scholarly journals Effect of nonsurgical periodontal therapy on serum levels of interleukin-1β and interleukin-8 in smokers and nonsmokers with chronic periodontitis

2020 ◽  
Vol 12 (5) ◽  
pp. 313
Author(s):  
Steffi Vijayakumar ◽  
Elizabeth Koshi ◽  
Arun Sadasivan ◽  
RS Indhuja ◽  
ChitraG Vallabhan
Keyword(s):  
Chronic Periodontitis ◽  
Serum Levels ◽  
Periodontal Therapy ◽  
Interleukin 8 ◽  
Interleukin 1Β ◽  
Nonsurgical Periodontal Therapy

scholarly journals Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Paschalina Goutoudi ◽  
Evdoxia Diza ◽  
Malamatenia Arvanitidou
Keyword(s):  
Interleukin 6 ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Strong Relationship ◽  
Periodontal Therapy ◽  
Interleukin 8 ◽  
Treatment Modalities ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

Purpose. The aim of this study was to analyse the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in gingival crevicular fluid (GCF) of patients with chronic periodontitis prior to and following surgical and/or nonsurgical periodontal therapy for a period of 32 weeks.Methods. GCF samples were obtained from 24 nondiseased and 72 diseased sites of 12 periodontal patients prior to as well as at 6, 16, and 32 weeks following non-surgical and surgical periodontal therapy. IL-6 and IL-8 levels were determined by enzyme-linked immunosorbent assay (ELISA).Results. Periodontal treatment improved all clinical parameters. Both treatment modalities resulted in similar IL-6 as well as IL-8 levels. Mean IL-6 and IL-8 concentrations were significantly higher in non-diseased compared to diseased sites and increased significantly following treatment in diseased sites. Mean total amounts of IL-6 and IL-8 (TAIL-6, TAIL-8) did not differ significantly between diseased and nondiseased sites, while following therapy TAIL-8 levels decreased significantly.Conclusions. The data suggest that periodontal therapy reduced the levels of IL-8 in GCF. However, a strong relationship between IL-6, IL-8 amounts in GCF and periodontal destruction and inflammation was not found.

Alkaline Phosphatase Levels Before and After Nonsurgical Periodontal Therapy

2019 ◽  
Vol 3 (2) ◽  
pp. 62-65
Author(s):  
Shaili Pradhan ◽  
Pramod Kumar Koirala
Keyword(s):  
Alkaline Phosphatase ◽  
Chronic Periodontitis ◽  
Correct Diagnosis ◽  
Serum Levels ◽  
Periodontal Therapy ◽  
Inflammatory Conditions ◽  
Nonsurgical Periodontal Therapy ◽  
Before And After ◽  
Periodontal Destruction ◽  
Supporting Structures

Introduction: Chronic periodontitis is a multifactorial disease resulting in the inflammation and destruction of the supporting structures. Early detection of periodontal changes, prognosis and efficacy of treatment have been monitored by Alkaline Phosphatase Levels (ALP) levels. Objective: This study was carried out to determine level of ALP in saliva and serum before and after periodontal therapy. Methods: This pretest posttest study included 22 patients with generalised chronic periodontitis (GCP). The patients received nonsurgical periodontal therapy (NSPT). Saliva and serum levels of ALP were measured at baseline and after two months of periodontal therapy. Results: Twenty-two patients of mean age 44 years were analysed. Participants had significantly better periodontal parameters after two months. Salivary ALP levels, which were high at baseline, decreased after periodontal treatment. A significant positive correlation (0.0001) was found between the salivary levels of ALP and periodontal inflammatory conditions. Gingival index was found directly proportional with salivary ALP level but not with serum ALP. Conclusion: Periodontal therapy lowered the levels of ALP saliva in GCP patients with high ALP levels. Biochemical analysis of enzymes found in saliva may help in patients’ evaluation to determine the control and progression of periodontal destruction and aid in a correct diagnosis, prognosis and, consequently, better treatment.

scholarly journals The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients

2017 ◽  
Vol 65 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Ewa Dolińska ◽  
Anna Skurska ◽  
Małgorzata Pietruska ◽  
Violetta Dymicka-Piekarska ◽  
Robert Milewski ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

scholarly journals Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012 ◽  
Vol 32 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Swati Pradeep Patel ◽  
Nishanth S. Rao ◽  
A. R. Pradeep
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pocket Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

Background: Plasma glutathione peroxidase (eGPx) is an important selenium containing antioxidant in human defense against oxidative stress. While crevicular fluid (GCF) eGPx levels and its association with periodontal disease is well documented, there is no data on correlation of GCF and serum eGPx levels in chronic periodontitis. Hence this study was undertaken to further probe into the role of oxidative stress in periodontal diseases and effect of nonsurgical periodontal therapy (NSPT) by correlating GCF and serum levels of eGPx.Materials and methods: Thirty subjects (16-Males and 14-Females; age: 30–38 years) participated in the study. The subjects were divided, based on gingival index, probing pocket depth and clinical attachment level into: Healthy (group-1,n=10), Gingivitis (group-2,n=10) and Periodontitis (group-3,n=10). Chronic periodontitis patients after NSPT constituted group 4. GCF and serum samples collected from each subject were quantified for eGPx levels using Enzyme linked Immunosorbent Assay.Results: The mean eGPx concentrations increased from health (14.01 ng/μl and 78.26 ng/ml) to gingivitis (22.86 ng/μl and 90.44 ng/ml) and then to periodontitis (29.89 ng/μl and 103.43 ng/ml), in GCF and serum respectively. After NSPT, there was statistically significant reduction in eGPx concentration in GCF and serum (19.41 ng/μl and 85.21 ng/ml). Further, all the GCF eGPx values showed a positive correlation to that of serum eGPx level.Conclusion: Thus, increased eGPx concentration in GCF can be considered as an indicator of local increase in oxidative stress. While, increase in serum eGPx levels indicates that periodontal disease can also lead to increased oxidative stress at the systemic level.

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