scholarly journals GAMBARAN HEMATOLOGI MENCIT (Mus musculus) MODEL TOKSISITAS SUBKRONIS

2017 ◽  
Vol 4 (2) ◽  
pp. 75
Author(s):  
Ita Nur Eka Pujiastuti ◽  
Sri Rahayu Lestari ◽  
Abdul Gofur
Keyword(s):  
Mus Musculus ◽  
Allium Sativum ◽  
Hematological Parameters ◽  
Garlic Extract ◽  
Toxic Effects ◽  
Herbal Remedies ◽  
Male Mice ◽  
Research Reporting ◽  
Cholesterol Treatment ◽  
Published Research

Garlic commonly is consumed as medicine to prevent or heal illness or to maintain someone's health. Many societies prefer garlic (Allium sativum) among other herbal remedies for cholesterol treatment. It consists of several types, and one of them is single bulb garlic used to treat hypertension. There has been, however, no published research reporting the toxicological properties of single bulb garlic. The purpose of this study was to determine subchronic toxic effects of single bulb garlic administered to mice using hematological parameters. The experiment parameters were hemoglobin and hematocrit levels, the number of erythrocytes and leukocytes. Male mice (Mus musculus) strain Balb-C were treated with single bulb garlic extract for 28 days with dosage levels of 0% (N ), 0.25% (P1 ), 0.5% (P2 ), 1% (P3 ), and 2% (P4 ). Single bulb garlic showed no effect on hemoglobin and hematocrit levels but increased the number of erythrocyte and leucocyte. We concluded that single bulb garlic did not cause subchronic toxic effects.

scholarly journals INDUCTION EFFECT OF MICROALGAE SCENEDESMUS DIMORPHUS AGAINST HEMATOLOGY ON MICE (MUS MUSCULUS) SUFFERING ANEMIA DISEASES

2018 ◽  
Vol 11 (7) ◽  
pp. 348
Author(s):  
Armaini Armaini ◽  
Marniati Salim ◽  
Panji Pribadi
Keyword(s):  
Weight Loss ◽  
Aplastic Anemia ◽  
Mus Musculus ◽  
Blood Count ◽  
Hematological Parameters ◽  
Hemoglobin Level ◽  
Induction Effect ◽  
Male Mice ◽  
Total Blood ◽  
Scenedesmus Dimorphus

Objective: This study aims to investigate the potential of Scenedesmus dimorphus as a cure for aplastic anemia in mice (Mus musculus).Methods: Fifty male mice divided into five groups, mice suffering anemia due to induction of chloramphenicol. Oral administrated of S. dimorphus for 28 days with a dose of 2.5 g/50 ml, 5.0 g/50 ml, and 7.5 g/50 ml, respectively, to cure aplastic anemia in mice and samcobion as standard drug.Results: Induction of chloramphenicol caused the mice to suffering aplastic anemia and weight loss in mice. Biomass of S. dimorphus has an effect of against hematological parameters and total blood count estimation. The result shows significant (p<0.05 ANOVA) on weight gain, an increase of erythrocyte counts, and hemoglobin level, whereas an increase of hematocrit and reticulocyte values have non-significant, and a dose of S. dimorphus 5.0 g/50 ml were the treatment most effective for anemia in mice.Conclusion: Based on the results of this study, S. dimorphus biomass has the healing benefit of aplastic anemia due to the administration of chloramphenicol.

scholarly journals Efficacy of Oral Administration of Allium sativum Powder “Garlic Extract” on Lipid Profile, Inflammation, and Cardiovascular Indices among Hemodialysis Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Masoumeh Asgharpour ◽  
Armin Khavandegar ◽  
Parastoo Balaei ◽  
Noora Enayati ◽  
Parham Mardi ◽  
...  
Keyword(s):  
Oral Administration ◽  
Lipid Profile ◽  
Allium Sativum ◽  
Venous Blood ◽  
Laboratory Data ◽  
Hemodialysis Patients ◽  
Garlic Extract ◽  
Herbal Remedies ◽  
P Value ◽  
Garlic Powder

Background. Inflammation plays a prominent role in the deteriorating cardiovascular risk of hemodialysis patients. Utilization of herbal remedies, especially garlic extract, in these patients has resulted in promising improvement in lipid profile, inflammation, and cardiovascular markers. Purpose. In this survey, we aimed to determine the effects of oral administration of Allium sativum powder on lipid profile, inflammation, and cardiovascular markers among hemodialysis patients. Methods. In this interventional double-blinded randomized crossover study, 70 patients were enrolled and assigned in two groups. Each group received 300 mg of garlic powder BID or placebo for eight weeks; after a six-week wash-out period, the agents were switched between two groups so that the group who received garlic powder in the first eight weeks received placebo for the second eight weeks, and vice versa. Venous blood samples were obtained in baseline, wash-out period, and at the end of study. Following obtaining laboratory data, BUN, creatinine, Na, K, Ca, Ph, homocysteine, and lipid profile were compared. Results. No significant differences were shown at baselines of outcomes between the garlic and placebo group ( p value>0.05). However, there was a significant decrease in absolute values of OXLDL (mean placebo = 979.63, mean garlic = 676.54; p value<0.001) and HCY (mean placebo = 36.54, mean garlic = 27.78; p value<0.001). In addition, significant treatment differences were seen in change values of Ca (placebo = 1.17, garlic = 0.21; p value = 0.006), TG (placebo = −6.71, garlic = -24.14; p value = 0.014), OXLDL (placebo = −281.30, garlic = -699.78; p value<0.001), and HCY (placebo = −0.24, garlic = −6.68; p value<0.001). Conclusion. In this study, Allium sativum powder demonstrated efficacy in lipid profile improvement and renal protective effects among hemodialysis patients.

EFEKTIVITAS ANTIBAKTERI BAWANG PUTIH (Allium sativum L) SEBAGAI PENGAWET ALAMI PADA IKAN LELE DUMBO (Clarias gariephinus) SEGAR

2019 ◽  
Vol 14 (1) ◽  
pp. 26
Author(s):  
Dyah Anggraeni ◽  
Nurlela Nurlela
Keyword(s):  
Room Temperature ◽  
Allium Sativum ◽  
Research Result ◽  
Clarias Gariepinus ◽  
Storage Period ◽  
The Body ◽  
Garlic Extract ◽  
African Catfish ◽  
Natural Preservatives ◽  
Colony Counter

Background: Natural preservatives are compounds produced by natural ingredients that can suppress bacterial growth and development. Natural preservatives are carried out because most of the preservatives circulating are chemicals and unsafe for the body. One of the natural preservatives is by using garlic extract (Allium sativum L).  Objective: This study is aimed to determine the effectiveness of the antibacterial garlic (Allium sativum L) as a natural preservative in fresh African catfish (Clarias gariepinus).  Method: This research used the Pour Plate iroculation method. African catfish (Clarias gariepinus) which is soaked with garlic (Allium sativum L) with a concentration of 7%, 14% and 21% for 30 minutes, then the fish will be kept at room temperature with a storage period of 24 hours and 48 hours and calculated growth in bacterial numbers with the Colony counter.  Result: Based on the research result, it was found that garlic extract (Allium sativum L) can obstruct the effectiveness of antibacterial in African catfish (Clarias gariepinus) at a concentration of 14%.

Garlic Extract (Allium sativum L.) Effectively Inhibits Staphylococcus aureus and Escherichia coli by Invitro Test

2020 ◽  
Vol 2 (2) ◽  
pp. 61-68
Author(s):  
Agnina Listya Anggraini ◽  
Ratih Dewi Dwiyanti ◽  
Anny Thuraidah
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Bacterial Infections ◽  
Allium Sativum ◽  
Antibacterial Properties ◽  
Herbal Medicines ◽  
Garlic Extract ◽  
Dilution Method ◽  
Initial Stage

Infection is a disease caused by the presence of pathogenic microbes, including Staphylococcus aureus and Escherichia coli. Garlic (Allium sativum L.) has chemical contents such as allicin, alkaloids, flavonoids, saponins, tannins, and steroids, which can function as an antibacterial against Staphylococcus aureus and Escherichia coli. This study aims to determine the antibacterial properties of garlic extract powder against Staphylococcus aureus and Escherichia coli. This research is the initial stage of the development of herbal medicines to treat Staphylococcus aureus and Escherichia coli infections. The antibacterial activity test was carried out by the liquid dilution method. The concentrations used were 30 mg/mL, 40 mg/mL, 50 mg/mL, 60 mg/mL and 70 mg/mL. The results showed that the Minimum Inhibitory Concentration (MIC) against Staphylococcus aureus and Escherichia coli was 40 mg/mL and 50 mg / mL. Minimum Bactericidal Concentration (MBC) results for Staphylococcus aureus and Escherichia coli are 50 mg/mL and 70 mg/mL. Based on the Simple Linear Regression test, the R2 value of Staphylococcus aureus and Escherichia coli is 0.545 and 0.785, so it can be concluded that there is an effect of garlic extract powder on the growth of Staphylococcus aureus and Escherichia coli by 54.5% and 78.5%. Garlic (Allium sativum L.) extract powder has potential as herbal medicine against bacterial infections but requires further research to determine its effect in vivo.

Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)

2021 ◽  
Vol 406 ◽  
pp. 124644
Author(s):  
Yongfeng Deng ◽  
Zehua Yan ◽  
Ruqin Shen ◽  
Yichao Huang ◽  
Hongqiang Ren ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Male Mice

Behavioral Characterization of Wild Derived Male Mice (Mus musculus musculus) of the PWD/Ph Inbred Strain: High Exploration Compared to C57BL/6J

2004 ◽  
Vol 34 (6) ◽  
pp. 621-630 ◽  
Author(s):  
Cathy Fernandes ◽  
Lin Liu ◽  
Jos� L. Paya-Cano ◽  
So?a Gregorov� ◽  
Ji?� Forejt ◽  
...  
Keyword(s):  
Inbred Strain ◽  
Mus Musculus ◽  
Male Mice ◽  
Mus Musculus Musculus ◽  
Behavioral Characterization

The effect of garlic extract (Allium sativum L.) (Amaryllidaceae) to eradicate the Porphyromonas endodontalis biofilm: An in-vitro research

2021 ◽  
Vol 5 (3) ◽  
pp. 138
Author(s):  
AdiDharma Widjaya ◽  
MeinyFaudah Amin ◽  
Aryadi ◽  
BoediOetomo Roeslan
Keyword(s):  
Allium Sativum ◽  
Garlic Extract

scholarly journals The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11934
Author(s):  
Jiashun Chen ◽  
Fang Wang ◽  
Yexin Yin ◽  
Xiaokang Ma
Keyword(s):  
Allium Sativum ◽  
Animal Feed ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Bioactive Molecules ◽  
Herbal Remedies ◽  
Organosulfur Compounds ◽  
Beneficial Effects ◽  
Stress Markers

Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.

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