scholarly journals Disseminated Histoplasmosis detected on peripheral blood smear examination in immunocompetent patients from non endemic region – Report of two cases from a tertiary care hospital

2020 ◽  
Vol 63 (4) ◽  
pp. 645
Author(s):  
Satyaprakash Sharma ◽  
Neha Bagga ◽  
Kamna Sharma ◽  
RajatK Tuteja ◽  
SR Negi ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Peripheral Blood Smear ◽  
Care Hospital ◽  
Endemic Region ◽  
Disseminated Histoplasmosis ◽  
Blood Smear Examination ◽  
Immunocompetent Patients

scholarly journals Pattern of hematological malignancies diagnosed by peripheral smear examination

2018 ◽  
Vol 1 (1) ◽  
pp. 25-35
Author(s):  
Punam Paudyal ◽  
A Pradhan ◽  
S Pokharel ◽  
N Shah ◽  
B Pradhan ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Tertiary Care ◽  
Peripheral Blood Smear ◽  
Care Hospital ◽  
Hematopoietic Stem ◽  
Chronic Leukemia ◽  
Smear Examination

 Background: Leukemia is a malignant neoplasm of the hematopoietic stem cells. Examination of the peripheral blood smear is an inexpensive but powerful diagnostic tool in both children and adults suffering from leukemia because it provides rapid, reliable access to information about a variety of hematologic disorders.Objectives: To study the various patterns of leukemia, clinicoepidemiological profile and hematological features of leukemia.Materials and Methods: This is a cross sectional study conducted in the Hematology section of Department of Pathology of a tertiary care hospital. This study included all consecutive cases of leukemia diagnosed by peripheral blood smear examination from 1st June 2013 to 30th May 2014. The demographic indices were noted in a proforma. Investigations including haemoglobin estimation, total leucocyte count and platelet count were done for the study of hematological features. The morphological sub-typing was done according to the FAB classification system for leukemia.Results: Out of total 52 cases, majority of cases were of acute leukemia (65.38%), followed by chronic leukemia (26.92%) and lymphoma spill/ acute leukemia (7.69%). The age range was 2 to 90 years. Mean age was 37.6 year. Majority were male. Mean hemoglobin count for AML and ALL was 6.8 and 5.3 gm/dl respectively.Conclusion: The finding of this study reflects the pattern of leukemia at BPKIHS. Majority of acute leukemia constituted of acute myeloid leukemia (36.53%) cases and majority of chronic leukemia constituted of chronic myeloid leukemia (17.30%) cases.Journal of BP Koirala Institute of Health Sciences, Vol. 1, No. 1, 2018, Page: 25-35

scholarly journals Screening for Thalassemia in Healthy Population at a Tertiary Care Hospital in Eastern Nepal

2020 ◽  
Vol 9 (1) ◽  
pp. 41-45
Author(s):  
Manish Kumar Das ◽  
Niraj Nepal ◽  
Prabesh Chaudhary
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Tertiary Care ◽  
Age Groups ◽  
Peripheral Blood Smear ◽  
Healthy Population ◽  
Care Hospital ◽  
Red Cell ◽  
Thalassemia Minor ◽  
Red Cell Indices

Background: Thalassemia is a type of congenital anemia, where there is deficient synthesis of one or more type of globin subunits of normal hemoglobin. This study was undertaken with aims & objective to study the prevalence of thalassemia by comparing Red Blood Cell indices, Peripheral Blood Smear and Electrophoresis in adult volunteers. Material and Methods: The study comprised of 518 cases attending hematological department, who were enrolled in our study after proper informed consent, of which 462 cases were further studied. All cases were subjected to blood sampling for estimation of Hemoglobin, red cell indices and peripheral blood smear. Those samples where peripheral blood smear and Red cell indices were suggestive of thalassemia were subjected to Bio-Rad High Performance Liquid Chromatography based electrophoresis to observe the presence of any abnormal hemoglobin. Results: The mean age of screening sample was 42.91 ± 16.85 years with minimum age of 18 years and maximum age of 85 years. The highest number of cases was in between 21-30 years age groups (19.5%) followed by 41-50 years (17.7%). In the study group, 299 (64.7%) cases were male and 163 (35.3%) cases were female. The prevalence of anemia was found to be 48.16% in males and 68.71% in females with overall prevalence of 55.41%. On electrophoresis reports, 19 cases were diagnosed with thalassemia. The only thalassemia observed was thalassemia minor. The prevalence of thalassemia was found to be 4.11%. Conclusion: Significantly high prevalence of thalassemia minor is found in healthy population.

A CLINICOPATHOLOGICAL STUDY OF ACUTE AND CHRONIC LEUKEMIA IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 72-74
Author(s):  
Sarat Das ◽  
Prasanta Kr. Baruah ◽  
Sandeep Khakhlari ◽  
Gautam Boro
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Lymphoblastic Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Lymphoblastic Leukemia ◽  
Peripheral Blood Smear ◽  
Care Hospital ◽  
Cytochemical Study ◽  
Acute Myeloid

Introduction: Leukemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Typing of leukemia is essential for effective therapy because prognosis and survival rate are different for each type and sub-type Aims: this study was carried out to determine the frequency of acute and chronic leukemias and to evaluate their clinicopathological features. Methods: It was a hospital based cross sectional study of 60 patients carried out in the department of Pathology, JMCH, Assam over a period of one year between February 2018 and January 2019. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination (as on when available marrow sample) for morphology along with cytochemical study whenever possible. Results: In the present study, commonest leukemia was Acute myeloid leukemia (AML, 50%) followed by Acute lymphoblastic leukemia (ALL 26.6%), chronic myeloid leukemia (CML, 16.7%) and chronic lymphocytic leukemia (CLL, 6.7%). Out of total 60 cases, 36 were male and 24 were female with Male:Female ratio of 1.5:1. Acute lymphoblastic leukemia was the most common type of leukemia in the children and adolescents. Acute Myeloid leukemia was more prevalent in adults. Peripheral blood smear and bone Conclusion: marrow aspiration study still remains the important tool along with cytochemistry, immunophenotyping and cytogenetic study in the diagnosis and management of leukemia.

scholarly journals Erythrocyte Morphology in Women of Reproductive Age (WORA) with Anemia

Biomedika ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 83-91
Author(s):  
Alex Jekson Tukira ◽  
Lucia Sincu Gunawan ◽  
Edy Prasetya
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Reproductive Age ◽  
Target Cells ◽  
Women Of Reproductive Age ◽  
Erythrocyte Morphology ◽  
Smear Examination ◽  
Blood Smear Examination ◽  
Laboratory Technology

Anemia is a decrease in the number of erythrocytes in the blood circulation or the level of hemoglobin that is less than normal. The three major body mechanisms that cause anemia are excessive destruction of erythrocytes, blood loss, and decreased erythrocyte production. Based on the Basic Health Research (Riskesdas) in 2013, the prevalence of anemic women of reproductive age (WORA) aged 15-44 years in Indonesia was 35.3%. Anemia is classified based on the morphology of erythrocytes, including hypochromic microcytic, normocytic normochromic, and macrocytic. Erythrocyte morphology can be observed using peripheral blood smear examination. The objective of this study was to determine the morphology of erythrocytes in anemic women of reproductive age. This study belongs to descriptive research. The population of the study was 136 women of reproductive age, covering the students of D-IV in Medical Laboratory Technology at Setia Budi University. Forty-one respondents suffering from anemia were taken using a purposive sampling technique. The types of anemia were determined with examination using an Easy Touch hemoglobinometer with the Hb level of less than 12g/dL. Preparation of peripheral blood smear examination using EDTA venous blood and stained with Giemsa. Microscopic examination was performed with 1000x objective magnification. The peripheral blood smear reading showed the erythrocyte morphology that includes normocytic normochromic (38 samples or 93%), microcytic hypochromic (three samples or 7%), and poikilocytosis consisting of teardrop cells, target cells, ellipstocytes, and stomatocytes (five samples or 18%). Further study is required to investigate the correlation of erythrocyte index and peripheral blood smear in anemia.

scholarly journals Hematological and biochemical profile of person with macrocytic anemia in a tertiary health care centre of Nepal

2020 ◽  
Vol 10 (2) ◽  
pp. 1722-1727
Author(s):  
Rakesh Pathak ◽  
Sujata Pudasaini ◽  
Sushmita Ghimire ◽  
Anil Singh Basnyat ◽  
Anuj KC
Keyword(s):  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Hematological Parameters ◽  
Macrocytic Anemia ◽  
Peripheral Blood Smear ◽  
Blood Smear Examination ◽  
Red Blood Cell Indices

Background: Anemia is a nutritional problem worldwide with an increased risk of morbidity and mortality in all age groups. Macrocytic anemia often originates from abnormalities that impair the erythroid precursor maturation in the bone marrow. Since the clinical manifestations of different types of anemias are similar, hematological parameters including hemoglobin, Red blood cell indices, and Peripheral Blood Smear examination are useful in the diagnosis of anemia. Materials and Methods: This was a cross-sectional study done in the Department of Pathology at Nepal Medical College Teaching hospital. A total of 42 patients between 14 to 62 years with low Hb concentration according to the World Health Organization criteria for anemia were selected and a mean cell volume > 100 fL was taken for study. Peripheral blood smear examination, Red blood cell indices, Vitamin B12, and Folic acid level were evaluated. Results: There were 42 patients with macrocytic anemia enrolled in the study with a mean age of 31.85±12.49 years and with female preponderance. Hemoglobin level was slightly low in males compared to females. Red blood cell indices were slightly higher in males. The difference of serum Vit B12 and Folic acid in male and female was found to be significant. Conclusions: It was concluded that for the diagnosis of a specific type of anemia, hemoglobin, Red blood cell indices, reticulocytes percent, and PBS examination were important parameters. Serum Folic acid and Vitamin B12 level estimation along with other hematological parameters are important for the diagnosis of macrocytic anemia and its correlation

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