Patterns of lymph node involvement and role of common iliac lymphadenectomy in early-stage cervical cancers: A retrospective analysis from tertiary care cancer centerin Eastern India

e15068 Background: Despite radical oncologic resection with extended lymph node removal, patients with adenocarcinoma of the gastro-esophageal junction or stomach in UICC stage I show only a 5-year survival of 60-80% (Hölscher et al, 2009; Siewert et al. 1998). The aim of this retrospective study was to analyze the long-term survival of caucasian patients with early stage gastric cancer as for this population exist only sparse data. Patients with lymph-node involvement were not included as this parameter is a well-known negative prognostic marker. Methods: Tissue specimens and clinical data from patients with gastric cancer treated in the years 1993 to 2010 at the Charité, Berlin were collected retrospectively. Patients with stage T1 and T2 pN0M0 gastric cancer treated only by surgery including D1- and D2-lymphnode dissection were included in this study. Patients without relapse were followed-up for a minimum period of 24 months. Results: 97 patients (w = 36, m = 61, age 29-90 years) with a follow-up time from 6 to 208 months were identified. The 5-year survival was 94.85% (for details, see Table). Conclusions: The present data indicate a much better prognosis (5-year survival of 95%) of UICC I patients than previously described (60-80%). In harmony with other studies, our data demonstrate that R1, L1 or V1 resection seem to be a risk factor for recurrence whereas signet-ring differentiation was not found as a risk factor in our patient cohort. Ongoing work involves a broad panel of immunohistochemical markers to select prognostic expression profiles which help to identify patients with early gastric cancer at higher risk. This study was supported by the Berliner Krebsgesellschaft, grant DAFF201101. [Table: see text]

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Role of prostate dose escalation in patients with greater than 15% risk of pelvic lymph node involvement

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2004.06.023 ◽

2005 ◽

Vol 61 (3) ◽

pp. 695-701 ◽

Cited By ~ 51

Author(s):

Rojymon Jacob ◽

Alexandra L. Hanlon ◽

Eric M. Horwitz ◽

Benjamin Movsas ◽

Robert G. Uzzo ◽

...

Keyword(s):

Lymph Node ◽

Dose Escalation ◽

Lymph Node Involvement ◽

Pelvic Lymph Node ◽

Node Involvement ◽

Pelvic Lymph Node Involvement

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Detection of extracapsular lymph node involvement in computed tomography (CT) in patients with squamous cell carcinoma of the head and neck – a retrospective analysis

10.1055/s-0038-1640219 ◽

2018 ◽

Author(s):

I Zimmermann ◽

M Durisin ◽

P Raab ◽

JD Tschammer ◽

T Lenarz ◽

...

Keyword(s):

Computed Tomography ◽

Squamous Cell Carcinoma ◽

Lymph Node ◽

Cell Carcinoma ◽

Head And Neck ◽

Retrospective Analysis ◽

Squamous Cell ◽

Lymph Node Involvement ◽

Node Involvement

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Frozen section examination of sentinel lymph nodes can be used as a decisional tool in the surgical management of early cervical cancer

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2019-000904 ◽

2020 ◽

Vol 30 (3) ◽

pp. 358-363 ◽

Cited By ~ 5

Author(s):

Agnieszka Rychlik ◽

Martina Aida Angeles ◽

Federico Migliorelli ◽

Sabrina Croce ◽

Eliane Mery ◽

...

Keyword(s):

Cervical Cancer ◽

Lymph Node ◽

Early Stage ◽

Frozen Section ◽

Lymph Node Involvement ◽

Stage Iiic ◽

Frozen Section Examination ◽

Early Stage Cervical Cancer ◽

Node Involvement ◽

The Impact

IntroductionSentinel lymph node (SLN) detection has been shown to be accurate in detecting lymph node involvement in early-stage cervical cancer. The objective of this study was to evaluate the accuracy of frozen section examination in the assessment of SLN status, with the aim of adequately driving the intra-operative decision.MethodsWe designed a retrospective study including patients from two comprehensive cancer centers between January 2001 and December 2018 with early-stage cervical cancer (IA1-IB2 according to International Federation of Gynecology and Obstetrics (FIGO) 2018) undergoing SLN dissection. The SLN procedure was performed using a cervical injection with technetium-99m combined with blue dye or indocyanine green in most cases.ResultsA total of 176 patients fulfilled inclusion criteria. Bilateral mapping was detected in 153 (86.7%) of them. Nineteen of these patients (12.4%) had SLN involvement: 13 with macrometastases, three with micrometastases and three with isolated tumor cells (ITC). Macrometastatic disease was missed on frozen section in 3/13 FIGO 2018 stage IIIC patients. The three patients with ITC were also missed by frozen section examination.Considering only macrometastases as lymph node involvement, frozen section sensitivity was 76.9% (95% CI 49.7 to 91.8) and negative predictive value (NPV) was 97.9% (95% CI 94.0 to 99.3) in patients with bilateral detection. Including micrometastases, sensitivity was 81.2% (95% CI 57.0 to 93.4) and NPV remained at 97.9% (95% CI 93.9 to 99.3).ConclusionsWith a prevalence of final-stage IIIC in patients with pre-operative early-stage cervical cancer of the order of 10% in this series, the NPV of frozen section examination of SLN is very high, with an inferior limit of the CI superior to 94%. Diagnostic accuracy remains acceptable even if micrometastases are considered. The impact of missed ITC has not been established. Frozen section examination can be incorporated in the intra-operative decision algorithm.

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Sa1650 Incidence and Predictors of Lymph Node Involvement in Early Stage Gastric Adenocarcinoma in the United States

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2014.05.268 ◽

2014 ◽

Vol 79 (5) ◽

pp. AB289

Author(s):

Jennifer a. Luke ◽

Sungjin Kim ◽

Anthony M. Gamboa ◽

Katherine Shaffer ◽

Sunil Dacha ◽

...

Keyword(s):

United States ◽

Lymph Node ◽

Gastric Adenocarcinoma ◽

Early Stage ◽

The United States ◽

Lymph Node Involvement ◽

Node Involvement

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Cancers of the Appendix: Review of the Literatures

ISRN Oncology ◽

10.5402/2011/728579 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 15

Author(s):

Carl Ruoff ◽

Louay Hanna ◽

Wanqing Zhi ◽

Ghulamullah Shahzad ◽

Vladimir Gotlieb ◽

...

Keyword(s):

Lymph Node ◽

Carcinoid Syndrome ◽

Randomized Trials ◽

Surgical Intervention ◽

Somatostatin Analogues ◽

Lymph Node Involvement ◽

Right Hemicolectomy ◽

Peritoneal Seeding ◽

Node Involvement

Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of appendix are only 0.08% of all cancers and the treatment remains controversial. Here we are reporting a 46-year-old male presented with symptoms of appendicitis, diagnosed with adenocarcinoma of the appendix. The patient was treated with appendectomy and refused further surgical intervention to complete hemicolectomy. Up to date, he remains asymptomatic. We performed literature review of the tumors of the appendix. Most of the benign conditions are treated with surgery alone. Lymphomas require CHOP-like chemotherapy and carcinoid syndrome treatment with somatostatin analogues. It is generally recommended that right hemicolectomy is the preferred treatment for adenocarcinoma of appendix. The role of chemotherapy is unclear due to lacking randomized trials but seems to be accepted if there is lymph node involvement or peritoneal seeding.

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