scholarly journals The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study

2007 ◽  
Vol 156 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Bjørn O Åsvold ◽  
Lars J Vatten ◽  
Tom I L Nilsen ◽  
Trine Bjøro
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Reference Range ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Population Based Study

Objective: The association between TSH and serum lipids in people with no apparent thyroid disease is insufficiently understood. We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids. Design: Cross-sectional, population-based study with 30 656 individuals without known thyroid disease. Methods: Using general linear models, we calculated mean concentrations of total serum cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol and triglycerides across categories of TSH. Results: Within the reference range of TSH, there was a linear and significant (P for trend <0.001) increase in total serum cholesterol, LDL cholesterol, non-HDL cholesterol and triglycerides, and a linear decrease (P for trend <0.001) in HDL cholesterol with increasing TSH. Subgroup analyses showed statistically significant associations for all lipids in men above 50 years of age, and for triglycerides in all age groups. For women, associations were statistically significant in all age groups except for HDL cholesterol in women below 50 years of age. The associations with triglycerides and HDL cholesterol were stronger among overweight than normal weight individuals. Conclusions: Within the range of TSH that is considered clinically normal, we found that increasing level of TSH was associated with less favourable lipid concentrations. The association with serum lipids was linear across the entire reference range of TSH.

scholarly journals Lipid profiles in the Isfahan population: an Isfahan cardiovascular disease risk factor survey, 1994

1999 ◽  
Vol 5 (4) ◽  
pp. 766-777
Author(s):  
M. Rafiei ◽  
M. Boshtam ◽  
N. Sarraf Zadegan
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Low Density Lipoprotein ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Cardiovascular Disease Risk Factor ◽  
Population Based Study ◽  
Disease Risk Factor

A population-based study was conducted in 1994 in Isfahan to define the prevalence of various types of hyperlipidaemia and the mean concentrations of serum total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein [HDL]cholesterol. In all, 2200 people were randomly chosen and classified into five age groups [20-70 years]. The data were obtained by questionnaires and anthropometric measurements and serum lipids and fasting blood sugar were measured. The prevalence of hyperlipidaemia was higher in women than men. Multiple linear regression showed only HDL cholesterol and triglycerides to be associated with body mass index. The most prevalent lipid abnormality was HDL cholesterol. Diet modification and physical activity should be encouraged to reduce hyperlipidaemia

scholarly journals Evaluation of some biochemical changes in the serum of phensedyl addicts of Gaibandha District, Bangladesh

2014 ◽  
Vol 20 ◽  
pp. 57-65
Author(s):  
Md Rashidul Hasan ◽  
Parvez Hassan ◽  
Md Abdul Jalil Miah
Keyword(s):  
Serum Cholesterol ◽  
Biochemical Parameters ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
P Value

Context: Abuse of the drug, Phensedyl like any other drug might exert adverse effects on vital organs of th e h u m an body like liver, kidney and heart. Objectives: To determine the effects of Phensedyl intake on the serum biochemical parameters of the addicts in order to access for damages of vital human organs like liver, kidney and heart. Materials and Methods: Study population consisted of 127 male Phensedyl addicts within the ages of 18–55 years of defined criteria from Gaibandha district, a Northern part of Bangladesh, during July 2009 to December 2011. Fifty (50) non-drug dependent healthy men of matched age, height, and socioeconomic status were included as controls from the same community. Biochemical parameters analyzed were – Serum creatinine, SGOT, SGPT and Lipid profiles (total serum cholesterol (TC), Serum triglyceride (TG), serum high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol determined by semiautomatic biochemistry analyzer using commercially available kits Results: Abuse of Phensedyl appears not to hamper the normal renal and liver function in most of the addicts even after 8 years of Phensedyl intake irrespective of age except in case of 4 abusers. Serum total cholesterol (TC) remained almost unchanged among the addicts abusing Phensedyl for less than 8 years. But very strikingly, addicts taking Phensedyl for more than 8 years had higher trends in serum cholesterol i.e. more than 200 ml/dl. Of the addict’s, 44.36% abusing Phensedyl for less than 8 years had normal triglyceride (TG) values whereas, in 45.66% addicts abusing the drug for more than 8 years had clinically very significantly elevated triglyceride levels, which was also found to be statistically very significant (p value =0.0001), indicating the risk of developing cardiac diseases. Of the total addicts 53.53% had low levels of HDL cholesterol, which is clinically and statistically found to be very significant (p value =0.002). Of the addict’s 43% taking the drug for less than 8 years had normal LDL levels but significantly elevated values were recorded in 34% of the abusers who had been taking the drug for more than 8 years. Conclusion: Long time (> 8 years) Phensedyl abusers are at the high risk of developing Brain stroke, Coronary Heart Disease (CHD), Ischemic stroke or transient ischemic attack (TIA) as there is the triad of: Elevated LDL cholesterol, Low HDL cholesterol and elevated Triglyceride. DOI: http://dx.doi.org/10.3329/jbs.v20i0.17656 J. bio-sci. 20: 57-65, 2012

scholarly journals NIGELLA SATIVA (KALONJI)

2011 ◽  
Vol 18 (01) ◽  
pp. 142-146
Author(s):  
MUHAMMAD ANWAR BURIRO ◽  
MUHAMMAD TAYYAB ◽  
ALLAH DITTA
Keyword(s):  
Serum Cholesterol ◽  
Ldl Cholesterol ◽  
Nigella Sativa ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Control Group ◽  
Total Serum Cholesterol ◽  
Blood Samples ◽  
Cholesterol Levels

The increased level of LDL-c in the serum has a high risk and the increased serum HDL-c level has a low risk for the development of atherosclerosis. The effect of Nigella Sativa on levels of cholesterol fractions were determined in this study on rats. Methods: 24 albino rats of 08 weeks age having equal number of males and females were kept at optimum atmospheric condition. The blood samples were taken at the start and different control and experimental diets were given for 24 weeks. The experimental diets were added with Nigella Sativa as 30 mg/kg body weight. The blood samples were taken at the end of study. The blood samples drawn at the start and end of the study were estimated for serum cholesterol. The results of control and experimental groups were compared. Results: Total serum cholesterol in the control group showed increase from 8.3±3.30 to 13.96±9.3 at 24 weeks. The serum HDL cholesterol showed increase from 44.4±6.12 to 80.45±5.95 level at 24 weeks. The serum LDL cholesterol showed increase from 8.3±3.30 to 13.96±9.3 at 24 weeks. The total serum cholesterol in experimental group was increased from 76.9±6.5 to 117.5± 6.65 at 24 weeks. The serum HDL cholesterol levels was increased from 41.7±4.9 to 83.42±5.92 at 24 weeks as compared with control group. The LDL cholesterol levels were decreased from 12.7±6.9 to 8.5±7.8 at 24 weeks. Conclusions: This study shows significant decrease in serum low density lipoprotein cholesterol level, and increase in serum high density lipoprotein cholesterol levels.

scholarly journals Effect of interventions with ingestion of legumes and/or supervised exercise on the lipid profile of young, healthy sedentary women

2010 ◽  
pp. 224-234 ◽  
Author(s):  
Luis F. Fajardo ◽  
Dora G. Castellanos ◽  
Myriam Chinchilla ◽  
Luz N. Vargas ◽  
Martha Guerra ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Life Style ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Supervised Exercise ◽  
Healthy Life Style ◽  
Sedentary Women

Objective: To contribute to the knowledge of some aspects of the Healthy Life Style by studying the effects of including legumes in the diet and exercise at two intensity levels, along with the lipid profile of young sedentary women living at 2640 meters above sea level. Materials and methods: The study included a non-randomized clinical trial with four intervention groups: exercise at 45% VO2 peak plus legumes in diet, exercise at 65% VO2 peak plus legumes in diet, only exercise at 65% VO2 peak, and only inclusion of legumes in diet. In each group, 20 to 23 sedentary women were included. The intervention was carried out for four weeks, three days a week. Exercise prescription was based on measurement of VO2 peak by ergospirometry; and the current intervention was monitored with heart-rate monitors. The outcome variables were total serum cholesterol, LDL cholesterol, HDL cholesterol, and triacylglycerols measured at baseline and after two and four weeks of intervention. Results: The measurements taken of participants in the group of exercise at 65% VO2 peak plus legumes in diet showed a reduction of 19.8 mg/dl in total cholesterol, of 21.8 mg/dl of LDL cholesterol, of 20.7 mg/dl of tracylglycerol, and an increase of 6.2 mg/dl of HDL cholesterol. The serum levels of HDL also increased in the group of only exercise at 65% VO2 peak. No significant changes in serum levels were documented for participants in the group with only dietary modifications. Conclusions: The results suggest that different interventions that meet some of the criteria for healthy eating and life style show different effects with regards to the level of change in the lipid profile components.

scholarly journals EFFECTS OF VITAMIN B12 ON SERUM LIPIDS AND LIPOPROTEINS OF PIGS FED DIETS SUPPLEMENTED WITH PROPIONIC ACID OR CALCIUM PROPIONATE

1982 ◽  
Vol 62 (2) ◽  
pp. 527-536 ◽  
Author(s):  
P.A. THACKER ◽  
J.P. BOWLAND ◽  
M. FENTON
Keyword(s):  
Propionic Acid ◽  
Feed Intake ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Vitamin B ◽  
Calcium Propionate ◽  
Lipids And Lipoproteins

Effects of vitamin B12 supplementation of diets containing propionic acid (PA), or calcium propionate (CP) on feed intake, serum lipids and lipoproteins were studied utilizing 80 crossbred pigs averaging 22.5 kg. Diets, based on barley-soybean meal, containing 0, 3.5 or 7% PA or CP, were fed with and without the addition of 4.95 mg vitamin B12/kg diet. Inclusion of PA or CP with or without the addition of vitamin B12 had no significant effect on feed intake. Addition of PA or CP depressed serum cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and serum triglycerides. Vitamin B12 supplementation had no effect on serum total cholesterol or HDL cholesterol, caused a reduction in LDL cholesterol, and tended to overcome the reduction in serum triglyceride. Supplementation of diets with vitamin B12 reduced liver lipid levels, largely as a result of a decrease in cholesterol and phospholipids. These data suggest that the cholesterol-lowering effect of PA is not simply a result of a depression in feed intake, but arises from a direct action of PA on cholesterol metabolism. Key words: Vitamin B12, lipids, lipo protein, pigs, propionic, propionate

scholarly journals Alagille Syndrome: Resolution of Xanthomas

1995 ◽  
Vol 9 (4) ◽  
pp. 187-190
Author(s):  
NJ Leonard ◽  
V Dias ◽  
HG Parsons
Keyword(s):  
Pulmonary Stenosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Alagille Syndrome ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Autosomal Dominant Disorder ◽  
Chronic Cholestasis ◽  
Peripheral Pulmonary Stenosis

Alagille syndrome is a rare autosomal dominant disorder characterized by chronic cholestasis due to paucity of intrahepatic biliary ducts, characteristic facies, peripheral pulmonary stenosis, ocular posterior embryotoxon and skeletal abnormalities. Very little information is available on the cholestatic, lipid and lipoprotein profiles in individuals with Alagille syndrome. The course of xanthomatosis and the lipid-lipoprotein profile of a 15-year-old male with incomplete Alagille syndrome with marked xanthomatosis and extremely elevated cholesterols secondary to cholestasis is reported. He showed gradual resolution of xanthomas beginning at age 12 years with a concurrent reduction in his total serum cholesterol. The lipid studies showed that the majority of cholesterol was found in low density lipoprotein (LDL) with lesser amounts in lipoprotein (Lp)-X, a lipoprotein precursor complex seen in patients with cholestasis, and high density lipoprotein (HDL). With resolution of xanthomas, LDL and Lp-X decreased while HDL-cholesterol and apolipoprotein (Apo) A-I increased. Gamma glutamyltransferase and bilirubin decreased but remained 15- and threefold elevated, respectively.

scholarly journals Serum Lipid Concentrations and Prevalence of Dyslipidemia in a Large Professional Population in Beijing

2005 ◽  
Vol 51 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Zhiyan Li ◽  
Ruifeng Yang ◽  
Guobing Xu ◽  
Tiean Xia
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Preventive Measures ◽  
Age Groups ◽  
Hdl Cholesterol ◽  
Coronary Artery Diseases ◽  
Lipid Concentration ◽  
The Past ◽  
Low Hdl ◽  
Lipid Abnormalities

Abstract Background: Lipid abnormalities are major risk factors for premature coronary artery diseases. We investigated serum lipids and the prevalence of dyslipidemia in a professional population in Beijing and compared these data with those obtained in a similar population during 1984–1986. Methods: We studied 14 963 individuals 20–90 years of age. Health status was determined by questionnaires and physical check-ups. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and total triglycerides (TGs) were measured. TC &gt;5.7 mmol/L, LDL-C &gt;3.6 mmol/L, TGs &gt;1.7 mmol/L, and HDL-C &lt;0.9 mmol/L were defined as abnormal. Results: Mean serum TC, LDL-C, and TG concentrations were increased compared with the values obtained in 1984–1986, with 52.7% of males and 42.9% of females having at least one abnormal lipid concentration. Hypercholesterolemia occurred in 6% of males and 2.8% of females in the younger group (20–39 years) and in 20.2% of males and 38.7% of females in the older group (&gt;60 years). HDL-C was abnormally low in ∼7% of males and in 1.6% of females. The prevalences of hypercholesterolemia, hypertriglyceridemia, and abnormally low HDL-C, especially the presence of slight hypertriglyceridemia, were higher than in 1984–1986 in all age groups. The increase was most prominent in the middle age group (40–59 years). Conclusions: Hypercholesterolemia, hypertriglyceridemia, and abnormally low HDL-C have increased considerably over the past 20 years in professional populations in Beijing. Dietary changes and less physical activity resulting from rapid improvements in living conditions may be the causes for the increases. Enhanced preventive measures should be undertaken to modify these situations.

Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations

1993 ◽  
Vol 39 (10) ◽  
pp. 2125-2129 ◽  
Author(s):  
G Eggertsen ◽  
R Tegelman ◽  
S Ericsson ◽  
B Angelin ◽  
L Berglund
Keyword(s):  
Allele Frequency ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Variation ◽  
Total Serum ◽  
Serum Triglycerides ◽  
Swedish Population ◽  
Apo E

Abstract We analyzed blood samples from 407 healthy Swedish individuals, 244 men and 163 women, ages 17 to 86 years, for apolipoprotein (apo) E isoforms and serum triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol. Parallel genotyping by means of polymerase chain reaction (PCR)-amplified DNA was performed in 200 subjects. Identical results were obtained by genotyping and phenotyping in 95% of all subjects analyzed. The apo E allelic frequencies were 7.8% for epsilon 2, 71.9% for epsilon 3, and 20.3% for epsilon 4. Compared with other Caucasian populations, the present population had a high relative allelic frequency of epsilon 4. The epsilon 4 frequency decreased with increasing age and was significantly lower in individuals &gt; 60 years of age (14.7%). When controlling for age and sex, there were strong correlations between total serum and LDL cholesterol and the various epsilon alleles. The epsilon 4 and epsilon 3 alleles correlated positively with serum cholesterol and the epsilon 4 allele correlated positively with LDL cholesterol. In contrast, HDL cholesterol and serum triglycerides did not show any correlation to the allele types. Thus, the results demonstrate a considerable age variation of the epsilon allele frequency among healthy Swedes and an influence of apo E alleles on serum and LDL cholesterol concentrations.

Biological Variation Data Applied to the Selection of Serum Lipid Ratios Used as Risk Markers of Coronary Heart Disease

1992 ◽  
Vol 38 (1) ◽  
pp. 56-59 ◽  
Author(s):  
J Ortolá ◽  
M J Castiñeiras ◽  
X Fuentes-Arderiu
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Biological Variation ◽  
Index Of Individuality ◽  
Hdl2 Cholesterol

Abstract The biological variation of several relative lipid quantities, calculated as the ratios between the concentrations of various serum lipids and apolipoproteins, has been estimated over a one-year period. The medians of the within-subject biological coefficient of variation, separated by sex when significant differences exist, were 15.4% for [apolipoprotein A-I]/[apolipoprotein B], 6.8% for [high-density lipoprotein (HDL)-cholesterol]/[cholesterol], 10.5% and 17.6% (women and men, respectively) for [HDL2-cholesterol]/[HDL-cholesterol], 13.6% for [HDL2-cholesterol]/[HDL3-cholesterol], 10.6% for [low-density lipoprotein (LDL)-cholesterol]/[apolipoprotein B], 10.6% and 8.7% (women and men, respectively) for [LDL-cholesterol]/[cholesterol], and 6.3% for [LDL-cholesterol]/[HDL-cholesterol]. From these data, we have calculated the critical difference for significant change detection, the index of individuality, and the goal for the between-day imprecision. Concerning within-subject biological variation, the best ratios for the detection of risk of coronary heart disease and the monitoring of intervention are [LDL-cholesterol]/[HDL-cholesterol] and [HDL-cholesterol]/[cholesterol]. The index of individuality obtained in this study indicates that the use of population-based reference values is inadequate for interpreting the ratios studied.

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