Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

2013 ◽  
Vol 182 ◽  
pp. 63-69 ◽  
Author(s):  
Xijin Xu ◽  
Taofeek Akangbe Yekeen ◽  
Qiongna Xiao ◽  
Yuangping Wang ◽  
Fangfang Lu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Electronic Waste ◽  
Igfbp 3

scholarly journals The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study

2020 ◽  
Vol 9 (10) ◽  
pp. 3256
Author(s):  
Tomasz Gęca ◽  
Anna Kwaśniewska
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Control Group ◽  
Study Group ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

Background: Gestational diabetes mellitus (GDM), defined as impaired glucose tolerance with onset or first recognition in pregnancy, increases the risk of not only maternal but also fetal and neonatal complications. Given the structural similarity of insulin-like growth factors with insulin and participation of components of the insulin-like growth factor system in glucose homeostasis, we hypothesized that the IGF axis is involved in the development of GDM complications or its pathogenesis. The aim of this study was to evaluate the effect of GDM on the selected parameters of the insulin-like growth factors (IGF-1, IGF-2, IGFBP1-3) in the maternal and fetal blood. Methods: The clinical material of this case-control study included 109 pregnant women and their offspring. The study group (n = 120) consisted of 60 patients with diagnosed gestational diabetes and their newborn babies. The control group (n = 98) comprised 49 healthy parturients and their offspring. We measured the concentrations of IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, insulin and glucose made by the ELISA method in peripheral blood serum in patients suffering from GDM and pregnant women without GDM, and in the umbilical cord blood of newborn babies born to them. Results: The analysis of concentrations of IGF-1, -2 and IGFBP-3 in peripheral blood as well as umbilical cord blood did not demonstrate a statistically significant difference between the study group and the control group. Significantly lower concentration of IGFBP-1, IGFBP-2 in peripheral blood and in umbilical cord blood was detected in the study group in comparison to the control group. A statistically positive correlation between the concentration of IGF-1 in umbilical cord serum of newborn babies born to women with gestational diabetes and the length of a baby after its birth was observed. Conclusions: Gestational diabetes mellitus does not significantly affect the concentrations of IGF-1, -2, IGFBP-3 in the peripheral blood and umbilical cord blood, but has the greatest influence on maternal and fetal IGFBP-2 concentrations. A positive correlation between the concentration of IGF-1 in umbilical cord blood and the length of a newborn suggests an influence of IGF-1 on the process of fetal development.

scholarly journals Effects of prenatal exposure to methylmercury in children auditory processing

2016 ◽  
Vol 24 (1) ◽  
pp. 70-76
Author(s):  
Marilene Danieli Simões Dutra ◽  
Marcia Cavadas ◽  
Iracina Maura de Jesus ◽  
Elisabeth Oliveira Santos ◽  
Volney de Magalhães Câmara
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Auditory Processing ◽  
Total Mercury ◽  
Central Auditory Processing ◽  
Prenatal Period ◽  
Blood Samples ◽  
Significant Difference

Abstract Objective: to assess the central auditory processing of children exposed to mercury during the prenatal period. Design/Study sample: this study evaluated 90 children age eight to ten years, of both genders divided into two groups according to the levels of mercury exposure during the prenatal period: the study group (SG) was composed of children who had total mercury levels in umbilical cord blood samples equal or higher than 8µg/L, and the control group (CG) of children who had Mercury levels lower than 8µg/L. The procedures included a questionnaire, tonal threshold audiometry, word recognition audiometry, tests that assess auditory processing skills; and analysis of the total levels of mercury in umbilical cord blood samples collected at birth. Result: The SG presented mean total mercury in umbilical cord blood of 19.36µg/L and the CG had mean of 4.78µg/L. Regarding the tests that assess central auditory processing, the SG showed worse performance than the CG, and there was a statistically significant difference observed in the Staggered Spondaic Word Test. Conclusion: Children presented disorders in the tests that assess central auditory processing, indicating a possible effect of prenatal exposure to mercury in the central auditory system.

scholarly journals Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study

2019 ◽  
Vol 19 (6) ◽  
Author(s):  
Jihyun Kim ◽  
Seonwoo Kim ◽  
Sook-young Woo ◽  
Jin-Yong Chung ◽  
Young-Seoub Hong ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood

scholarly journals Prenatal exposure to metals and neurodevelopment in infants at six months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project).

2021 ◽  
Author(s):  
Monica Seefelder de Assis Araujo ◽  
Nataly Damasceno de figueiredo ◽  
Jorge Fonte de Rezende Flho ◽  
Joffre Amim Junior ◽  
Marlos Melo Martins ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Blood Lead ◽  
Maternal Blood ◽  
Childhood Development ◽  
Birth Cohort Study

Abstract The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal (n = 49) and umbilical cord blood (n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of the infants (17–33%) exhibited at least one fail in the neurodevelopment evaluation (fail group). Maternal blood arsenic concentrations were significantly (p = 0.02) higher in the "fail group" (GM: 11.85 µg /L) compared to infants who did not fail (not fail group) (GM: 8.46 µg /L). Maternal and umbilical cord blood arsenic concentrations were higher in all Denver Test’s domains (except personal/social) in the “fail group”, albeit non-statistically significant. These findings indicate the need to further investigate the toxic effects of prenatal exposure to metals on infant neurodevelopment.

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