Artesunate Induced Hepato-Toxicity and its Amelioration by Allium sativum in Swiss Albino Male Mice

This study aimed to determine the effect of ethanolic extract of garlic (Allium sativum s.) and ginger on the levels of glucose, cholesterol, and triglycerides in the blood serum of adult white mice with induced diabetes. This study included 40 male mice of Balb/c, which were divided into four experimental groups (ten mice per group). The results showed a significant increase (p<0.05) in the concentration of glucose, cholesterol and triglycerides in the blood serum of the group of mice injected with alloxan compared with the physiological control. The results also showed a significant decrease (p<0.05) in the concentration of glucose, cholesterol and triglycerides in the blood serum of the group of mice treated with garlic and ginger extract compared to control glucose. Results showed that ethanolic extract of garlic (Allium sativum s.) and ginger has an important effect on lowering the level of biochemical to normal values equivalent to glibenclamide. KEYWORDS Alcoholic extract, alloxan, glucose, balb/c total cholesterol, triglycerides

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The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice

Food and Chemical Toxicology ◽

10.1016/j.fct.2010.01.002 ◽

2010 ◽

Vol 48 (3) ◽

pp. 928-936 ◽

Cited By ~ 69

Author(s):

Veena Sharma ◽

Arti Sharma ◽

Leena Kansal

Keyword(s):

Oral Administration ◽

Allium Sativum ◽

Lead Nitrate ◽

Male Mice

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GAMBARAN HEMATOLOGI MENCIT (Mus musculus) MODEL TOKSISITAS SUBKRONIS

Scripta Biologica ◽

10.20884/1.sb.2017.4.2.371 ◽

2017 ◽

Vol 4 (2) ◽

pp. 75

Author(s):

Ita Nur Eka Pujiastuti ◽

Sri Rahayu Lestari ◽

Abdul Gofur

Keyword(s):

Mus Musculus ◽

Allium Sativum ◽

Hematological Parameters ◽

Garlic Extract ◽

Toxic Effects ◽

Herbal Remedies ◽

Male Mice ◽

Research Reporting ◽

Cholesterol Treatment ◽

Published Research

Garlic commonly is consumed as medicine to prevent or heal illness or to maintain someone's health. Many societies prefer garlic (Allium sativum) among other herbal remedies for cholesterol treatment. It consists of several types, and one of them is single bulb garlic used to treat hypertension. There has been, however, no published research reporting the toxicological properties of single bulb garlic. The purpose of this study was to determine subchronic toxic effects of single bulb garlic administered to mice using hematological parameters. The experiment parameters were hemoglobin and hematocrit levels, the number of erythrocytes and leukocytes. Male mice (Mus musculus) strain Balb-C were treated with single bulb garlic extract for 28 days with dosage levels of 0% (N ), 0.25% (P1 ), 0.5% (P2 ), 1% (P3 ), and 2% (P4 ). Single bulb garlic showed no effect on hemoglobin and hematocrit levels but increased the number of erythrocyte and leucocyte. We concluded that single bulb garlic did not cause subchronic toxic effects.

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Physiological and histological effect of aqueous and alcoholic extract of Garlic (Allium sativum) on testicular function of albino male mice treated with lead acetate

Journal of Biotechnology Research Center ◽

10.24126/jobrc.2014.8.2.328 ◽

2014 ◽

Vol 8 (2) ◽

pp. 41-48

Author(s):

Salah M.M. AL-chalabi ◽

Rashaa F. Abdul-Lattif ◽

Dalia A. Sabrei

Keyword(s):

Testosterone Level ◽

Lead Acetate ◽

Allium Sativum ◽

Sperm Concentration ◽

Control Group ◽

Testicular Function ◽

Alcoholic Extract ◽

Male Mice ◽

Abnormal Sperm ◽

Histological Effect

This study was carried out to investigate the effect of oral administration of aqueous and alcoholic extract of Allium sativum (Garlic) on testicular function in male mice exposed to lead acetate. Sixty adult (7-8) weeks old male mice were divided into six groups (10 micegroup), first and second group were administered with 150mgkg body weight BWday of aqueous and alcoholic extract of plant respectively. However, the third group was treated with 100 mgkgBWday of lead acetate. While the fourth and fifth groups were administered with 150 mgkgBWday. Of aqueous and alcoholic extract combination with 100 gmkg. BW of lead acetate. The sixth group treated with distilled water and served as control group throughout five weeks. At the end of experiment, treated animals were sacrificed and sperm were collected from caudal epidydymis to use for following tests: sperm concentration, motility, deadalive sperm and morphological abnormalities. Serum was isolated to assay for the analysis of, FSH, LH and testosterone level. The results showed a significant increase in sperm concentration, motility and decrease in dead and abnormal sperm in the group treated with aqueous and alcoholic extract of Allium sativum. However, the results showed decrease in sperm concentration, motility and increase in dead and abnormal sperm in the group treated with lead acetate. The other groups of animals groups treated with aqueous and alcoholic extract combination with lead acetate showed improvement in sperm concentration and motility compared to that treated with lead acetate The FSH, LH and testosterone level significantly increased in treated groups with aqueous and alcoholic extract of plant compared to group treated with lead acetate. It's concluded that aqueous and alcoholic extract of Allium sativum were significantly improved fertility in treated medicine compared to animals treated with lead acetate.

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MITIGATION OF EARLY DELTAMETHRIN INDUCED HEPATOTOXICITY IN MALE MICE OF SWISS STRAIN BY ALLIUM SATIVUM

World Journal of Pharmaceutical Research ◽

10.20959/wjpr20179-9296 ◽

2017 ◽

pp. 935-949

Author(s):

Prof. Dr. Hyacinth N. Highland

Keyword(s):

Allium Sativum ◽

Male Mice ◽

Swiss Strain

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Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100068035 ◽

1970 ◽

Vol 28 ◽

pp. 208-209

Author(s):

K.K. SEKHRI ◽

C.S. ALEXANDER ◽

H.T. NAGASAWA

Keyword(s):

Osmium Tetroxide ◽

Male Mice ◽

Alcohol Group ◽

Group Iii ◽

Group I ◽

C57bl Mice ◽

Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

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