Concentration and Prevalence of Aflatoxin M1 in Human Breast Milk in Iran: Systematic Review, Meta-Analysis, and Carcinogenic Risk Assessment: A Review

2019 ◽  
Vol 82 (5) ◽  
pp. 785-795 ◽  
Author(s):  
YADOLAH FAKHRI ◽  
RAHEB GHORBANI ◽  
MAHMOUD TAGHAVI ◽  
HASSAN KERAMATI ◽  
NAZAK AMANIDAZ ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Meta Analysis ◽  
Hazard Index ◽  
Carcinogenic Risk ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Human Breast ◽  
Male And Female ◽  
The Mean

ABSTRACTThis meta-analysis was designed to review the published reports regarding the concentration and/or prevalence of aflatoxin M1 (AFM1) in human breast milk in Iran. The carcinogenic risk for Iranian infants consuming this milk was estimated with the hazard index. The PubMed and Scopus databases and the Scientific Information Database were screened for relevant studies between 1995 and 2017, and 11 of the 112 collected studies were included in the systematic review and meta-analysis. The mean (95% confidence interval) concentration of AFM1 was 5.85 ng/L (4.54 to 7.15 ng/L), which was lower than the European Union standard (25 ng/L). The mean prevalence of AFM1 in breast milk in Iran was 42% (11 to 77%). The estimated daily intakes for male and female infants were 0.02 to 5.57 ng/kg and 0.02 to 3.68 ng/kg of body weight per day, respectively. The rank order of estimated daily intake for both male and female infants according to age was 1 week > 1 month > 6 months > 12 months. The hazard index for all age groups of infants in all provinces in Iran was less than 1. Therefore, infants in Iran were not considered at carcinogenic risk from AFM1 in human breast milk.

Aflatoxin M1 in human breast milk: A global systematic review, meta-analysis, and risk assessment study (Monte Carlo simulation)

2019 ◽  
Vol 88 ◽  
pp. 333-342 ◽  
Author(s):  
Yadolah Fakhri ◽  
Jamal Rahmani ◽  
Carlos Augusto Fernandes Oliveira ◽  
Larissa Tuanny Franco ◽  
Carlos Humberto Corassin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Assessment ◽  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Breast Milk ◽  
Meta Analysis ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Human Breast ◽  
Assessment Study

Concentrations of bisphenols, parabens, and benzophenones in human breast milk: A systematic review and meta-analysis

2021 ◽  
pp. 150437
Author(s):  
L.M. Iribarne-Durán ◽  
F.M. Peinado ◽  
C. Freire ◽  
I. Castillero-Rosales ◽  
F. Artacho-Cordón ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Meta Analysis ◽  
Human Breast Milk ◽  
Human Breast

Human Breast Milk Assessed by the Deuterium Dose Mother Technique with Less Than 30 g Deuterium Using the Agilent 4500S for Fourier Transform Infrared Spectroscopy: A Pilot Study in the Democratic Republic of Congo

2020 ◽  
Author(s):  
Christine Chimanuka Murhima’Alika ◽  
Ghislain Maheshe Balemba ◽  
Daniella Bugugu Mapendo ◽  
Aminata Kapapa ◽  
Grace Munthali ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Breast Milk ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Human Breast Milk ◽  
Human Breast ◽  
Lactating Mothers ◽  
Milk Output ◽  
The Mean ◽  
Different Doses

Abstract Background: Good breastfeeding practice is essential in preventing malnutrition in children. The deuterium method is the best technique for assessing human breast milk output. We investigated whether deuterium doses < 30 g can be used to assess human breast milk using saliva and the new Agilent 4500S for Fourier transform infrared spectroscopy (FTIR). Methods: In a cross-sectional study, the breastmilk output of lactating mothers was evaluated using four different doses of deuterium in the Miti-Murhesa Health Zone (Democratic Republic of Congo). Lactating mothers of infants aged 3-23 months were recruited and assigned to a dosage group. Weight, height, and mid-upper arm circumference were measured and the body mass index calculated as weight/height2. Body composition (fat mass, free fat mass, total body water, and breastmilk output) was assessed using standard deuterium dilution methods. One-way ANOVA was used to compare the means in different groups and the chi² test to compare proportions. Results: Seventy-five lactating mothers were included in the study: 19 received 6 g, 20 received 10 g, 18 received 15 g, and 18 received 20 g deuterium. The mean ± standard deviation infant age was 10.6 ± 5.2, 11.1 ± 4.4, 10.9 ± 4.4, and 11.0 ± 3.9 months, respectively (p=0.076). We found no difference in the age and anthropometric parameters of the lactating mothers in the different groups. The mean ± standard deviation breast milk output rate was 796.6 ± 292.4, 260.8± 23.2, 749.8 ± 244.2, and 733.6 ± 207.1 g/d in the 6 g, 10 g, 15 g, and 20 g groups, respectively (p=0.883). Conclusions: The different doses of deuterium administered to lactating mothers resulted in similar breast milk output values. Thus, it is possible to evaluate human breast milk with deuterium doses <30 g when using the Agilent 4500S.

Occurrence of Ochratoxin A and Aflatoxin M1 in human breast milk in Sari, Iran

Food Control ◽  
2013 ◽  
Vol 31 (2) ◽  
pp. 525-529 ◽  
Author(s):  
P. Afshar ◽  
M. Shokrzadeh ◽  
S. Kalhori ◽  
Z. Babaee ◽  
S.S. Saeedi Saravi
Keyword(s):  
Breast Milk ◽  
Ochratoxin A ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Human Breast

Incidence of aflatoxin M1 in human breast milk in Tehran, Iran

Food Control ◽  
2009 ◽  
Vol 20 (1) ◽  
pp. 75-78 ◽  
Author(s):  
Naficeh Sadeghi ◽  
Mohammad Reza Oveisi ◽  
Behrooz Jannat ◽  
Mannan Hajimahmoodi ◽  
Hengameh Bonyani ◽  
...  
Keyword(s):  
Breast Milk ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Human Breast

Detection of Aflatoxin M1 in Human Breast Milk and Raw Cow's Milk in Istanbul, Turkey

2009 ◽  
Vol 72 (4) ◽  
pp. 885-889 ◽  
Author(s):  
YAŞAR KESKIN ◽  
RUHTAN BAŞKAYA ◽  
SEHER KARSLI ◽  
TÜRKAN YURDUN ◽  
OĞUZ ÖZYARAL
Keyword(s):  
Breast Milk ◽  
High Performance ◽  
Aflatoxin M1 ◽  
Cow’S Milk ◽  
Enzyme Linked Immunosorbent Assay ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cow's Milk ◽  
Milk Samples ◽  
Raw Cow’S Milk

This survey was undertaken to determine the extent of aflatoxin M1 (AFM1) contamination in human breast milk and raw cow's milk in Istanbul, Turkey. Samples of human and raw cow's milk were collected randomly and analyzed for AFM1 using an enzyme-linked immunosorbent assay and high-performance liquid chromatography with fluorescence detection in which the samples were cleaned up with immunoaffinity columns. In this study, AFM1 was detected in 8 (13.1%) of 61 human breast milk samples examined (mean ± SD level, 5.68 ± 0.62 ng/liter; range, 5.10 to 6.90 ng/liter) and 20 (33.3%) of 60 raw cow's milk samples examined (range, 5.40 to 300.20 ng/liter). Five (8.3%) of the positive raw cow's milk samples had AFM1 levels (153.52 ± 100.60 ng/liter; range, 61.20 to 300.20 ng/liter) that were higher than the maximum tolerance limit (0.05 ppb) stipulated by regulations in Turkey and some other countries.

scholarly journals Systematic Review Protocol for the Current State of Chemical Exposure in Infants via Breast Milk, Artificial Milk and Dairy Products

2021 ◽  
Vol 18 (9) ◽  
pp. 4436
Author(s):  
Manal A. M. Mahmoud ◽  
Hosnia Abdel-Mohsein ◽  
Usama Mahmoud ◽  
Zhaoqing Lyu ◽  
Sani Rachman Soleman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Primary Source ◽  
Chemical Exposure ◽  
Human Breast Milk ◽  
Human Breast ◽  
Current State ◽  
Full Text Review ◽  
Review Protocol ◽  
Milk And Dairy Products

Many studies have shown that human breast milk is contaminated with various chemicals. In the proposed systematic review, the aim is to identify and summarize the available literature regarding chemical exposure via breastfeeding or the feeding of artificial formula. MEDLINE (PubMed) will be the primary source in this literature search. Primary studies that analyzed one or more chemicals of interest in breast milk or artificial milk and that reported information on concentrations will be eligible for this review. Conference abstracts will not be included in the review unless access to the data is easy. First, the titles and abstracts of identified articles will be screened by two or more researchers. Then, a full-text review will be conducted to extract data from the included articles and code them for classification. The results of the search and classification will be summarized narratively and bibliometrically. The aim of the review is to analyze trends in publications according to year and region from the viewpoint of target chemicals, location, range of concentrations, and health outcomes.

IL-8 May Be the Target of Arsenic in Human Breast Milk

2020 ◽  
Author(s):  
Khodayar Ghorban ◽  
Maryam Dadmanesh ◽  
Mahmood Sheikh Fathollahi ◽  
Zeynab Rezai ◽  
Paria Ezati ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cytokine Production ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Dependent Manner ◽  
Positive Relation ◽  
Human Breast ◽  
Milk Samples ◽  
Milk Contamination ◽  
Normal Controls

Background and Aims: The critical aim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M1 (AFM1) on the milk levels of IL-6 and IL-8. Materials and Methods: Breast milk was collected from 76 mothers on the 30th day post-parturition and milk levels of AFM1, Nickel, Arsenic, IL-6 and IL-8 were evaluated. Results: The results showed 8 and 29 out of 76 collected samples being contaminated with AFM1, Nickel and Arsenic, respectively. Levels of IL-6 and IL-8 in the milk samples did not differ in AFM1 and Nickel and Arsenic contaminated milk compared with the normal controls (non-contaminated milks). There was a moderate positive relation between milk levels of IL-8 and Arsenic. Conclusions: Although AFM1, Nickel and Arsenic are the inducers of cytokine production; they are unable to induce secretion of IL-6 in breast milk. Arsenic can be a trigger of IL-8, which is a strong chemoattract for neutrophils. Thus, it appears that Arsenic may induce an inflammation in milk in IL-8 dependent manner.

Aflatoxin M1 in human breast milk in southeastern Turkey

2016 ◽  
Vol 33 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Serap Kılıç Altun ◽  
Semra Gürbüz ◽  
Emin Ayağ
Keyword(s):  
Breast Milk ◽  
Aflatoxin M1 ◽  
Human Breast Milk ◽  
Human Breast
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