scholarly journals Duration of exposure dependent effect of carbamate treated net on serum lipid profile of Wistar rats

2021 ◽  
Vol 27 (1) ◽  
pp. 27-34
Author(s):  
R.U. Ukpanukpong ◽  
L.K. Eban ◽  
G.I. Ekpo ◽  
U.I. Aletan ◽  
D.D. Asuquo
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Dependent Effect

The duration of exposure dependent effect of Carbamate treated net on serum lipid profile of female Wistar rats was investigated in this study. Eighteen (18) animals were randomly divided into three (3) study groups with six (6) rats each. Group 1 was designated as the control group while groups 2 and 3 constituted the experimental groups containing rats exposed to Carbamate treated net for 30 and 60 days respectively. The rats were exposed daily to Carbamate treated net by whole body and nose inhalation mode of exposure. The body weight of rats was measured at the commencement of the experiment and at the end of the experiment. The organ weight result obtained indicated that the body weight increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The result obtained indicated that the body weight increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations in the sera of the rats were determined at the end of the experiment. The result obtained showed that the TC, TG, HDL-C and LDL-C levels increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The observation from this study suggests that long-term exposure to Carbamate treated net in household setting may alter the level of the serum lipid profile of the experimental animals, thereby leading to various health complications.

scholarly journals Effect of short-term naturopathy and yoga intervention on anthropometric variables, lipid profile and thyroid profile in obese hypothyroid patients: a randomised controlled trial

2020 ◽  
Vol 9 (2) ◽  
pp. 247
Author(s):  
Geetha B. Shetty ◽  
Balakrishna Shetty ◽  
Prashanth Shetty
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Thyroid Profile ◽  
Hypothyroid Patients

Background: Hypothyroidism reflects decreased thyroid function and is one of the most common conditions seen in clinical practice. Practice of naturopathy and yoga has shown improvement in anthropometric variables and lipid profile in obesity and other chronic diseases. So, the aim of this study was to find out the effect of naturopathy and yoga in obese hypothyroid patients.Methods: A total of 60 subjects, of which 29 males (age 44.2±7.0 years) and 31 females (age 40.6±7.4 years) with body mass index (BMI), ≥30 were randomly assigned to case group (n=30) and wait list control group (n=30). The subjects of case group underwent naturopathy and yoga intervention for 10 days. Anthropometric variables, viz., body weight, BMI, waist circumference (WC) and hip circumference, serum lipid profile, and serum thyroid profile were assessed at 1st day (pre), at the end of 10 day (post).Results: The result showed a significant reduction in body weight, BMI, WC, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and thyroid stimulating hormone (TSH) along with significant improvement in high density lipoprotein-cholesterol (HDL-C) in case group compared with control group in independent samples t test. Significant reduction in body weight, BMI, total cholesterol, LDL-C and TSH were observed in case group unlike in control group in student's paired t test.Conclusions: Reduction in the body weight, BMI and improvement in serum lipid profile and serum thyroid profile in case group subjects compared to control group suggest that naturopathy and yoga have therapeutic and protective effects in the management of obese hypothyroid patients.

scholarly journals Study of gallbladder lesions and its relationship with serum lipid profile

2018 ◽  
Vol 5 (5) ◽  
pp. 1245
Author(s):  
Sushama Bhatta ◽  
Samir Singh
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Chronic Cholecystitis ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
P Value ◽  
Low Density Lipoprotein Cholesterol ◽  
Histopathological Lesion

Background: Gallbladder disease is one of the most common gastrointestinal diseases. Various studies have shown association between gallstone and alteration in serum lipids. The objective of this study was to evaluate histological patterns of cholecystectomy specimens and compare serum lipid profile of gallstone patients with controls.Methods: This study was conducted over a period of two years (April 2016 to April 2018). Records of 287 specimens who underwent cholecystectomy were analysed in which gallstones were found only in 186 patients. Out of 186 patients with gallstones, records of serum lipid profile were available in 32 patients which were compared with 32 control of similar age. Independent t- test was used to compare the data between cases and control.Results: Out of 287 cases, 68 were male and 219 were female with male to female ratio of 1:3.2. The predominant histopathological lesion was chronic cholecystitis (73.17%). Malignancy was observed in 0.7% cases. Serum total cholesterol, triglycerides and low density lipoprotein cholesterol were found to be higher and statistically significant in patients with gallstone compared to controls (p value 0.024, <0.001and 0.016 respectively). Serum High density lipoprotein cholesterol was lower in gallstone patient than in control but not statistically significant (p value 0.23).Conclusions: Chronic cholecystitis was the most common histopathological lesion. Serum total cholesterol, triglyceride and low density lipoprotein cholesterol level were elevated and statistically significant in patients with gallstone.

scholarly journals Provitamin A Cassava Hydrolysate with Lactobacillus rhamnosus Gg Improves Serum Lipid Profile in Wistar Rats

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 445-445
Author(s):  
Modupeola Oguntoye ◽  
Olufunke Ezekiel
Keyword(s):  
Body Weight ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Weight Management ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Lactobacillus Rhamnosus ◽  
Density Lipoprotein ◽  
Provitamin A ◽  
Lactobacillus Rhamnosus Gg

Abstract Objectives There is considerable interest in the development of high quality food products and dietary supplements that help in weight management. Drug intervention could have a negative side effect. Consumption of probiotics such as Lactobacillus rhamnosus GG cells through food products could offer a positive approach to weight management. Thus, probiotic beverages could serve as a healthy alternative in weight management. The objective of this study is to determine the effect of probiotic beverage such as provitamin A cassava hydrolysate carrying Lactobacillus rhamnosus GG in weight management. Methods Provitamin A cassava hydrolysate was inoculated with free (PHF) or alginate-encapsulated (PHE) Lactobacillus rhamnosus GG (LGG) cells in doses 1, 2 or 4 × 1010 CFU/ml, and administered orally to adult Wistar rats (120–150 g, n = 40 males, 8 groups). All rats were dosed orally once daily for 4 weeks, recording weekly body weight changes as percentage change, and compared against Control (distilled water). Serum lipid profile (total cholesterol, triglycerides and high density lipoprotein) were determined after sacrificing the rats. Data were analyzed using descriptive statistics and ANOVA at α0.05. Results The body weight gain in control rats was significantly higher (α0.05) by the end of the 4th week (40.00%) than PHF or PHE groups at doses 1, 2 or 4 × 1010 CFU/ml (34.59, 24.38 and 8.04%, or 30.34, 23.49 and 18.24% respectively) which reduced with increasing doses. Total cholesterol, triglycerides and high density lipoprotein were higher in control rats (65.40, 56.60 and 29.48 mg/dL respectively) than in PHF or PHE groups at dose 4 × 1010 CFU/ml (54.60, 44.40 and 27.48 mg/dL, and 62.40, 46.60 and 23.12 mg/dL respectively). Conclusions Provitamin A cassava hydrolysate with L. rhamnosus GG was able to induce a transient weight reduction in rats, owing to its potential in reducing serum cholesterol and exerting anti-obesity effect. Thus it could be consumed as a beverage targeting weight management. Funding Sources Self.

Serum lipid and electrolyte profiles of Wistar rats fed with Vernonia amygdalina supplemented Vigna subterranea (Bambara groundnut) pudding

2020 ◽  
Vol 3 ◽  
pp. 40-45
Author(s):  
Godwin E. Egbung ◽  
Nyakno A. Essien ◽  
John E. Mgbang ◽  
Josephine E. Egbung
Keyword(s):  
Lipid Profile ◽  
Normal Control ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Total Cholesterol Level ◽  
Bambara Groundnut ◽  
The Body ◽  
Serum Lipid Profile ◽  
Vernonia Amygdalina ◽  
Group 2

Objective: This study investigated the effects of Vernonia amygdalina supplementation on Vigna subterrenea (bambara groundnut) pudding on serum lipid profile and electrolyte levels in Wistar rats. Materials and Methods: Twenty five weanling rats were randomly selected into 5 groups of 5 rats each. Group 1 received normal rat pellet. Groups 2 and 3 received 10% and 5% (w/w) non supplemented bambara pudding, respectively. Groups 4 and 5 were fed with 10% and 5% (w/w) Vernonia supplemented bambara pudding, respectively, for 21 days. The animals were sacrificed using anaesthesia at the end of the experiment and blood sample collected for serum lipid profile and serum electrolyte determinations using standard methods. Results: There was a significant increase (p<0.05) in total cholesterol level in groups 2 (1.64 ± 0.01 mmol/L) and 4 (1.66 ± 0.01 mmol/L) compared to normal control (1.31 ± 0.02 mmol/L). Triacylglycerol level increased significantly in groups 2, 3, and 4 compared to normal control. The high density lipoprotein cholesterol (HDL-c) and Serum sodium level were significantly increased (p < 0.05) in group 2 and 4 respectively compared to the normal control. Potassium, chloride, bicarbonate and calcium levels showed significant increases in group 2 relative to normal control. Phosphate level decreased significantly in group 2 (1.37 ± 0.03 mmol/L), 3 (1.43 ± 0.03 mmol/L) and 5 (1.37 ± 0.03 mmol/L) when compared to normal control (1.75 ± 0.03 mmol/L) respectively. Conclusion: Consumption of bambara groundnut pudding supplemented with Vernonia leaves increases HDL-c level as well as supply appreciable amounts of electrolytes in the body.

scholarly journals Randomized Control Trial Study On The Effect Of Wet Cupping On Lipid Profile

2020 ◽  
Vol 16 (2) ◽  
Author(s):  
Suhaily MH ◽  
Ismail AA ◽  
Najib MY
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Controlled Trial ◽  
Low Density Lipoprotein ◽  
Venous Blood ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
The Third

Introduction: Dyslipidaemia is one of the risk factors contributing to the pathogenesis of cardiovascular   diseases (CVDs). This study was conducted to investigate the effect of wet cupping on lipid profile. Methods: This randomized controlled trial was conducted in 2012 at the School of Medical Sciences, Universiti Sains Malaysia, Malaysia. Sixty-two healthy volunteers ranging from 30 to 60 years old were randomized into control and intervention groups. Subjects in the intervention group were assigned to two sessions of wet cupping at the beginning of the study and at the third month; individuals in the control group did not undergo any cupping procedure. Venous blood sample was collected for serum lipid profile: Total Cholesterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), and triglycerides; measured at baseline, first, third and fourth month. Results: Subjects in the cupping group had significant improvements from baseline to third and fourth month for TC (MD=-0.56, P=0.004), HDL-C (MD=-0.22, P<0.001) and LDL-C (MD=0.58, P=0.001). There was also a significant reduction from baseline to one month for triglycerides (MD=0.38, P<0.001). Subjects in the cupping group had significantly better values in HDL-C and LDL-C as compared with the control group at the third and fourth month. Significantly lower levels of TC and triglycerides in the cupping group of the fourth month. In the control group, there were no significant changes in any serum lipid profiles. Conclusion: After two sessions of wet cupping, TC, HDL-C, LDL-C and triglycerides were significantly improved by 8.2%, 13.7%, 16.4% and 20.8% respectively.

scholarly journals Serum lipid profile of broilers fed diets with inclusion of mango waste meal

2016 ◽  
Vol 37 (5) ◽  
pp. 3327 ◽  
Author(s):  
Patrícia Aparecida Fontes Vieira ◽  
Christiane Silva Souza ◽  
Anderson De Almeida Barbosa ◽  
Heder José D’Ávila Lima ◽  
Edimar Aparecida Filomeno Fontes ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Albumin Concentration ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

We evaluated the effect of including 2.5, 5.0, 7.5 and 10.0% mango waste meal (MWM) variety UBA in corn and soybean meal-based diet son the serum lipid profile of broilers. The experimental design was completely randomized, with five treatments and six replicates with 20 birds per experimental unit. Concentrations of creatinine, albumin, total protein, total cholesterol, triacylglycerols (TAG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very-low-density lipoprotein cholesterol (VLDL-C), were evaluated at the ages of 14, 28 and 42 days, with 30 birds evaluated per age. At 14 days, there was no difference serum creatinine, total cholesterol, HDL, triacylglycerols, total proteins or VLDL-C concentrations as compared with control. Albumin concentration was the highest at the MWM inclusion levels of 5.0, 7.5 and 10.0%. At 28 days, triacylglycerols, VLDL-C and LDL-C were the lowestat 7.5% inclusion whereas at 42 days, these same variables were the lowest with addition of 10.0% meal. At 14, 28 and 42 days of age, the VLDL-C, LDL-C and total TAG contents were found to decrease at mango waste meal inclusion levels of 5.0 and 7.5% in the diets, which maybe considered an indicator of improvements in the metabolic conditions of broilers.

scholarly journals Evaluation of Predictor like Maternal Serum Lipid Profile in 2nd Trimester in Pregnancy Related Hypertensive Disorders

2021 ◽  
pp. 195-201
Author(s):  
Arpita Jaiswal ◽  
Dhruva Halani
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Clinical Symptoms ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Maternal Serum ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Hypertensive Disorders ◽  
In Pregnancy

Background: The most leading cause of perinatal and maternal deaths and morbidity in developed and developing countries like India is pregnancy related hypertensive disorders especially pre-eclampsia. PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes.    Increased TG, low-density lipoprotein cholesterol (LDL-C), cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) concentrations leading to dyslipidemia was found in majority of the studies. Aim: The study aims to evaluate predictor like maternal sr. lipid profile in 2nd trimester in pregnancy related hypertensive disorders. Objective: To evaluate the occurrence of normal maternal and altered maternal serum lipid profile serum lipid profile in 2nd trimester of pregnancy in pregnancy related hypertensive disorders and compare them . Materials and Methods: The design of the study will be prospective as well as observational conducted from September 2020 to august 2022 with an estimated sample size of 1000. Patients included were nnormotensive and non-proteinuric in second trimester (13-20 weeks of gestation). Subjects will be evaluated on the basis of preformed and pretested proforma consisting of history, clinical symptoms and presentation and investigations. Blood samples for serum lipid profile will be collected in plain bulb with aseptic conditions and analyzed at the biochemistry laboratory by enzymatic method. Expected Results: We expect that from our results, altered maternal serum lipid profile in 2nd trimester will be positively associated with pregnancy related hypertensive disorders.

scholarly journals Effect of Stellaria media Tea on Lipid Profile in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Virág Demján ◽  
Tivadar Kiss ◽  
Andrea Siska ◽  
Márton Richárd Szabó ◽  
Márta Sárközy ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Stellaria Media ◽  
Experimental Proof ◽  
Cardiac Morphology ◽  
Liver And Kidney ◽  
And Function

Background. In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media tea in hypercholesterolemic rats. Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media tea lyophilizate for 8 weeks. Blood samples were collected to determine serum lipid profile as well as liver and kidney function, and echocardiography was performed to assess cardiac morphology and function. Results. Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media tea lyophilizate. Conclusion. Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia.

scholarly journals Correlation between hemoglobin A1c and serum lipid profile in Afghani patients with type 2 diabetes: hemoglobin A1c prognosticates dyslipidemia

2017 ◽  
Vol 8 (4) ◽  
pp. 51-57 ◽  
Author(s):  
Arshad Hussain ◽  
Iftikhar Ali ◽  
Muhammad Ijaz ◽  
Afaq Rahim
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Hemoglobin A1c ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Preventive Measure ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile

Background: Patients with type 2 diabetes (T2DM) have an increased prevalence of dyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). This study is an attempt to determine the correlation between hemoglobin A1c (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia in Afghani patients with T2DM. Methods: A total of 401 Afghani patients with T2DM (men, 175; women, 226; mean age, 51.29 years) were included in this study. The whole blood and sera were analyzed for fasting blood sugar (FBS), HbA1c, total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Dyslipidemia was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Diabetes was defined as per American Diabetes Association criteria. The correlation of FBS, HbA1c with lipid ratios and individual lipid indexes were analyzed. The statistical analysis was done by SPSS statistical package version 16.0. Results: The mean age ± standard deviation of male and female patients were 51.71 ± 11.70 and 50.97 ± 10.23 years respectively. There was a significant positive correlation between HbA1c, TC, TG, LDL-C and LDL-C/HDL-C ratio. The correlation between HbA1c and HDL-C was negative and was statistically nonsignificant. Furthermore, HbA1c was found to be a predictor of hypercholesterolemia, LDL-C and TG via a linear regression analysis. Patients with HbA1c value greater than 7.0% had significantly higher value of cholesterol, LDL-C, and LDL-C/HDL-C ratio compared with patients with an HbA1c value up to 7.0%. Conclusions: Apart from a reliable glycemic index, HbA1c can also be used as a predictor of dyslipidemia and thus early diagnosis of dyslipidemia can be used as a preventive measure for the development of CVD in patients with T2DM.

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