scholarly journals Metastasis in central nervous system: Clinicopathological study with review of literature in a tertiary care center in South India

2013 ◽  
Vol 02 (04) ◽  
pp. 245-249
Author(s):  
Rashmi Patnayak ◽  
Amitabh Jena ◽  
Bodagala Vijaylaxmi ◽  
Amancharla Y. Lakshmi ◽  
BCM Prasad ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
South India ◽  
Care Center ◽  
Tertiary Care ◽  
Cns Tumors ◽  
Histopathological Diagnosis ◽  
Tertiary Care Center ◽  
Female Ratio ◽  
Immunohistochemical Markers

Abstract Background: Secondary central nervous system (CNS) tumors are common in Western countries, but in Indian literature, scant data are available. With the advent of newer imaging techniques, the confirmatory histopathological diagnosis has become comparatively easier. Hereby, we have analyzed our data from a single tertiary care center in south India. Materials and Methods: In this retrospective study from January 2000 to December 2010, histopathologically diagnosed secondary CNS tumors were reviewed along with clinical, imaging, and relevant immunohistochemical findings. Meningeal, lymphoproliferative, and myeloproliferative tumors and autopsy data were not included in the study group. Results: There were 40 secondary CNS tumors. Male to female ratio was 2.3:1. Age range was wide (28-75 years). Majority of cases were seen in the fourth and fifth decade. Imaging-wise, (computed tomography and magnetic resonance imaging) majority were single lesions (n = 34, 85%). Most commonly, these single lesions were present in the cerebral hemisphere (n = 20, 50%) followed by cerebellum (n = 10, 25%). Adenocarcinoma accounted for maximum number of cases (n = 25, 62.5%) with lungs being the most common primary. Conclusion: We have noted 25% metastatic adenocarcinomas in cerebellar location, which is higher when compared with available world literature. However, we also encountered a good number of cases (30%) due to unknown primary. Though histopathological examination with use of immunohistochemical markers can reliably distinguish primary from secondary CNS tumors in addition to available clinical and imaging data, particularly in developing countries, still a better work-up with an array of immunohistochemical markers and newer imaging modalities is desirable.

Pediatric tumors of the central nervous system: a retrospective study of 1,043 cases from a tertiary care center in South India

2011 ◽  
Vol 27 (8) ◽  
pp. 1257-1263 ◽  
Author(s):  
Jaya Ruth Asirvatham ◽  
A. Narasimhaiah Deepti ◽  
Rila Chyne ◽  
M. S. N. Prasad ◽  
Ari G. Chacko ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
South India ◽  
Care Center ◽  
Tertiary Care ◽  
Pediatric Tumors ◽  
Tertiary Care Center ◽  
System A ◽  
The Central Nervous System

Clinicopathological correlates of primary central nervous system lymphoma: Experience from a tertiary care center in South India

2015 ◽  
Vol 63 (1) ◽  
pp. 77 ◽  
Author(s):  
Geeta Chacko ◽  
Sheila Nair ◽  
Jamie Anandan ◽  
AriG Chacko ◽  
Vedantam Rajshekhar ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
South India ◽  
Care Center ◽  
Tertiary Care ◽  
Central Nervous System Lymphoma ◽  
Tertiary Care Center

GASTRIC CANCER: A 5 YEAR RETROSPECTIVE ANALYSIS OF CLINICAL, PATHOLOGICAL AND TREATMENT ASPECTS FROM A TERTIARY CARE CENTER IN SOUTH INDIA.

2021 ◽  
pp. 129-132
Author(s):  
B. Ramkumar ◽  
J. Kannan ◽  
Ingersal. N ◽  
Srigopal mohanty ◽  
Amit saklani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
South India ◽  
Care Center ◽  
Tertiary Care ◽  
Tumor Location ◽  
Advanced Stage ◽  
Tertiary Care Center ◽  
Nodal Disease ◽  
Female Ratio

Context: Gastric cancer(GC) is fth most common cancer worldwide. Mostly presents with advanced stage and poor overall survival. Methods: Retrospective study on clinical, pathological, pattern of distant metastasis(DM) , treatment aspect of GC treated between January 2014 to December 2018 in a tertiary care center in south India. Statistical analysis : Chi square test and multivariate analysis (MVA) were used for analysis. P <0.05 was considered signicant. Results: Median age at diagnosis is 57 years. Higher male : female ratio. Most common presentation was abdominal pain followed vomiting. Malignant Gastric outlet obstruction(MGOO) was present in 22.7%. Histologically , all patients had adenocarcinoma with predominantly moderate differentiation (51.1%). Liver (19.1%)was most common site of metastasis . Curative surgery was done in 35.5% of patients. D2 lymph node dissection was performed in 12.4% of patient. Patients were given perioperative /preoperative/ adjuvant / palliative chemotherapy. MVA revealed history of tobacco use, body of stomach tumor location, nodal disease were risk factors for DM. Conclusion : The present analysis revealed use of tobacco, alcohol intake were main risk factors for GC. Most of the patients present in advanced stage , so prevention by avoiding risk factors and early detection by signs , symptoms and endoscopy are necessary. Use of tobacco,site of tumor location, nodal disease were factors associated with DM. Aggressive management with both surgery and chemotherapy is warranted for locally advanced disease.

Central nervous system and muscle involvement in dengue patients: A study from a tertiary care center

2015 ◽  
Vol 72 ◽  
pp. 146-151 ◽  
Author(s):  
Usha Kant Misra ◽  
Jayantee Kalita ◽  
Vinita Elizabeth Mani ◽  
Prashant Singh Chauhan ◽  
Pankaj Kumar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Muscle Involvement

scholarly journals Pharmacovigilance by World Health Organisation Uppsala Monitoring Center Causality Assessment Algorithm in Medicine Ward of Tertiary Care Hospital of New Delhi

2017 ◽  
Vol 1 (1) ◽  
pp. 61-64
Author(s):  
R.C. Shah ◽  
S. Karki ◽  
S.B. Parajuli ◽  
P. Bhattarai ◽  
P.K. Chowdhary
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Causality Assessment ◽  
Care Center ◽  
Tertiary Care ◽  
World Health Organisation ◽  
World Health ◽  
Care Hospital ◽  
Tertiary Care Center ◽  
A Prospective Study

Introduction Pharmacovigilance is not new to India and has in fact been going on since 1998. Adverse drugs reaction (ADRs) are important causes of morbidity and mortality all over the world. They account for approximately 10-20% of all hospitalized patients. The overall incidence of serious ADRs is 6.7% and that of fatal is 0.32%.Objective The objectives of the study was to find the pattern of adverse drug reactions in patients attending medicine ward of a tertiary care center of New Delhi.Methodology A prospective study was conducted from March 2013 to December 2013. On the basis of WHO-UMC causality assessment algorithm, the incidence and pattern of ADRs were assessed from 300 patients of 18 to 70 years of age. The collected data was entered in Microsoft Excel, Common Terminology Criteria for Adverse Events (CTCAE) and analysed by SPSS.Results The incidence of ADRs was found to be 13.67%. More than one ADRs has been reported from some patients. The gender of the patients has no significance in the occurance of ADRs (p=0.194). Highest number of ADRs were found in gastrointestional system followed by central nervous system. Gastrointestional ADRs were must commonly associated with the uses of antimicrobials. The most frequently seen ADRs were diarrhea, gastritis, abdominal pain followed by nausea and vomiting. Decreased level of consciousness (sedation, drowsiness) followed by dizziness and tremors were the frequent ADRs related to the central nervous systems. Based on WHO-UMC causality assessment algorithm, it was observed that a total of 57 ADRs were possible and 2 were probable. No other causality assessment category was observed.Conclusion The ADRs incidence was common even in a tertiary care center. The Gastrointestional and central nervous system disorder were common. The concern of Pharmacovigilance should be initiated.Birat Journal of Health Sciences 2016 1(1): 61-64

scholarly journals A study of histopathological spectrum of central nervous system lesions at a tertiary health care center of South Gujarat, India

2020 ◽  
Vol 8 (4) ◽  
pp. 1451
Author(s):  
Nidhi V. Shihora ◽  
Himanshu U. Patel ◽  
S. M. Patel ◽  
Pankaj R. Ramani ◽  
Bhumika N. Nandasana
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Care Center ◽  
Tertiary Care ◽  
Management Strategies ◽  
Histopathological Diagnosis ◽  
Health Care Center ◽  
Stage Of Development ◽  
Neoplastic Lesions ◽  
Intracranial Lesions

Background: Central nervous system lesions can have varied aetiology like infectious, inflammatory and neoplastic. Establishing an accurate aetiology is essential for timely diagnosis and neurosurgical intervention. The annual incidence of tumours of CNS ranges from 10 to 17 per 100,000 people for intracranial tumours and 1 to 2 per 100,000 people for intraspinal tumours; the majority of these are primary tumours, and only one fourth to one half are metastastic. The present study attempts to provide preliminary data on morphological patterns of intracranial lesions and to study clinicopathological spectrum.Methods: The present study was carried out at a tertiary care center from January 2015 to September 2017. A total of 65 cases of CNS lesions were analyzed. In case of CNS tumours reporting were done according to WHO criteria for classification and grading.Results: Out of 65 cases studied, 51 cases (78.46%) were of neoplastic lesions and 14 cases (21.54%) of non-neoplastic lesions. Among 14 cases of non-neoplastic lesions 2 cases were of reactive/cystic lesions, 4 cases  were of infective lesions, and 8 cases were of congenital lesions. In the present study, out of 51 neoplastic cases most common cases were of astrocytoma.Conclusions: The exact histopathological diagnosis of Central Nervous system lesions is essential to predict the prognosis and treatment. Management strategies and prognosis of tumours depends on the correlation of factors like the types, grades of tumours, its location, size and stage of development.

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