone and reached the 3log reduction and 5log reduction criteria in the manufacturer recommended time, respectively. No conclusion could be drawn for Opti-Free Replenish since the minimum recommended disinfection time was overnight, whereas it was noted for 6 hr only, and it should have been experimented further. The effectiveness of multipurpose solutions varies against different bacterial species. We have observed that the antimicrobial activity of different solutions varies with respect to time of incubation, and also there was a marked difference in the activity of some solutions against S. aureus and P. aeruginosa. So, it is necessary for the contact lens users to store their lenses in solutions for longer duration of hours. It is also recommended to use solutions that clear the ISO 14729 standards for better health conditions of the eye.

scholarly journals Bacterial adhesion to Conventional and Silicone hydrogel contact lenses

2021 ◽  
Vol 23 (1) ◽  
pp. 25-35
Author(s):  
Eghosasere Iyamu ◽  
Frederick Osaro Ekhaise
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Bacterial Adhesion ◽  
Contact Lenses ◽  
Bacterial Species ◽  
Soft Contact ◽  
Silicone Hydrogel ◽  
Soft Contact Lenses ◽  
Lens Wear

Purpose: The aim of this study was to investigate the adhesion of bacteria to worn silicone hydrogel and conventional soft contact lenses.Methods: Bacterial adhesion experiments / assays were performed on 24 worn and 6 unworn soft contact lenses each of different materials (high- and low- gas permeable lenses) using the strains such as Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 25923.Results: P. aeruginosa adhered in increased number to worn than unworn Lotrafilcon A and conventional lenses. However, a higher number of P. aeruginosa adhered to unworn than worn Lotrafilcon B, the difference in the mean adhesion was not significant (p = 0.66). S. aureus adhered in significantly decreased number to worn Lotrafilcon A, nelfilcon A, nesofilcon A, etafilcon A and omafilcon A (p<0.05); butsignificantly higher number adhered to worn than unworn polymacon (p<0.05). Lens wear had no effect on the adhesion of S. aureus to Lotrafilcon B (p>0.05). The least adhesion of P. aeruginosa to worn contact lenses was seen with polymacon, while S. aureus adhered in least number to worn Lotrafilcon A compared to the other contact lens materials that demonstrated the same trend in adhesion.Conclusion: The higher adhesion of P. aeruginosa to worn lenses is consistent with the claim that it is the most implicated in all culture-positive contact lens related bacterial keratitis. Lens wear has different effects on bacterial adhesion, which may be due to type of lens materials and bacterial species/genera studied. Keywords: Silicone hydrogel lenses, conventional lenses, Pseudomonas aeruginosa, Staphylococcus aureus, bacterial adhesion.

scholarly journals Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaohong Hu ◽  
Lingyun Hao ◽  
Huaiqing Wang ◽  
Xiaoli Yang ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Contact Lenses ◽  
Drug Carriers ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

Cosmetics and Contact Lenses: Influence on Safety

The Eye ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 59-63
Author(s):  
S. V. Zimovets ◽  
A. Ya. Sverdlik
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Cosmetic Products ◽  
Soft Contact ◽  
Dry Eyes ◽  
Soft Contact Lenses

The article describes the effect of decorative cosmetics on the material of soft contact lenses and studies specific features that can be observed in SCL wearers who use cosmetics extensively. Examples of complications associated with the use of various cosmetic products that may occur in contact lens wearers are given. Conclusion: in cases when patients have complaints about discomfort and dry eyes, doctors should pay attention to the amount of decorative cosmetics used as well as study the effect it can have on the surface of the contact lenses.

scholarly journals The impact of wearing single vision soft contact lenses on the peripheral refractive error

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2803
Author(s):  
Kareem Allinjawi ◽  
Sharanjeet-Kaur Sharanjeet-Kaur ◽  
Saadah Mohamed Akhir ◽  
Haliza Abdul Mutalib
Keyword(s):  
Visual Field ◽  
Open Field ◽  
Refractive Error ◽  
Contact Lens ◽  
Contact Lenses ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Single Vision ◽  
The Right ◽  
The Impact

Aim: The purpose of this study was to determine the changes in the relative peripheral refractive error produced by soft single vision contact lenses in myopic schoolchildren. Methods: 27 myopic schoolchildren aged between 13 to 15 years were included in this study. The measurements of central and peripheral refraction were made only on the right eye using a Grand-Seiko WR-5100K open-field autorefractometer without contact lens (WL), and with wearing single vision contact lens (SVCL). Refractive power was measured at center and horizontal eccentricity between 35° temporal to 35° nasal visual field (in 5° steps). Results: SVCL showed an increase in peripheral hyperopic defocus at the nasal and temporal visual field compare with baseline, but this change was not statistically significant (p=0.129). Conclusion: Wearing single vision soft contact lenses increases the relative peripheral hyperopic defocus in myopic schoolchildren.

scholarly journals Tannic acid-modified silver nanoparticles enhance anti-Acanthamoeba activity without increasing cytotoxicity of three multipurpose contact lens solutions

2020 ◽  
Author(s):  
Edyta Beata Hendiger ◽  
Marcin Padzik ◽  
Agnieszka Żochowska ◽  
Wanda Baltaza ◽  
Gabriela Olędzka ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Tannic Acid ◽  
Contact Lens ◽  
Contact Lenses ◽  
Colorimetric Assay ◽  
Statistical Significance ◽  
Plant Metabolites ◽  
Contact Lens Solutions ◽  
Preventive Actions

Abstract Background: Free living amoebae of Acanthamoeba genus are cosmopolitan, widely distributed protozoans causing severe, vision-threatening corneal infection known as Acanthamoeba keratitis (AK). Majority of the increasing number of AK cases are associated with contact lenses use. Due to lack of effective therapies against AK, proper eye hygiene and effective contact lenses disinfection are crucial in prevention of this infection. Currently available multipurpose contact lens disinfection systems are not fully effective against Acanthamoeba trophozoites and cysts. There is an urgent need to increase the disinfecting activity of these systems to prevent Acanthamoeba keratitis infections. Synthesized nanoparticles have been recently studied and proposed as a new generation of anti-microbial agents. It is also known that plant metabolites, including tannins, present anti-parasitic activity. The aim of this study was to evaluate the anti-amoebic activity and cytotoxicity of the tannic acid-modified silver nanoparticles (AgTANPs) conjugated with the selected multipurpose contact lens solutions.Methods: The anti-amoebic activity of pure contact lens care solutions and nanoparticles conjugated with contact lens care solutions were examined in vitro by colorimetric assay, based on the oxido-reduction of AlamarBlue. The cytotoxicity assays were performed using a fibroblast HS-5 (ATCC CRL-11882) cell line. The results were statistically analyzed by ANOVA and Student-Newman-Keuls tests using the p<0.05 level of a statistical significance.Results: The obtained results showed that nanoparticles enhanced anti-Acanthamoeba activity of the tested contact lens solutions without increasing their cytotoxicity profile. The activity is enhanced within minimal disinfection time recommended by the manufacturer.Conclusions: The conjugation of the selected contact lens solutions with AgTANPs might be a novel and promising approach as a part of preventive actions of Acanthamoeba keratitis infections among contact lens users.

scholarly journals STUDY OF THE OPTICAL POWER OF NANOPHOTONIC SOFT CONTACT LENSES BASED ON POLY (2- HYDROXYETHYL METHACRYLATE) AND FULLERENE

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Aleksandra Debeljković Mitrović ◽  
Dragomir Stamenković ◽  
Manuel Conte ◽  
Božica Bojović ◽  
Spomenko Mihajlović
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Measurement Techniques ◽  
Optical Power ◽  
Soft Contact ◽  
Standard Material ◽  
Soft Contact Lenses ◽  
Soft Contact Lens ◽  
Power Cylinder

In this paper results of comparative study of the optical power of soft contact lenses (SCL) made of standard material for SCL and nanophotonic materials with different measurement techniques used for the final contact lens controllers are presented. Three types of nanophotonic soft contact lenses were made of standard polymacon material (Soleko SP38TM) incorporated with fullerene C60, fullerol C60(OH)24 and fullerene metformin hydroxylate C60(OH)12(OC4N5H10)12. For the purposes of material characterization for potential application as soft contact lenses, the optical properties of the soft contact lenses were measured by Rotlex and Nidek device. With Rotlex device the following optical results were obtained: optical power and map of defects, while with the Nidek device: optical power, cylinder power and cylinder axis. The obtained values of optical power and map of defects showed that the optical power of synthesized nanophotonic soft contact lens is same to the nominal value, while this was not the case for the standard soft contact lens. Also, the quality of the nanophotonic soft contact lens is better than the standard one. Hence, it is possible to synthesize new nanophotonic soft contact lenses of desired optical characteristics, implying possibilities for their application in this field.

The Effect of Photoinitiator Concentration on the Physicochemical Properties of Hydrogel Contact Lenses

2014 ◽  
Vol 679 ◽  
pp. 118-127 ◽  
Author(s):  
Deirdre M. McElroy ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
Sinead M. Devery
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Contact Lens ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.

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