A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries

Epidemiological evidence supports vitamin D deficiency as a risk factor for tuberculosis. Differences in solar ultraviolet B (UV-B) exposure, the major source of vitamin D, might therefore partially explain global variation in tuberculosis incidence.In a global country-based ecological study, we explored the correlation between vitamin D-proxies, such as solar UV-B exposure, and other relevant variables with tuberculosis incidence, averaged over the period 2004–2013.Across 154 countries, annual solar UV-B exposure was associated with tuberculosis incidence. Tuberculosis incidence in countries in the highest quartile of UV-B exposure was 78% (95% CI 57–88%, p<0.001) lower than that in countries in the lowest quartile, taking into account other vitamin D-proxies and covariates. Of the explained global variation in tuberculosis incidence, 6.3% could be attributed to variations in annual UV-B exposure. Exposure to UV-B had a similar, but weaker association with tuberculosis notification rates in the multilevel analysis with sub-national level data for large countries (highestversuslowest quartile 29% lower incidence; p=0.057).The potential preventive applications of vitamin D supplementation in high-risk groups for tuberculosis merits further investigation.

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Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 Deaths

10.21203/rs.3.rs-32953/v1 ◽

2020 ◽

Author(s):

Rahul Kalippurayil Moozhipurath ◽

Lennart Kraft ◽

Bernd Skiera

Keyword(s):

Vitamin D ◽

Growth Rates ◽

Protective Role ◽

Negative Association ◽

Ultraviolet B ◽

Cumulative Number ◽

Uvb Radiation ◽

Daily Growth ◽

Percentage Points

Abstract Background. Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths.Methods. We apply a fixed-effect log-linear regression model to a panel dataset of 152 countries over 108 days (n=6524). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables and isolate UVI effect from potential confounding factors.Findings. After controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] and a 1.0 percentage points decline in the CFR daily growth rate [p < 0.05]. These results represent a significant percentage reduction in terms of daily growth rates of cumulative COVID-19 deaths (-11.88%) and CFR (-38.46%).Interpretation. We find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention will be very attractive.

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Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths

Scientific Reports ◽

10.1038/s41598-020-74825-z ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 4

Author(s):

Rahul Kalippurayil Moozhipurath ◽

Lennart Kraft ◽

Bernd Skiera

Keyword(s):

Vitamin D ◽

Growth Rates ◽

Protective Role ◽

Negative Association ◽

Ultraviolet B ◽

Cumulative Number ◽

Uvb Radiation ◽

Daily Growth ◽

Percentage Points

Abstract Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths. We apply a fixed-effect log-linear regression model to a panel dataset of 152 countries over 108 days (n = 6524). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables and isolate the UVI effect from potential confounding factors. After controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] and a 1.0 percentage points decline in the CFR daily growth rate [p < 0.05]. These results represent a significant percentage reduction in terms of daily growth rates of cumulative COVID-19 deaths (− 12%) and CFR (− 38%). We find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention would be very attractive.

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Role of Ultraviolet B Irradiance and Vitamin D in Prevention of Ovarian Cancer

American Journal of Preventive Medicine ◽

10.1016/j.amepre.2006.08.018 ◽

2006 ◽

Vol 31 (6) ◽

pp. 512-514 ◽

Cited By ~ 83

Author(s):

C GARLAND ◽

S MOHR ◽

E GORHAM ◽

W GRANT ◽

F GARLAND

Keyword(s):

Ovarian Cancer ◽

Vitamin D ◽

Ultraviolet B

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Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia

Dermato-Endocrinology ◽

10.4161/derm.1.1.7250 ◽

2009 ◽

Vol 1 (1) ◽

pp. 37-42 ◽

Cited By ~ 32

Author(s):

William B. Grant

Keyword(s):

Vitamin D ◽

Ultraviolet B ◽

Solar Ultraviolet

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Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2005.06.003 ◽

2005 ◽

Vol 97 (1-2) ◽

pp. 111-120 ◽

Cited By ~ 31

Author(s):

C. Spina ◽

V. Tangpricha ◽

M. Yao ◽

W. Zhou ◽

M.M. Wolfe ◽

...

Keyword(s):

Colon Cancer ◽

Vitamin D ◽

Ultraviolet B ◽

Ultraviolet B Radiation ◽

Prevention And Treatment ◽

Solar Ultraviolet

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Vitamin D and Temporomandibular Disorders: What Do We Know So Far?

Nutrients ◽

10.3390/nu13041286 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1286

Author(s):

Andreea Kui ◽

Smaranda Buduru ◽

Anca Labunet ◽

Silvia Balhuc ◽

Marius Negucioiu

Keyword(s):

Vitamin D ◽

Temporomandibular Disorders ◽

Potential Role ◽

Current Knowledge ◽

Masticatory Muscles ◽

The Body ◽

Ultraviolet B ◽

Pathological Conditions ◽

Temporomandibular Joints

Background and aims. Vitamin D is synthesized in the skin with the aid of ultraviolet-B radiation, playing a variety of roles in the body. Temporomandibular disorders (TMDs) are a group of pathological conditions involving the temporomandibular joints as well as the masticatory muscles and othersurrounding tissues. In the present narrative review, we investigated the potential role of vitamin D in the etiology of temporomandibular disorders in order todetermine whether the current knowledge supports 25-hidroxyvitamin D (25-OHD) supplementation in temporomandibular disorders associated with insufficient or deficient levels of vitamin D. Methods. A literature research was performed in PubMed, Scopus, Science Direct, and Google Scholar databases, and a total of 10 articles were included for analysis. Results.Among the observational studies published to date, investigating the role for vitamin D in the etiology of TMDs, six of them suggest that there is a connection between the two aspects. In this context, patients suffering from TMD, with deficient levels of vitamin D (<30 ng/mL), are most likely to benefit from supplementation, whereas individuals with vitamin D level >50ng/mL probably have little benefit from supplementation.Conclusion.Vitamin D might be a safe, simple, and potentially beneficial way to prevent TMDs or to reduce pain; however, more randomized and placebo-controlled trials are required before any firm conclusions can be drawn.

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Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 Deaths Manuscript

10.1101/2020.05.06.20093419 ◽

2020 ◽

Cited By ~ 4

Author(s):

Rahul Kalippurayil Moozhipurath ◽

Lennart Kraft ◽

Bernd Skiera

Keyword(s):

Vitamin D ◽

Growth Rates ◽

Protective Role ◽

Negative Association ◽

Ultraviolet B ◽

Time Varying ◽

Uvb Radiation ◽

Daily Growth ◽

Percentage Points

AbstractBackgroundResearch is ongoing to identify an effective way to prevent or treat COVID-19, but thus far these efforts have not yet identified a possible solution. Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of deaths attributed to COVID-19 (COVID-19 deaths).MethodsWe carry out an observational study, applying a fixed-effect log-linear regression model to a panel dataset of 64 countries over a period of 78 days (n=4992). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables to test our hypothesis and isolate UVI effect from potential confounding factors such as underlying time trends, country-specific time-constant and time-varying factors such as weather.FindingsAfter controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 2.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] as well as a 1.9 percentage points decline in the daily growth rates of CFR [p < 0.05]. These results represent a significant percentage reduction in terms of the daily growth rates of cumulative COVID-19 deaths (−22.92%) and CFR (−73.08%). Our results are consistent across different model specifications.InterpretationWe find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention will be very attractive because it is cost-effective and widely available.

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