The relationship between eating disorder symptoms and obsessive compulsive disorder in primigravida women

Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetic factors in the expression of eating disorders and OCD/anxiety phenotypes. We examined whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorders, OCD, and anxiety symptoms in a large population-based developmental cohort. Using summary statistics files from the Psychiatric Genomics Consortium Freeze 2 AN and Freeze 1 OCD GWAS, we first conducted an AN/OCD transdiagnostic GWAS meta-analysis and then calculated PGS for AN, OCD, and AN/OCD in participants from the Avon Longitudinal Study of Parents and Children with available genetic and phenotype data on eating disorder, OCD, and anxiety diagnoses and symptoms (sample size 3,212-5,369 per phenotype). We observed sex differences in the PGS prediction of eating disorder, OCD, and anxiety-related phenotypes, with AN genetic risk manifesting at an earlier age and playing a more prominent role in eating disorder phenotypes in boys than in girls. Compulsive exercise was the only phenotype predicted by all three PGS (e.g., PAN(boys)=0.0141 at age 14; POCD(girls)=0.0070 at age 16; PAN/OCD(all)=0.0297 at age 14). Our results suggest that earlier detection of eating disorder, OCD, and anxiety-related symptoms could be made possible by including measurement of genetic risk for these psychiatric conditions while being mindful of sex differences.

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The Mediating Role of Alexithymia in the Relationship of Coping Strategies and Personality Traits With Obsessive-Compulsive Disorder

Quarterly of Horizon of Medical Sciences ◽

10.32598/hms.27.1.3355.1 ◽

2021 ◽

Vol 27 (1) ◽

pp. 62-81

Author(s):

Masoud Bagheri ◽

◽

Kazem Nematollah Zadeh Mahani ◽

Maryam Pour Amrollahi ◽

◽

...

Keyword(s):

Personality Traits ◽

Coping Strategies ◽

Obsessive Compulsive Disorder ◽

Psychological Health ◽

Obsessive Compulsive ◽

Positive Correlation ◽

Compulsive Disorder ◽

Mediating Role ◽

The Relationship

Aims: Obsessive-Compulsive Disorder (OCD) is one of the severe psychological health problems imposing considerable social and economic costs on society. OCD debilitating symptoms can disrupt interpersonal relations, job performance, and life quality. The purpose of this study is to investigate the mediating role of alexithymia in the relationship between coping strategies and personality traits with OCD. Methods & Materials: This is a descriptive correlational study. The study population consists of all people with OCD referred to psychiatric clinics in Kerman City, Iran, during 2018-2019. Of this population, 200 patients were selected using a convenience sampling method. Research instruments included the ways of coping questionnaire, NEO five-factor personality inventory, Toronto alexithymia scale, and Maudsley obsessive-compulsive test. The obtained data were analyzed using the Pearson correlation test and simultaneous and hierarchical regression in SPSS v. 23. Findings: Personality traits had a negative significant correlation with alexithymia (r=0.523, P<0.000) and OCD (r=0.253, P<0.000). Alexithymia had a significant positive correlation with OCD (r=0.272, P<0.000). There was no correlation between problem-focused coping and alexithymia (r=-0.045, P<0.531). There was a positive correlation between emotion-focused coping and OCD (r=0.198, P<0.000). The fit indices indicated a good fit of the proposed model (P<0.005). Conclusion: Alexithymia, as a mediator of the relationship between coping styles and personality traits with OCD, plays an essential role in improving the psychological health of people with OCD.

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Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder

10.21203/rs.3.rs-362348/v1 ◽

2021 ◽

Author(s):

Yanrong Wang ◽

Shaohua Chang ◽

Xiaomin Ma ◽

Jiying Li ◽

Ruixia Zhang ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Clinical Characteristics ◽

Healthy Controls ◽

Obsessive Compulsive ◽

Lower Lip ◽

Compulsive Disorder ◽

Correlational Research ◽

Nasolabial Angle ◽

The Difference ◽

The Relationship

Abstract We examined the relationship between facial morphological features and clinical characteristics of adolescents with obsessive-compulsive disorder (OCD). The enrolled study sample comprised 40 adolescents diagnosed with OCD using the Obsessive Compulsive Inventory Child Version (OCI-CV) and 38 healthy controls (HCs). Facial photos, 21 facial diameters, and nine facial angles were collected using image software. In males, lower lip red height was significantly lower in OCD patients than in HCs (P < 0.05); no significant differences were observed in other facial indicators (all P > 0.05). In females, the nasolabial angle was smaller in OCD patients than in HCs (P < 0.05); no significant differences were observed in other facial indicators (all P > 0.05). The difference in lower lip red height between the OCD group and HC group was positively correlated with mental neutralization symptoms (r = 0.401, P < 0.05). Our findings highlight the relationship between facial and clinical characteristics in OCD patients.

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Obsessive–compulsive disorder: subclassification based on co-morbidity

Psychological Medicine ◽

10.1017/s0033291708004753 ◽

2008 ◽

Vol 39 (9) ◽

pp. 1491-1501 ◽

Cited By ~ 60

Author(s):

G. Nestadt ◽

C. Z. Di ◽

M. A. Riddle ◽

M. A. Grados ◽

B. D. Greenberg ◽

...

Keyword(s):

Anxiety Disorder ◽

Obsessive Compulsive Disorder ◽

Clinical Characteristics ◽

Latent Class ◽

Age At Onset ◽

Separation Anxiety Disorder ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Co Morbidity ◽

The Relationship

BackgroundObsessive–compulsive disorder (OCD) is probably an etiologically heterogeneous condition. Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes.MethodSeven hundred and six individuals with OCD were assessed in the OCD Collaborative Genetics Study (OCGS). Multi-level latent class analysis was conducted based on the presence of eight co-morbid psychiatric conditions [generalized anxiety disorder (GAD), major depression, panic disorder (PD), separation anxiety disorder (SAD), tics, mania, somatization disorders (Som) and grooming disorders (GrD)]. The relationship of the derived classes to specific clinical characteristics was investigated.ResultsTwo and three classes of OCD syndromes emerge from the analyses. The two-class solution describes lesser and greater co-morbidity classes and the more descriptive three-class solution is characterized by: (1) an OCD simplex class, in which major depressive disorder (MDD) is the most frequent additional disorder; (2) an OCD co-morbid tic-related class, in which tics are prominent and affective syndromes are considerably rarer; and (3) an OCD co-morbid affective-related class in which PD and affective syndromes are highly represented. The OCD co-morbid tic-related class is predominantly male and characterized by high conscientiousness. The OCD co-morbid affective-related class is predominantly female, has a young age at onset, obsessive–compulsive personality disorder (OCPD) features, high scores on the ‘taboo’ factor of OCD symptoms, and low conscientiousness.ConclusionsOCD can be classified into three classes based on co-morbidity. Membership within a class is differentially associated with other clinical characteristics. These classes, if replicated, should have important implications for research and clinical endeavors.

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Variable Insight in OCD

10.1093/med/9780190228163.003.0013 ◽

2017 ◽

Author(s):

Rebecca J. Hamblin ◽

Jennifer Moonjung Park ◽

Monica S. Wu ◽

Eric A. Storch

Keyword(s):

Obsessive Compulsive Disorder ◽

Assessment Tools ◽

Schizophrenia Spectrum Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

Definition Of ◽

The Relationship ◽

Insight Into

Individuals with obsessive-compulsive disorder (OCD) often have good insight into the irrational nature of their obsessions and the excessive character of their compulsions, but insight exists along a continuum and is markedly poor in some patients. This chapter reviews the assessment and phenomenological correlates of variable insight in OCD in both pediatric and adult populations. It reviews the definition of insight and its relationship to the evolution of diagnostic criteria for obsessive-compulsive disorder, as well as the major assessment tools used to measure and quantify insight for clinical and research purposes. The relationships between insight and clinical characteristics of OCD, including symptom severity, comorbidity, and treatment response are reviewed, followed by a review of neurobiological correlates of insight and the relationship between poor insight and schizophrenia spectrum disorders.

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Anger and aggressiveness in obsessive–compulsive disorder (OCD) and the mediating role of responsibility, non-acceptance of emotions, and social desirability

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-020-01199-8 ◽

2020 ◽

Author(s):

Barbara Cludius ◽

Anna K. Mannsfeld ◽

Alexander F. Schmidt ◽

Lena Jelinek

Keyword(s):

Emotion Regulation ◽

Obsessive Compulsive Disorder ◽

Social Desirability ◽

Self Concept ◽

Trait Anger ◽

Healthy Controls ◽

Obsessive Compulsive ◽

Anger Suppression ◽

Compulsive Disorder ◽

The Relationship

Abstract According to psychodynamic and cognitive models of obsessive–compulsive disorder (OCD), anger and aggression play an important role in the development and maintenance of the disorder. (Sub-) clinical samples with OCD have reported higher anger and anger suppression. Patients with checking-related symptoms of OCD showed a less aggressive self-concept as assessed by an Implicit Association Test (IAT). This study assessed anger and aggressiveness self-concepts in OCD as well as possible mediators of the link between OCD and aggressiveness. A total of 48 patients with OCD and 45 healthy controls were included. Measures included the State-Trait Anger Expression Inventory-II and an aggressiveness self-concept IAT (Agg-IAT). An inflated sense of responsibility, non-acceptance of emotions, and social desirability were tested as mediators. As expected, patients with OCD reported higher trait anger and anger suppression compared to healthy controls. Contrary to hypotheses, the aggressiveness self-concept (Agg-IAT) did not differ between groups. The inflated sense of responsibility mediated the relationship between group and anger suppression. Non-acceptance of negative emotions mediated the relationship between group and trait anger, as well as anger suppression. However, comorbidities and medication may account for some effect in anger suppression. Elevated trait anger and anger suppression in OCD patients could be explained by dysfunctional beliefs or maladaptive emotion regulation strategies. Emotion regulation therapy might help to enhance awareness and acceptance of emotions and possibly improve treatment outcomes.

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Death obsession’s potential mediational role in the relation between pregnancy-related anxiety and prenatal obsessive-compulsive disorder

South African Journal of Psychology ◽

10.1177/0081246320961535 ◽

2020 ◽

pp. 008124632096153

Author(s):

Sadi Cordelia Bambo ◽

Solomon Mashegoane

Keyword(s):

South Africa ◽

Pregnant Women ◽

Obsessive Compulsive Disorder ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Mediator Role ◽

Mediational Role ◽

Composite Scores ◽

The Relationship

The study investigated the mediator role of death obsession in the relationship between pregnancy-related anxiety and prenatal obsessive-compulsive disorder among pregnant women in the Capricorn district, South Africa. Two hundred and six conveniently selected respondents completed questionnaires individually. Statistically significant associations were found between pregnancy-related anxiety and death obsession, death obsession and prenatal obsessive-compulsive disorder, and pregnancy-related anxiety and prenatal obsessive-compulsive disorder ( ps ⩽ .05). Analysis further showed that death obsession mediates the relationship between pregnancy-related anxiety and both composite scores of a prenatal obsessive-compulsive disorder measure (Obsessive-Compulsive Inventory–Revised) and most of its components. The findings suggest that death obsession is a likely mediator that has to be studied further.

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