scholarly journals Intact protein LC–MS for pharmacokinetics

2019 ◽  
Vol 4 (4) ◽  
pp. IPK05
Author(s):  
John F Kellie
Keyword(s):  
Large Mass ◽  
Intact Protein ◽  
Clinical Samples ◽  
Quality Attribute ◽  
Human Brain Tissue ◽  
Indiana University ◽  
Disease Biomarker ◽  
Protein Quantitation ◽  
Northwestern University ◽  
Product Quality Attribute

Biography: John Kellie is currently a GlaxoSmithKline (GSK) fellow in the Bioanalysis, Immunogenicity, and Biomarkers group at GSK. John received his B.Sc. in Biochemistry from Indiana University (USA) and his PhD in Chemistry from Northwestern University (USA) studying under Dr Neil Kelleher. He was a post-doctoral scientist at Eli Lilly and Company, where he developed methods for intact protein quantitation of a Parkinson’s Disease biomarker from human brain tissue. At GSK, John utilizes mass spectrometry for development of novel bioanalytical methods for biotherapeutic and protein quantitation from pre-clinical and clinical samples, with a focus on intact protein and large mass quantitation for pharmacokinetics, catabolism, biotransformation and product quality attribute support. John Kellie speaks to the International Journal of Pharmacokinetics about intact protein LC–MS for pharmacokinetic application.

Intact Protein Quantitation Using Pseudoisobaric Dimethyl Labeling

2016 ◽  
Vol 88 (14) ◽  
pp. 7198-7205 ◽  
Author(s):  
Houqin Fang ◽  
Kaijie Xiao ◽  
Yunhui Li ◽  
Fan Yu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Intact Protein ◽  
Protein Quantitation ◽  
Dimethyl Labeling

A Strategy of Plasma Protein Quantitation by Selective Reaction Monitoring of an Intact Protein

2003 ◽  
Vol 75 (24) ◽  
pp. 7008-7014 ◽  
Author(s):  
Qin C. Ji ◽  
Ramona Rodila ◽  
Eric M. Gage ◽  
Tawakol A. El-Shourbagy
Keyword(s):  
Plasma Protein ◽  
Intact Protein ◽  
Reaction Monitoring ◽  
Selective Reaction Monitoring ◽  
Selective Reaction ◽  
Protein Quantitation

Managing product development resources through the use of product quality attribute mapping

2003 ◽  
Vol 217 (9) ◽  
pp. 1229-1241 ◽  
Author(s):  
A C Elliott ◽  
E Swain ◽  
I C Wright
Keyword(s):  
Product Development ◽  
Product Quality ◽  
Quality Index ◽  
Primary Data ◽  
Quality Attribute ◽  
Manufacturing Companies ◽  
Product Attributes ◽  
Attribute Importance ◽  
Product Attribute ◽  
Product Quality Attribute

A technique using product quality attribute mapping to assist product resourcing decisions is described. Primary data from respondents via quantitative questionnaire surveys of four different industrial manufacturing companies were collected and analysed. Care was taken with the data source and type of scales employed to ensure meaningful comparisons could be made. The first objective of the data analysis was to determine the importance of each of the companies' customers. This was followed by determining the importance of the product attributes to each customer. An overall perception of product attribute importance was obtained by combining the customer importance with the importance of product attributes. The respondents' perceptions of the competitive situation was then combined with the overall perception of product attribute importance to give a quality index for each product attribute. The derived picture product attributes relative to one another are shown by bubble maps indicating the position of the competitive index against attribute importance, with the quality index represented by the bubble size. The significance of these bubble maps, particularly in relation to resourcing decisions for the companies, is discussed. It is concluded that companies can use data in this form to guide product development in a quantifiable manner.

Field Days: Melville J. Herskovits in Dahomey

1989 ◽  
Vol 16 ◽  
pp. 1-22 ◽  
Author(s):  
Suzanne Preston Blier
Keyword(s):  
New York ◽  
Economic History ◽  
Critical Role ◽  
Field Research ◽  
African Studies ◽  
Indiana University ◽  
Research Methodologies ◽  
Northwestern University ◽  
History Of ◽  
Field Notes

In recent years anthropologists and literary critics, most importantly George Stocking Jr. (1983), James Clifford and George E. Marcus (1986), and Clifford Geertz (1987), have led the way to a closer reading of the writings of early anthropologists and a fuller exploration of the intellectual climates in which they were working. As the founder of African studies in this country, Melville J. Herskovits is of considerable importance in terms of related scholarship in the 1930s, 1940s, and 1950s. Although an anthropologist by training, Herskovits had a major impact on the development of African scholarship in many other disciplines—from the history of art to folklore to political and economic history. Herskovits' field research methodologies and orientations thus potentially are of considerable significance. Despite Herskovits' critical role in African studies, there has been relatively little scholarly interest to date in his African research methodologies.Herskovits' unpublished field notes of his Dahomey research provide us with an inside look at the principal field strategies and orientations of this important African scholar. These field materials today are housed in the archives of three different research institutions: The Schomburg Center for Research in Black Culture in New York City; the library of Northwestern University in Evanston, Illinois; and the Archives of Traditional Music at Indiana University in Bloomington, Indiana. The largest grouping of Herskovits' Dahomey field materials (journals, financial records, artifact collection, photographs, correspondence) are at the Schomburg Center. At Northwestern University are found various diary extracts, song transcriptions, and the bulk of Herskovits' early and later correspondence. Recordings that Herskovits made in the course of the Dahomey research are located at Indiana University.

Sign in / Sign up

Export Citation Format

Share Document