Role of the Rosa canina L. leaf extract as an antidiarrheal drug in rodents

The main purpose of this study is to investigate the role of citrus leaf extract in carbon tetrachloride-induced hepatic injury and its potential molecular mechanism. Carbon tetrachloride was used to construct hepatic injury animal model. To this end, rats were randomly divided into 4 groups: control, carbon tetrachloride-treated, and two carbon tetrachloride + citrus leaf extract-treated groups. The results show that citrus leaf extract treatment significantly reversed the effects of carbon tetrachloride on the body weight changes and liver index. Besides, treatment with citrus leaf extract also reduced the levels of serum liver enzymes and oxidative stress in a dose-dependent manner. H&E staining and western blotting suggested that citrus leaf extract could repair liver histological damage by regulating AMPK and Nrf-2.

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Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae)

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2017-0058 ◽

2018 ◽

Vol 29 (6) ◽

pp. 609-619 ◽

Cited By ~ 1

Author(s):

Lucky Legbosi Nwidu ◽

Yibala I. Oboma ◽

Ekramy Elmorsy ◽

Wayne Grant Carter

Keyword(s):

Carbon Tetrachloride ◽

Leaf Extract ◽

Protective Role ◽

Lipid Peroxidation Product ◽

Hematological Indices ◽

Hepatocellular Damage ◽

Antioxidant Parameters ◽

Mechanistic Basis ◽

Histopathological Studies

Abstract Background Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims. Methods A hepato-protective role of G. brevis hydromethanolic (GBH) leaf extract was established against carbon tetrachloride (CCl4)-induced hepatotoxicity. Twenty-four hours after a CCl4 challenge, rats were sacrificed and serum hematological indices, lipid profile, and biochemical parameters were determined. The antioxidant enzymes parameters (glutathione, catalase, and superoxide dismutase) and lipid peroxidation product (thiobarbituric reactive substances) levels in liver homogenates were evaluated. Changes in the liver cyto-architecture of different treatment groups were also investigated. Results The GBH extract produced no significant impact on weight and hematological indices. Intoxication with CCl4 significantly (p<0.001–0.05) increased total cholesterol (TC) and low-density lipoproteins (LDL) compared with control rats. Pretreatment with GBH leaf extract significantly reduced triglycerides, TC, and LDL to approaching control levels (p<0.001–0.05). The GBH leaf extract significantly alleviated CCl4-induced elevation of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and the CCl4-induced depression of total protein, and albumin. Liver antioxidant parameters were significantly increased in plant extract-treated rats, and this antagonized the pro-oxidant effect of CCl4. Histopathological studies also supported a hepato-protective effect of GBH. Collectively, the GBH leaf extract alleviated the CCl4-induced hepatotoxicity through improvement of innate antioxidant enzyme levels and lipid metabolism and stabilized the hepatocyte cyto-architecture of intoxicated rats. Conclusions This study establishes the ethnomedicinal role of G. brevis leaf in hepatitis and the mechanistic basis of hepato-protection against CCl4-induced hepatotoxicity.

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Shrub vegetation shores strengthening and protection in Kalachevsky district of Volgograd area

FORESTRY BULLETIN ◽

10.18698/2542-1468-2021-3-65-72 ◽

2021 ◽

Vol 25 (3) ◽

pp. 65-72

Author(s):

A.S. Solomentseva ◽

Keyword(s):

Surface Runoff ◽

Climatic Conditions ◽

Forest Stands ◽

Effective Measure ◽

Rosa Canina ◽

Fine Grained ◽

Fine Grained Soil ◽

Subsurface Runoff ◽

Protective Forest

The critical abrasion situation manifests itself on the coastal part of the Kalachevsky district due to the increasing anthropogenic load. The most important element of the complex of measures to combat silting of reservoirs and coastal abrasion, as well as an effective measure to strengthen the banks is forest vegetation. The objectives of the research were to study the soil, forest and climatic conditions of the object under study, to develop an assortment of shrubs and features of the formation of protective forest stands, as well as criteria for selecting an adapted assortment of tree and shrub vegetation and methods of caring for the soil and plantings. During the research, the most promising types of shrubs for creating upper protective forest stands were identified: Ligustrum vilgare L., Berberis vulgaris L., Cotoneaster lucidus Schltdl., Amelanchier Medik., Ribes aureum Pursh., Rosa canina L. It was found that the useful role of forest stands is manifested in their ability to convert surface runoff into subsurface runoff, to clean surface stock water from fine-grained soil, to weaken the speed of movement and to extinguish the energy of waves, binding the soil with roots. Recommendations are given for the creation and placement of anti-abrasion plantings, depending on the steepness and height of the slope. It is stated that one of the main measures for the care of the aboveground part of the plantings is the pruning of the crown, carried out taking into account the biological characteristics of their growth and development, including the removal of dry and damaged branches, thinning of the crown, preservation of the previously given crown size, rejuvenation of the crown. It is recommended to place shrubs depending on the landscape, soil and climatic conditions and features of abrasive processes in areas of constant, periodic, episodic flooding and strong moderate and weak flooding of the coastline.

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