scholarly journals Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)

2021 ◽  
Vol 5 ◽  
Author(s):  
Fungai Musaigwa ◽  
Ravnit Grewal ◽  
Akin Abayomi ◽  
Carmen C. Swanepoel
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Developed Countries ◽  
Tertiary Hospital ◽  
Men And Women ◽  
Laboratory Service ◽  
Younger Age ◽  
Trisomy 12 ◽  
Chromosome 13Q14 ◽  
Age Range

Background: Chronic lymphocytic leukaemia (CLL) is a common lymphoproliferative disorder in developed countries. However, this condition is rare in Africa and there is a paucity of information on CLL, specifically on the continent.Aim: This study described, retrospectively, the frequency, demographics and laboratory features of CLL cases diagnosed from 2011 to 2016.Setting: Department of Pathology, National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town.Methods: A retrospective analysis was performed for all CLL diagnoses made between 01 January 2011 and 31 December 2016.Results: Eighty CLL cases were diagnosed between 2011 and 2016. Men and women presented with the disease equally (48.8% vs. 51.2%, p 0.05). The mean age at diagnosis was 66.79 years (range of 37–95 years) and the modal age range (36.3%) was 60–69 years. Men presented with the disease at a significantly younger age than women (mean = 64 years vs. mean = 69.5 years, p 0.05). There were three (3.75%) human immunodeficiency virus (HIV)-positive patients (age range 43–50 years). Chromosome 13q14 deletion was found in 6 out of 19 patients (31.6%). Trisomy 12 and deletion 11q22 were found in 5 out of 21 (24%) and 7 out of 21 (33.3%) patients, respectively. Deletions 13q34 and 17p were negative for 6 and 20 patients, respectively.Conclusion: Chronic lymphocytic leukaemia at our facility presented equally in men and women. Men presented with the disease at a younger age than women. Additionally, our findings suggested that HIV is uncommon amongst CLL patients tested for HIV.

Characterization of Electroencephalographic Findings at an Electrodiagnostic Unit of a Tertiary Hospital, North-central Nigeria

2021 ◽  
Vol 2 (1) ◽  
pp. 49-55
Author(s):  
E U Iwuozo ◽  
J O Enyikwola ◽  
I O Obekpa ◽  
O O Ijachi ◽  
A A Godwin ◽  
...  
Keyword(s):  
Tertiary Hospital ◽  
Seizure Disorder ◽  
Cross Sectional ◽  
North Central ◽  
Younger Age ◽  
High Prevalence ◽  
Diagnosis And Classification ◽  
Age Range

Electroencephalography (EEG) remains an important investigative tool in supporting the diagnosis and classification of various seizure types. We sought to examine and characterize the EEG findings from all patients referred for the procedure. This cross-sectional retrospective study was carried out at an EEG unit in Federal Medical Centre, Makurdi, Benue State, North Central Nigeria from May 2016 to December 2020. Relevant patients' information were extracted and analysed using SPSS version 21. A total of 484 patients were seen over the study period with age range of 1-87 years and median age of 23 years. They comprised of 254 (52.5%) male and 230 (47.5%) female. The psychiatrist and the Physicians/Neurologist referred most of them for EEG, 201 (41.5%) and 124 (25.6%) respectively. The most reported indication for EEG was clinical suspicion of seizure disorder 291 (60.1%), whilst some did not have a clear indication 111 (22.9%). About 417 (86.2%) of our patients had abnormal EEG finding out of which 414 (99.3%) were diagnostic of seizure disorder made up of generalized seizure in 255 (61.6%) and focal seizure in 159 (38.4%). About 237 (48.9%) of them were already on antiepileptic drugs (AEDs) at referral of which 190 (80.2%0 were taking carbamazepine. This study showed a high prevalence of abnormal EEG with most of them diagnostic of seizure disorder especially generalized seizure. They were mostly of younger age group with about half of them already on AEDs at referral, majority of who were sent by the Psychiatrist.

scholarly journals Free Flaps in a Resource Constrained Environment: A Five-Year Experience—Outcomes and Lessons Learned

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Wanjala F. Nangole ◽  
Stanley Khainga ◽  
Joyce Aswani ◽  
Loise Kahoro ◽  
Adelaine Vilembwa
Keyword(s):  
Free Flaps ◽  
Developed Countries ◽  
Tertiary Hospital ◽  
Lessons Learned ◽  
Resource Constrained ◽  
Free Flap Surgery ◽  
Flap Monitoring ◽  
The Many ◽  
A Prospective Study ◽  
Age Range

Introduction. Free flap surgery is a routine procedure in many developed countries with good surgical outcomes. In many developing countries, however, these services are not available. In this paper, we audit free flaps done in a resource constrained hospital in Kenya. Objective. This is a five-year audit of free flaps done in a tertiary hospital in Kenya, between 2009 and 2014. Materials and Methods. This was a prospective study of patients operated on with free flaps between 2009 and 2014. Results. A total of one hundred and thirty-two free flaps in one hundred and twenty patients were performed during the five-year duration. The age range was eight to seventy-two years with a mean of 47.2. All the flaps were done under loupe magnification. The overall flap success rate was eighty-nine percent. Conclusion. Despite the many limitations, free flaps in our setup were successful in the majority of patients operated on. Flap salvage was noted to be low due to infrequent flap monitoring as well as unavailability of theatre space. One therefore has to be meticulous during surgery to reduce any possibilities of reexploration.

scholarly journals Association and clonal distribution of trisomy 12 and 13q14 deletions in chronic lymphocytic leukaemia

1998 ◽  
Vol 102 (5) ◽  
pp. 1330-1334 ◽  
Author(s):  
Blanca Navarro ◽  
JosÉ A. GarcÍA-Marco ◽  
David Jones ◽  
Cathy M. Price ◽  
Daniel Catovsky
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Clonal Distribution ◽  
Trisomy 12

scholarly journals 4CPS-079 Sequencing of ibrutinib, idelalisib and venetoclax in chronic lymphocytic leukaemia: experience in a tertiary hospital

2020 ◽  
Author(s):  
R García-Fumero ◽  
C Alarcón-Payer ◽  
A Jiménez-Morales ◽  
MDM García-Valdés ◽  
JM Puerta-Puerta ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Tertiary Hospital

Chronic Lymphocytic Leukaemia Has a More Aggressive Phenotype in Asians Compared to Caucasians.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4965-4965
Author(s):  
Belinda Austen ◽  
Chaminda Gunawardana ◽  
Guy Pratt ◽  
Farooq Wandroo ◽  
Abe Jacobs ◽  
...  
Keyword(s):  
Overall Survival ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Age Of Onset ◽  
Western World ◽  
Control Group ◽  
Aggressive Phenotype ◽  
Racial Origin ◽  
Asian Patients ◽  
Younger Age

Abstract Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia in the western world with an incidence of 3 per 100,000. The precise aetiology remains obscure but there is clear evidence for a genetic predisposition. CLL has a seven-fold increased incidence amongst relatives of index cases compared to controls and the disease is also more common in males. These genetic subgroups can also determine phenotype as familial CLL has a younger age of onset and increased association with second malignancies compared to sporadic cases. Similarly, CLL is more aggressive and more frequently requires treatment in males in comparison to female patients. The incidence of CLL also varies according to racial origin and has been found to be up to 20-fold less common in Japanese and Asian populations compared to Caucasian populations. However, it is not known whether or not there is also phenotypic variation in CLL patients according to racial origin. We studied 29 Asian patients with a diagnosis of CLL and compared disease characteristics with a control group of 277 Caucasians. We found that CLL in Asians was diagnosed at a younger age (median age 62yr in Asians vs 70yr Caucasians, p=0.001) and was also more common in males (M:F Asians 3.1:1; Caucasians 1.3:1, p=0.023). No association was seen between racial origin and either IGVH status or CD38 status. Interestingly, we also found that the Asian population had a more aggressive clinical phenotype as indicated by a shorter time to the requirement of first treatment (TTFT) (p=0.019). This observation was independent of both age and gender. Although no difference was seen in overall survival between the two groups, ‘non-leukaemia related’ deaths were more common in the older Caucasian population. 27.5% of Caucasian deaths occurred in patients who had never required treatment for CLL whereas no deaths occurred among untreated Asian patients, for whom the primary cause of death was progressive leukaemia. The failure to observe a difference in overall survival was therefore partly accounted for by an increase in non-leukaemia related deaths in Caucasians. In conclusion, we have shown that there are phenotypic differences in CLL patients according to the racial origin. CLL in Asian patients occurs at a younger age and is associated with a more aggressive phenotype. The mechanisms underlying these observations are unknown but warrant further investigation.

scholarly journals Trisomy 19 is associated with trisomy 12 and mutatedIGHVgenes in B-chronic lymphocytic leukaemia

2007 ◽  
Vol 138 (2) ◽  
pp. 217-220 ◽  
Author(s):  
Ludger Sellmann ◽  
Stefan Gesk ◽  
Christoph Walter ◽  
Matthias Ritgen ◽  
Lana Harder ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Trisomy 12
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