scholarly journals Plasma Copper and Zinc Concentration in Individuals with Autism Correlate with Selected Symptom Severity

2012 ◽  
Vol 5 ◽  
pp. NMI.S8761 ◽  
Author(s):  
Anthony J. Russo ◽  
Andrea P. Bazin ◽  
Richard Bigega ◽  
Robert S. Carlson ◽  
Martin G. Cole ◽  
...  
Keyword(s):  
Motor Skills ◽  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Receptive Language ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Plasma Zinc ◽  
Inductively Coupled ◽  
Copper And Zinc

Aim To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. Subjects and Methods Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms. Results Autistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity. Discussion These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.

scholarly journals Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism

2011 ◽  
Vol 6 ◽  
pp. BMI.S7286 ◽  
Author(s):  
A.J. Russo ◽  
Robert deVito
Keyword(s):  
Pervasive Developmental Disorder ◽  
Symptom Severity ◽  
Plasma Levels ◽  
Asperger's Syndrome ◽  
Developmental Disorder ◽  
Asperger’S Syndrome ◽  
Receptive Language ◽  
Plasma Zinc ◽  
Not Otherwise Specified ◽  
Copper And Zinc

Aim To assess plasma zinc and copper concentration in individuals with Asperger's Syndrome, Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) and autistic disorder, and to analyze the efficacy of zinc therapy on the normalization of zinc and copper levels and symptom severity in these disorders. Subjects and methods Plasma from 79 autistic individuals, 52 individuals with PDD-NOS, 21 individuals with Asperger's Syndrome (all meeting DSM-IV diagnostic criteria), and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic and PDD-NOS individuals had significantly elevated plasma levels of copper. None of the groups (autism, Asperger's or PDD-NOS) had significantly lower plasma zinc concentrations. Post zinc and B-6 therapy, individuals with autism and PDD-NOS had significantly lower levels of copper, but individuals with Asperger's did not have significantly lower copper. Individuals with autism, PDD-NOS and Asperger's all had significantly higher zinc levels. Severity of symptoms decreased in autistic individuals following zinc and B-6 therapy with respect to awareness, receptive language, focus and attention, hyperactivity, tip toeing, eye contact, sound sensitivity, tactile sensitivity and seizures. None of the measured symptoms worsened after therapy. None of the symptoms in the Asperger's patients improved after therapy. Discussion These results suggest an association between copper and zinc plasma levels and individuals with autism, PDD-NOS and Asperger's Syndrome. The data also indicates that copper levels normalize (decrease to levels of controls) in individuals with autism and PDD-NOS, but not in individuals with Asperger's. These same Asperger's patients do not improve with respect to symptoms after therapy, whereas many symptoms improved in the autism group. This may indicate an association between copper levels and symptom severity.

scholarly journals Analysis of Plasma Zinc and Copper Concentration, and Perceived Symptoms, in Individuals with Depression, Post Zinc and Anti-Oxidant Therapy

2011 ◽  
Vol 4 ◽  
pp. NMI.S6760 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Copper Concentration ◽  
Plasma Zinc ◽  
Elevated Plasma ◽  
Inductively Coupled ◽  
Clinically Depressed ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Normal Controls

Aim To assess plasma Zn and Cu levels in individuals with depression. Subjects and Methods Plasma from 73 clinically depressed individuals, 38 individuals with anxiety and 16 controls were tested for plasma Zn and Cu concentration using inductively-coupled plasma-mass spectrometry. Results Depressed individuals, with and without secondary anxiety, had decreased plasma Zn and elevated plasma Cu compared to controls. Zn normalized (increased to the level of normal controls) but Cu increased in individuals with depression (with and without secondary anxiety), after Zn therapy, whereas both plasma Zn increased and Cu levels decreased in anxiety, with and without secondary depression, after Zn therapy. Individuals with depression, with and without secondary anxiety, had significantly higher symptom severity when compared to neurotypical controls. Symptom severity in individuals with anxiety (both with and without secondary depression) significantly decreased after Zn therapy, whereas symptoms remained the same in individuals with primary depression. Discussion These data show an association between Zn and Cu plasma levels and clinically depressed individuals, and suggest that high Cu levels are associated with high symptom severity.

Prediction of Fine Motor Skills of Children Having Language and Speech Disorders

1988 ◽  
Vol 67 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Ronald K. Sommers
Keyword(s):  
Motor Skills ◽  
Receptive Language ◽  
Speech Disorders ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Auditory Comprehension ◽  
Fine Motor Skill ◽  
Language Tests ◽  
Cas A ◽  
Fine Motor Performance

Relationships between the fine motor skills and linguistic abilities of 37 developmentally delayed children, ages 5 to 9 yr., were studied using a battery of expressive and receptive language tests, a measure of fine motor performance, a dichotic listening test, and individual intelligence tests. While IQs and MAs were not related to fine motor skills, both expressive and receptive language test scores showed moderate to moderately high correlations, the highest single relationship being the Test for the Auditory Comprehension of Language. In concert with CAs, a dichotic right-ear test score, the Auditory Comprehension Test, predicted fine motor-skill indices substantially; R = .80. Strong relationships appear between linguistic and fine motor skills in an age group not previously investigated and at higher levels than reported in studies of infants and very young children. Dichotic results were abnormal in a majority of the children.

scholarly journals Decreased Zinc and Increased Copper in Individuals with Anxiety

2011 ◽  
Vol 4 ◽  
pp. NMI.S6349 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Plasma Levels ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Plasma Zinc ◽  
Normal Range ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Preliminary Study ◽  
Post Therapy

Aim To assess plasma zinc and copper levels in individuals with anxiety and to test the hypothesis that there is a relationship between copper and zinc concentration and improved symptoms. Subjects and Methods Serum from 38 individuals with anxiety and 16 neurotypical age, gender and size similar controls were tested for plasma zinc and copper concentration using inductively-coupled plasma-mass spectrometry. Zinc and copper levels, pre and post therapy, were compared and assessed for perceived anxiety symptoms. Results In this preliminary study, individuals with anxiety had significantly higher plasma levels of Cu ( P = 0.0348), Cu/Zn ( P = 0.0493) and lower Zn ( P = 0.0294) compared to controls. Zn levels normalized (increased to the normal range) and Cu/Zn significantly decreased after zinc therapy ( P = 0.0004, P = 0.0033, respectively), but Cu did not significantly decrease (0.3577). These same patients improved significantly with respect to perceived overall symptoms after zinc and anti-oxidant therapy ( P = 0.013). Discussion These results suggest an association between Zn plasma levels and individuals with anxiety, demonstrate that zinc therapy is effective in increasing zinc plasma levels, and show that zinc supplementation may play a role in improved symptoms.

scholarly journals Effects of Fine Motor Development in the Subsequent Expressive and Receptive Language Skills of Children with Special Needs

2020 ◽  
Vol 3 (2) ◽  
pp. 143-144
Author(s):  
David Karlo I. Equipaje ◽  
Deborah Natalia E. Singson
Keyword(s):  
Special Needs ◽  
Motor Skills ◽  
Motor Development ◽  
Language Skills ◽  
Expressive Language ◽  
Development Program ◽  
Receptive Language ◽  
Fine Motor ◽  
International Studies ◽  
Fine Motor Skills

Studies related to developmental psychology have long recognized the importance of motor development but have recently begun to systematically map out its subsequent developmental pathways.  In many international studies, finding evidence on the effects of fine motor skills development on children's language skills with special needs (CSNs) has significantly grown much interest.  Fine motor skills and language skills play a vital role in a child's early development.  Hence, the study describes the level of performance in the fine motor domain, expressive language domain, and receptive language domain of preschool-aged CSNs of a private intervention center in Bacolod City during the school year 2019-2020. Likewise, it explores the existing relationship of the fine motor skills and language skills between the CSN's age and sex before and after participating in a fine motor development program.  Also, it determines the subsequent consequences of the fine motor development program on the expressive language skills and receptive language skills of the CSNs.

scholarly journals Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism

2013 ◽  
Vol 8 ◽  
pp. BMI.S11270 ◽  
Author(s):  
Anthony J. Russo
Keyword(s):  
Growth Factor ◽  
Motor Skills ◽  
Symptom Severity ◽  
The United States ◽  
Receptive Language ◽  
Autism Spectrum ◽  
Fine Motor ◽  
Autistic Children ◽  
Gross Motor ◽  
Gross Motor Skills

Background Autism spectrum disorders (ASDs), characterized by impaired social interactions and deficits in verbal and nonverbal communication, are thought to affect 1 in 88 children in the United States. There is much support for the role of growth factors in the etiology of autism. Recent research has shown that epithelial growth factor (EGF) is decreased in young autistic children (2–4 years of age). This study was designed to determine plasma levels of EGF in an older group of autistic children (mean age 10.6 years) and to correlate these EGF levels with putative biomarkers HGF, uPA, uPAR, GAD2, MPO GABA, and HMGB1, as well as symptom severity of 19 different symptoms. Subjects and Methods Plasma from 38 autistic children, 11 children with pervasive developmental disorder (PDD-NOS) and 40 neurotypical, age and gender similar controls was assessed for EGF concentration using ELISAs. Severity of 19 symptoms (awareness, expressive language, receptive language, (conversational) pragmatic language, focus/attention, hyperactivity, impulsivity, perseveration, fine motor skills, gross motor skills, hypotonia (low muscle tone), tiptoeing, rocking/pacing, stimming, obsessions/fixations, eye contact, sound sensitivity, light sensitivity, and tactile sensitivity) was assessed and then compared to EGF concentrations. Results In this study, we found EGF levels in autistic children and those with PDD-NOS to be significantly lower when compared with neurotypical controls. EGF levels correlated with HMGB1 levels but not the other tested putative biomarkers, and EGF correlated negatively with hyperactivity, gross motor skills, and tiptoeing but not other symptoms. Conclusions These results suggest an association between decreased plasma EGF levels and selected symptom severity. We also found a strong correlation between plasma EGF and HMGB1, suggesting inflammation is associated with decreased EGF.

PENGEMBANGAN FISIK MOTORIK ANAK USIA DINI DENGAN BERMAI

Edupedia ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. 67-77
Author(s):  
Farhatin Masrurah ◽  
Khulusinniyah Khulusinniyah
Keyword(s):  
Early Childhood ◽  
High Activity ◽  
Motor Skills ◽  
Motor Development ◽  
Rapid Growth ◽  
Skills Development ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Gross Motor ◽  
Gross Motor Skills

The first five years of a children’s age is the period of rapid growth with physical and motor development. Those process will develop well if stimulated continuously. Early childhood always identic with high activity requires the opportunity to express their abilities. Therefore playing method is very urgent inchildren’s gross motor skills and fine motor skills development through a variety of playing activities both indoors and outdoors. Playing is an activity that cannot be separated from early childhood’s world. All playing activities will be carried out happily. By the same token learning by playing will be done happily without any sense of being forced or oppressed.

Development of an arcade controller for children with intellectual disabilities to improve fine motor skills through video games

2020 ◽  
Author(s):  
Domenica A. Merchan-Garcia ◽  
Alejandro S. Enriquez-Mancheno ◽  
Victor H. Uguna-Uguna ◽  
Paola F. Suquilanda-Cuesta ◽  
Vladimir E. Robles-Bykbaev
Keyword(s):  
Video Games ◽  
Intellectual Disabilities ◽  
Motor Skills ◽  
Fine Motor ◽  
Fine Motor Skills

scholarly journals P110 Sex differences in hand osteoarthritis symptoms and function

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Brona Dinneen ◽  
David Heath ◽  
Mohammed Tauseef Ghaffar ◽  
Miriam O'Sullivan ◽  
Carmel Silke ◽  
...  
Keyword(s):  
Sex Differences ◽  
Pain Intensity ◽  
Motor Skills ◽  
Functional Assessment ◽  
Functional Ability ◽  
Fine Motor ◽  
Hand Osteoarthritis ◽  
Fine Motor Skills ◽  
Males And Females ◽  
And Function

Abstract Background/Aims  There is currently no consensus regarding sex-related differences in pain intensity and functional abilities among patients with hand osteoarthritis (OA). In this study we determine sex-related differences in pain intensity and functional ability among patients with hand OA, as assessed by a self-report questionnaire and by performance-based tests. Methods  Using the AUSCAN tool for symptom and functional assessment of hand OA with dynamometry we prospectively accessed patients meeting the ACR criteria for hand osteoarthritis. Using this analysis, assessments of pain and function were compared in male and female patients. The outcome measures included self-reported pain measures, functional assessment and dynamometry measures. Results  The study population included 106 patients (90 females and 16 males) with a mean age of males 48.44 (7.48) and females 52.67 (9.43). All patients with symptomatic hand osteoarthritis meeting ACR Criteria. When accessing difference between sexes, men were found to be significantly heavier (p = 0.003) and have greater grip and pinch strength.As part of function and pain assessments there was a significant correlation between difficulty with fine motor skills such as difficulty doing buttons, difficulty when doing jewellery, or peeling vegetables associated with pain when turning objects e.g. doorknobs, taps and faucets for men in comparison to women. Difficulty in these fine motor skills also correlated with stiffness on wakening and pain on lifting heavy objects regardless of sex. A Mann-Whitney U test was run on 106 participants to determine if there were differences in pain or functional scores between males and females. This reviled Median score for males () and females () was statistically significantly different,There were sex differences noted in the correlation associated with pain with rotational movements e.g. turning objects and functional difficulty with fine motor movements including difficulty when doing up buttons ( Males r(14) = -0.109, p = 0.698, Females r(88) =0.489, p = <0.01 value.= ), difficulty when doing jewellery ( Males r(14) =-0.265, p = 0.339.= Females r(88) = 0.570, p = <0.01) , difficulty peeling vegetables ( Males r(14) = -0.207, p = 0.458 Females r(88) = 0.519, <0.01 ) Conclusion  The results demonstrate the presence of sex differences in patients suffering from hand osteoarthritis self-reported functional ability and pain scales. These differences indicate the need for further studies to explore the mechanisms of hand OA and to understanding the specific impact of gender on the development and progression of disease. With further understanding we can obtain the proper strategy to provide better individualised treatment. It also highlights that rehabilitation programs should consider these differences and each patients’ performance limitations in order to address the specific needs of each individual patient. In doing so, improved pain and functional status will improve morbidity in hand OA Disclosure  B. Dinneen: None. D. Heath: None. M. Ghaffar: None. M. O'Sullivan: None. C. Silke: None. B. Whelan: None.

Delaying cord clamping is linked to improvements in fine motor skills

BMJ ◽  
2015 ◽  
Vol 350 (may26 22) ◽  
pp. h2828-h2828
Author(s):  
J. Wise
Keyword(s):  
Motor Skills ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Cord Clamping
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