PI3K Inhibitors: Novel Molecular-Targeted Drug Candidates for Cancer Therapy

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

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Identification and validation of a five-lncRNA signature for predicting survival with targeted drug candidates in ovarian cancer

Bioengineered ◽

10.1080/21655979.2021.1946632 ◽

2021 ◽

Vol 12 (1) ◽

pp. 3263-3274

Author(s):

Nuan Lin ◽

Jia-zhe Lin ◽

Yoshiaki Tanaka ◽

Pingnan Sun ◽

Xiaoling Zhou

Keyword(s):

Ovarian Cancer ◽

Drug Candidates ◽

Targeted Drug

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Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

Nanocarriers for Drug Delivery ◽

10.1016/b978-0-12-814033-8.00006-0 ◽

2019 ◽

pp. 173-204 ◽

Cited By ~ 3

Author(s):

Mahadevappa Y. Kariduraganavar ◽

Geetha B. Heggannavar ◽

Sandra Amado ◽

Geoffrey R. Mitchell

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

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Targeted drug delivery for cancer therapy

Biomaterials for Cancer Therapeutics ◽

10.1533/9780857096760.1.31 ◽

2013 ◽

pp. 31-56 ◽

Cited By ~ 2

Author(s):

D.L. Stirland ◽

J.W. Nichols ◽

T.A. Denison ◽

Y.H. Bae

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

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Current Therapies and Future Prospects

Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer - Advances in Medical Technologies and Clinical Practice ◽

10.4018/978-1-7998-5049-6.ch015 ◽

2021 ◽

pp. 306-318

Author(s):

Muddukrishnaiah K.

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Cancer Therapy ◽

Cancer Diagnosis ◽

Biomarker Discovery ◽

Future Prospects ◽

Cancer Treatments ◽

Therapeutic Uses ◽

Current Therapies ◽

Targeted Drug

Due to drug resistance, lack of cancer cell selectivity, and solubility, conventional cancer treatments lose their therapeutic uses, and as such, new therapeutic agents need to be developed. Nanomaterials and peptides are increasingly being used in the fields of cancer diagnosis, biomarker discovery due to their therapeutic values and novel way of targeting and curing the disease. Synergism among the peptide-conjugated nanoparticles is an exhilarating group of materials, not only sharing the benefits of conventional nanomedicine, but also possessing the unique properties of excellent biocompatibility, biodegradability, versatile sensitivity, specific biological purpose, and synthetic feasibility. These virtues inspired by the scientists and have taken advantage in the peptide-conjugated nano drugs for the accurate delivery of drugs reliably to the site of the lesion. This chapter offers a summary of emerging technologies that have recently been developed in the broad field of peptide-conjugated nanoparticles and offers guidance for targeted drug delivery and cancer therapy.

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ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy

International Journal of Nanomedicine ◽

10.2147/ijn.s249240 ◽

2020 ◽

Vol Volume 15 ◽

pp. 3333-3346 ◽

Cited By ~ 2

Author(s):

Srinivasan Ayyanaar ◽

Chandrasekar Balachandran ◽

Rangaswamy Chinnabba Bhaskar ◽

Mookkandi Palsamy Kesavan ◽

Shin Aoki ◽

...

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Cancer Therapy ◽

Iron Oxide Nanoparticles ◽

Targeted Drug Delivery ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Iron Oxide ◽

Targeted Drug

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Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

Chemical Communications ◽

10.1039/c9cc07831b ◽

2019 ◽

Vol 55 (100) ◽

pp. 15101-15104 ◽

Cited By ~ 4

Author(s):

Xiaoting Ji ◽

Haoyuan Lv ◽

Xinxin Sun ◽

Caifeng Ding

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Carcinoembryonic Antigen ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Antigen Detection ◽

Targeted Cancer Therapy ◽

Carbon Dot ◽

Targeted Drug

Bifunctional composite nanospheres for carcinoembryonic antigen sensing and targeted drug delivery, based on carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels.

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Recent advances in combinatorial cancer therapy via multifunctionalized gold nanoparticles

Nanomedicine ◽

10.2217/nnm-2020-0051 ◽

2020 ◽

Vol 15 (12) ◽

pp. 1221-1237

Author(s):

Touqeer Ahmad ◽

Rizwana Sarwar ◽

Ayesha Iqbal ◽

Uzma Bashir ◽

Umar Farooq ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Photothermal Therapy ◽

Therapeutic Implications ◽

Therapeutic Applications ◽

Diagnosis Of Cancer ◽

Targeted Drug ◽

Cancerous Cells

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

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