Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced  Obese Rats

Obesity is considered a disease of the century and several treatment methods have been researched. Traditional Chinese medicine describes several findings that can be used to treat this disease. Thus, the aim of the present study was to evaluate, from an experimental perspective of Western medicine, the biochemical and behavioral effects of pharmacopuncture (21 and 40) in obese Wistar rats. The HDP21 group, treated with pharmacopuncture, exhibited a reduction in body weight compared to controls, who were also fed a high-calorie diet. In the eating behavior test, the latency was lower in the HDP40 group, and in this group, animals consumed with a higher number of cereals compared to other obese groups, or with suggestions of high acupuncture or appetite in this group. The HDP21 group, on the other hand, exhibited the shortest time in closed arms when compared to the other groups, suggesting a reduction in anxiety. Regarding the perirenal fat weight and abdominal postmortem of groups fed a high calorie diet, the HDP21 group had the lowest weight of perirenal fat and abdominal fat compared to the others. Similarly, a reduction in cholesterol, triglyceride and glucose levels was observed in the HDP21 group compared to other groups that received a high calorie diet. In conclusion, the present study demonstrated the effectiveness of the pharmacopuncture that uses bee venom in ST21 with weight loss in obese rats, as well as the reduction in biochemical tests and with loss of anxiety.

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Influence of Fat Burners and Functional Foods on Lipid Profile of Obese Rats

Basic and Applied Sciences - Scientific Journal of King Faisal University ◽

10.37575/b/agr/0033 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Haneen Jadir ◽

Mohammed Jassim ◽

Feryal Hussein

Keyword(s):

Functional Foods ◽

Positive Control ◽

Low Density Lipoproteins ◽

Sprague Dawley ◽

Control Groups ◽

Sprague Dawley Rats ◽

Obese Rats ◽

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

This study was designed to identify the effects of certain fat burners and functional foods on lipid profiles including total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL-C), and antioxidants such as glutathione peroxidase (GPx) and malondialdehyde (MDA) in adult male Sprague–Dawley rats. The rats were separated into seven groups, each group containing six rats. Both the (T1) negative and (T2) positive control groups and the five other groups were fed with a high-calorie diet to achieve obesity. After the end of the feeding period, over 56 days the rats were treated with Orlistat 0.3mg/g (T3), C4 RIPPED 1.2 mg/g (T4), Garcinia Herb 0.5 mg/g (T5), Ispaghula Herb 0.02g/g (T6), and Functional Yoghurt 1ml (T7). The results showed significantly increased (p≤0.05) cholesterol in the serum of T2 rats compared with T1 rats. Transactions with T3, T4, T5, T6, and T7 rats led to a significant decrease in TC. There was a significant increase in TG and LDL-C in T2 rats compared with T1 rats; a significant decrease occurred in the serum of the animals treated in groups T3, T4, T5, T6, T7 and T7. Rats in groups T3, T5, T6, and T7 showed increased GPx and decreased MDA compared with T1 and T4.

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Effects of low glycemic index/high-fat, high-calorie diet compared to the high-fat, high-calorie diet on glycemic control, lipid profile, and inflammatory markers in children and adolescence with cystic fibrosis: A study protocol for a randomized double-blind controlled clinical trial

10.21203/rs.2.16168/v1 ◽

2019 ◽

Author(s):

Zahra Gorji ◽

Mohammadreza Modaresi ◽

Saeed Yekanni-Nejad ◽

Maryam Mahmoudi

Keyword(s):

Cystic Fibrosis ◽

Lipid Profile ◽

Glycemic Index ◽

Inflammatory Markers ◽

High Fat ◽

Calorie Diet ◽

Children And Adolescence ◽

High Calorie Diet ◽

High Calorie ◽

Low Glycemic Index

Abstract Background: Inflammation plays an important role in pathogenesis of cystic fibrosis, and diet is considered as an effective factor in controlling inflammation. Low glycemic index diet seems to be effective for improving glycemic control and reducing the inflammation and lipid profile. Hence, this study was planned to compare the effects of a low glycemic index/high fat, high calorie diet with the high fat, high calorie diet on glycemic status, lipid profile, and inflammatory markers in patients with cystic fibrosis. Methods: A total of 60 children and adolescence with cystic fibrosis will be randomized to receive a high fat, high calorie diet (n=30) or low glycemic index/high fat, high calorie diet (n=30) with similar calorie and macronutrients composition, for three months. Patients in high fat, high calorie diet arm will be able to use all sources of carbohydrates with different glycaemic indices; while those in another arm will be received their carbohydrate from low glycemic index sources. Before and after the intervention, serum levels of lipid profile (triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol), insulin, glucose, HbA1c, the homeostasis model assessment-estimated insulin resistance index, and some inflammatory markers (IL-6, IL-10, IL-17A, and IFNγ) will be measured. Discussion: To our knowledge, this study will be the first to examine the effects of a low glycemic index/high fat, high calorie diet compared to the high fat, high calorie diet in cystic fibrosis patients. The findings of this study might provide evidence to improve the nutritional status and immune system as well as to prevent the disease complications in these patients.

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Treat CF-Related Diabetes With Insulin, High-Calorie Diet

Pediatric News ◽

10.1016/s0031-398x(06)71279-6 ◽

2006 ◽

Vol 40 (9) ◽

pp. 9

Author(s):

BRUCE JANCIN

Keyword(s):

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

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The evaluation of lipid peroxidation and oxidative modification of proteins in blood serum under obesity development and the consumption of aqueous kidney beans Phaseolus vulgaris pods extract

Current Issues in Pharmacy and Medical Sciences ◽

10.2478/cipms-2020-0008 ◽

2020 ◽

Vol 33 (1) ◽

pp. 38-44

Author(s):

Alona Yurchenko ◽

Daryna Krenytska ◽

Olexii Savchuk ◽

Tetiana Halenova ◽

Natalia Raksha ◽

...

Keyword(s):

Lipid Peroxidation ◽

Oxidative Modification ◽

Resistance Development ◽

Oxidative Modification Of Proteins ◽

Kidney Beans ◽

Calorie Diet ◽

Diet Control ◽

High Calorie Diet ◽

High Calorie

AbstractOur interest has focused on the investigation of the anti-obese potential of kidney beans (P. vulgaris) pods extract. In the course of the study, obesity development in rats was induced with high-calorie diet. Control and obese rats then have consumed with aqueous kidney beans (P. vulgaris) pods extract during 6 weeks (200 mg/kg). Results show that the long-term consumption of P. vulgaris pods extract can lead to the reduction of hyperglycemia and insulin resistance development. Furthermore, we saw a normalization of lipid peroxidation parameters and oxidative modification of protein due to the consumption of the kidney beans (P. vulgaris) pods extract. Our experimental data demonstrate the ability of the kidney beans (P. vulgaris) pod extracts to mitigate obesity development but the details of this mechanism remains to be not fully understood.

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