scholarly journals A Case-control Study of Urinary Tract Infection, 25‑hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses

2021 ◽  
Vol 9 (1) ◽  
pp. 51-60
Author(s):  
Leila Pirdel ◽  
◽  
Manijeh Pirdel ◽  
Keyword(s):  
Vitamin D ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Case Control ◽  
Hematological Indices ◽  
Lymphocyte Ratio ◽  
Hydroxyvitamin D ◽  
Tnf Α ◽  
25 Hydroxyvitamin D ◽  
Ifn Γ

Background: Vitamin D plays a key role in the modulation of numerous immune functions against infectious agents. We aimed to explore the association between serum 25‑hydroxyvitamin D (25[OH] D) levels and cytokine responses, along with hematological changes, in patients with urinary tract infection (UTI). Materials and Methods: Vitamin D level, cytokines (interferon [IFN]−γ, interleukin [IL]−4, IL−6, IL–10, IL−17A, tumor necrosis factor [TNF]−α, and transforming growth factor [TGF]−β), hematological indices (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], neutrophil-to-monocyte ratio [NMR], platelet-to-lymphocyte ratio [PLR], and mean platelet volume [MPV]), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated in a case-control human study included 65 patients and 45 controls. Results: Among the enhanced cytokine levels in patients, the cytokines IFN-γ, IL-17A, and IL-10 had a significant association with 25(OH)D, but not IL-6, TNF-α, and TGF-β. The IL-4 levels remained unchanged. By comparing hematological indices, we found the association of increased NLR and MLR with 25(OH)D and the cytokines IFN-γ and IL-17A, along with a decrease in the PLR without showing such an association. The NMR did not show any significant difference. The platelet count showed an association with IL-6, IL-17A, and TGF-β, but the association of MPV with 25(OH)D was significant. The ESR results exhibited statistically non-significant differences. CRP elevation was directly associated with IL-6 and IL-17A, but not with 25(OH)D. Conclusion: 25(OH)D-mediated inflammatory cytokine milieu might alter the proportion and function of peripheral blood cells in a regulated manner to support bacterial clearance which needs further studies to be validated.

scholarly journals Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection

2014 ◽  
Vol 112 (12) ◽  
pp. 1938-1943 ◽  
Author(s):  
Shalbha Tiwari ◽  
Daliparthy Devi Pratyush ◽  
Sanjeev Kumar Gupta ◽  
Surya Kumar Singh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Diabetic Foot ◽  
Inflammatory Cytokine ◽  
Diabetic Foot Infection ◽  
Hydroxyvitamin D ◽  
Severe Vitamin ◽  
Tnf Α ◽  
25 Hydroxyvitamin D ◽  
Ifn Γ

Vitamin D has been recognised as a potent immunomodulator and its deficiency is common in different population groups including patients with diabetic foot infection. Diabetic foot infection reflects the altered immune status of the host. As cytokine regulation plays a significant role in infection and wound-healing processes, the present study aimed to evaluate the association between vitamin D status and inflammatory cytokine profiles in patients with diabetic foot infection. The serum concentrations of vitamin D (25-hydroxyvitamin D), IL-1β, IL-6, TNF-α and interferon-γ (IFN-γ) were measured in 112 diabetic foot infection cases and 109 diabetic controls. Severe vitamin D deficiency (25-hydroxyvitamin D concentration < 25 nmol/l) was more common in cases than in controls (48·2v.20·5 %). Although age, duration of diabetes, HbA1C(glycosylated Hb) concentration and BMI were similar, cases had significantly higher concentrations of IL-6 (P≤ 0·001), IL-1β (P≤ 0·02) and TNF-α (P≤ 0·006) than controls. A significant negative correlation was also observed between 25-hydroxyvitamin D concentration and circulating concentrations of IL-1β (r− 0·323;P≤ 0·001) as well as IL-6 (r− 0·154;P≤ 0·04), but not between 25-hydroxyvitamin D and TNF-α and IFN-γ concentrations. Furthermore, a significant difference in IL-1β (P≤ 0·007) and IL-6 (P≤ 0·02) concentrations was observed in patients with severe 25-hydroxyvitamin D deficiency compared with patients with 25-hydroxyvitamin D concentration ≥ 25 nmol/l, and this difference was remarkable for TNF-α. In conclusion, severe vitamin D deficiency is associated with elevated inflammatory cytokine concentrations in diabetic patients, particularly in those with foot infection. A 25-hydroxyvitamin D concentration value < 25 nmol/l is suggested as the ‘cut-off’ for such immunological alterations in patients with diabetes mellitus.

scholarly journals Impact of Circulating Vitamin D Binding Protein Levels on the Association between 25-Hydroxyvitamin D and Pancreatic Cancer Risk: A Nested Case–Control Study

2012 ◽  
Vol 72 (5) ◽  
pp. 1190-1198 ◽  
Author(s):  
Stephanie J. Weinstein ◽  
Rachael Z. Stolzenberg-Solomon ◽  
William Kopp ◽  
Helen Rager ◽  
Jarmo Virtamo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
Protein Levels ◽  
25 Hydroxyvitamin D ◽  
Nested Case Control ◽  
Control Study

Low serum 25-hydroxyvitamin D levels and secondary hyperparathyroidism in Fontan patients

2015 ◽  
Vol 26 (5) ◽  
pp. 876-884 ◽  
Author(s):  
Finn Holler ◽  
Tobias Hannes ◽  
Ingo Germund ◽  
Mathias Emmel ◽  
Heike Hoyer-Kuhn ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Deficiency ◽  
Systemic Inflammation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Protein Losing Enteropathy ◽  
Lymphocyte Ratio ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Fontan Patients

AbstractBackgroundLimited data exist on the vitamin D status in Fontan patients. We determined the prevalence and potential risk factors of vitamin D deficiency in this patient subset.Methods and resultsData were collected from 27 Fontan patients (55.6% male, mean age 8.1±5.3 years). Protein-losing enteropathy was diagnosed in six patients (22.2%). Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level of <20 ng/ml. The neutrophil-to-lymphocyte ratio, a marker of systemic inflammation, was calculated. Associations between laboratory measurements and patient characteristics were explored. Mean serum 25-hydroxyvitamin D level was 14.1±10.4 ng/ml. Vitamin D deficiency was found in 19/27 patients (70.3%). Only skin type was associated with vitamin D deficiency (p=0.04). Hyperparathyroidism was present in 5/21 (23.8%) patients, and was more prevalent in patients with protein-losing enteropathy (p<0.001). Parathyroid hormone levels correlated with parameters of systemic inflammation (neutrophil-to-lymphocyte ratio: r=0.484, p=0.026; relative lymphocyte count: r=−0.635, p=0.002). Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D levels (p<0.0001), and was accompanied by a reduction in parathyroid hormone concentrations (p=0.032).ConclusionsA high prevalence of vitamin D deficiency was found among Fontan patients, independent of age, time after Fontan procedure, ventricular morphology, and presence of protein-losing enteropathy. A potentially important link between parathyroid hormone levels and systemic inflammation is suggested.

scholarly journals Circulating vitamin D–binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma: A case-control study

2017 ◽  
Vol 77 (3) ◽  
pp. 575-577 ◽  
Author(s):  
Cristián Navarrete-Dechent ◽  
Constanza del Puerto ◽  
Montserrat Molgó ◽  
Sergio González ◽  
Guillermo Pérez-Mateluna ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Binding Protein ◽  
Case Control ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Control Study

scholarly journals Low serum 25-hydroxyvitamin D level and risk of urinary tract infection in infants

Medicine ◽  
2016 ◽  
Vol 95 (27) ◽  
pp. e4137 ◽  
Author(s):  
Jianhuan Yang ◽  
Guangdao Chen ◽  
Dexuan Wang ◽  
Minguang Chen ◽  
Chao Xing ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Serum

Association of serum vitamin D levels and urinary tract infection in pregnant women: A case control study

2019 ◽  
Vol 243 ◽  
pp. 51-56
Author(s):  
Simin Haghdoost ◽  
Farzaneh Pazandeh ◽  
Soodabeh Darvish ◽  
Mehdi Khabazkhoob ◽  
Reinhard Huss ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Control Study

scholarly journals Serum 25-hydroxyvitamin D level in psoriasis patients: a case-control study

2019 ◽  
Vol 5 (1) ◽  
pp. 27
Author(s):  
Surinder Gupta ◽  
Preeti Garg ◽  
Nakul Gupta
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Treatment Resistance ◽  
Case Control ◽  
The Body ◽  
North India ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Differentiation And Proliferation ◽  
Control Study

<p class="abstract"><strong>Background:</strong> Sufficient level of vitamin D in blood is required for proper regulation of cell differentiation and proliferation. Unchecked proliferation of cells leads to various disease states. Vitamin D also has immunomodulatory effects in the body. Psoriasis is a chronic inflammatory and hyperproliferative disease with vitamin D having an impact on it. This case – control study was done to judge the levels of vitamin D in patients of psoriasis compared to age and sex matched controls.</p><p class="abstract"><strong>Methods:</strong> A case control study was conducted including 50 patients (35 females and 15 males) of chronic plaque psoriasis from dermatology outpatient department of Maharaja Agrasen Medical College (MAMC), Agroha, Haryana, representing patients from north India and 50 healthy controls. Both urban and rural background patients were included.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean serum 25-hydroxyvitamin D (25-OHD) level in psoriasis patients was 22.865±11.386 ng/ml, whereas in controls it was 35.116±11.048 ng/ml (p&lt;0.001). Serum level of 25-OHD in psoriatic patients was deficient (&lt;20 ng/ml) in 26 (52%), insufficient (20-30 ng/ml) in 8 (16%) psoriatic patients.</p><p class="abstract"><strong>Conclusions:</strong> High prevalence of low vitamin D level was found in this study. We infer that vitamin D does play a role in the pathogenesis, precipitation, exacerbation, or treatment resistance of psoriasis.</p><p> </p>

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