Neutrophil-lymphocyte Ratio and Serum Ferritin, Folate, Vitamin B12 and 25-hydroxyvitamin D Levels in Children and Adolescents with Primary Headaches

AbstractBackgroundLimited data exist on the vitamin D status in Fontan patients. We determined the prevalence and potential risk factors of vitamin D deficiency in this patient subset.Methods and resultsData were collected from 27 Fontan patients (55.6% male, mean age 8.1±5.3 years). Protein-losing enteropathy was diagnosed in six patients (22.2%). Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level of <20 ng/ml. The neutrophil-to-lymphocyte ratio, a marker of systemic inflammation, was calculated. Associations between laboratory measurements and patient characteristics were explored. Mean serum 25-hydroxyvitamin D level was 14.1±10.4 ng/ml. Vitamin D deficiency was found in 19/27 patients (70.3%). Only skin type was associated with vitamin D deficiency (p=0.04). Hyperparathyroidism was present in 5/21 (23.8%) patients, and was more prevalent in patients with protein-losing enteropathy (p<0.001). Parathyroid hormone levels correlated with parameters of systemic inflammation (neutrophil-to-lymphocyte ratio: r=0.484, p=0.026; relative lymphocyte count: r=−0.635, p=0.002). Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D levels (p<0.0001), and was accompanied by a reduction in parathyroid hormone concentrations (p=0.032).ConclusionsA high prevalence of vitamin D deficiency was found among Fontan patients, independent of age, time after Fontan procedure, ventricular morphology, and presence of protein-losing enteropathy. A potentially important link between parathyroid hormone levels and systemic inflammation is suggested.

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Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents

American Journal of Clinical Nutrition ◽

10.1093/ajcn/86.1.150 ◽

2007 ◽

Vol 86 (1) ◽

pp. 150-158 ◽

Cited By ~ 164

Author(s):

Francis L Weng ◽

Justine Shults ◽

Mary B Leonard ◽

Virginia A Stallings ◽

Babette S Zemel

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Healthy Children ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Serum

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Serum 25-Hydroxyvitamin D Level and Influenza Vaccine Immunogenicity in Children and Adolescents

PLoS ONE ◽

10.1371/journal.pone.0083553 ◽

2014 ◽

Vol 9 (1) ◽

pp. e83553 ◽

Cited By ~ 19

Author(s):

Michelle Science ◽

Jonathon L. Maguire ◽

Margaret L. Russell ◽

Marek Smieja ◽

Stephen D. Walter ◽

...

Keyword(s):

Influenza Vaccine ◽

Children And Adolescents ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Vaccine Immunogenicity

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Effect of Bimonthly Supplementation With Oral Cholecalciferol on Serum 25-Hydroxyvitamin D Concentrations in HIV-Infected Children and Adolescents

PEDIATRICS ◽

10.1542/peds.2008-0176 ◽

2009 ◽

Vol 123 (1) ◽

pp. e121-e126 ◽

Cited By ~ 69

Author(s):

S. M. Arpadi ◽

D. McMahon ◽

E. J. Abrams ◽

M. Bamji ◽

M. Purswani ◽

...

Keyword(s):

Children And Adolescents ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Effect of Vitamin D Replacement on Hemoglobin Concentration in Subjects with Concurrent Iron-Deficiency Anemia and Vitamin D Deficiency: A Randomized, Single-Blinded, Placebo-Controlled Trial

Acta Haematologica ◽

10.1159/000357104 ◽

2014 ◽

Vol 133 (1) ◽

pp. 31-35 ◽

Cited By ~ 16

Author(s):

Basavraj Sooragonda ◽

Sanjay Kumar Bhadada ◽

Viral N. Shah ◽

Pankaj Malhotra ◽

Jasmina Ahluwalia ◽

...

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Controlled Trial ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Hb Concentration

Background: The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. Methods: We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum ferritin <15 µg/l) were randomized to an intervention arm (cholecalciferol, i.e. vitamin D3, 0.6 million units i.m. once) or placebo. In all subjects, iron deficiency was corrected with parental iron. Other causes of anemia were excluded with appropriate investigation. The primary end point was a rise in Hb concentration. Results: Baseline parameters of age, BMI, hemogram values and levels of serum ferritin, 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) were similar in the 2 arms. Twelve weeks after vitamin D replacement, there was a significant increase in 25 (OH)D levels (57.7 ± 20.5 vs. 14.1 ± 6.2 ng/ml, p < 0.0001) and a decrease in PTH levels (32.4 ± 16.4 vs. 52.9 ± 18.4 pg/ml, p = 0.003) in subjects in the intervention arm when compared to the placebo arm. However, the increments in serum ferritin and Hb concentration in the intervention and placebo arm did not differ. Conclusion: Vitamin D replacement in subjects with iron-deficiency anemia after iron correction does not improve Hb concentration further.

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Correlation Between Serum 25-Hydroxyvitamin D Levels and Allergic Rhinitis in Children and Adolescents in Korea

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2014.12.1823 ◽

2015 ◽

Vol 135 (2) ◽

pp. AB270 ◽

Cited By ~ 2

Author(s):

Seo Hee Yoon ◽

Yoon Hee Kim ◽

Young A. Park ◽

In Suk Sol ◽

Min Jung Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Children And Adolescents ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Comparison of Neutrophil / Lymphocyte Ratio, Vitamin B12 and Vitamin D Levels in Patients With Fibromyalgia and Myofascial Pain Syndrome

Kocaeli Medical Journal ◽

10.5505/ktd.2021.10437 ◽

2021 ◽

Vol 10 (1) ◽

pp. 1-6

Author(s):

Kağan Özkuk ◽

Bilal Uysal

Keyword(s):

Vitamin D ◽

Vitamin B12 ◽

Myofascial Pain ◽

Pain Syndrome ◽

Myofascial Pain Syndrome ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Vitamin D Levels

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A Case-control Study of Urinary Tract Infection, 25‑hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses

Research in Molecular Medicine ◽

10.32598/rmm.9.1.6 ◽

2021 ◽

Vol 9 (1) ◽

pp. 51-60

Author(s):

Leila Pirdel ◽

◽

Manijeh Pirdel ◽

Keyword(s):

Vitamin D ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Case Control ◽

Hematological Indices ◽

Lymphocyte Ratio ◽

Hydroxyvitamin D ◽

Tnf Α ◽

25 Hydroxyvitamin D ◽

Ifn Γ

Background: Vitamin D plays a key role in the modulation of numerous immune functions against infectious agents. We aimed to explore the association between serum 25‑hydroxyvitamin D (25[OH] D) levels and cytokine responses, along with hematological changes, in patients with urinary tract infection (UTI). Materials and Methods: Vitamin D level, cytokines (interferon [IFN]−γ, interleukin [IL]−4, IL−6, IL–10, IL−17A, tumor necrosis factor [TNF]−α, and transforming growth factor [TGF]−β), hematological indices (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], neutrophil-to-monocyte ratio [NMR], platelet-to-lymphocyte ratio [PLR], and mean platelet volume [MPV]), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated in a case-control human study included 65 patients and 45 controls. Results: Among the enhanced cytokine levels in patients, the cytokines IFN-γ, IL-17A, and IL-10 had a significant association with 25(OH)D, but not IL-6, TNF-α, and TGF-β. The IL-4 levels remained unchanged. By comparing hematological indices, we found the association of increased NLR and MLR with 25(OH)D and the cytokines IFN-γ and IL-17A, along with a decrease in the PLR without showing such an association. The NMR did not show any significant difference. The platelet count showed an association with IL-6, IL-17A, and TGF-β, but the association of MPV with 25(OH)D was significant. The ESR results exhibited statistically non-significant differences. CRP elevation was directly associated with IL-6 and IL-17A, but not with 25(OH)D. Conclusion: 25(OH)D-mediated inflammatory cytokine milieu might alter the proportion and function of peripheral blood cells in a regulated manner to support bacterial clearance which needs further studies to be validated.

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