scholarly journals Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study

2019 ◽  
Vol 19 (6) ◽  
Author(s):  
Jihyun Kim ◽  
Seonwoo Kim ◽  
Sook-young Woo ◽  
Jin-Yong Chung ◽  
Young-Seoub Hong ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood

scholarly journals Therapeutic effect of EGF secreted by human umbilical cord blood-derived mesenchymal stem cells on atopic dermatitis

2021 ◽  
Author(s):  
Namhee Jung ◽  
TaeHo Kong ◽  
Yeonsil Yu ◽  
Hwanhee Park ◽  
Eunjoo Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Atopic Dermatitis ◽  
Mast Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Th2 Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

Abstract Human mesenchymal stem cells (MSCs) are emerging as a treatment for atopic dermatitis (AD), which is a common inflammatory skin disorder that affects a large number of people across the world. Treatment of AD using human umbilical cord blood-derived MSCs (hUCB-MSCs) has recently been studied; however, the mechanism underlying the effects of these cells is unclear. This study investigated the effect of epidermal growth factor (EGF) secreted by hUCB-MSCs on AD. hUCB-MSCs secreted a high concentration of EGF compared with other cell types. To elucidate the effect of EGF secreted by hUCB-MSCs, EGF expression was downregulated in hUCB-MSCs using EGF-targeting small interfering RNA, and these cells were co-cultured with keratinocytes, Th2 cells, and mast cells. Depletion of EGF expression disrupted the immunomodulatory effects of hUCB-MSCs on these AD-related inflammatory cells. In a Dermatophagoides farinae-induced AD mouse model, subcutaneous injection of hUCB-MSCs ameliorated gross scoring, histopathologic damage, and mast cell infiltration, and significantly reduced the levels of inflammatory cytokines including interleukin (IL)-4, tumor necrosis factor-α (TNFa), thymus and activation-regulated chemokine (TARC), and IL-22, as well as the serum IgE level. These therapeutic effects were significantly attenuated at all evaluation points in mice injected with EGF-depleted hUCB-MSCs. Taken together, these results suggest that EGF secreted by hUCB-MSCs plays an important role in treatment of AD by regulating the inflammatory response in keratinocytes, Th2 cells, and mast cells.

scholarly journals Effects of prenatal exposure to methylmercury in children auditory processing

2016 ◽  
Vol 24 (1) ◽  
pp. 70-76
Author(s):  
Marilene Danieli Simões Dutra ◽  
Marcia Cavadas ◽  
Iracina Maura de Jesus ◽  
Elisabeth Oliveira Santos ◽  
Volney de Magalhães Câmara
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Auditory Processing ◽  
Total Mercury ◽  
Central Auditory Processing ◽  
Prenatal Period ◽  
Blood Samples ◽  
Significant Difference

Abstract Objective: to assess the central auditory processing of children exposed to mercury during the prenatal period. Design/Study sample: this study evaluated 90 children age eight to ten years, of both genders divided into two groups according to the levels of mercury exposure during the prenatal period: the study group (SG) was composed of children who had total mercury levels in umbilical cord blood samples equal or higher than 8µg/L, and the control group (CG) of children who had Mercury levels lower than 8µg/L. The procedures included a questionnaire, tonal threshold audiometry, word recognition audiometry, tests that assess auditory processing skills; and analysis of the total levels of mercury in umbilical cord blood samples collected at birth. Result: The SG presented mean total mercury in umbilical cord blood of 19.36µg/L and the CG had mean of 4.78µg/L. Regarding the tests that assess central auditory processing, the SG showed worse performance than the CG, and there was a statistically significant difference observed in the Staggered Spondaic Word Test. Conclusion: Children presented disorders in the tests that assess central auditory processing, indicating a possible effect of prenatal exposure to mercury in the central auditory system.

Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

2013 ◽  
Vol 182 ◽  
pp. 63-69 ◽  
Author(s):  
Xijin Xu ◽  
Taofeek Akangbe Yekeen ◽  
Qiongna Xiao ◽  
Yuangping Wang ◽  
Fangfang Lu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Electronic Waste ◽  
Igfbp 3

scholarly journals Prenatal exposure to metals and neurodevelopment in infants at six months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project).

2021 ◽  
Author(s):  
Monica Seefelder de Assis Araujo ◽  
Nataly Damasceno de figueiredo ◽  
Jorge Fonte de Rezende Flho ◽  
Joffre Amim Junior ◽  
Marlos Melo Martins ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Blood Lead ◽  
Maternal Blood ◽  
Childhood Development ◽  
Birth Cohort Study

Abstract The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal (n = 49) and umbilical cord blood (n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of the infants (17–33%) exhibited at least one fail in the neurodevelopment evaluation (fail group). Maternal blood arsenic concentrations were significantly (p = 0.02) higher in the "fail group" (GM: 11.85 µg /L) compared to infants who did not fail (not fail group) (GM: 8.46 µg /L). Maternal and umbilical cord blood arsenic concentrations were higher in all Denver Test’s domains (except personal/social) in the “fail group”, albeit non-statistically significant. These findings indicate the need to further investigate the toxic effects of prenatal exposure to metals on infant neurodevelopment.

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