Assessment of Potential Abatement provided by <i>Annona Muricata</i> (Prickly Custard Apple Leave) on the Toxic Effects of Aluminium Chloride on Albino Rats

In this study, the effects of 3-benzoyl-7-hydroxy coumarin molecule on mineral and antioxidant enzymes were investigated in rat liver exposed to oxidative stress with aluminium chloride (AlCl3). Adult male Wistar albino rats were divided into four groups as Control, Coumarin, AlCl3, and Coumarin + AlCl3. Coumarin at the dose of 10 mg/kg and AlCl3 at the dose of 8.3 mg/kg were administered for 30 days every other day. In AlCl3 group, malondialdehyde (MDA), iron (Fe), aluminium (Al) and copper (Cu) levels increased compared to the control group, while glutathione (GSH) level, glutathione S-transferase (GST), and carboxylesterase (Ces) enzyme activity levels decreased. In Coumarin + AlCl3 group, MDA, Fe, Al and Cu levels decreased with the effect of coumarin compared to AlCl3 group, while GSH level, and GST enzyme activity levels increased. According to our results, AlCl3 generates oxidative stress in rat livers, and we believe that 3-benzoyl-7-hydroxy coumarin has an ameliorative effect on antioxidant enzyme system, Al, Fe and Cu levels.

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Toxic Effects of Orlistat and Green Tea Extract on Testes of Adult Albino Rats:(Comparative Study)

Zagazig Journal of Forensic Medicine ◽

10.21608/zjfm.2021.96396.1092 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

yara elfakharany ◽

laila sabik ◽

Doaa Metwally ◽

eman Mohamed

Keyword(s):

Comparative Study ◽

Green Tea ◽

Green Tea Extract ◽

Toxic Effects ◽

Albino Rats ◽

Tea Extract

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Histoloical and Biochemichal Study on the Toxic Effects of Bisphenol A on the Thyroid Gland of Adult Male Albino Rats and the Possible Protection by Selenium

Egyptian Journal of Histology ◽

10.21608/ejh.2019.6757.1055 ◽

2019 ◽

Vol 42 (3) ◽

pp. 667-685

Author(s):

Heba Mohamed ◽

Amal Rateb

Keyword(s):

Thyroid Gland ◽

Bisphenol A ◽

Adult Male ◽

Toxic Effects ◽

Albino Rats

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POSTNATAL TOXIC EFFECTS OF FENITROTHION AND LEAD ACETATE IN ALBINO RATS

Mansoura Veterinary Medical Journal ◽

10.21608/mvmj.2017.190179 ◽

2017 ◽

Vol 18 (1) ◽

pp. 141-158

Author(s):

Mamdouh Abouelmagd ◽

Fathy Seleem ◽

M Abd-elgawad ◽

Fatma Abdelhamid ◽

Mohamed Hamed ◽

...

Keyword(s):

Lead Acetate ◽

Toxic Effects ◽

Albino Rats

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Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: An in vivo study

Toxicology and Industrial Health ◽

10.1177/0748233720933071 ◽

2020 ◽

Vol 36 (6) ◽

pp. 446-453

Author(s):

Salma Awad Taghyan ◽

Hend El Messiry ◽

Medhat Ahmed El Zainy

Keyword(s):

Silver Nanoparticles ◽

Ascorbic Acid ◽

Vitamin C ◽

Protective Effect ◽

Toxic Effect ◽

Toxic Effects ◽

Control Group ◽

Albino Rats ◽

Parotid Glands ◽

Ductal Cells

This study aimed to evaluate the toxic effect of silver nanoparticles (AgNPs) on the parotid glands (PGs) of albino rats histologically and ultrastructurally and assess the possible protective effect of ascorbic acid as an antioxidant. Thirty male albino rats weighing between 150 mg and 200 mg were divided into three groups: the control group (C1) contained 10 rats that received 2 mg/kg (body weight (bw)) of aqueous nitrate buffer by intraperitoneal (IP) injection daily for 28 days; the AgNPs group contained 10 rats that received 2 mg/kg (bw) IP AgNPs daily for 28 days; and the AgNPs-vitamin C group contained 10 albino rats that received 2 mg/kg (bw) AgNPs IP daily for 28 days with oral administration of 100 mg/kg (bw) vitamin C in drinking water daily for 28 days. The PG acinar and ductal cells of the AgNPs group showed signs of toxicity and degeneration characterized as pleomorphic nuclei, binucleation, cytoplasmic vacuolations, and stagnated secretion in the ductal lumen. In addition to degenerated mitochondria, dilated rough endoplasmic reticulum and lysosomes were filled with AgNPs ( p < 0.001). The AgNPs-vitamin C group showed significantly less degenerative changes histologically and ultrastructurally compared to the AgNPs group ( p = 0.002). AgNPs produced significant toxic effects on the PG of albino rats, presumably through the generation of reactive oxygen species and toxic ion release, and administration of vitamin C was shown effective in decreasing these toxic effects.

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Short term chronic toxicity of tributyltin on the testes of adult albino rats and the possible protective role of omega-3

Human & Experimental Toxicology ◽

10.1177/0960327120947451 ◽

2020 ◽

pp. 096032712094745

Author(s):

Marwa G Ahmed ◽

Mona El-Demerdash Ibrahim ◽

Hoda R El Sayed ◽

Samah M Ahmed

Keyword(s):

Treated Group ◽

Toxic Effects ◽

Cellular Damage ◽

Antioxidant Defenses ◽

Control Group ◽

Albino Rats ◽

Omega 3 ◽

Group I

The declining rate of male fertility is a growing concern. Tributyltin (TBT) is a well-known endocrine disruptor (ED), that induces imposex in female gastropods and is widely used in various industrial applications. The aim of this study was to evaluate the toxic effects of TBT on the testes of adult albino rats and the possible role of omega-3. Forty two adult male albino rats were divided into five groups; control group (Group I) and four experimental groups: omega-3 treated group, TBT treated group, TBT & omega-3 treated group and follow up group. At the end of the study, the rats were subjected to biochemical, histological, immunohistochemical staining for Ki-67 and seminal examinations. Our results clarfied that TBT induced a significant decrease in testosterone, FSH, LH and serum glutathione peroxidase levels and a significant increase in the serum Malondialdehyde as compared to the control group. Tributyltin induced disorganization and shrinkage of seminiferous tubules, apoptosis, cellular damage and marked reduction in the germinal epithelium. A significant decrease in the cell proliferation and arrested spermatogenesis were also detected. Seminal analysis of TBT group showed a significant affection of all parameters as compared to other groups. Omega-3 ameliorated all of these hazardous effects. Follow up group still showed toxic effects. In conclusion, TBT has a toxic effect on the testis. Increased testicular oxidative stress, cellular damage and arrest of spermatogenesis with attenuation in antioxidant defenses are all contributing factors. Omega-3 can protect against TBT induced reproductive toxicity.

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