The Role of Oliguria and the Absence of Fluid Administration and Balance Information in Illness Severity Scores

Pathogenic mechanisms relevant to rheumatoid arthritis occur in the mouse model of collagen-induced arthritis (CIA). Cytosolic phospholipase A2α (cPLA2α) releases arachidonic acid from cell membranes to initiate the production of prostaglandins and leukotrienes. These inflammatory mediators have been implicated in the development of CIA. To test the hypothesis that cPLA2α plays a key role in the development of CIA, we backcrossed cPLA2α-deficient mice on the DBA/1LacJ background that is susceptible to CIA. The disease severity scores and the incidence of disease were markedly reduced in cPLA2α-deficient mice compared with wild-type littermates. At completion of the study, >90% of the wild-type mice had developed disease whereas none of the cPLA2α-deficient mice had more than one digit inflamed. Furthermore, visual disease scores correlated with severity of disease determined histologically. Pannus formation, articular fibrillation, and ankylosis were all dramatically reduced in the cPLA2α-deficient mice. Although the disease scores differed significantly between cPLA2α mutant and wild-type mice, anti-collagen antibody levels were similar in the wild-type mice and mutant littermates. These data demonstrate the critical role of cPLA2α in the pathogenesis of CIA.

Download Full-text

Do we really ponder about necessity of intravenous hydration in acute bronchiolitis?

Colombia Medica ◽

10.25100/cm.v47i1.1933 ◽

2016 ◽

pp. 21-24

Author(s):

Şule Yıldırım ◽

Nazan Kaymaz ◽

Naci Topaloğlu ◽

Fatih Köksal Binnetoğlu ◽

Mustafa Tekin ◽

...

Keyword(s):

Length Of Stay ◽

Acute Bronchiolitis ◽

Retrospective Case ◽

Short Acting ◽

Severity Scores ◽

Significant Difference ◽

Intravenous Hydration ◽

Β2 Agonist ◽

Control Study

Objective: The goal was to establish the role of intravenous hydration therapy on mild bronchiolitis. Methods: This was a retrospective case control study. Infants between 1 month and 2 years of age admitted to our general pediatrics ward between June 2012 and June 2013 with a diagnosis of uncomplicated acute bronchiolitis were enrolled to the study. Hospital medical files were reviewed to get information about children personal history, symptoms of the disease, disease severity scores and their management. Patients were classified into 4 groups according to the management; nebulized short-acting β2-agonist (salbutamol) +hydration; nebulized short-acting β2-agonist (salbutamol); hydration and neither bronchodilator nor hydration. We examined length of stay in the hospital as an outcome measure. Results: A total of 94 infants were studied. There was no significant difference between groups in terms of length of stay in hospital. Conclusions: IV hydration is not effective on length of stay in hospital in mild acute bronchiolitis patients.

Download Full-text

Severity evaluation in acute pancreatitis: the role of SOFA score and general severity scores

Critical Care ◽

10.1186/cc961 ◽

2000 ◽

Vol 4 (Suppl 1) ◽

pp. P242 ◽

Cited By ~ 1

Author(s):

R Matos ◽

R Moreno ◽

T Fevereiro

Keyword(s):

Acute Pancreatitis ◽

Sofa Score ◽

Severity Scores

Download Full-text

Relationship of Illness Severity with Health and Life Satisfaction in Patients with Cardiovascular Disease: The Mediating Role of Self-efficacy Beliefs and Illness Perceptions

Journal of Happiness Studies ◽

10.1007/s10902-012-9397-4 ◽

2012 ◽

Vol 14 (5) ◽

pp. 1585-1599 ◽

Cited By ~ 11

Author(s):

P. Steca ◽

A. Greco ◽

M. D’Addario ◽

D. Monzani ◽

R. Pozzi ◽

...

Keyword(s):

Cardiovascular Disease ◽

Life Satisfaction ◽

Self Efficacy ◽

Illness Perceptions ◽

Efficacy Beliefs ◽

Illness Severity ◽

Mediating Role ◽

Relationship Of

Download Full-text

Advanced oxidation protein products in serum of patients with myotonic disease type I: association with serum γ-glutamyltransferase and disease severity

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2005.127 ◽

2005 ◽

Vol 43 (7) ◽

Cited By ~ 8

Author(s):

Gabriele Siciliano ◽

Livia Pasquali ◽

Anna Rocchi ◽

Michela Falorni ◽

Fabio Galluzzi ◽

...

Keyword(s):

Oxidative Stress ◽

Characteristic Curve ◽

Advanced Oxidation ◽

Clinical Severity ◽

Total Serum ◽

Type I ◽

Advanced Oxidation Protein Products ◽

Severity Scores

AbstractSteinert's disease (myotonic dystrophy type 1; MD) is caused by a CTG trinucleotide expansion on 19q13.3. Although the pathogenic mechanism underlying multisystem involvement in MD is still unclear, a role of oxidative stress in this disease has been suggested. We investigated 39 MD patients to assess the plasma concentration of advanced oxidation protein products (AOPPs) and γ-glutamyltransferase (GGT) and related them to clinical severity scores. Plasma AOPP levels (p=0.021), total serum GGT activity (p=0.0005) and GGT activity associated with low-density lipoprotein (p=0.0021) were significantly higher in patients than in controls. There was significant correlation between serum GGT levels and AOPPs (r=0.5831; p=0.0022). A statistically significant increase in serum GGT with age was found in MD patients (p=0.0193). Receiver operating characteristic curve analysis showed that higher AOPP levels were significantly associated with extra-muscular signs of the disease, i.e., cataracts and heart involvement (area under the curve±SE=0.908±0.083), but not with muscular involvement. The concomitant increment in GGT and AOPPs indicates a possible role of oxidative stress in the pathogenesis of MD type 1, while the association of increased AOPP levels with extra-muscular signs of the disease suggests that individual susceptibility to oxidative stress can modulate the extra-muscular phenotype of the disease.

Download Full-text

Serotonin–norepinephrine reuptake inhibitors for the prevention of migraine and vestibular migraine: a systematic review and meta-analysis

Regional Anesthesia and Pain Medicine ◽

10.1136/rapm-2019-101207 ◽

2020 ◽

Vol 45 (5) ◽

pp. 323-330 ◽

Cited By ~ 4

Author(s):

Fengzhi Wang ◽

Jiaoqi Wang ◽

Yumeng Cao ◽

Zhongxin Xu

Keyword(s):

Weighted Mean Difference ◽

Meta Analysis ◽

Mean Difference ◽

Vestibular Migraine ◽

Cochrane Library ◽

Severity Scores ◽

Significant Difference ◽

Norepinephrine Reuptake ◽

Better Than

Background and objectivesThe role of serotonin–norepinephrine reuptake inhibitors (SNRIs) in migraine prophylaxis has not been completely established. Current treatments for vestibular migraine (VM) are based on scarce evidence. We aimed to perform an updated review focusing on the efficacy and tolerability of SNRIs for migraine and VM prevention.MethodsWe searched the PubMed, Web of Science, and Cochrane Library databases for relevant studies. The primary outcome was migraine frequency. In the case of VM, the Dizziness Handicap Inventory (DHI) scores and Vertigo Severity Scores (VSSs) were extracted.ResultsSix randomized controlled trials involving 418 patients were analyzed. Patients receiving SNRIs had fewer migraine days than those receiving a placebo (standardized mean difference −0.38, 95% CI −0.76 to −0.01, p=0.04). The effects of SNRIs and other active drugs were comparable. In patients with VM, venlafaxine had a significant advantage over other active drugs in decreasing the VSS (weighted mean difference (MD) −1.45, 95% CI −2.11 to −0.78, p<0.0001) and the emotional domain score of the DHI (MD −2.64, 95% CI −4.97 to −0.31, p=0.03). We found no significant difference in the rate of withdrawals due to any reason or withdrawals due to side effects between SNRIs and active drugs and between SNRIs and a placebo.ConclusionsSNRIs were clinically safe and effective for migraine and VM prophylaxis, were better than a placebo, and not inferior to other active drugs. SNRIs may be a preferable choice for patients with VM with psychiatric disorders.

Download Full-text

Angiopoietin 2 Levels in the Risk Stratification and Mortality Outcome Prediction of Sepsis-Associated Coagulopathy

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029618786029 ◽

2018 ◽

Vol 24 (8) ◽

pp. 1223-1233 ◽

Cited By ~ 4

Author(s):

Stephen Statz ◽

Giselle Sabal ◽

Amanda Walborn ◽

Mark Williams ◽

Debra Hoppensteadt ◽

...

Keyword(s):

Plasma Levels ◽

Predictive Biomarker ◽

Illness Severity ◽

Assay Method ◽

Enzyme Linked Immunosorbent Assay ◽

Icu Admission ◽

Severity Scores ◽

Mortality Outcome ◽

Clinical Illness ◽

Angiopoietin 2

It has been well established that angiopoietin 2 (Ang-2), a glycoprotein involved in activation of the endothelium, plays an integral role in the pathophysiology of sepsis and many other inflammatory conditions. However, the role of Ang-2 in sepsis-associated coagulopathy (SAC) specifically has not been defined. The aim of this study was to measure Ang-2 plasma levels in patients with sepsis and suspected disseminated intravascular coagulation (DIC) in order to demonstrate its predictive value in SAC severity determination and 28-day mortality outcome. Plasma samples were collected from 102 patients with sepsis and suspected DIC at intensive care unit (ICU) admission. The Ang-2 plasma levels were quantified using a sandwich enzyme-linked immunosorbent assay method. The International Society on Thrombosis and Haemostasis DIC scoring system was used to compare the accuracy of Ang-2 levels versus clinical illness severity scores in predicting SAC severity. Mean Ang-2 levels in patients with sepsis and DIC were significantly higher in comparison to healthy controls ( P < 0.0001), and median Ang-2 levels showed a downward trend over time ( P = 0.0008). Baseline Ang-2 levels and clinical illness severity scores were higher with increasing severity of disease, and Ang-2 was a better predictor of DIC severity than clinical illness scores. This study demonstrates that Ang-2 levels are significantly upregulated in SAC, and this biomarker can be used to risk stratify patients with sepsis into non-overt DIC and overt DIC. Furthermore, the Ang-2 level at ICU admission in a patient with sepsis and suspected DIC may provide a predictive biomarker for mortality outcome.

Download Full-text