scholarly journals EFFECTS OF VITAMIN B12 ON SERUM LIPIDS AND LIPOPROTEINS OF PIGS FED DIETS SUPPLEMENTED WITH PROPIONIC ACID OR CALCIUM PROPIONATE

1982 ◽  
Vol 62 (2) ◽  
pp. 527-536 ◽  
Author(s):  
P.A. THACKER ◽  
J.P. BOWLAND ◽  
M. FENTON
Keyword(s):  
Propionic Acid ◽  
Feed Intake ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Vitamin B ◽  
Calcium Propionate ◽  
Lipids And Lipoproteins

Effects of vitamin B12 supplementation of diets containing propionic acid (PA), or calcium propionate (CP) on feed intake, serum lipids and lipoproteins were studied utilizing 80 crossbred pigs averaging 22.5 kg. Diets, based on barley-soybean meal, containing 0, 3.5 or 7% PA or CP, were fed with and without the addition of 4.95 mg vitamin B12/kg diet. Inclusion of PA or CP with or without the addition of vitamin B12 had no significant effect on feed intake. Addition of PA or CP depressed serum cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and serum triglycerides. Vitamin B12 supplementation had no effect on serum total cholesterol or HDL cholesterol, caused a reduction in LDL cholesterol, and tended to overcome the reduction in serum triglyceride. Supplementation of diets with vitamin B12 reduced liver lipid levels, largely as a result of a decrease in cholesterol and phospholipids. These data suggest that the cholesterol-lowering effect of PA is not simply a result of a depression in feed intake, but arises from a direct action of PA on cholesterol metabolism. Key words: Vitamin B12, lipids, lipo protein, pigs, propionic, propionate

HDL subfractions and adipose tissue metabolism in the reduced-obese state

1989 ◽  
Vol 256 (6) ◽  
pp. E740-E746
Author(s):  
R. H. Eckel ◽  
T. J. Yost
Keyword(s):  
Adipose Tissue ◽  
Weight Reduction ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Fasting Serum ◽  
Adipose Tissue Metabolism ◽  
Cholesterol Ratio ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Lipids And Lipoproteins

The effect of weight reduction on fasting serum lipids and lipoproteins and adipose tissue lipoprotein lipase responsiveness to insulin was assessed immediately after and 3 mo subsequent to a mean 11.7% weight reduction in 14 women. Whereas reduction in fasting serum triglycerides persisted after 3 mo, reductions in serum cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein (HDL) cholesterol were not found at 3 mo. In fact, at 3 mo, levels of HDL cholesterol were higher than before weight reduction. Maintenance of the reduced-obese state also increased the HDL2-to-HDL3 cholesterol ratio (P less than 0.01), an effect strongly associated with the change in the responsiveness of adipose tissue lipoprotein lipase to insulin (r = 0.821, P less than 0.001). Moreover, after maintenance of the reduced-obese state, the HDL2-to-HDL3 cholesterol ratio also increased after the ingestion of corn oil and a 6-h insulin-glucose infusion, a response not present before weight reduction. Thus the effect of weight reduction on serum lipids and lipoproteins was not only time dependent, but for HDL, was strongly associated with changes in adipose tissue metabolism.

Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations

1983 ◽  
Vol 104 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Stig Valdemarsson ◽  
Per Hansson ◽  
Pavo Hedner ◽  
Peter Nilsson-Ehle
Keyword(s):  
Lipoprotein Lipase ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Hepatic Lipase ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Overt Hypothyroidism ◽  
Full Spectrum

Abstract. Lipoprotein concentrations and activities of lipoprotein lipase (LPL) and hepatic lipase (HL) were measured in 70 subjects with thyroid function ranging from overt hypothyroidism over subclinical hypothyroidism and euthyroidism to hyperthyroidism. In parallel with serum T3 (S-T3) concentrations increasing from low in hypothyroidism to high in hyperthyroidism there were gradually higher HL activities over the full spectrum of thyroid function, accompanied by decreasing levels of total and low density lipoprotein (LDL) cholesterol. High density lipoprotein (HDL) cholesterol was lower (P < 0.05) in hyperthyroidism than in euthyroidism but not significantly changed in the hypothyroid groups. HL was correlated to S-T3 (r = 0.77, P< 0.001), LDL cholesterol to log S-T3 (r = -0.76, P < 0.001), and LDL cholesterol to log HL (r = -0.55, P <0.001). The activity of LPL was decreased (P< 0.001) in overt hypothyroidism compared to euthyroidism but, in contrast to HL, the activity of LPL was not increased in hyperthyroidism. The plasma triglyceride (P-TG) concentration was elevated (P< 0.01) in overt hypothyroidism but not significantly changed in subclinical hypothyroidism or in hyperthyroidism. The LPL activity was correlated to log S-T3 (r = 0.45, P < 0.001), P-TG to log S-T3 (r = -0.37, P< 0.01) and P-TG to log LPL activity (r= -0.71, P<0.001). Our results demonstrate that thyroid hormones influence HL and LPL activities in different ways, suggesting different mechanisms of action. Changes in HL activity seem to be an important mechanism for the disturbance of cholesterol metabolism in thyroid dysfunction while the thyroid hormone influence on LPL seems to be of importance mainly for the disturbance in triglyceride metabolism.

scholarly journals Correlations of Serum Lipids and Lipoproteins with Gamma-Glutamyltransferase and Attitude to Alcohol Consumption

1982 ◽  
Vol 19 (5) ◽  
pp. 345-349 ◽  
Author(s):  
G Fex ◽  
H Kristenson ◽  
E Trell
Keyword(s):  
Alcohol Consumption ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Similar Degree ◽  
Apolipoprotein Ai ◽  
Gamma Glutamyltransferase ◽  
Questionnaire Score ◽  
Lipids And Lipoproteins ◽  
Apo Ai

The correlation of three markers of alcohol consumption: serum concentration of gamma-glutamyltransferase (GT), high density lipoprotein cholesterol (HDL-cholesterol), apolipoprotein AI (Apo AI), and the results of a questionnaire (Mm-MAST) designed to measure the attitude towards alcohol consumption were determined in a population of healthy men aged 48 years. Apo AI (r = 0·27) and GT (r = 0·31) were correlated (p < 0·001) to the questionnaire score to a similar degree while the correlation between HDL-cholesterol and the questionnaire score was (r = 0·18), somewhat less good but statistically significant (p < 0·01). There was no correlation between GT and HDL-cholesterol or Apo AI.

Effect of ascorbate on serum lipids and urate metabolism during exhaustive training

2004 ◽  
Vol 106 (1) ◽  
pp. 107-109 ◽  
Author(s):  
Hidekatsu YANAI ◽  
Mie MORIMOTO
Keyword(s):  
Placebo Group ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Urate ◽  
Exhaustive Exercise ◽  
Controlled Study ◽  
Cholesterol Levels

Physical activity is associated with beneficial changes in serum lipids, but exhaustive exercise has been suggested to increase oxidative stress. To test the effect of ascorbate (vitamin C) on serum lipids and the metabolism of urate, which is the most important intrinsic antioxidant, during exhaustive exercise, we performed a randomized, blinded, placebo-controlled study on eight male well-trained athletes. subjects were randomly allocated to either a group given 1000 mg of ascorbate daily (n=4) or a placebo group (n=4). Fasting serum lipids and urate concentrations were measured before and after 3 weeks of training. Although serum low-density lipoprotein (LDL)-cholesterol levels decreased and high-density lipoprotein (HDL)-cholesterol levels increased significantly in the ascorbate group after the 3 weeks of training, serum LDL-cholesterol levels increased and HDL-cholesterol levels decreased significantly in the placebo group. Furthermore, serum urate levels were elevated significantly in the placebo group; however, these levels did not change in the ascorbate group. When compared with the placebo group, significantly higher serum HDL-cholesterol and lower serum LDL-cholesterol and urate levels were observed in the ascorbate group after training. In conclusion, our results suggested that ascorbate may contribute to the desirable changes in serum lipids during exhaustive training and suggest the significant association between ascorbate and urate under intense training.

scholarly journals Toremifene Improves Lipid Profiles in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer: Interim Analysis of a Multicenter Phase III Study

2008 ◽  
Vol 26 (11) ◽  
pp. 1824-1829 ◽  
Author(s):  
Matthew R. Smith ◽  
S. Bruce Malkowicz ◽  
Franklin Chu ◽  
John Forrest ◽  
Paul Sieber ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Placebo Group ◽  
Total Cholesterol ◽  
Interim Analysis ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Phase Iii ◽  
Fasting Serum

Purpose Androgen-deprivation therapy (ADT) is associated with greater risk of incident coronary heart disease and hospital admission for myocardial infarction; treatment-related increases in serum lipids may contribute to greater cardiovascular disease risk. We evaluated the effects of toremifene, a selective estrogen-receptor modulator, on fasting serum lipid levels in men receiving ADT for prostate cancer. Patients and Methods In an ongoing, multicenter, double-blind, placebo-controlled phase III fracture-prevention study, 1,389 men receiving ADT for prostate cancer were randomly assigned to receive toremifene (80 mg/d) or placebo. In this interim analysis of 188 patients, changes in fasting serum lipids from baseline to month 12 were compared between the placebo and toremifene groups. Results Changes in serum lipids differed significantly between the groups. Mean (± SE) total cholesterol decreased by 1.0% ± 1.7% from baseline to month 12 in the placebo group and decreased by 8.1% ± 1.4% in the toremifene group (P = .001 for between group comparison). Low-density lipoprotein (LDL) cholesterol increased by 0.8% ± 2.5% in the placebo group and decreased by 8.2% ± 2.5% in the toremifene group (P = .003). In contrast, high-density lipoprotein (HDL) cholesterol decreased by 4.9% ± 1.2% in the placebo group and increased by 0.5% ± 2.2% in the toremifene group (P = .018). Triglycerides increased by 6.9% ± 4.2% in the placebo group and decreased by 13.2% ± 3.6% in the toremifene group (P = .003). Conclusion Toremifene significantly decreased total cholesterol, LDL cholesterol, and triglycerides, and increased HDL cholesterol in men receiving ADT for prostate cancer.

Differential effects of medium- and long-chain saturated fatty acids on blood lipid profile: a systematic review and meta-analysis

2018 ◽  
Vol 108 (4) ◽  
pp. 675-687 ◽  
Author(s):  
Nisha Panth ◽  
Kylie A Abbott ◽  
Cintia B Dias ◽  
Katie Wynne ◽  
Manohar L Garg
Keyword(s):  
Fatty Acids ◽  
Blood Lipids ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Weighted Mean ◽  
Lipids And Lipoproteins ◽  
Long Chain

Abstract Background Medium-chain saturated fatty acids (MCFAs) may affect circulating lipids and lipoproteins differently than long-chain saturated fatty acids (LCSFAs), but the results from human intervention trials have been equivocal. Objective The aim of this study was to determine whether MCFAs and LCSFAs have differential impacts on blood lipids and lipoproteins. Design Five databases were searched (EMBASE, MEDLINE, CINAHL, Cochrane, and Scopus) until April 2018, and published clinical trials investigating the differential effects of dietary MCFAs and LCSFAs on blood lipids were included. Searches were limited to the English language and to studies with adults aged >18 y. Where possible, studies were pooled for meta-analysis using RevMan 5.2. The principle summary measure was the mean difference between groups calculated using the random-effects model. Results Eleven eligible crossover and 1 parallel trial were identified with a total of 299 participants [weighted mean ± SD age: 38 ± 3 y; weighted mean ± SD body mass index (kg/m2): 24 ± 2]. All studies were pooled for the meta-analysis. Diets enriched with MCFAs led to significantly higher high-density lipoprotein (HDL) cholesterol concentrations than diets enriched with LCSFAs (0.11 mmol/L; 95% CI: 0.07, 0.15 mmol/L) with no effect on triglyceride, low-density lipoprotein (LDL) cholesterol, and total cholesterol concentrations. Consumption of diets rich in MCFAs significantly increased apolipoprotein A-I (apoA-I) concentrations compared with diets rich in LCSFAs (0.08 g/L; 95% CI: 0.02, 0.14 g/L). There was no evidence of statistical heterogeneity for HDL cholesterol, apoA-I, and triglyceride concentrations; however, significant heterogeneity was observed for the total cholesterol (I2 = 49%) and LDL cholesterol analysis (I2 = 58%). Conclusion The findings of this research demonstrate a differential effect of MCFAs and LCSFAs on HDL cholesterol concentrations. Further investigations are warranted to elucidate the mechanism by which the lipid profile is altered. This trial was registered at www.crd.york.ac.uk/PROSPERO as CRD42017078277.

EFFECTS OF DIETARY PROPIONIC ACID ON SERUM LIPIDS AND LIPOPROTEINS OF PIGS FED DIETS SUPPLEMENTED WITH SOYBEAN MEAL OR CANOLA MEAL

1981 ◽  
Vol 61 (2) ◽  
pp. 439-448 ◽  
Author(s):  
P. A. THACKER ◽  
J. P. BOWLAND
Keyword(s):  
Propionic Acid ◽  
Serum Cholesterol ◽  
Soybean Meal ◽  
Cholesterol Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Canola Meal ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Lipids And Lipoproteins

Sixty-four crossbred pigs averaging 24 kg liveweight at allotment were used to study the effects of dietary propionic acid (PA) on cholesterol metabolism. Isonitrogenous and isoenergetic diets were based on either barley-soybean meal or barley-canola meal and contained either 0, 3, 6 or 9% PA. Inclusion of PA significantly reduced the levels of total serum cholesterol, associated entirely with a reduction in the high density lipoprotein fraction. There was a slight increase in the lipid content of both hearts and livers due to PA inclusion; hearts showed slight elevations in triglycerides, and livers had slightly elevated cholesterol and phospholipid levels. Pigs fed diets supplemented with soybean meal had lower levels of serum calcium, higher serum urea nitrogen, lower total serum cholesterol, lower low density lipoprotein cholesterol and lower circulating triglycerides compared with those fed canola meal. Hearts from pigs fed soybean meal appeared to have higher levels of total lipid, indicated by increases in triglycerides and phospholipids. There were no differences in lipid composition of livers due to source of protein supplement.

scholarly journals The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study

2007 ◽  
Vol 156 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Bjørn O Åsvold ◽  
Lars J Vatten ◽  
Tom I L Nilsen ◽  
Trine Bjøro
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Reference Range ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Population Based Study

Objective: The association between TSH and serum lipids in people with no apparent thyroid disease is insufficiently understood. We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids. Design: Cross-sectional, population-based study with 30 656 individuals without known thyroid disease. Methods: Using general linear models, we calculated mean concentrations of total serum cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol and triglycerides across categories of TSH. Results: Within the reference range of TSH, there was a linear and significant (P for trend <0.001) increase in total serum cholesterol, LDL cholesterol, non-HDL cholesterol and triglycerides, and a linear decrease (P for trend <0.001) in HDL cholesterol with increasing TSH. Subgroup analyses showed statistically significant associations for all lipids in men above 50 years of age, and for triglycerides in all age groups. For women, associations were statistically significant in all age groups except for HDL cholesterol in women below 50 years of age. The associations with triglycerides and HDL cholesterol were stronger among overweight than normal weight individuals. Conclusions: Within the range of TSH that is considered clinically normal, we found that increasing level of TSH was associated with less favourable lipid concentrations. The association with serum lipids was linear across the entire reference range of TSH.

Association between Serum Copper and Serum Lipids in Adults

2018 ◽  
Vol 73 (4) ◽  
pp. 282-289 ◽  
Author(s):  
Xingxing Song ◽  
Weijing Wang ◽  
Zongyao Li ◽  
Dongfeng Zhang
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Copper ◽  
High Serum ◽  
Lipid Concentration ◽  
High Tc

Background: As an essential trace element, copper has been considered to play an important role in lipid metabolism. However, the associations of serum copper with lipid concentration and dyslipidemia are still controversial. Methods: We used the 2011–2014 National Health and Nutrition Examination Survey to examine the relationship between serum copper and lipid concentration among participants aged 20 years and older. Multivariate linear regression was conducted to estimate the differences in the level of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol. Logistic regression was conducted to examine the association between serum copper and the risk of dyslipidemia. Results: A total of 2,678 subjects were eligible for our analyses. The multivariable adjusted average differences (95% CIs) comparing the highest to the lowest copper tertile were 8.42 (1.45–15.38) mg/dL for TC, and 2.96 (0.02–5.90) mg/dL for HDL cholesterol. Compared with the lowest tertile of serum copper, participants had significantly higher risks of High-TC dyslipidemia (OR 1.46; 95% CI 1.02–2.08) in tertile 3 and High-LDL cholesterol dyslipidemia (OR 1.48; 95% CI 1.03–2.14) in tertile 2 after adjusting for covariates. In the stratified analyses, we found that the copper-dyslipidemia association was statistically significant in women and subjects younger than 45 years of age. Conclusion: High serum copper was associated with elevated serum concentrations of TC and HDL cholesterol, and was associated with increased risks of High-TC and High-LDL cholesterol dyslipidemia. However, the real association between serum copper and serum lipids should be verified in larger prospective cohort studies in ­future.

Platelet Aggregation and Plasma Lipoproteins in Alcoholics During Alcohol Withdrawal

1986 ◽  
Vol 55 (02) ◽  
pp. 173-177 ◽  
Author(s):  
K Desai ◽  
J S Owen ◽  
D T Wilson ◽  
R A Hutton
Keyword(s):  
Platelet Aggregation ◽  
Alcohol Withdrawal ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Plasma Lipoprotein ◽  
Cholesterol Concentration ◽  
Arachidonic Acid Content ◽  
Low Density

SummaryPlatelet aggregation, platelet lipid composition and plasma lipoprotein concentrations were measured each week in a group of seventeen alcoholics, without overt liver disease, for one month, following acute, total alcohol withdrawal. The platelets were initially hypoaggregable but, within 1-2 weeks of cessation of drinking, they became hyperaggregable and then gradually returned towards normal values. Hyperaggregability could not be explained by increases in either the cholesterol or the arachidonic acid content of the platelets. Plasma very-low-density lipoprotein cholesterol levels remained high throughout the study, but the initially raised levels of high-density lipoprotein (HDL) cholesterol fell by 26%. Low-density lipoprotein (LDL) cholesterol concentration rose by 10% after two weeks of withdrawal but then returned to about the starting level. The resulting changes in the plasma LDL-cholesterol: HDL-cholesterol ratio, which had increased by more than 50% after two weeks of abstinence, essentially paralleled the time course of enhanced platelet reactivity in all but four of the alcoholics. These findings suggest that alterations in plasma lipoprotein concentrations during acute alcohol withdrawal may be a contributory factor to the haemostatic disorders present in such patients.

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