Comparison Evaluation of Periimplant Alveolar Crest Stress/Strain Distribution Ability Depending on Alveolar Bone Density: Mathematical Model

2015 ◽  
Vol 03 (03) ◽  
Author(s):  
Anna Yu Poghosyan
Keyword(s):  
Mathematical Model ◽  
Bone Density ◽  
Strain Distribution ◽  
Alveolar Bone ◽  
Stress Strain ◽  
Alveolar Crest

scholarly journals The role of inhibition of osteocyte apoptosis in mediating orthodontic tooth movement and periodontal remodeling: a pilot study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Michele Kaplan ◽  
Zana Kalajzic ◽  
Thomas Choi ◽  
Imad Maleeh ◽  
Christopher L. Ricupero ◽  
...  
Keyword(s):  
Bone Density ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Tartrate Resistant Acid Phosphatase ◽  
Osteocyte Apoptosis ◽  
Saline Administration ◽  
Group 2 ◽  
Group 1

Abstract Background Orthodontic tooth movement (OTM) has been shown to induce osteocyte apoptosis in alveolar bone shortly after force application. However, how osteocyte apoptosis affects orthodontic tooth movement is unknown. The goal of this study was to assess the effect of inhibition of osteocyte apoptosis on osteoclastogenesis, changes in the alveolar bone density, and the magnitude of OTM using a bisphosphonate analog (IG9402), a drug that affects osteocyte and osteoblast apoptosis but does not affect osteoclasts. Material and methods Two sets of experiments were performed. Experiment 1 was used to specifically evaluate the effect of IG9402 on osteocyte apoptosis in the alveolar bone during 24 h of OTM. For this experiment, twelve mice were divided into two groups: group 1, saline administration + OTM24-h (n=6), and group 2, IG9402 administration + OTM24-h (n=6). The contralateral unloaded sides served as the control. The goal of experiment 2 was to evaluate the role of osteocyte apoptosis on OTM magnitude and osteoclastogenesis 10 days after OTM. Twenty mice were divided into 4 groups: group 1, saline administration without OTM (n=5); group 2, IG9402 administration without OTM (n=5); group 3, saline + OTM10-day (n=6); and group 4, IG9402 + OTM10-day (n=4). For both experiments, tooth movement was achieved using Ultra Light (25g) Sentalloy Closed Coil Springs attached between the first maxillary molar and the central incisor. Linear measurements of tooth movement and alveolar bone density (BVF) were assessed by MicroCT analysis. Cell death (or apoptosis) was assessed by terminal dUTP nick-end labeling (TUNEL) assay, while osteoclast and macrophage formation were assessed by tartrate-resistant acid phosphatase (TRAP) staining and F4/80+ immunostaining. Results We found that IG9402 significantly blocked osteocyte apoptosis in alveolar bone (AB) at 24 h of OTM. At 10 days, IG9402 prevented OTM-induced loss of alveolar bone density and changed the morphology and quality of osteoclasts and macrophages, but did not significantly affect the amount of tooth movement. Conclusion Our study demonstrates that osteocyte apoptosis may play a significant role in osteoclast and macrophage formation during OTM, but does not seem to play a role in the magnitude of orthodontic tooth movement.

scholarly journals On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mehran Ashrafi ◽  
Farzan Ghalichi ◽  
Behnam Mirzakouchaki ◽  
Manuel Doblare
Keyword(s):  
Mathematical Model ◽  
Bone Density ◽  
Bone Remodeling ◽  
Dental Implants ◽  
Implant Design ◽  
Patient Specific ◽  
Dental Implantation ◽  
Antiresorptive Agents ◽  
Antiresorptive Drugs

AbstractBone remodeling identifies the process of permanent bone change with new bone formation and old bone resorption. Understanding this process is essential in many applications, such as optimizing the treatment of diseases like osteoporosis, maintaining bone density in long-term periods of disuse, or assessing the long-term evolution of the bone surrounding prostheses after implantation. A particular case of study is the bone remodeling process after dental implantation. Despite the overall success of this type of implants, the increasing life expectancy in developed countries has boosted the demand for dental implants in patients with osteoporosis. Although several studies demonstrate a high success rate of dental implants in osteoporotic patients, it is also known that the healing time and the failure rate increase, necessitating the adoption of pharmacological measures to improve bone quality in those patients. However, the general efficacy of these antiresorptive drugs for osteoporotic patients is still controversial, requiring more experimental and clinical studies. In this work, we investigate the effect of different doses of several drugs, used nowadays in osteoporotic patients, on the evolution of bone density after dental implantation. With this aim, we use a pharmacokinetic–pharmacodynamic (PK/PD) mathematical model that includes the effect of antiresorptive drugs on the RANK/RANK-L/OPG pathway, as well as the mechano-chemical coupling with external mechanical loads. This mechano-PK/PD model is then used to analyze the evolution of bone in normal and osteoporotic mandibles after dental implantation with different drug dosages. We show that using antiresorptive agents such as bisphosphonates or denosumab increases bone density and the associated mechanical properties, but at the same time, it also increases bone brittleness. We conclude that, despite the many limitations of these very complex models, the one presented here is capable of predicting qualitatively the evolution of some of the main biological and chemical variables associated with the process of bone remodeling in patients receiving drugs for osteoporosis, so it could be used to optimize dental implant design and coating for osteoporotic patients, as well as the drug dosage protocol for patient-specific treatments.

Evaluation of alveolar bone density by intraoral periapical radiography

2014 ◽  
Vol 52 (3) ◽  
pp. 233
Author(s):  
Eun-Jin Park ◽  
David-Hyungjin Kim ◽  
Eun-Suk Kim
Keyword(s):  
Bone Density ◽  
Alveolar Bone ◽  
Periapical Radiography

Routes towards Novel Active Pressure Sensors in SOI Technology

2011 ◽  
Vol 276 ◽  
pp. 145-155
Author(s):  
Benoit Olbrechts ◽  
Bertrand Rue ◽  
Thomas Pardoen ◽  
Denis Flandre ◽  
Jean Pierre Raskin
Keyword(s):  
Finite Elements ◽  
Strain Distribution ◽  
Pressure Sensors ◽  
High Sensitivity ◽  
Stress Strain ◽  
Pressure Transducers ◽  
Active Devices ◽  
Active Pressure ◽  
Soi Technology

In this paper, novel pressure sensors approach is proposed and described. Active devices and oscillating circuits are directly integrated on very thin dielectric membranes as pressure transducers. Involved patterning of the membrane is supposed to cause a drop of mechanical robustness. Finite elements simulations are performed in order to better understand stress/strain distribution and as an attempt to explain the early burst of patterned membranes. Smart circuit designs are reported as solutions with high sensitivity and reduced footprint on membranes.

scholarly journals Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial

2019 ◽  
Vol 20 (12) ◽  
pp. 1430-1435
Author(s):  
Venith J Pulikkottil ◽  
Lakshmi Lakshmanan ◽  
Sanju T Varughese ◽  
Pavithra U Shamanna ◽  
Neeraj Goyal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Bone Density ◽  
Alveolar Bone ◽  
Controlled Trial ◽  
Spiral Ct ◽  
Randomized Controlled ◽  
Canine Distalization

scholarly journals Current approach to bone augmentation with allogeneic cortical graft: A case report

2021 ◽  
Vol 11 (Suppl. 1) ◽  
pp. 299-302
Author(s):  
Utku Nezih Yılmaz ◽  
Fatma Eriş Derkuş
Keyword(s):  
Case Report ◽  
Dental Implant ◽  
Soft Tissues ◽  
Alveolar Bone ◽  
Healing Process ◽  
Bone Defects ◽  
Current Approach ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Alveolar Crest

Aim: Today, dental implant applications have become the most preferred option in the treatment of tooth deficiencies. Long-term successful results in dental implant applications depend largely on the volume and quality of the hard and soft tissues in the relevant region. Insufficient soft tissues and alveolar crest resorption complicate implant applications. Grafts and additional surgical procedures are required to compensate for resorption and to provide bone augmentation. Shell technique, one of the augmentation methods used in the treatment of alveolar bone defects, is an important procedure for guided bone regeneration. The purpose of this case report is to describe the treatment of vertical and horizontal bone loss with the Shell technique using allogeneic cortical grafts. Methodology: A 58-year-old female patient without any systemic disease was admitted to our clinic with the complaint of tooth loss in the right posterior mandibular region. In the intraoral and radiological examinations, it was determined that the bone volume in the relevant region was not sufficient for dental implant. Two-stage surgical treatment was planned for the patient. First, vertical and horizontal bone defects were augmented with allogeneic cortical graft application under local anesthesia. After the healing process, dental implants were placed in the sufficient volume of the alveolar bone and the patient's treatment was completed. Conclusion: Allogeneic grafts in the treatment of alveolar crest defects; it is a good alternative to autogenous bone grafts,there is no need for a second surgical field and the resulting reduction in morbidity.   How to cite this article: Eriş Derkuş F, Yılmaz UN. Current approach to bone augmentation with allogeneic cortical graft: A case report. Int Dent Res 2021;11(Suppl.1):299-302. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.44     Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

scholarly journals The combination of miacalcic, calcium lactate, and vitamin C as postextracted alveolar bone resorption inhibitor

2010 ◽  
Vol 43 (3) ◽  
pp. 141
Author(s):  
Sri Kentjananingsih
Keyword(s):  
Vitamin D ◽  
Bone Density ◽  
Bone Resorption ◽  
Vitamin C ◽  
Group Treatment ◽  
Alveolar Bone ◽  
Vitamin D Supplementation ◽  
Calcium Lactate ◽  
Control Group ◽  
Significant Difference

Background: Tooth extraction can cause alveolar resorption, and will reduce the denture retention. The process of bone resorption looks like the process of osteoporosis. Calcium and vitamin D supplementation is the rational therapy for minimizing bone loss. Miacalcic is the drug of choice for osteporotic patient. Purpose: This study is aimed to know whether the combination of miacalcic, calcium lactate, and vitamin C are effective in inhibiting post extracted alveolar resorption. Methods: Thirty three healthy postmenopausal women were chosen as samples and they were classified randomly into control group (without treatment), 1st experiment group (treatment was started 3 months post extraction), and 2nd experiment group (treatment was started at the 2nd day post extraction). The treatment was done by giving miacalcic nasal spray, calcium lactate 500 mg and vitamin C 100 mg tablets every morning in 10 days every month for 3 months. X-ray photo of the post extracted area were taken an hour, 3 months, and 6 months post-extraction. Results: After 6 month, there was significant difference in buccolingual thickness decreasing among three groups (p<0.05). The maximum mean difference of buccolingual thickness decreasing was 0.72 mm, between control and 2nd experiment groups. There was no significant difference about decreasing bone density among them (p>0.10). The maximum difference of the mean of density decreasing was 1,906 g/cm2/mm between control and 2nd experiment groups. The increasing density mostly occurred in the 2nd experiment group. Conclusion: The combination of miacalcic, calcium lactate, and vitamin C are effective for inhibiting alveolar resorption, although statistically there was no significant difference about bone density decreasing. The sooner this treatment is given the better result will be achieved.Latar belakang: Pencabutan gigi menyebabkan resorpsi tulang alveolaris, dan akan mengurangi retensi geligi tiruan. Proses resorpsi tulang alveol pada osteoporosis mirip dengan proses resorpsi tulang pada penyembuhan luka bekas pencabutan. Miacalcic adalah obat utama untuk penderita osteoporosis. Kalsium dan vitamin D merupakan terapi yang rasional untuk meminimalkan resorpsi tulang. tujuan: Membuktikan apakah kombinasi miacalcic, kalsium laktat, and vitamin C juga efektif menghambat resorpsi tulang alveol pasca pencabutan. Metode: Sampel 33 wanita postmenopause yang sehat, terbagi secara acak ke dalam kelompok kontrol (tanpa perlakuan), kelompok eksperimen 1 (perlakuan mulai 3 bulan pasca pencabutan) dan kelompok eksperimen 2 (perlakuan mulai hari kedua pasca pencabutan). Perlakuannya yaitu: pemberian miacalcic semprot hidung, tablet kalsium laktat 500 mg dan vitamin C 100 mg setiap pagi, 10 hari dalam sebulan, selama tiga bulan. Foto sinar-X dari regio pasca pencabutan dibuat satu jam, 3 bulan, dan 6 bulan pasca pencabutan. Hasil: 6 bulan pasca-cabut, ada beda bermakna perihal selisih tebal bukolingual tulang alveol antar ketiga kelompok (p<0,05). Rerata penurunan ketebalan ini maksimal sebanyak 0.72 mm, antara kelompok kontrol dan kelompok eksperimen 2. Penurunan kepadatan tulang antar ketiga kelompok tidak bermakna (p>0,10). Beda maksimum rerata kepadatan tulang antara kelompok kontrol dan kelompok eksperimen 2 sebesar 1,906 g/cm2/mm. Peningkatan kepadatan terbanyak dialami anggota kelompok eksperimen 2. Kesimpulan: Kombinasi miacalcic, kalsium laktat, vitamin C efektif menghambat resorpsi tulang alveolaris, walaupun secara statistik beda penurunan kepadatan tidak bermakna. Makin awal pemberian perlakuan, hasilnya akan lebih baik.

scholarly journals Mathematical Models and Evaluation Software for Stress-Strain State of the Earth’s Lithosphere

2019 ◽  
pp. 51-66
Author(s):  
Alexander O. Faddeev ◽  
Svetlana A. Pavlova ◽  
Tatiana M. Nevdakh
Keyword(s):  
Mathematical Model ◽  
Strain State ◽  
Uniform Grid ◽  
Shear Stresses ◽  
Stress Strain ◽  
Gravitation Field ◽  
Vertical Movements ◽  
Stress Strain State ◽  
The Earth ◽  
Viscous Shear

Introduction. For the purposes of this article, geodeformation processes mean processes associated with deformations arising from the movement of species and blocks of the lithosphere at various depths, including surfaces. The objective is to reconstruct geodynamic stress fields, which cause modern shifts and deformations in the Lithosphere. A mathematical model and software for estimating the stress-strain state of the Earth Lithosphere are considered. Materials and Methods.For mathematical modeling of stresses, isostatically reduced data on abnormal gravitation field were used. The methods of continuum mechanics and methods of the theory of differential equations were used to design a model for estimating the stressstrain state of the Earth Lithosphere. For processing input, intermediate and outcoming data, the Fourier transform method of spectral analysis for constructing grid functions and spectral-temporal method were used. To model for the stress-strain state of the Lithosphere globally, stress calculation was corrected on the basis of sputnik-derived velocity data at the surface of the earth crust. The data on the rates of horizontal and vertical movements at the surface of the Earth crust were processed to obtain a distribution of velocities in the uniform grid embracing longitudes and latitudes. The processing procedure was carried out on the basis of the Kraiging method. The software was developed in Borland Delphi 7.0 programming environment. Results. Based on the data on the abnormal gravitation field in isostatic reduction and information on the distribution of velocities of horizontal motions on the surface of the Earth crust, a mathematical model of the stress-strain state of the Lithosphere was constructed. With the help of the obtained mathematical model and software complex, the stress-strain state of the Lithosphere was calculated at various depth using elastic and elastic-viscous models, and maps of equipotential distribution of shear elastic-viscous deformations in the lithosphere at the depth of 10 km were constructed. Discussion and Conclusion. The presented mathematical model and software allow restoring fields of both elastic and elastic-viscous deformations that is fundamental for quantification of elastic-viscous shear stresses deep in the Earth Lithosphere.

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