Association of serum ferritin level and depression with respect to the body mass index in Korean male adults

Background: Hair loss is a common distressing disease and challenging problem for many dermatologist. Telogen effluvium is the most common hair loss disease in which nutritional deficiencies may precipitate the disease through their effect on hair structure and growth. Study Aim : Validating role of serum ferritin level and body mass index in Chronic Telogen Effluvium and analyzing association between these factors with socioeconomic, demographic, gynecological factors and weight loss effect. Establishing a nutritional preventive advice to improve treatment successfulness and decrease the disease occurrence. Methods : A case series study on 327 chronic telogen effluvium patients (15-65 years old) main teaching dermatological outpatients' clinics in Baghdad. Data were collected by direct interview and questionnaire filling to analyze the associations between variables set in the data collection tool with serum ferritin level and body mass, which in turn may precipitate chronic telogen effluvium. Results :Mean patients' age was 39±9 years, 93.6% of patients had serum ferritin below normal for hair cycle requirement (≤70μg/l). Serum ferritin significantly associated with age (p value= 0.002) and 41.1% of poor socioeconomic patients had serum ferritin ≤20μg/l. Nearly half of the patients with ≥3 pregnancies, 43.9% of patients on weight-losing diet and 52.7% of those who actually lost weight had low ferritin levels with statistically significant associations. Being obese is a risk factor for having low serum ferritin (OR= 0.297). Conclusion : Serum ferritin found to be ≤ 70μg/l in the majority of chronic telogen effluvium patients, which is significantly associated with patients' socioeconomic status, age, and weight status.

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Association of Body mass index and serum ferritin level in pediatrics with Beta-thalassemia major disease

Iranian Journal of Pediatric Hematology & Oncology ◽

10.18502/ijpho.v12i1.8359 ◽

2022 ◽

Author(s):

Saeed Yousefian ◽

Ghassem Miri Aliabad ◽

Rana Saleh ◽

Majid Khedmati

Keyword(s):

Body Mass Index ◽

Blood Transfusion ◽

Body Mass ◽

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Major Disease ◽

Beta Thalassemia Major

Background: Beta-thalassemia major is a type of inherited blood disease that results in variable outcomes such as severe anemia due to haemoglobin chains. Recurrent and lifelong blood transfusions as a treatment in beta-thalassemia major disease lead to iron deposition in various organs and cause the failure of multiple organs. Failure of affected organs leads to Body mass index (BMI) abnormality. This study aimed to evaluate the association between BMI and serum ferritin level as a marker for iron overload. Materials and Methods: A cross-sectional study designed and conducted with total number of 740 paediatrics, with mean age about 14.2±8.7 years old and with beta-thalassemia major requiring recurrent blood transfusion. Patient information, including demographics, serum ferritin level and percentage of BMI, was recorded and analysed by SPSS 25.0 and the statistical significant level, considered as 0.05. Results: A total number of 740 paediatrics with beta-thalassemia major disease (mean age about 14.2±8.7 years) were included to study to examine the association between serum ferritin level and their BMI. The total mean serum level of ferritin calculated about 3326 ± 3859 Nanogram/mililitter (ng/ml). Totally, 447 (60.4%) case of them had BMI percentile less than 5%, 274 (37.02%), 16 (2.16%) and 3 (0.4%) had BMI percentile 5%-85%, 85%-95% and more than 95%. There was no relation between gender and serum ferritin levels. The relationship between age and BMI has been positive (P=0.002). Finally, it resulted that there was a negative relationship between the BMI percentile and mean serum ferritin levels in paediatrics with beta-thalassemia major (P=0.031). Conclusion: Frequent Blood transfusion is associated with elevated serum ferritin level in paediatrics with beta-thalassemia major disease and experiencing lower percentiles of BMI in these patients.

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Noninvasive assessment of iron overload by magnetic resonance imaging

Pediatric Hematology/Oncology and Immunopathology ◽

10.24287/1726-1708-2020-19-3-158-163 ◽

2020 ◽

Vol 19 (3) ◽

pp. 158-163

Author(s):

E. E. Nazarova ◽

D. A. Kupriyanov ◽

G. A. Novichkova ◽

G. V. Tereshchenko

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Iron Overload ◽

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Iron Concentration ◽

The Body ◽

Iron Accumulation ◽

Resonance Imaging

The assessment of iron accumulation in the body is important for the diagnosis of iron overload syndrome or planning and monitoring of the chelation therapy. Excessive iron accumulation in the organs leads to their toxic damage and dysfunction. Until recently iron estimation was performed either directly by liver iron concentration and/or indirectly by measuring of serum ferritin level. However, noninvasive iron assessment by Magnetic resonance imaging (MRI) is more accurate method unlike liver biopsy or serum ferritin level test. In this article, we demonstrate the outlines of non-invasive diagnostics of iron accumulation by MRI and its specifications.

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Assessment of serum Ferritin level and its correlation with HbA1c in Diabetic Nephropathy

Asian Journal of Medical Sciences ◽

10.3126/ajms.v11i2.27296 ◽

2020 ◽

Vol 11 (2) ◽

pp. 46-51

Author(s):

Madhura Navule Siddappa ◽

Kowsalya Ramprasad

Keyword(s):

Diabetic Nephropathy ◽

Glycemic Control ◽

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Pearson Correlation ◽

The Body ◽

Control Group ◽

Type Ii

Background: Serum ferritin levels reflecting the body iron stores, is known to be elevated in type 2 Diabetes Mellitus. However its association with diabetic complications including Diabetic nephropathy (DN), and overall glycemic control needs to be validated. Aims and Objectives: The aim of this study was to find the Serum Ferritin level abnormalities in DM patients with nephropathy in comparison with DM patients without nephropathy and to find correlation of Serum Ferritin (SF) levels with levels of Glycated Hemoglobin (HbA1c) in patients with diabetic nephropathy. Materials and Methods: This is a retrospective study, which included eighty five registered patients with Type 2 DM (44 Type II DM without nephropathy cases and 41 cases of Type II DM with nephropathy). SF and HbA1c was estimated in all cases across both the groups and were compared with age and sex matched controls and analysed. Results: Serum Ferritin levels were higher in diabetics with nephropathy compared to diabetics without nephropathy (p<0.0001). SF levels were higher in diabetic groups compared to control group (p <0.001).The correlation between HbA1c and SF was assessed among all cases of DM with nephropathy group using pearson correlation test and it showed a significantly positive correlation (r=0.431) with a SF (mean = 938±148) and HbA1c (mean = 9.2±2.02). Conclusion: Serum ferritin levels positively correlate with HbA1c levels in Type II DM cases with nephropathy, which suggests that serum Ferritin levels can be used as a surrogate marker of glycemic control in Type II DM with nephropathy.

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Correlation of hepatic steatosis with body mass index, serum ferritin level and hepatic fibrosis in Japanese patients with chronic hepatitis C

Hepatology Research ◽

10.1111/j.1872-034x.2007.00038.x ◽

2007 ◽

Vol 37 (4) ◽

pp. 263-269 ◽

Cited By ~ 4

Author(s):

Yoshio Sumida ◽

Kazuyuki Kanemasa ◽

Kohei Fukumoto ◽

Naohisa Yoshida ◽

Kyoko Sakai

Keyword(s):

Body Mass Index ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Hepatic Steatosis ◽

Chronic Hepatitis C ◽

Hepatic Fibrosis ◽

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Japanese Patients

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Correlation between levels of serum ferritin and lipid profile status.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.12.4254 ◽

2020 ◽

Vol 27 (12) ◽

Author(s):

Safia Rahman ◽

Muhammad Ihtesham Khan ◽

Samiyah Rahman ◽

Saman Waqar

Keyword(s):

Lipid Profile ◽

Serum Ferritin ◽

Serum Cholesterol ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Tertiary Care ◽

Serum Triglyceride ◽

The Body ◽

High Density Lipoproteins ◽

Tertiary Care Centre

Objectives: To analyse the correlation between ferritin level in serum and lipid profile in patients presenting to a Tertiary Care Centre. Study Design: Cross Sectional Descriptive study. Setting: Khyber Teaching Hospital Peshawar. Period: 1st January 2019 to 31st July 2019. Material & Methods: About 60 patients presenting to the laboratory referred for serum lipid profile or serum ferritin were included in the study. Sampling was done by purposive non probability technique. Blood was taken from patients in gel tube. Serum ferritin levels and lipid profile were done in all cases. Lipid profile included serum cholesterol, triglyceride level, low density lipoprotein and high density lipoproteins. The levels were recorded in a proforma. The serum ferritin level was correlated with the lipid profile status in all patient and the results were drawn accordingly. Results: About 60 patients were analysed. The mean age was 20.8± 5.2 years (range: 2 years to 60 years). There were 39 (65%) males and 21(35%) females. Out of 60 cases, serum ferritin level was normal, increased and lower in 15(25%), 40(66.6%) and 5 (8.3%) cases respectively. The cases where serum ferritin was abnormally raised, the significant changes in lipid profile were raised cholesterol and raised triglyceride (in 62.5% and 82.5% cases respectively). Conclusion: There is an association between raised serum ferritin and raised serum cholesterol level and serum triglyceride levels. This supports the link between serum ferritin regulation and lipid metabolism in the body. As dyslipidemia is a major cardiovascular risk factor. Therefore, a raised ferritin level must alert the physician about lipid profile of the patient and should prompt the physician to think about preventive measures against cardiovascular events in order to decrease the morbidity and mortality in patients at risk.

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Concomitant Administration of Recombinant Human Erythropoietin (rHuEPO) and Oral Iron Chelator Deferiprone May Stabilize Iron Balance in Transfusion Dependent Patients with Early Myelodysplastic Syndrome (MDS).

Blood ◽

10.1182/blood.v106.11.4901.4901 ◽

2005 ◽

Vol 106 (11) ◽

pp. 4901-4901

Author(s):

Jaroslav Cermak

Keyword(s):

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Concomitant Administration ◽

Iron Chelator ◽

Oral Iron ◽

The Body ◽

Refractory Anemia ◽

Transfusion Independence ◽

Oral Iron Chelator

Abstract Eight transfusion dependent patients with refractory anemia (RA) or refractory anemia with ringed sideroblasts (RARS) subtypes of MDS (according to the FAB classification) with serum ferritin ranging from 1630 to 4227 μg/l were treated with oral iron chelator deferiprone (Ferriprox, Apotex Ltd., Canada) in a daily dose of 75–80 mg/kg for at least 12 months. Beginning the second month of therapy, rHuEPO (Eprex, Cilag AG, Switzerland or NeoRecormon, Roche Diagnostic, Germany) was administered concomitantly with deferiprone in a dose of 10 000 IU 3 times per week. A significant increase in urinary iron excrection after addition of rHuEPO compared to treatment with deferiprone as a single agent was observed in all patients and the amount of excreted iron ranged from 7.5mg to almost 20mg per day. In one patient with complete response to rHuEPO (Hb > 115 g/l + transfusion independence) and in another patient with partial response resulting in transfusion independence, serum ferritin level decreased from 3034 to 1872 μg/l and from 2086 to 879 μg/l, respectively. The results corresponded with a moderate decrease in liver iron documented by NMR imaging. In 6 patients who did not respond to rHuEPO and remained transfusion dependent a simultaneous administration of rHuEPO and deferiprone enabled to stablize serum ferritin level despite continuing iron load from transfusions. The treatment was well tolerated except one patient, in whom adverse GIT symptoms led to cessation of deferiprone administration after 4 months of treatment. The ability of deferiprone to bind intracellular iron that may be either excreted from the body or donated to partially saturated transferrin for utilization in bone marrow for rHuEPO stimulated erythropoiesis on one hand and an increased excretion of deferiprone chelated non transferrin bound iron originating from an increased amount of destroyed red blood cells on the other hand may be a possible explanation of observed phenomenon. A concomitant administration of rHuEPO and deferiprone might be an effective tool for maintaining iron balance in transfusion dependent iron overloaded patients with early MDS who are not indicated for intensive treatment.

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Evaluation of the Correlation between Echocardiographic Findings and Serum Ferritin in Thalassemia Major Patients

Global Journal of Health Science ◽

10.5539/gjhs.v8n12p190 ◽

2016 ◽

Vol 8 (12) ◽

pp. 190

Author(s):

Mohammad Reza Khalilian ◽

Roozbeh Moghaddar ◽

Abdolrahman Emami-Moghadam ◽

Bijan Keikhaei ◽

Ali Amin-Asnafi ◽

...

Keyword(s):

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Globin Gene ◽

Thalassemia Major ◽

The Body ◽

Cardiac Complications ◽

Systolic Pulmonary Artery Pressure ◽

Iron Loading ◽

Echocardiographic Findings

INTRODUCTION: Thalassemia is a disorder that affects beta globin gene production and the resultant need for erythrocyte transfusions puts the patient at risk for iron loading, especially cardiac iron loading. Cardiac complications are the most serious ones accompanied by morbidity and mortality. The most harm to the heart is caused by iron overload. Ferritin is generally associated with the amount of stored iron in the body. The aim of this study was to investigate the relationship between echocardiographic findings and serum ferritin level.MATERIALS & METHODS: 107 patients with thalassemia major were enrolled in this prospective analytical study. Serum ferritin levels and echocardiographic findings (diastolic, systolic, pulmonary artery pressure, valvular dysfunctions) were assessed. The data were analyzed by spearman statistical test.RESULTS: Serum ferritin levels of the thalassemia major patients in the study were 2419.13±1772.65 ng/ml. there wasn’t any significant relationship between echocardiographic findings and serum ferritin level.CONCLUSION: Although our findings didn’t support the association between ferritin level and echocardiographic data but we suggest serial cardiac assessment to prevent the effect of increasing iron on the heart.

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