MITIGATION OF EARLY DELTAMETHRIN INDUCED HEPATOTOXICITY IN MALE MICE OF SWISS STRAIN BY ALLIUM SATIVUM

2017 ◽  
pp. 935-949
Author(s):  
Prof. Dr. Hyacinth N. Highland
Keyword(s):  
Allium Sativum ◽  
Male Mice ◽  
Swiss Strain

scholarly journals Uji Efek Analgetik Infusa Daun Beluntas (Pluchea indica L.) Pada Mencit Jantan Galur Swiss

2018 ◽  
Vol 7 (2) ◽  
pp. 61-67
Author(s):  
Sri S. Wahyuningsih ◽  
Linda Widyastuti
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Positive Control ◽  
Test Substance ◽  
Male Mice ◽  
Group Iii ◽  
Group I ◽  
Homogeneity Of Variance ◽  
Kolmogorov Smirnov ◽  
Swiss Strain

Beluntas leaves (Pluchea indica L.) have been known as analgetic reducer. The study about this research has been going on right now. The goal of this research is to study the analgesic effect of beluntas (P. indica) leaf infused into male mice of swiss strain. The method used is the stretching chemical stimuli using acetic acid as an inducer of pain. Healthy male mice of Swiss strain were divided into five groups, and each group consisted of 5 mice. Group I was given paracetamol at a dose of 65 mg/kg of body weight, group II were given distilled water , the group III-V were given beluntas leaf infuse in the variation of 10 %, 20 % and 40 %. Thirty minutes after test substance application, acetic acid of 100 mg/kg of body weight were given intraperitoneally in all groups and stretching of mice was observed every 5 minutes for 1 hour. The data was analyzed by using normality test of Kolmogorov-Smirnov; the  test of homogeneity of variance was analyzed by ANOVA and post hoc tests were to differenciate the percentage analgetic of every group. Statistical test showed normal distributed and homogeneous data; there are significant differences of percentage analgesic between paracetamol and beluntas leaf infuse of 10, 20, and 40 % (p < 0.05). There was significant differences between infuse of beluntas leaves with positive control (parasetamol) in mice. Key words: Analgetic, leave of beluntas (P. indica), infuse, mice.

scholarly journals Comparison of Garlic and Ginger Extract with Glibenclamide on Some Biochemical Standards in Diabetic Mice

2021 ◽  
pp. 1-6
Author(s):  
Kholoud Yousef ◽  
Hiam Fadel ◽  
Mofeed Yaseen
Keyword(s):  
Blood Serum ◽  
Total Cholesterol ◽  
Allium Sativum ◽  
Normal Values ◽  
Ethanolic Extract ◽  
Alcoholic Extract ◽  
Diabetic Mice ◽  
Male Mice ◽  
Physiological Control ◽  
Ginger Extract

This study aimed to determine the effect of ethanolic extract of garlic (Allium sativum s.) and ginger on the levels of glucose, cholesterol, and triglycerides in the blood serum of adult white mice with induced diabetes. This study included 40 male mice of Balb/c, which were divided into four experimental groups (ten mice per group). The results showed a significant increase (p<0.05) in the concentration of glucose, cholesterol and triglycerides in the blood serum of the group of mice injected with alloxan compared with the physiological control. The results also showed a significant decrease (p<0.05) in the concentration of glucose, cholesterol and triglycerides in the blood serum of the group of mice treated with garlic and ginger extract compared to control glucose. Results showed that ethanolic extract of garlic (Allium sativum s.) and ginger has an important effect on lowering the level of biochemical to normal values equivalent to glibenclamide. KEYWORDS Alcoholic extract, alloxan, glucose, balb/c total cholesterol, triglycerides

scholarly journals ANALGETICACTIVITY TEST OF ETHANOL EXTRACT OFTAMARIND LEAVES (TamarindusIndica L.) TO MALEMICE OF SWISS STRAIN

2018 ◽  
Vol 1 (1) ◽  
pp. 34-38
Author(s):  
Sri Saptuti Wahyuningsih
Keyword(s):  
Emotional Experience ◽  
Ethanol Extract ◽  
Male Mice ◽  
Optimal Activity ◽  
Normality Test ◽  
Cumulative Amount ◽  
Kolmogorov Smirnov ◽  
Analysis Of Results ◽  
Post Hoc ◽  
Swiss Strain

Tamarind is a medicinal plant that has benefits as an antiseptic, antipyretic and analgetic (anti-pain). Pain is an unpleasant sensory and emotional experience due to actual or potential damage.The purpose thisstudy to determine the optimal analgetic and dosage activity of tamarind leaf ethanol extract on male mice swiss strain induced by acetic acid. The method used is analysis of results by observing the amount of stretching of mice every five minutes for an hour. The cumulative amount of stretching in mice to calculate the analgetic activity was obtained from the amount of stretching of mice induced by acetid acid intraperitoneally within 30 minutes after orally induced. Statistical analgetic data using kolmogorov-smirnov normality test, test of homogenity of variances followed by Anova test and post hoc tests using SPSS 24.0 for windows. Percentanalgesic activity of ethanol extract of leaves tamarind dosage 5%, 10%, 20%wererespectively (9,81 ± 2,24)%, (24,68 ± 2,10)% and (36,39 ± 3,06)%. Ethanol extract of leaves tamarind dosage 20% provide the most optimal activity analgesic

scholarly journals GAMBARAN HEMATOLOGI MENCIT (Mus musculus) MODEL TOKSISITAS SUBKRONIS

2017 ◽  
Vol 4 (2) ◽  
pp. 75
Author(s):  
Ita Nur Eka Pujiastuti ◽  
Sri Rahayu Lestari ◽  
Abdul Gofur
Keyword(s):  
Mus Musculus ◽  
Allium Sativum ◽  
Hematological Parameters ◽  
Garlic Extract ◽  
Toxic Effects ◽  
Herbal Remedies ◽  
Male Mice ◽  
Research Reporting ◽  
Cholesterol Treatment ◽  
Published Research

Garlic commonly is consumed as medicine to prevent or heal illness or to maintain someone's health. Many societies prefer garlic (Allium sativum) among other herbal remedies for cholesterol treatment. It consists of several types, and one of them is single bulb garlic used to treat hypertension. There has been, however, no published research reporting the toxicological properties of single bulb garlic. The purpose of this study was to determine subchronic toxic effects of single bulb garlic administered to mice using hematological parameters. The experiment parameters were hemoglobin and hematocrit levels, the number of erythrocytes and leukocytes. Male mice (Mus musculus) strain Balb-C were treated with single bulb garlic extract for 28 days with dosage levels of 0% (N ), 0.25% (P1 ), 0.5% (P2 ), 1% (P3 ), and 2% (P4 ). Single bulb garlic showed no effect on hemoglobin and hematocrit levels but increased the number of erythrocyte and leucocyte. We concluded that single bulb garlic did not cause subchronic toxic effects.

scholarly journals Physiological and histological effect of aqueous and alcoholic extract of Garlic (Allium sativum) on testicular function of albino male mice treated with lead acetate

2014 ◽  
Vol 8 (2) ◽  
pp. 41-48
Author(s):  
Salah M.M. AL-chalabi ◽  
Rashaa F. Abdul-Lattif ◽  
Dalia A. Sabrei
Keyword(s):  
Testosterone Level ◽  
Lead Acetate ◽  
Allium Sativum ◽  
Sperm Concentration ◽  
Control Group ◽  
Testicular Function ◽  
Alcoholic Extract ◽  
Male Mice ◽  
Abnormal Sperm ◽  
Histological Effect

This study was carried out to investigate the effect of oral administration of aqueous and alcoholic extract of Allium sativum (Garlic) on testicular function in male mice exposed to lead acetate. Sixty adult (7-8) weeks old male mice were divided into six groups (10 micegroup), first and second group were administered with 150mgkg body weight BWday of aqueous and alcoholic extract of plant respectively. However, the third group was treated with 100 mgkgBWday of lead acetate. While the fourth and fifth groups were administered with 150 mgkgBWday. Of aqueous and alcoholic extract combination with 100 gmkg. BW of lead acetate. The sixth group treated with distilled water and served as control group throughout five weeks. At the end of experiment, treated animals were sacrificed and sperm were collected from caudal epidydymis to use for following tests: sperm concentration, motility, deadalive sperm and morphological abnormalities. Serum was isolated to assay for the analysis of, FSH, LH and testosterone level. The results showed a significant increase in sperm concentration, motility and decrease in dead and abnormal sperm in the group treated with aqueous and alcoholic extract of Allium sativum. However, the results showed decrease in sperm concentration, motility and increase in dead and abnormal sperm in the group treated with lead acetate. The other groups of animals groups treated with aqueous and alcoholic extract combination with lead acetate showed improvement in sperm concentration and motility compared to that treated with lead acetate The FSH, LH and testosterone level significantly increased in treated groups with aqueous and alcoholic extract of plant compared to group treated with lead acetate. It's concluded that aqueous and alcoholic extract of Allium sativum were significantly improved fertility in treated medicine compared to animals treated with lead acetate.

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

1859: The Histone Deycetylase Inhibitor Trichostatin-a Arrests Meiosis in Male Mice

2007 ◽  
Vol 177 (4S) ◽  
pp. 617-617
Author(s):  
Klaus Steger ◽  
Irina Fenic ◽  
Hamid M. Hossain ◽  
Violetta Sonnack ◽  
Svetlin Tchatalbachev ◽  
...  
Keyword(s):  
Trichostatin A ◽  
Male Mice

1625: Role of Estrogen Receptor β in the Regulation of Sexual Behavior in Male Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 429-429
Author(s):  
Masayoshi Nomura ◽  
Naohiro Fujimoto ◽  
Donald W. Pfaff ◽  
Sonoko Ogawa ◽  
Tetsuro Matsumoto
Keyword(s):  
Estrogen Receptor ◽  
Sexual Behavior ◽  
Estrogen Receptor Β ◽  
Male Mice
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