A study of the relationship between pulmonary function tests and both fasting plasma glucose and glycated hemoglobin levels among asymptomatic cigarette smokers

Abstract BackgroundTriglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance. However, study on the relationship between TyG index and incident diabetes remains limited. This study aimed to investigate the association between TyG index and incident diabetes in a large cohort of Chinese population.MethodsThe present study was a retrospective cohort study using healthy screening programme data in China. A total of 201,298 subjects free of baseline diabetes were included who received a health check with all medical records from 2010 to 2016. TyG index was calculated as Ln[fasting triglyceride level (mg/dl) x fasting plasma glucose (mg/dl)/2]. Diagnosis of diabetes was based on fasting plasma glucose ≥ 7.00 mmol/L and/or self-reported diabetes. Cox proportion-hazard model was used to assess the relationship between TyG index at baseline and the risk of incident diabetes. It should be noted that the data was uploaded to the DATADRYAD website, and we only used this data for secondary analysis.ResultsDuring a mean follow-up of 3.12 years of 201,298 individuals aged ≥ 20 years old, 3389 subjects developed diabetes. After adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, serum creatinine, smoking, drinking and family history of diabetes, multivariate cox hazards regression analysis indicated that TyG index was positive correlation with the risk of developing diabetes in Chinese population (HR, 3.34; 95% CI, 3.11 to 3.60). The risk of incident diabetes increased with increasing TyG index. Subjects with TyG index in the fourth quartile were 6.26 times more likely to develop diabetes than the lowest quartile (P trend < 0.001). Subgroup analysis showed the stronger association was observed in the population with age < 40, BMI (≥ 18.5, < 24 kg/m2), SBP < 140 mmHg or females (all P for interaction < 0.0001).Conclusions TyG index was independently correlated with the increased risk of diabetes in Chinese adults, suggesting that TyG index may be a useful marker for identifying individuals at high risk of developing diabetes.

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The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension

Cardiovascular Diabetology ◽

10.1186/s12933-019-0859-4 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 6

Author(s):

Mika Geva ◽

Gadi Shlomai ◽

Anat Berkovich ◽

Elad Maor ◽

Avshalom Leibowitz ◽

...

Keyword(s):

Future Development ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Hemoglobin ◽

Fasting Plasma

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The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

Medical Principles and Practice ◽

10.1159/000487760 ◽

2018 ◽

Vol 27 (2) ◽

pp. 139-144 ◽

Cited By ~ 1

Author(s):

Hatice Kılıc ◽

Asiye Kanbay ◽

Ayşegul Karalezlı ◽

Elif Babaoglu ◽

H. Canan Hasanoglu ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Tests ◽

Serum Magnesium ◽

Multiple Logistic Regression Analysis ◽

Categorical Variables ◽

Control Group ◽

Chronic Asthma ◽

Asthmatic Patients ◽

Function Tests ◽

The Relationship

Objective: To investigate the relationship between serum values of magnesium and the parameters of the pulmonary function tests (PFT) in patients with chronic asthma. Subjects and Methods: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT, and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured. To evaluate differences between groups, the Student t test or Mann-Whitney U test was performed for continuous variables, and the χ2 test for categorical variables. Results: In the asthma group, 10% (n = 9) of the patients had hypomagnesemia and 5.5% (n = 5) had hypophosphatemia. Patients with asthma were divided into two groups: the hypomagnesemic group (n = 9) and the normomagnesemic group (n = 41). Forced expiratory volume in 1 s (FEV1), FEV1%, peak expiratory flow (PEF), and PEF% were lower in the hypomagnesemic group than in the normomagnesemic group (p = 0.02). Multiple logistic regression analysis revealed a statistically significant association between hypomagnesemia and PFT in the hypomagnesemic asthmatic group. The correlations of age with FEV1, FEV1%, PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03, r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The correlation of serum magnesium levels with PFT (FEV1, FEV1%, PEF, PEF%) were as follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p = 0.001, r = 0.38, respectively. The other electrolytes were within the normal range in both groups. Conclusion: In this study, hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. FEV1, FEV1%, PEF, and PEF% were significantly lower in asthmatic patients with hypomagnesemia compared to asthmatic patients with normomagnesemia.

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Fasting Plasma Glucose and Coronary Heart Disease in a Rural Population of North Henan, China

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/2348583 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Quan Guo ◽

Fei Lin ◽

Yi Liu ◽

Yang Li ◽

Xue-Hui Wang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Rural Areas ◽

Odds Ratio ◽

Coronary Artery Lesions ◽

Fasting Plasma ◽

The Relationship ◽

Different Levels

Even in individuals without diabetes, the incidence of coronary heart disease (CHD) increases with the rise in fasting plasma glucose (FPG); however, the threshold of FPG for CHD in rural areas of China is unclear. We retrospectively examined 2,987 people. Coronary angiography records were used to determine the presence of CHD as well as its severity. Risk factors for CHD and the relationship between different levels of FPG and CHD were analyzed. After adjusting for age, hypertension, dyslipidemia, smoking, drinking, chronic kidney disease, and previous ischemic stroke, the incidence of CHD in nondiabetic women began to increase when FPG exceeded 5.2 mmol/L (odds ratio (OR) = 1.438, 95% confidence interval (CI) = 1.099–1.880, p=0.008), and the degree of coronary artery lesions also became more severe (OR = 1.406, 95% CI = 1.107–1.788, p=0.005). However, no such correlations were found in nondiabetic men. In conclusion, among the nondiabetic women in rural areas of northern Henan, both the incidence of CHD and the severity of lesions increased when FPG levels were greater than 5.2 mmol/L, while no significant correlation between FPG and CHD was observed in diabetes-free men.

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Demographic Associations of Diabetes Status by Both Fasting Plasma Glucose Concentration and Glycated Hemoglobin in a Community Survey in Galle District, Sri Lanka

Journal of Nutrition and Metabolism ◽

10.1155/2020/6127432 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Keddagoda Gamage Piyumi Wasana ◽

Anoja Priyadarshani Attanayake ◽

Thilak Priyantha Weerarathna ◽

Kamani Ayoma Perera Wijewardana Jayatilaka

Keyword(s):

Sri Lanka ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Hemoglobin ◽

Diagnostic Tools ◽

Oral Glucose ◽

Family History Of Diabetes ◽

Fasting Plasma ◽

Diabetes Status ◽

Significant Difference

Diagnostic tools used in detecting individuals with diabetes mellitus (DM) include fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), and oral glucose tolerance test (OGTT). The present study was aimed to determine the demographic associations of diabetes status by both tests (FPG and HbA1C) in Galle district, Sri Lanka. 147 adults (30–60 years) who are having FPG ≥ 126 mg/dL underwent demographic evaluations and testing for HbA1C. Group 01 (diabetes status diagnosed by both tests) and group 2 (diabetes status diagnosed only by FPG) were compared using independant sample t-test and chi-square test. Logistic regression was used to study the association between the demographic factors and the diabetes status by both tests. Of the 147 study subjects, 38.1% were males, 61.9% were females, and 63.3% had a family history of diabetes among first-degree relatives (FDR). Mean age, body mass index (BMI), waist circumference (WC), FPG, and HbA1C of the participants were 48.4 ± 7.2 years, 25.1 ± 4.0 kg/m2, 88.8 ± 9.0 cm, 139.4 ± 30.1 mg/dL, and 6.4 ± 0.7%, respectively. The prevalence of diabetes based on both tests was 55.1%. There is a significant difference in mean BMI and WC while no significant differences in mean age between groups 01 and 02. No association was seen between gender and diabetes status (X2(1) = 0.086, p=0.770), while a significant difference was observed between DM among FDR and diabetes status (X2(1) = 33.215, p<0.001). Significance of odds of having diabetes by both tests with rising BMI (OR = 1.97, CI 1.15–3.36, p=0.013) and DM among FDR (OR = 7.95, CI 3.54–17.88, p=0.000) was seen. We conclude rising BMI and having DM among FDR are strongly associated with diabetes status diagnosed by both tests of FPG and HbA1C in community screening.

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