Toxicity and Role of Fumonisins in Animal Diseases and Human Esophageal Cancer

1994 ◽  
Vol 57 (6) ◽  
pp. 522-527 ◽  
Author(s):  
WILLIAM P. NORRED ◽  
KENNETH A. VOSS
Keyword(s):  
Esophageal Cancer ◽  
Fusarium Proliferatum ◽  
Brain Lesions ◽  
Lung Edema ◽  
Laboratory Rats ◽  
The World ◽  
Causative Agents ◽  
Human Esophageal Cancer ◽  
Action Levels

Fumonisins are secondary metabolites of Fusarium moniliforme, Fusarium proliferatum and several other Fusaria that commonly contaminate corn. Only recently discovered in 1988, these mycotoxins appear to be the causative agents of several toxicoses in animals that result from ingestion of moldy corn or corn-based feeds. The syndromes observed vary considerably among the different species affected and include brain lesions in equids, lung edema in swine, and nephrotoxicity, hepatotoxicity and hepatocellular carcinoma in laboratory rats. There is also evidence that suggests that F. moniliforme and fumonisins may also be responsible for esophageal cancer in humans in certain areas of the world where moldy corn is frequently consumed. Studies are currently underway to determine the extent of the hazards posed by fumonisins, and whether controls in the form of regulatory action levels may be necessary.

scholarly journals Expression and biological role of DKK1 in human esophageal cancer

2011 ◽  
Vol 19 (20) ◽  
pp. 2116
Author(s):  
Shu-Jun Li ◽  
Yu-Zheng He ◽  
Bao-Lei Lv ◽  
Xiu-Lan Niu ◽  
Ai-Rong Cui ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Biological Role ◽  
Human Esophageal Cancer

Assessment of Human Exposure to Fumonisin B1

1998 ◽  
Vol 61 (7) ◽  
pp. 879-884 ◽  
Author(s):  
MONIQUE de NIJS ◽  
HANS P. van EGMOND ◽  
MAARTEN NAUTA ◽  
FRANK M. ROMBOUTS ◽  
SERVÉ H. W. NOTERMANS
Keyword(s):  
Esophageal Cancer ◽  
The Netherlands ◽  
Human Exposure ◽  
Human Population ◽  
Fumonisin B1 ◽  
Contamination Level ◽  
Fusarium Spp ◽  
Gluten Intolerance ◽  
The World ◽  
Human Esophageal Cancer

Fumonisin B1 is currently regarded as the most significant mycotoxin produced by Fusarium spp. It has carcinogenic properties and may play a role in the etiology of human esophageal cancer. The human population is exposed to fumonisin B1 primarily by intake of fumonisin B1-contaminated maize. Maize consumed in the Netherlands is imported from all parts of the world. Since processing will not affect the overall toxic effect, the fumonisin B1 intake is directly related to the quantity of maize consumed. Literature results concerning the occurrence of fumonisin B1 in a total of 349 samples of maize from 18 countries worldwide demonstrated the presence of this mycotoxin in 93% of the samples. The median fumonisin B1 contamination of all samples was 420 ng of fumonisin B1 per g of maize, and the average contamination level was 1,359 ng of fumonisin B1 per g of maize. Human intake of fumonisin B1 was estimated based on the maize consumption of all people in the Netherlands in 1992. A probability distribution was derived to allow estimation of the exposure of the population to fumonisin B1 intake in relation to maize intake. It showed that among those in the group considered to be at risk, people with gluten intolerance such as people with celiac or Dühring's disease, 37% are estimated to be exposed to an intake of at least 105 ng and 97% to an intake of at least 103 ng of fumonisin B1 per person per day. For all people in the Netherlands these percentages would be 1% and 49%, respectively.

scholarly journals Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress

2016 ◽  
Vol 38 (3) ◽  
pp. 1226-1244 ◽  
Author(s):  
Yingtong Feng ◽  
Yang Yang ◽  
Chongxi Fan ◽  
Shouyin Di ◽  
Wei Hu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Esophageal Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Apoptotic Index ◽  
Related Protein ◽  
Apoptosis Related Protein ◽  
Human Esophageal Cancer ◽  
Esophageal Cancer Cells

Background/Aims: Pterostilbene (PTE), a natural dimethylated resveratrol analog from blueberries, is known to have diverse pharmacological activities, including anticancer properties. In this study, we investigated the anticancer activity of PTE against human esophageal cancer cells both in vitro and in vivo and explored the role of endoplasmic reticulum (ER) stress (ERS) signaling in this process. Methods: Cell viability, the apoptotic index, Caspase 3 activity, adhesion, migration, reactive oxygen species (ROS) levels, and glutathione (GSH) levels were detected to explore the effect of PTE on human EC109 esophageal cancer cells. Furthermore, siRNA transfection and a chemical inhibitor were employed to confirm the role of ERS. Results: PTE treatment dose- and time-dependently decreased the viability of human esophageal cancer EC109 cells. PTE also decreased tumor cell adhesion, migration and intracellular GSH levels while increasing the apoptotic index, Caspase 3 activity and ROS levels, which suggest the strong anticancer activity of PTE. Furthermore, PTE treatment increased the expression of ERS-related molecules (GRP78, ATF6, p-PERK, p-eIF2α and CHOP), upregulated the pro-apoptosis-related protein PUMA and downregulated the anti-apoptosis-related protein Bcl-2 while promoting the translocation of cytochrome c from mitochondria to cytosol and the activation of Caspase 9 and Caspase 12. The downregulation of ERS signaling by CHOP siRNA desensitized esophageal cancer cells to PTE treatment, whereas upregulation of ERS signaling by thapsigargin (THA) had the opposite effect. N-Acetylcysteine (NAC), a ROS scavenger, also desensitized esophageal cancer cells to PTE treatment. Conclusions: Overall, the results indicate that PTE is a potent anti-cancer pharmaceutical against human esophageal cancer, and the possible mechanism involves the activation of ERS signaling pathways.

scholarly journals PD-L1 Expression Promotes Epithelial to Mesenchymal Transition in Human Esophageal Cancer

2017 ◽  
Vol 42 (6) ◽  
pp. 2267-2280 ◽  
Author(s):  
Lujun Chen ◽  
Yuqi Xiong ◽  
Jing Li ◽  
Xiao Zheng ◽  
Qi Zhou ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
Cancer Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Esophageal Cancer Cell ◽  
Human Esophageal Cancer ◽  
Cancer Tissues

Background/Aims: PD-L1 (Programmed cell death 1 ligand 1, PD-L1), an essential immune checkpoint molecule in the tumor microenvironment, is an important target for cancer immunotherapy. We have previously reported that its expression in human gastric and esophageal cancer tissues is significantly associated with cancer progression and patients’ postoperative prognoses. Its expression in cancer cells is well known to inhibit the T cell-mediated anti-tumor response, and this mechanism of action has been targeted for cancer immunotherapy. As of now, the autonomous effect of PD-L1 on cancer cells is not well understood, thus our present study aimed to examine the role of PD-L1 intervention in cellular biological functions, especially epithelial to mesenchymal transition (EMT), of the human esophageal cancer cell line, Eca-109 cells. Methods: Immunohistochemistry assay was used to investigate the correlation between expression of PD-L1 and EMT markers in human esophageal cancer tissues. Intervention of PD-L1 by using RNAi and over-expression methods were used to study the role of PD-L1 in regulation of biological behaviors and EMT in Eca-109 cells. Results: Our clinical and pathological data demonstrated that tumor samples in the EMT positive subgroup had higher PD-L1 expression than those in the EMT negative subgroup. By manipulating PD-L1 expression in Eca-109 cells either through ablation or overexpression of wild type and the cytoplasmic domain-truncated mutant, we demonstrated that PD-L1 expression significantly promoted the cell viability, migration and EMT phenotype. Furthermore, our study also indicated that PD-1 fusion protein mediated stimulation of PD-L1 and the cytoplasmic domain of PD-L1 played a critical role in promoting EMT phenotype of Eca-109 cells, thereby suggesting that PD-1 receptor usually by triggering the reverse signaling can effect PD-L1 mediated regulation of esophageal cancer cell response. Conclusion: Our present study reveals a tumor cell-autonomous role of PD-L1 signaling in promoting EMT in human esophageal cancer.

The essence and causes of the spiritual and moral decline of mankind in the XX century

1998 ◽  
pp. 124-127
Author(s):  
V. Tolkachenko
Keyword(s):  
Well Being ◽  
Religious Institutions ◽  
Social Force ◽  
The World ◽  
Role Of Religion

One of the most important reasons for such a clearly distressed state of society was the decline of religion as a social force, the external manifestation of which is the weakening of religious institutions. "Religion," Baha'u'llah writes, "is the greatest of all means of establishing order in the world to the universal satisfaction of those who live in it." The weakening of the foundations of religion strengthened the ranks of ignoramuses, gave them impudence and arrogance. "I truly say that everything that belittles the supreme role of religion opens way for the revelry of maliciousness, inevitably leading to anarchy. " In another Tablet, He says: "Religion is a radiant light and an impregnable fortress that ensures the safety and well-being of the peoples of the world, for God-fearing induces man to adhere to the good and to reject all evil." Blink the light of religion, and chaos and distemper will set in, the radiance of justice, justice, tranquility and peace. "

The problem of periodization of the history of religion

1997 ◽  
pp. 3-8
Author(s):  
Borys Lobovyk
Keyword(s):  
Religious Studies ◽  
Human Being ◽  
Religious Development ◽  
History Of Religion ◽  
The Social ◽  
The World ◽  
History Of ◽  
Role Of Religion

An important problem of religious studies, the history of religion as a branch of knowledge is the periodization process of the development of religious phenomenon. It is precisely here, as in focus, that the question of the essence and meaning of the religious development of the human being of the world, the origin of beliefs and cult, the reasons for the changes in them, the place and role of religion in the social and spiritual process, etc., are converging.

External Factors of Big Business Transformation in Russia

2005 ◽  
pp. 72-89 ◽  
Author(s):  
Ya. Pappe ◽  
Ya. Galukhina
Keyword(s):  
Financial Market ◽  
Capital Market ◽  
Business Groups ◽  
External Factors ◽  
Big Business ◽  
Business Transformation ◽  
Global Standards ◽  
The World ◽  
Principal Subject

The paper is devoted to the role of the global financial market in the development of Russian big business. It proves that terms and standards posed by this market as well as opportunities it offers determine major changes in Russian big business in the last three years. The article examines why Russian companies go abroad to attract capital and provides data, which indicate the scope of this phenomenon. It stresses the effects of Russian big business’s interaction with the world capital market, including the modification of the principal subject of Russian big business from integrated business groups to companies and the changes in companies’ behavior: they gradually move away from the so-called Russian specifics and adopt global standards.

Thoughts on the Long-Term Strategy, Science and Democracy

2006 ◽  
pp. 4-19 ◽  
Author(s):  
L. Abalkin
Keyword(s):  
Strategy Development ◽  
Russian Science ◽  
Global Trends ◽  
The World ◽  
World Development ◽  
Crucial Condition

The article covers unified issues of the long-term strategy development, the role of science as well as democracy development in present-day Russia. The problems of budget proficit, the Stabilization Fund issues, implementation of the adopted national projects, an increasing role of regions in strengthening the integrity and prosperity of the country are analyzed. The author reveals that the protection of businessmen and citizens from the all-embracing power of bureaucrats is the crucial condition of democratization of the society. Global trends of the world development and expert functions of the Russian science are presented as well.

On retroeconomy

2017 ◽  
pp. 148-159
Author(s):  
V. Papava
Keyword(s):  
Developing Countries ◽  
Detrimental Effect ◽  
International Competition ◽  
The World ◽  
The Government ◽  
Role Of The Government

This paper analyzes the problem of technological backwardness of economy. In many mostly developing countries their economies use obsolete technologies. This can create the illusion that this or that business is prosperous. At the level of international competition, however, it is obvious that these types of firms do not have any chance for success. Retroeconomics as a theory of technological backwardness and its detrimental effect upon a country’s economy is considered in the paper. The role of the government is very important for overcoming the effects of retroeconomy. The phenomenon of retroeconomy is already quite deep-rooted throughout the world and it is essential to consolidate the attention of economists and politicians on this threat.

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