scholarly journals Comparing BST-CarGel® with Hyalofast for the Treatment of Hyaline Cartilage Defects

2021 ◽  
Vol 37 (4) ◽  
pp. 217-222
Author(s):  
Kürşad Aytekin ◽  
Cem Zeki Esenyel
Keyword(s):  
Hyaline Cartilage ◽  
Cartilage Defects

Knee Arthrography

2019 ◽  
pp. 158-159
Author(s):  
Matthew DelGiudice
Keyword(s):  
Clinical Practice ◽  
Hyaline Cartilage ◽  
Cruciate Ligament ◽  
Cartilage Defects ◽  
Osteochondral Lesions ◽  
Imaging Findings ◽  
Younger Patients ◽  
Osteochondral Injuries ◽  
Knee Arthrography

Chapter 102 describes indications, technique, and imaging findings of knee arthrography. Knee arthrography is selectively performed in clinical practice for MRA, typically in younger patients. Indications include evaluation for meniscal re-tear after prior repair, osteochondral injuries, and therapeutic injections (most commonly steroid). Extension of intraarticular contrast into the meniscal substance indicates a tear or re-tear. Abnormal course of the cruciate ligament fibers indicates a tear. Contrast undermines unstable osteochondral lesions and extends into the hyaline cartilage defects. Complications are rare but include infection and bleeding.

scholarly journals CELL TECHNOLOGIES AND TISSUE ENGINEERING IN THE TREATMENTOF ARTICULAR CHONDRAL DEFECTS

2013 ◽  
Vol 4 (1) ◽  
pp. 52-66 ◽  
Author(s):  
N N Sovetnikov ◽  
V A Kalsin ◽  
M A Konoplyannikov ◽  
V V Mukhanov
Keyword(s):  
Tissue Engineering ◽  
Surgical Repair ◽  
Hyaline Cartilage ◽  
Cartilage Defects ◽  
Review Of Literature ◽  
Cell Technology ◽  
Chondral Defects ◽  
Cell Technologies ◽  
Cartilage Biology ◽  
Repair Techniques

A review of literature considers the problem of hyaline cartilage biology and repair following by injury, and surgical repair of cartilage defects. Repair techniques based on direct cartilage substitution (mosaicplasty, osteochondral allotransplantation, minced cartilage autotransplantation in gel), bone morrow stimulation techniques (abrasion, drilling, microfracture, matrix-induced chondrogenesis) were characterized in terms of biology and clinics. Most attention was addressed to cell technology and tissue engineering.

scholarly journals MODERN TRENDS IN THE TREATMENT OF FOCAL CARTILAGE DEFECTS OF THE KNEE

2020 ◽  
pp. 65-72
Author(s):  
K. A. Egiazaryan ◽  
G. D. Lazishvili ◽  
A. P. Ratyev ◽  
I. V. Sirotin ◽  
A. B. But-Gusaim ◽  
...  
Keyword(s):  
Knee Joint ◽  
Treatment Outcomes ◽  
Hyaline Cartilage ◽  
Current Trend ◽  
Cartilage Defects ◽  
Operation Technique ◽  
Treatment Results ◽  
High Quality ◽  
Collagen Membranes ◽  
Femoral Condyles

The article is devoted to the current trend of modern orthopedics – the surgical treatment of local full-thickness defects in the hyaline cartilage of the knee joint. This pathology is diagnosed in 5-10% of patients with diseases and injuries of the knee joint.Materials and methods: The authors of the article presented one of the most modern and available technologies for the restoration of cartilage defects – the technology of matrix-induced autochondrogenesis (AMIC – autologous matrix-induced chondrogenesis). This operation technique was used in 63 patients. The article presents the indications and technique of surgery, considers possible errors, complications, criteria for evaluating treatment outcomes.Results: treatment outcomes in terms of up to 13 years were studied in 56 patients. Good treatment results were observed in 53 patients. In all cases, high-quality and regeneration of the cartilaginous surface of the femoral condyles was achieved.Conclusion: Analysis of the outcomes of treatment of patients after implantation of collagen membranes in various modifications allows the authors of the article to recommend this technique for widespread use in clinical practice.

scholarly journals Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration

2019 ◽  
Vol 21 (1) ◽  
pp. 149 ◽  
Author(s):  
Eriko Toyoda ◽  
Masato Sato ◽  
Takumi Takahashi ◽  
Miki Maehara ◽  
Eri Okada ◽  
...  
Keyword(s):  
Hyaline Cartilage ◽  
Skeletal Development ◽  
Enrichment Analysis ◽  
Cartilage Regeneration ◽  
Dna Aptamer ◽  
Cartilage Defects ◽  
Expression Of Genes ◽  
Xenogeneic Transplantation ◽  
Potential Mode ◽  
Proteomic Analyses

Chondrocyte sheet transplantation is a novel and promising approach to treating patients who have cartilage defects associated with osteoarthritis. Hyaline cartilage regeneration by autologous chondrocyte sheets has already been demonstrated in clinical research. In this study, the efficacy of polydactyly-derived chondrocyte sheets (PD sheets) as an allogeneic alternative to standard chondrocyte sheets was examined using an orthotopic xenogeneic transplantation model. In addition, the expression of genes and the secreted proteins in the PD sheets was analyzed using a microarray and a DNA aptamer array. The efficacy of PD sheets with respect to cartilage defects was assessed using histological scores, after which the expressions of genes and proteins exhibiting a correlation to efficacy were identified. Enrichment analysis of efficacy-correlated genes and proteins showed that they were associated with extracellular matrices, skeletal development, and angiogenesis. Eight genes (ESM1, GREM1, SERPINA3, DKK1, MIA, NTN4, FABP3, and PDGFA) exhibited a positive correlation with the efficacy of PD sheets, and three genes (RARRES2, APOE, and PGF) showed a negative correlation for both transcriptomic and proteomic analyses. Among these, MIA, DKK1, and GREM1 involved in skeletal development pathways and ESM1 involved in the angiogenesis pathway exhibited a correlation between the amount of secretion and efficacy. These results suggest that these secreted factors may prove useful for predicting PD sheet efficacy and may therefore contribute to hyaline cartilage regeneration via PD sheets.

scholarly journals Key parameters of autologous biomedical product for cartilage tissue repair

2020 ◽  
Author(s):  
AV Eremeev ◽  
OA Zubkova ◽  
ES Ruchko ◽  
MA Lagarkova ◽  
VS Sidorov ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Hyaline Cartilage ◽  
Normal Function ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Pharmaceutical Drugs ◽  
Cell Product ◽  
Basic Parameters ◽  
Basic Characteristics ◽  
Registration Dossier

Repair of cartilage defects associated with injury or pathology is a clinically relevant problem. Chondral tissue, especially articular cartilages, has a poor regenerative potential. Inflammation triggers the growth of connective tissue, which cannot exert the normal function of the hyaline cartilage. This contributes to the progression of the pathology and eventually raises the need for surgery. At present, there are no pharmaceutical drugs capable of restoring the damaged cartilage. However, advances in cell-based technology hold promise for regenerative medicine. Reports describing fabrication of autologous cartilage transplants pose a special interest. A registration dossier of a biomedical cell product must contain the product’s specifications, presenting the basic characteristics of the product that can be used to assess its quality. This review looks at a few basic parameters that can be used to verify the authenticity of the cell product derived from autologous chondrocytes and describe its specifications.

scholarly journals Assessment of modern chondroplasty methods using for knee hyaline cartilage defects treatment

2008 ◽  
Vol 0 (6) ◽  
pp. 82
Author(s):  
A A Stadnikov ◽  
G M Kavalersky ◽  
S. K. Arlupov ◽  
Y P Pavlov ◽  
S A Makarov ◽  
...  
Keyword(s):  
Hyaline Cartilage ◽  
Cartilage Defects

scholarly journals Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage

2020 ◽  
Author(s):  
Zelong Dou ◽  
Daniel Muder ◽  
Marta Baroncelli ◽  
Ameya Bendre ◽  
Alexandra Gkourogianni ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Subchondral Bone ◽  
Fluorescent Protein ◽  
Bone Marrow Cells ◽  
Hyaline Cartilage ◽  
Cartilage Defects ◽  
Trochlear Groove ◽  
Post Surgery ◽  
Articular Cartilage Defects

AbstractReconstruction of articular surfaces destroyed by infection or trauma is hampered by the lack of suitable graft tissues. Perichondrium autotransplants have been used for this purpose. However, the role of the transplanted perichondrium in the healing of resurfaced joints have not been investigated. Perichondrial and periosteal tissues were harvested from rats hemizygous for a ubiquitously expressed enhanced green fluorescent protein (EGFP) transgene and transplanted into full-thickness articular cartilage defects at the trochlear groove of distal femur in wild-type littermates. As an additional control, cartilage defects were left without a transplant (no transplant control). Distal femurs were collected 3, 14, 56, 112 days after surgery. Transplanted cells and their progenies were readily detected in the defects of perichondrium and periosteum transplanted animals but not in defects left without a transplant. Perichondrium transplants expressed SOX9 and with time differentiated into a hyaline cartilage that expanded and filled out the defects with Col2a1-positive chondrocytes and a matrix rich in proteoglycans. Interestingly, at later timepoints the cartilaginous perichondrium transplants were actively remodeled into bone at the transplant-bone interface and at post-surgery day 112 EGFP-positive perichondrium cells at the articular surface were positive for Prg4. In addition, both perichondrium and periosteum transplants contributed cells to the subchondral bone and bone marrow, suggesting differentiation into osteoblast/osteocytes as well as bone marrow cells. In summary, we found that perichondrium transplanted to articular cartilage defects develops into an articular-like, hyaline cartilage that integrates with the subchondral bone, and is maintained for an extended time. The findings indicate that perichondrium is a suitable tissue for repair and engineering of articular cartilage.

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