scholarly journals Corrigendum for “Stereocomplexes Formed from Select Oligomers of Polymer D-lactic Acid (PDLA) and L-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers—Applications of the Warburg Effect”

2014 ◽  
Vol 6 ◽  
pp. PMC.S16685
Author(s):  
Joel S. Goldberg
Keyword(s):  
Lactic Acid ◽  
Cancer Cells ◽  
Warburg Effect ◽  
The Warburg Effect

Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review

2017 ◽  
Vol 18 (9) ◽  
Author(s):  
Mohadeseh Hasanpourghadi ◽  
Chung Yeng Looi ◽  
Ashok Kumar Pandurangan ◽  
Gautam Sethi ◽  
Won Fen Wong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Warburg Effect ◽  
The Warburg Effect

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

2018 ◽  
Vol 1870 (1) ◽  
pp. 51-66 ◽  
Author(s):  
Linchong Sun ◽  
Caixia Suo ◽  
Shi-ting Li ◽  
Huafeng Zhang ◽  
Ping Gao
Keyword(s):  
Cancer Cells ◽  
Warburg Effect ◽  
Metabolic Reprogramming ◽  
The Warburg Effect

scholarly journals Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin

2020 ◽  
Vol 21 (5) ◽  
pp. 1661
Author(s):  
Anamarija Mojzeš ◽  
Marko Tomljanović ◽  
Lidija Milković ◽  
Renata Novak Kujundžić ◽  
Ana Čipak Gašparović ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Warburg Effect ◽  
Aerobic Glycolysis ◽  
Intracellular Localization ◽  
Lactate Production ◽  
Glucose Consumption ◽  
Cell Type ◽  
Cell Type Specific ◽  
The Warburg Effect

In order to support uncontrolled proliferation, cancer cells need to adapt to increased energetic and biosynthetic requirements. One such adjustment is aerobic glycolysis or the Warburg effect. It is characterized by increased glucose uptake and lactate production. Curcumin, a natural compound, has been shown to interact with multiple molecules and signaling pathways in cancer cells, including those relevant for cell metabolism. The effect of curcumin and its solvent, ethanol, was explored on four different cancer cell lines, in which the Warburg effect varied. Vital cellular parameters (proliferation, viability) were measured along with the glucose consumption and lactate production. The transcripts of pyruvate kinase 1 and 2 (PKM1, PKM2), serine hydroxymethyltransferase 2 (SHMT2) and phosphoglycerate dehydrogenase (PHGDH) were quantified with RT-qPCR. The amount and intracellular localization of PKM1, PKM2 and signal transducer and activator of transcription 3 (STAT3) proteins were analyzed by Western blot. The response to ethanol and curcumin seemed to be cell-type specific, with respect to all parameters analyzed. High sensitivity to curcumin was present in the cell lines originating from head and neck squamous cell carcinomas: FaDu, Detroit 562 and, especially, Cal27. Very low sensitivity was observed in the colon adenocarcinoma-originating HT-29 cell line, which retained, after exposure to curcumin, a higher levels of lactate production despite decreased glucose consumption. The effects of ethanol were significant.

scholarly journals A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57712 ◽  
Author(s):  
Alejandro San Martín ◽  
Sebastián Ceballo ◽  
Iván Ruminot ◽  
Rodrigo Lerchundi ◽  
Wolf B. Frommer ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Warburg Effect ◽  
Single Cancer ◽  
Lactate Sensor ◽  
The Warburg Effect

scholarly journals Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells

2014 ◽  
Vol 5 (6) ◽  
pp. e1302-e1302 ◽  
Author(s):  
C A Caneba ◽  
L Yang ◽  
J Baddour ◽  
R Curtis ◽  
J Win ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ovarian Cancer ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Ovarian Cancer Cells ◽  
Positive Regulator ◽  
The Warburg Effect

scholarly journals LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect

2018 ◽  
Vol 115 (7) ◽  
pp. E1465-E1474 ◽  
Author(s):  
Shaoxun Xiang ◽  
Hao Gu ◽  
Lei Jin ◽  
Rick F. Thorne ◽  
Xu Dong Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Enzymatic Activity ◽  
Cancer Cells ◽  
Long Noncoding Rna ◽  
Warburg Effect ◽  
Noncoding Rna ◽  
Ros Production ◽  
Xenograft Growth ◽  
The Relationship ◽  
The Warburg Effect

The oncoprotein c-Myc plays an important role in regulating glycolysis under normoxia; yet, in cancer cells, HIF1α, which is essential for driving glycolysis under hypoxia, is often up-regulated even in the presence of oxygen. The relationship between these two major regulators of the Warburg effect remains to be fully defined. Here we demonstrate that regulation of a long noncoding RNA (lncRNA), named IDH1-AS1, enables c-Myc to collaborate with HIF1α in activating the Warburg effect under normoxia. c-Myc transcriptionally repressed IDH1-AS1, which, upon expression, promoted homodimerization of IDH1 and thus enhanced its enzymatic activity. This resulted in increased α-KG and decreased ROS production and subsequent HIF1α down-regulation, leading to attenuation of glycolysis. Hence, c-Myc repression of IDH1-AS1 promotes activation of the Warburg effect by HIF1α. As such, IDH1-AS1 overexpression inhibited cell proliferation, whereas silencing of IDH1-AS1 promoted cell proliferation and cancer xenograft growth. Restoring IDH1-AS1 expression may therefore represent a potential metabolic approach for cancer treatment.

scholarly journals Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

2021 ◽  
Vol 12 (1) ◽  
pp. 207-216
Author(s):  
Jie Li ◽  
Yuliang Zou ◽  
Meili Pei ◽  
Yun Zhang ◽  
Yu Jiang
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Ovarian Cancer Cells ◽  
The Warburg Effect

scholarly journals Hepatitis C Virus Downregulates Core Subunits of Oxidative Phosphorylation, Reminiscent of the Warburg Effect in Cancer Cells

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1410 ◽  
Author(s):  
Gerresheim ◽  
Roeb ◽  
Michel ◽  
Niepmann
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Citric Acid ◽  
Oxidative Phosphorylation ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Citric Acid Cycle ◽  
Host Cells ◽  
Acid Cycle ◽  
The Warburg Effect

Hepatitis C Virus (HCV) mainly infects liver hepatocytes and replicates its single-stranded plus strand RNA genome exclusively in the cytoplasm. Viral proteins and RNA interfere with the host cell immune response, allowing the virus to continue replication. Therefore, in about 70% of cases, the viral infection cannot be cleared by the immune system, but a chronic infection is established, often resulting in liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Induction of cancer in the host cells can be regarded to provide further advantages for ongoing virus replication. One adaptation in cancer cells is the enhancement of cellular carbohydrate flux in glycolysis with a reduction of the activity of the citric acid cycle and aerobic oxidative phosphorylation. To this end, HCV downregulates the expression of mitochondrial oxidative phosphorylation complex core subunits quite early after infection. This so-called aerobic glycolysis is known as the “Warburg Effect” and serves to provide more anabolic metabolites upstream of the citric acid cycle, such as amino acids, pentoses and NADPH for cancer cell growth. In addition, HCV deregulates signaling pathways like those of TNF-β and MAPK by direct and indirect mechanisms, which can lead to fibrosis and HCC.

Sign in / Sign up

Export Citation Format

Share Document