Hyperspectral imaging: A non-invasive method of imaging melanoma lesions in a patient with stage IV melanoma, being treated with a RAF inhibitor

New developments in instrumentation and data analysis have further improved the perspectives of hyperspectral imaging in clinical use. Thus, hyperspectral imaging can be considered as “Next Generation Imaging” for future clinical research. As a contactless, non-invasive method with short process times of just a few seconds, it quantifies predefined substance classes. Results of hyperspectral imaging may support the detection of carcinomas and the classification of different tissue structures as well as the assessment of tissue blood flow. Taken together, this method combines the principle of spectroscopy with imaging using conventional visual cameras. Compared to other optical imaging methods, hyperspectral imaging also analyses deeper layers of tissue.

Download Full-text

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

Zeitschrift für Neuropsychologie ◽

10.1024//1016-264x.12.1.8 ◽

2001 ◽

Vol 12 (1) ◽

pp. 8-14

Author(s):

Gertraud Teuchert-Noodt ◽

Ralf R. Dawirs

Keyword(s):

Prefrontal Cortex ◽

Mental Disorders ◽

Dentate Gyrus ◽

Cognitive Functions ◽

Experimental Approach ◽

Regulatory Mechanisms ◽

Hippocampal Dentate Gyrus ◽

Non Invasive ◽

Invasive Method ◽

Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

Download Full-text

Feasibility of a New Non Invasive Method for the Evaluation of Coronary Blood Flow in the Left Anterior Descending Coronary Artery: Contrast-enhanced Transthoracic Harmonic Echo Doppler

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84245-3 ◽

1998 ◽

Vol 31 (2) ◽

pp. 124A-125A ◽

Cited By ~ 1

Author(s):

C Caiati

Keyword(s):

Blood Flow ◽

Coronary Artery ◽

Coronary Blood Flow ◽

Non Invasive ◽

Contrast Enhanced ◽

Invasive Method

Download Full-text

Bioimpedance Spectroscopy as a Non-invasive Method of Determination of the Hydration Status in Hemodialysis Patients

Acta Mechanica Slovaca ◽

10.2478/v10147-011-0023-y ◽

2010 ◽

Vol 14 (2) ◽

pp. 72-77

Author(s):

J. Rosina ◽

Jana Vranova ◽

Ondrej Remes ◽

Katarina Nehezova ◽

I. Rychlik

Keyword(s):

Hemodialysis Patients ◽

Hydration Status ◽

Bioimpedance Spectroscopy ◽

Non Invasive ◽

Method Of Determination ◽

Invasive Method

Download Full-text

Role of shear wave elastography of liver and spleen “as non-invasive method” in prediction of oesophgeal varices in Egyptian patients with liver cirrhosis

Journal of Recent Advances in Medicine ◽

10.21608/jram.2020.112528 ◽

2020 ◽

Vol 1 (2) ◽

pp. 80-89

Author(s):

Madiha Elzeiny ◽

Mohamed Taha ◽

Wafaa El-zefzafy ◽

Eslam Mohamed

Keyword(s):

Liver Cirrhosis ◽

Shear Wave ◽

Shear Wave Elastography ◽

Non Invasive ◽

Egyptian Patients ◽

Invasive Method

Download Full-text

CT perfusion in peripheral arterial disease—hemodynamic differences before and after revascularisation

European Radiology ◽

10.1007/s00330-021-07692-5 ◽

2021 ◽

Author(s):

Patrick Veit-Haibach ◽

Martin W. Huellner ◽

Martin Banyai ◽

Sebastian Mafeld ◽

Johannes Heverhagen ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Ct Perfusion ◽

Arterial Disease ◽

Lower Leg ◽

Therapy Control ◽

Non Invasive ◽

Before And After ◽

Invasive Method ◽

The Mean ◽

Peripheral Arterial

Abstract Objectives The purpose of this study was the assessment of volumetric CT perfusion (CTP) of the lower leg musculature in patients with symptomatic peripheral arterial disease (PAD) before and after interventional revascularisation. Methods Twenty-nine consecutive patients with symptomatic PAD of the lower extremities requiring interventional revascularisation were assessed prospectively. All patients underwent a CTP scan of the lower leg, and hemodynamic and angiographic assessment, before and after intervention. Ankle-brachial pressure index (ABI) was determined. CTP parameters were calculated with a perfusion software, acting on a no outflow assumption. A sequential two-compartment model was used. Differences in CTP parameters were assessed with non-parametric tests. Results The cohort consisted of 24 subjects with an occlusion, and five with a high-grade stenosis. The mean blood flow before/after (BFpre and BFpost, respectively) was 7.42 ± 2.66 and 10.95 ± 6.64 ml/100 ml*min−1. The mean blood volume before/after (BVpre and BVpost, respectively) was 0.71 ± 0.35 and 1.25 ± 1.07 ml/100 ml. BFpost and BVpost were significantly higher than BFpre and BVpre in the treated limb (p = 0.003 and 0.02, respectively), but not in the untreated limb (p = 0.641 and 0.719, respectively). Conclusions CTP seems feasible for assessing hemodynamic differences in calf muscles before and after revascularisation in patients with symptomatic PAD. We could show that CTP parameters BF and BV are significantly increased after revascularisation of the symptomatic limb. In the future, this quantitative method might serve as a non-invasive method for surveillance and therapy control of patients with peripheral arterial disease. Key Points • CTP imaging of the lower limb in patients with symptomatic PAD seems feasible for assessing hemodynamic differences before and after revascularisation in PAD patients. • This quantitative method might serve as a non-invasive method, for surveillance and therapy control of patients with PAD.

Download Full-text

Forensic analysis of beverage stains using hyperspectral imaging

Scientific Reports ◽

10.1038/s41598-021-85737-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Binu Melit Devassy ◽

Sony George

Keyword(s):

Hyperspectral Imaging ◽

Crime Scene ◽

Forensic Analysis ◽

Classification Model ◽

Support Vector ◽

Additional Information ◽

Non Invasive ◽

Spectral Bands ◽

Data Dimensionality Reduction ◽

Gradient Based

AbstractDocumentation and analysis of crime scene evidences are of great importance in any forensic investigation. In this paper, we present the potential of hyperspectral imaging (HSI) to detect and analyze the beverage stains on a paper towel. To detect the presence and predict the age of the commonly used drinks in a crime scene, we leveraged the additional information present in the HSI data. We used 12 different beverages and four types of paper hand towel to create the sample stains in the current study. A support vector machine (SVM) is used to achieve the classification, and a convolutional auto-encoder is used to achieve HSI data dimensionality reduction, which helps in easy perception, process, and visualization of the data. The SVM classification model was re-established for a lighter and quicker classification model on the basis of the reduced dimension. We employed volume-gradient-based band selection for the identification of relevant spectral bands in the HSI data. Spectral data recorded at different time intervals up to 72 h is analyzed to trace the spectral changes. The results show the efficacy of the HSI techniques for rapid, non-contact, and non-invasive analysis of beverage stains.

Download Full-text

Material characterisation of a painted beehive panel by advanced spectroscopic and chromatographic techniques in combination with hyperspectral imaging

Heritage Science ◽

10.1186/s40494-020-00468-y ◽

2020 ◽

Vol 8 (1) ◽

Author(s):

Klara Retko ◽

Maša Kavčič ◽

Lea Legan ◽

Polonca Ropret ◽

Bojana Rogelj Škafar ◽

...

Keyword(s):

Raman Spectroscopy ◽

Hyperspectral Imaging ◽

Cross Sections ◽

Extreme Temperature ◽

Transformation Products ◽

Paint Layer ◽

Non Invasive ◽

Painting Technique ◽

Invasive Techniques ◽

Conservation Interventions

AbstractIn this study, a painted beehive panel from the collection of the Slovene Ethnographic Museum was examined with respect to its material composition with the aim to reveal the painting technique. Due to the state of degradation due to outdoor weathering (UV irradiation, rainfall, extreme temperature and humidity fluctuations), as well as past conservation interventions, the object represented a complex analytical challenge. We aimed for non-invasive techniques (FTIR in reflection mode, Raman spectroscopy and hyperspectral imaging in the range of 400–2500 nm); however, in order to explore paint layers, cross-sections were also analysed using Raman spectroscopy. FTIR spectroscopy in transmission mode and gas chromatography coupled to mass spectrometry were also used on sample fragments. Various original materials were identified such as pigments and binders. The surface coating applied during conservation interventions was also characterised. Additionally, organic compounds were found (oxalate, carboxylate), representing transformation products. The potential use of Prussian blue as a background paint layer is discussed.

Download Full-text

Asymmetric TCD Findings in Malignant MCA Infarction, Resolution after Decompressive Hemicraniectomy: A Case Report

Case Reports in Neurology ◽

10.1159/000508589 ◽

2020 ◽

Vol 12 (Suppl. 1) ◽

pp. 127-136

Author(s):

Hazel Gaile Barrozo ◽

Maria Anna De Guzman ◽

Jose Navarro ◽

Narayanaswamy Venketasubramanian

Keyword(s):

Pressure Effects ◽

Mean Flow ◽

Brain Swelling ◽

Decompressive Hemicraniectomy ◽

Non Invasive ◽

Invasive Method ◽

Malignant Mca Infarction ◽

Subsequent Rise ◽

Very High ◽

Hemispheric Infarct

Transcranial Doppler (TCD) is a non-invasive method for assessing cerebral hemodynamics in the acute phase of stroke. We report a case of a 33-year-old man who presented with a massive left hemispheric infarct developing into “malignant” MCA infarction. TCD was utilized to monitor intracranial hemodynamics while the clinical and neuroimaging findings were used to help us in the decision to proceed with decompressive craniectomy (DC). Pre-operatively, there was reduced mean flow velocities (MFV) of the middle cerebral artery (MCA) with increasing pulsatility index (PI) ipsilateral to the infarct. The subsequent but smaller rise in the PI in the contralateral MCA was suggestive of very high intracranial pressure (ICP) from massive brain swelling. Serial TCD examinations post-operatively showed normalization of the PI, and subsequent rise in the left MCA MFV. Clinical improvement was also noted as the TCD findings improved. The asymmetry in TCD findings can be attributed to occlusion of the MCA with subsequent spontaneous recanalisation, occlusion of the MCA with subsequent recanalisation due to the DC, or initial occlusion and subsequent pressure effects on the arterioles of the MCA due to the “malignant” edema of that hemisphere that was relieved by DC. This case illustrates the value of TCD as a useful modality in monitoring intracranial hemodynamics in acute stroke.

Download Full-text