scholarly journals Non-invasive method for preventing intradialytic hypotension: A pilot study

2015 ◽  
Vol 26 (5) ◽  
pp. 896 ◽  
Author(s):  
Anita Saxena ◽  
RK Sharma ◽  
Amit Gupta ◽  
MannsManohar John
2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Claire L Emson ◽  
Sarah Fitzmaurice ◽  
Glen Lindwall ◽  
Kelvin W Li ◽  
Marc K Hellerstein ◽  
...  

2020 ◽  
pp. 1-10
Author(s):  
Jakub Novak ◽  
Andrew Busch ◽  
Pavel Kolar ◽  
Alena Kobesova

BACKGROUND: The abdominal muscles play an important respiratory and stabilization role, and in coordination with other muscles regulate intra-abdominal pressure (IAP) to stabilize the spine. OBJECTIVE: To examine a new, non-invasive method to measure activation of the abdominal wall and compare changes in muscle activation during respiration while breathing under a load, and during instructed breathing. METHODS: Thirty-five healthy individuals completed this observational crossover study. Two capacitive force sensors registered the abdominal wall force during resting breathing stereotype, instructed breathing stereotype and under a load. RESULTS: Mean abdominal wall force increased significantly on both sensors when holding the load compared to resting breathing (Upper Sensor: P< 0.0005, d=-0.46, Lower Sensor: P< 0.0005, d=-0.56). The pressure on both sensors also significantly increased during instructed breathing compared to resting breathing (US: P< 0.0005, d=-0.76, LS: P< 0.0005, d=-0.78). CONCLUSIONS: The use of capacitive force-sensors represent a new, non-invasive method to measure abdominal wall activity. Clinically, belts with capacitive force sensors can be used as a feedback tool to train abdominal wall activation.


Antibiotics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 100
Author(s):  
Jolein Gyonne Elise Laumen ◽  
Saïd Abdellati ◽  
Christophe Van Dijck ◽  
Delphine Martiny ◽  
Irith De Baetselier ◽  
...  

Commensal Neisseria provide a reservoir of resistance genes that can be transferred to the pathogens Neisseria gonorrhoeae and N. meningitidis in the human oropharynx. Surveillance programs are thus needed to monitor resistance in oropharyngeal commensal Neisseria, but currently the isolation and antimicrobial susceptibility testing of these commensals is laborious, complex and expensive. In addition, the posterior oropharyngeal/tonsillar swab, which is commonly used to sample oropharyngeal Neisseria, is poorly tolerated by many individuals. We evaluated an alternative non-invasive method to isolate oropharyngeal commensal Neisseria and to detect decreased susceptibility to azithromycin using selective media (LBVT.SNR) with and without azithromycin (2 µg/mL). In this pilot study, we compared paired posterior oropharyngeal/tonsillar swabs and oral rinse-and-gargle samples from 10 participants and demonstrated that a similar Neisseria species diversity and number of colonies were isolated from both sample types. Moreover, the proportion of Neisseria colonies that had a decreased susceptibility to azithromycin was similar in the rinse samples compared to the swabs. This pilot study has produced encouraging data that a simple protocol of oral rinse-and-gargle and culture on plates selective for commensal Neisseria with and without a target antimicrobial can be used as a surveillance tool to monitor antimicrobial susceptibility in commensal oropharyngeal Neisseria. Larger studies are required to validate these findings.


2017 ◽  
Vol 52 (6) ◽  
pp. 962-965 ◽  
Author(s):  
Daniel Lodwick ◽  
Molly Dienhart ◽  
Jennifer N. Cooper ◽  
Bonita Fung ◽  
Joseph Lopez ◽  
...  

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.


2015 ◽  
Vol 24 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Ramesh P. Arasaradnam ◽  
Michael McFarlane ◽  
Emma Daulton ◽  
Erik Westenbrink ◽  
Nicola O’Connell ◽  
...  

Background & Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) is the commonest cause of chronic liver disease in the western world. Current diagnostic methods including Fibroscan have limitations, thus there is a need for more robust non-invasive screening methods. The gut microbiome is altered in several gastrointestinal and hepatic disorders resulting in altered, unique gut fermentation patterns, detectable by analysis of volatile organic compounds (VOCs) in urine, breath and faeces. We performed a proof of principle pilot study to determine if progressive fatty liver disease produced an altered urinary VOC pattern; specifically NAFLD and Non-Alcoholic Steatohepatitis (NASH).Methods: 34 patients were recruited: 8 NASH cirrhotics (NASH-C); 7 non-cirrhotic NASH; 4 NAFLD and 15 controls. Urine was collected and stored frozen. For assay, the samples were defrosted and aliquoted into vials, which were heated to 40±0.1°C and the headspace analyzed by FAIMS (Field Asymmetric Ion Mobility Spectroscopy). A previously used data processing pipeline employing a Random Forrest classification algorithm and using a 10 fold cross validation method was applied.Results: Urinary VOC results demonstrated sensitivity of 0.58 (0.33 - 0.88), but specificity of 0.93 (0.68 - 1.00) and an Area Under Curve (AUC) 0.73 (0.55 -0.90) to distinguish between liver disease and controls. However, NASH/NASH-C was separated from the NAFLD/controls with a sensitivity of 0.73 (0.45 - 0.92), specificity of 0.79 (0.54 - 0.94) and AUC of 0.79 (0.64 - 0.95), respectively.Conclusions: This pilot study suggests that urinary VOCs detection may offer the potential for early non-invasive characterisation of liver disease using 'smell prints' to distinguish between NASH and NAFLD.


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